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234 Cruises (527 Cruise Departures)
11 Day Palms & Panama Canal with Oceania Cruises
Cruise

11 Days (10 Nights) Tampa to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$5,026
OCEANVIEW
$5,482
BALCONY
$7,927
SUITE
$10,927
Save 2,034
From 5,026
View Trip
12 Day Caribbean And Antilles with MSC Cruises
Cruise

12 Days (11 Nights) Miami to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 01 March 2026
Countries Visited: USA, Jamaica, Colombia, Panama (+3 more), Costa Rica, Honduras, Bahamas
Early Booking Offer
INSIDE
$2,008
OCEANVIEW
$2,295
BALCONY
$2,622
SUITE
$3,721
From 2,008
View Trip
22 Day Panama Canal with Holland America
Cruise

22 Days (21 Nights) Vancouver to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Amsterdam
Departure: 29 September 2024
Countries Visited: Canada, USA, Mexico, Guatemala (+2 more), Costa Rica, Aruba
Have It All Offer
INSIDE
$5,250
OCEANVIEW
$5,804
BALCONY
$7,051
SUITE
$11,833
From 5,250
View Trip
12 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Tampa to Panama City
Ship: Norwegian Jade
Departure: 29 January 2025
Countries Visited: USA, Mexico, Cayman Islands, Jamaica (+3 more), Colombia, Panama, Costa Rica
Exclusive Solo Offer
INSIDE
$2,803
OCEANVIEW
$3,063
BALCONY
$4,654
SUITE
$4,746
From 2,803
View Trip
13 Day Panama Canal with Costa Rica & Caribbean Holiday with Princess
Cruise

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Princess
Ship: Caribbean Princess
Departure: 17 November 2025
Countries Visited: USA, Aruba, Curacao, Colombia (+3 more), Panama, Costa Rica, Jamaica
Exclusive Deal
INSIDE
$2,089
OCEANVIEW
$2,140
BALCONY
$3,237
SUITE
$4,168
From 2,089
View Trip
21 Day Panama Canal Connoisseur with Oceania Cruises
Cruise

21 Days (20 Nights) Tampa to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Countries Visited: USA, Mexico, Belize, Honduras (+7 more), Costa Rica, Panama, Colombia, Curacao, Aruba, Jamaica, Cayman Islands
Exclusive Deal
INSIDE
$8,894
OCEANVIEW
$9,804
BALCONY
$14,388
SUITE
$20,071
Save 2,056
From 8,894
View Trip
20 Day Panama Canal with Holland America
Cruise

20 Days (19 Nights) Fort Lauderdale to Vancouver
Cruise Line: Holland America
Ship: Eurodam
Departure: 05 April 2026
Countries Visited: USA, Colombia, Costa Rica, El Salvador (+3 more), Guatemala, Mexico, Canada
Have It All Offer
INSIDE
$6,279
OCEANVIEW
$6,972
BALCONY
$8,457
SUITE
$11,724
From 6,279
View Trip
17 Day Bridgetown to Fort Lauderdale with Silversea
Cruise

17 Days (16 Nights) Bridgetown to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Moon
Departure: 21 December 2024
Countries Visited: Barbados, Trinidad and Tobago, Saint Lucia, Saint Vincent (+8 more), Curacao, Aruba, Colombia, Panama, Honduras, Belize, Mexico, USA
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$14,206
BALCONY
$16,582
SUITE
$43,807
Save 894
From 14,206
View Trip
16 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Miami to Panama City
Ship: Norwegian Jade
Departure: 04 January 2025
Countries Visited: USA, Dominican Republic, Puerto Rico, Virgin Islands (+7 more), Saint Lucia, Trinidad and Tobago, Grenada, Aruba, Colombia, Panama, Costa Rica
INSIDE
$3,338
OCEANVIEW
$3,766
BALCONY
$5,402
SUITE
$5,861
From 3,338
View Trip
6 Day Western Caribbean with Norwegian Cruise Line
Cruise

6 Days (5 Nights) Miami to Miami
Ship: Norwegian Aqua
Departure: 07 October 2025
Countries Visited: USA, Belize, Mexico
INSIDE
$2,159
OCEANVIEW
$2,588
BALCONY
$2,925
SUITE
$3,506
From 2,159
View Trip
12 Day Panama Canal & the Alluring Islands of the Caribbean with Scenic
New ReleaseCruise

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 13 April 2026
Countries Visited: Panama, Colombia, Aruba, Curacao (+2 more), Saint Vincent, Barbados
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$11,727
SUITE
$14,538
Save 3,618
From 11,727
View Trip
12 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Miami to Miami
Ship: Norwegian Pearl
Departures: Jan 2025 to Jan 2026
Countries Visited: USA, Jamaica, Colombia, Panama (+3 more), Costa Rica, Belize, Mexico
Exclusive Solo Offer
INSIDE
$3,235
OCEANVIEW
$3,984
BALCONY
$5,681
SUITE
$5,986
From 3,235
View Trip
17 Day Panama Canal Westward Cruise with Celebrity Cruises
Cruise

