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Panama Cruises

Are you looking for a cruise to Panama? Choose from 27 unique cruise itineraries to Panama, departing from Colon, Fort Lauderdale, Lima, Los Angeles, Miami and more. December and January are the most popular months to cruise to Panama and we have over 37 departures available from eleven of the world's leading cruise lines.
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8 Days
20 Days
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$21,670pp
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27 Cruises (37 Cruise Departures)
12 Day The Panama Canal & Costa Rica - Westbound with Tauck
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 18 January 2025
Trip Styles: Group, Cruise
Countries Visited: Panama, Costa Rica
From 14,250
View Trip
12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) San Jose to Panama City
Operated By: Tauck
Departures: Jan 2025 to Jan 2025
Trip Styles: Group, Cruise
Countries Visited: Costa Rica, Panama
From 13,640
View Trip
14 Day Chile, Peru & Panama Voyage with Azamara Cruises
Cruise
 (1)

14 Days (13 Nights) San Antonio to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 March 2026
Countries Visited: Chile, Peru, Panama
INSIDE
$5,330
OCEANVIEW
$6,365
BALCONY
$7,515
SUITE
$8,780
From 5,330
View Trip
8 Day Fort Lauderdale to Panama City with Silversea
Cruise

8 Days (7 Nights) Fort Lauderdale to Panama City
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 17 December 2024
Countries Visited: USA, Colombia, Panama
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$5,148
BALCONY
-
SUITE
-
From 5,148
View Trip
14 Day Highlights Of South America – Land And Sea Expedition with Hurtigruten
Tour + Cruise

14 Days Colon to Lima
Operated By: Hurtigruten
Ship: MS Fram
Departure: 06 October 2024
Countries Visited: Panama, Ecuador, Peru
Exclusive Deal
INSIDE
$19,313
OCEANVIEW
$20,598
BALCONY
-
SUITE
$22,835
Save 2,357
From 19,313
View Trip
8 Day Lima to Panama City with Silversea
Cruise

8 Days (7 Nights) Lima to Panama City
Cruise Line: Silversea
Ship: Silver Ray
Departure: 04 January 2025
Countries Visited: Peru, Ecuador, Panama
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$3,960
From 3,960
View Trip
8 Day A Journey Traversing The Panama Canal with Explora Journeys
Cruise

8 Days (7 Nights) Panama City to Miami
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 24 May 2024
Countries Visited: Panama, Colombia, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$6,583
SUITE
$7,672
From 5,593
View Trip
8 Day Panama City to Fort Lauderdale with Silversea
Cruise

8 Days (7 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 20 May 2025
Countries Visited: Panama, Colombia, USA
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$4,158
BALCONY
$5,049
SUITE
-
From 4,158
View Trip
15 Day Treasures Of The Pacific Coast - Panama To Chile with Hurtigruten
Cruise

15 Days (14 Nights) Colon to Valparaiso
Cruise Line: Hurtigruten
Ships: MS Fram, MS Roald Amundsen
Departures: Oct 2024 to Oct 2024
Countries Visited: Panama, Ecuador, Peru, Chile
Exclusive Deal
INSIDE
$11,486
OCEANVIEW
$13,098
BALCONY
$15,587
SUITE
$17,786
Save 4,542
From 11,486
View Trip
12 Day Panama City to Los Angeles with Silversea
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 24 December 2024
Countries Visited: Panama, Costa Rica, Mexico, USA
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$7,227
BALCONY
-
SUITE
-
From 7,227
View Trip
12 Day Los Angeles to Panama City with Silversea
Cruise

12 Days (11 Nights) Los Angeles to Panama City
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 09 May 2025
Countries Visited: USA, Mexico, Costa Rica, Panama
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$6,138
BALCONY
$7,326
SUITE
-
From 6,138
View Trip
10 Day Panama City to Fort Lauderdale with Silversea
Cruise

10 Days (9 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Ray
Departure: 11 January 2025
Countries Visited: Aruba, Colombia, Panama, USA
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$5,989
From 5,989
View Trip
19 Day Andes & South America with Princess
Cruise
 (3)

19 Days (18 Nights) Los Angeles to Santiago
Cruise Line: Princess
Ship: Majestic Princess
Departure: 01 December 2024
Countries Visited: USA, Mexico, Panama, Peru (+1 more), Chile
INSIDE
$2,334
OCEANVIEW
-
BALCONY
$3,057
SUITE
$3,888
From 2,334
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (1)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Coral Princess
Departures: Jan 2026 to Apr 2026
Countries Visited: USA, Colombia, Panama, Costa Rica (+1 more), Mexico
INSIDE
$3,359
OCEANVIEW
$3,666
BALCONY
$4,824
SUITE
$5,705
From 3,359
View Trip
18 Day New York To San Francisco with Cunard
Cruise

