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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? September is the most popular month to cruise between Italy and Spain and there are 222 departures available from sixteen of the world's leading cruise lines.
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125 Cruises (222 Cruise Departures)
10 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 13 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+2 more), Sardinia, Spain
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$7,049
SUITE
$8,593
From 7,049
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 08 June 2026
Countries Visited: Italy, Croatia, Malta, Spain (+1 more), France
INSIDE
$3,172
OCEANVIEW
$3,518
BALCONY
$3,964
SUITE
$8,518
From 3,172
View Trip
10 Day Italian Riviera & France Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 05 August 2025
Countries Visited: Italy, France, Spain
Exclusive Offer
INSIDE
$2,727
OCEANVIEW
$3,288
BALCONY
$3,391
SUITE
$8,496
Save 3,525
From 2,727
View Trip
10 Day Wonders Of Spain with Regent Seven Seas
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 May 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,644
SUITE
$13,465
Save 5,266
From 12,644
View Trip
10 Day Italian Riviera & France Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: May 2025 to Oct 2025
Countries Visited: Italy, France, Spain
Exclusive Offer
INSIDE
$2,171
OCEANVIEW
$2,823
BALCONY
$2,932
SUITE
$8,050
Save 3,532
From 2,171
View Trip
11 Day Greek Isles & Turkey with Celebrity Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jul 2024 to Oct 2024
Countries Visited: Italy, Greece, Turkey, Malta (+1 more), Spain
Exclusive Offer
INSIDE
$2,663
OCEANVIEW
$2,711
BALCONY
$3,315
SUITE
$7,848
Save 3,441
From 2,663
View Trip
13 Day Sunset Over Tuscany with Regent Seven Seas
Cruise

13 Days (12 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 22 October 2025
Countries Visited: Italy, Malta, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$14,202
SUITE
$16,271
Save 6,328
From 14,202
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Genoa to Alicante
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 26 April 2025
Countries Visited: Italy, France, Spain, Portugal
Early Booking Offer
INSIDE
$1,702
OCEANVIEW
$1,831
BALCONY
$2,098
SUITE
-
From 1,702
View Trip
8 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+1 more), Spain
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,197
SUITE
$6,341
From 5,197
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 09 June 2025
Countries Visited: Italy, Corsica, Spain
INSIDE
$1,338
OCEANVIEW
$1,556
BALCONY
$1,783
SUITE
$3,744
From 1,338
View Trip
16 Day Civitavecchia to Barcelona with Silversea
Cruise

16 Days (15 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 30 May 2025
Countries Visited: Italy, Sicily, France, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$17,919
From 17,919
View Trip
8 Day A Journey From Rome To Tarragona with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 16 September 2024
Countries Visited: Spain, Malta, Sicily, Italy
Exclusive DealUnique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$6,014
SUITE
$7,311
From 6,014
View Trip
8 Day Azure Summer with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 31 May 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,034
SUITE
$9,766
Save 5,826
From 9,034
View Trip
13 Day Greek Isles, Italy & Turkey with Celebrity Cruises
Cruise

13 Days (12 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 23 September 2024
Countries Visited: Italy, Greece, Turkey, Malta (+1 more), Spain
Exclusive Offer
INSIDE
$3,694
OCEANVIEW
-
BALCONY
$14,080
SUITE
$11,659
Save 4,290
From 3,694
View Trip
8 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Aug 2025 to Sep 2025
Countries Visited: Italy, Sicily, Sardinia, Spain
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,846
SUITE
$7,108
From 5,846
View Trip
8 Day Western Mediterranean with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 01 September 2025
Countries Visited: Italy, France, Spain
INSIDE
$1,427
OCEANVIEW
$1,645
BALCONY
$1,873
SUITE
$3,833
From 1,427
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Venice to Barcelona
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departures: Jun 2024 to Jul 2024
Countries Visited: Italy, Sicily, France, Spain
Exclusive Deal
INSIDE
$1,500
OCEANVIEW
$2,483
BALCONY
$2,386
SUITE
$5,096
Save 934
From 1,332
View Trip
9 Day Italy, France & Spain Cruise with Celebrity Cruises
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 06 June 2025
Countries Visited: Italy, France, Spain
Exclusive Offer
INSIDE
$2,040
OCEANVIEW
$2,723
BALCONY
$3,290
SUITE
$8,173
Save 2,925
From 2,040
View Trip
17 Day Civitavecchia to Barcelona with Silversea
Cruise

17 Days (16 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 22 July 2025
Countries Visited: Italy, Sicily, Monaco, France (+1 more), Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$18,513
From 18,513
View Trip
15 Day Greece, Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 August 2025
Countries Visited: Italy, Croatia, Montenegro, Greece (+2 more), France, Spain
INSIDE
$2,766
OCEANVIEW
$3,212
BALCONY
$3,568
SUITE
$7,667
From 2,766
View Trip
11 Day Mediterranean Hideaways with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 26 October 2024
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Corsica, Monaco, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,111
SUITE
$19,268
Save 2,069
From 8,111
View Trip
13 Day Greek Isles, Italy & Turkey with Celebrity Cruises
Cruise

13 Days (12 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 14 October 2024
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Exclusive Offer
INSIDE
$3,105
OCEANVIEW
$3,902
BALCONY
$4,939
SUITE
$11,265
Save 3,910
From 3,105
View Trip
11 Day Italy, Greece, & France: Mediterranean Jewels with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Venice to Barcelona
Ships: Norwegian Breakaway, Norwegian Escape
Departures: Oct 2024 to Oct 2025
Countries Visited: Italy, Croatia, Greece, Sicily (+2 more), France, Spain
Exclusive Solo Offer
INSIDE
$3,091
OCEANVIEW
$3,779
BALCONY
$4,696
SUITE
$5,079
From 3,091
View Trip
15 Day Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, Greece, Montenegro, Croatia (+2 more), Malta, Spain
INSIDE
$2,677
OCEANVIEW
$3,033
BALCONY
$3,390
SUITE
$7,399
From 2,677
View Trip
9 Day Springtime Rivieras with Oceania Cruises
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 18 May 2025
Countries Visited: Italy, Corsica, France, Spain
Cabin Upgrade Offer
INSIDE
$4,734
OCEANVIEW
$5,417
BALCONY
$6,338
SUITE
$7,021
From 4,734
View Trip
3 Day MSC Grand Voyages with MSC Cruises
Cruise

3 Days (2 Nights) Genoa to Tarragona
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 13 November 2024
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$324
OCEANVIEW
$403
BALCONY
$492
SUITE
-
From 324
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Genoa to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 16 November 2024
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$344
OCEANVIEW
$403
BALCONY
$492
SUITE
$829
From 344
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Naples to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 27 September 2025
Countries Visited: Italy, Sicily, Greece, Turkey (+2 more), Montenegro, Spain
INSIDE
$4,050
OCEANVIEW
$5,054
BALCONY
$6,430
SUITE
$7,499
From 4,050
View Trip
13 Day Mediterranean with MSC Cruises
Cruise

13 Days (12 Nights) Venice to Palma de Mallorca
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 17 November 2024
Countries Visited: Italy, Croatia, Montenegro, Spain (+2 more), Sardinia, France
Best Deal Offer
INSIDE
$1,942
OCEANVIEW
$2,328
BALCONY
-
SUITE
$4,051
From 1,942
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Genoa to Valencia
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 05 May 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$804
OCEANVIEW
$933
BALCONY
$1,111
SUITE
$1,992
From 804
View Trip
Results: 91-120 of 125

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