18 Days (17 Nights) New York to San Francisco
Cruise Line: Cunard
Ship: Queen Anne
Departure: 18 January 2025
Countries Visited: USA, Aruba, Panama, Guatemala (+1 more), Mexico
INSIDE
$4,945
OCEANVIEW
$7,242
BALCONY
$7,846
SUITE
$14,914
From 4,945
View Trip
13 Day Tropical Waters And Remote Island Communities In The Caribbean with Hurtigruten
Cruise

13 Days (12 Nights) Miami to Colon
Cruise Line: Hurtigruten
Ship: MS Roald Amundsen
Departure: 25 September 2024
Countries Visited: USA, Belize, Honduras, Nicaragua (+1 more), Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
$11,640
BALCONY
$13,561
SUITE
$15,646
Save 3,520
From 11,640
View Trip
13 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

13 Days (12 Nights) Miami to Lima
Ship: Norwegian Jade
Departure: 27 February 2026
Countries Visited: USA, Colombia, Panama, Ecuador (+1 more), Peru
INSIDE
$3,763
OCEANVIEW
$3,947
BALCONY
$6,013
SUITE
$6,212
From 3,763
View Trip
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 January 2026
Countries Visited: Panama, Costa Rica, Nicaragua, Mexico (+1 more), USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,618
SUITE
$10,143
Save 6,132
From 9,618
View Trip
10 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Miami to Panama City
Ship: Norwegian Gem
Departure: 02 December 2024
Countries Visited: USA, Dominican Republic, Curacao, Aruba (+1 more), Panama
Exclusive Solo Offer
INSIDE
$2,072
OCEANVIEW
$2,300
BALCONY
$3,478
SUITE
$3,632
From 2,072
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise

20 Days (19 Nights) Santiago to New York
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2026 to Mar 2026
Countries Visited: Chile, Peru, Panama, Jamaica (+1 more), Bahamas
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$17,815
SUITE
$25,735
Save 1,180
From 17,815
View Trip
18 Day Panama Canal & the Pacific Coast with Viking Cruises
Cruise

18 Days (17 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Neptune
Departure: 05 April 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+1 more), Colombia
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$10,885
SUITE
$20,785
Save 1,110
From 10,885
View Trip
18 Day Panama Canal & the Pacific Coast with Viking Cruises
Cruise

18 Days (17 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Viking Cruises
Ships: Viking Neptune, Viking Sky
Departures: Oct 2024 to Dec 2025
Countries Visited: USA, Mexico, Colombia, Panama (+1 more), Costa Rica
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$9,895
SUITE
$19,795
Save 1,110
From 9,895
View Trip
10 Day Western Caribbean Cruise with Royal Caribbean
Cruise

10 Days (9 Nights) Tampa to Tampa
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2024 to Feb 2025
Countries Visited: USA, Cayman Islands, Panama, Costa Rica (+1 more), Mexico
Exclusive Deal
INSIDE
$1,367
OCEANVIEW
$1,443
BALCONY
$1,964
SUITE
$3,156
Save 1,222
From 1,367
View Trip
16 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Miami to Los Angeles
Ship: Norwegian Joy
Departure: 30 November 2024
Countries Visited: USA, Colombia, Panama, Guatemala (+1 more), Mexico
INSIDE
$2,950
OCEANVIEW
$3,347
BALCONY
$4,066
SUITE
$4,372
From 2,950
View Trip
19 Day Los Angeles to Fort Lauderdale with Silversea
Cruise

19 Days (18 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 09 May 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+1 more), Colombia
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$14,058
BALCONY
$15,345
SUITE
$24,948
From 14,058
View Trip
13 Day A Journey Of Pacific Pleasures And The Panama Canal with Explora Journeys
Cruise

13 Days (12 Nights) Los Angeles to Panama City
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 12 May 2024
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+1 more), Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,791
SUITE
$13,167
From 7,554
View Trip
10 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Miami to Panama City
Ship: Norwegian Jade
Departure: 01 November 2025
Countries Visited: USA, Dominican Republic, Aruba, Colombia (+1 more), Panama
INSIDE
$2,370
OCEANVIEW
$2,829
BALCONY
$3,977
SUITE
$4,282
From 2,370
View Trip
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Travel Styles

Luxury Cruises

Trip Lengths

10 Day

Departure Months

May 2024 September 2024 October 2024 November 2024 December 2024 January 2025 February 2025 April 2025 May 2025 November 2025 December 2025 January 2026 February 2026 March 2026 April 2026

Cities

Colon Panama City Santiago

Routes

Miami to Panama City Panama City to Miami

Country Routes

Panama to USA USA to Panama

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