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Celebrity Cruises
Ship: Celebrity Summit
Departure: 17 April 2025
Countries Visited: USA, Cayman Islands, Colombia, Panama (+3 more), Costa Rica, Guatemala, Mexico
Exclusive DealExclusive Offer
INSIDE
$3,329
OCEANVIEW
$3,750
BALCONY
$5,550
SUITE
-
Save 4,703
From 3,329
View Trip
13 Day Panama Canal with Costa Rica & Caribbean with Princess
Cruise

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Princess
Ship: Caribbean Princess
Departure: 09 February 2026
Countries Visited: USA, Aruba, Curacao, Colombia (+3 more), Panama, Costa Rica, Jamaica
Exclusive Deal
INSIDE
$2,522
OCEANVIEW
$2,603
BALCONY
$3,908
SUITE
$4,680
From 2,522
View Trip
15 Day Panama Canal - Tampa with Norwegian Cruise Line
Cruise

15 Days (14 Nights) Tampa to Tampa
Ship: Norwegian Jewel
Departure: 03 January 2025
Countries Visited: USA, Cayman Islands, Jamaica, Dominican Republic (+5 more), Curacao, Aruba, Colombia, Panama, Costa Rica
INSIDE
$3,932
OCEANVIEW
$4,268
BALCONY
$7,358
SUITE
$8,245
From 3,932
View Trip
17 Day Cartagena to Philipsburg with Silversea
Cruise

17 Days (16 Nights) Cartagena to Philipsburg
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 03 February 2026
Countries Visited: Colombia, Aruba, Bonaire, Curacao (+8 more), Saint Lucia, Saint Vincent, Barbados, Martinique, Dominica, Virgin Islands, Antigua and Barbuda, Sint Maarten
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$11,286
BALCONY
$13,662
SUITE
$21,879
From 11,286
View Trip
11 Day Canal & Coral Isles with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 April 2026
Countries Visited: Panama, Colombia, Costa Rica, Honduras (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$5,026
OCEANVIEW
$5,482
BALCONY
$7,927
SUITE
$10,927
Save 2,034
From 5,026
View Trip
21 Day Panama Canal with Holland America
Cruise

21 Days (20 Nights) Fort Lauderdale to Vancouver
Cruise Line: Holland America
Ship: Eurodam
Departure: 12 April 2025
Countries Visited: USA, Colombia, Costa Rica, Guatemala (+2 more), Mexico, Canada
Have It All Offer
INSIDE
$5,799
OCEANVIEW
$6,353
BALCONY
$7,046
SUITE
$11,689
From 5,799
View Trip
17 Day Southern Caribbean Beauty with Regent Seven Seas
Cruise

17 Days (16 Nights) Miami to Bridgetown
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 17 November 2025
Countries Visited: USA, Mexico, Belize, Honduras (+8 more), Costa Rica, Panama, Colombia, Aruba, Curacao, Bonaire, Grenada, Barbados
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,878
SUITE
$15,016
Save 7,062
From 12,878
View Trip
10 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Panama City to Miami
Ship: Norwegian Gem
Departure: 11 December 2024
Countries Visited: Panama, Costa Rica, Jamaica, Cayman Islands (+3 more), Mexico, Bahamas, USA
INSIDE
$2,285
OCEANVIEW
$2,560
BALCONY
$3,629
SUITE
$3,813
From 2,285
View Trip
17 Day Panama Canal Westward Cruise with Royal Caribbean
Cruise

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 13 April 2025
Countries Visited: USA, Cayman Islands, Colombia, Panama (+2 more), Guatemala, Mexico
Exclusive Deal
INSIDE
$3,231
OCEANVIEW
$3,395
BALCONY
$5,532
SUITE
-
Save 1,026
From 2,859
View Trip
21 Day Panama Canal with Holland America
Cruise

21 Days (20 Nights) Fort Lauderdale to Seattle
Cruise Line: Holland America
Ship: Eurodam
Departure: 05 April 2026
Countries Visited: USA, Colombia, Costa Rica, El Salvador (+3 more), Guatemala, Mexico, Canada
Have It All Offer
INSIDE
$6,553
OCEANVIEW
$7,345
BALCONY
$8,830
SUITE
$12,097
From 6,553
View Trip
22 Day Panama Canal with Holland America
Cruise

22 Days (21 Nights) Fort Lauderdale to Seattle
Cruise Line: Holland America
Ship: Eurodam
Departure: 12 April 2025
Countries Visited: USA, Colombia, Costa Rica, Guatemala (+2 more), Mexico, Canada
Have It All Offer
INSIDE
$6,122
OCEANVIEW
$6,676
BALCONY
$7,369
SUITE
$12,012
From 6,122
View Trip
22 Day Panama Canal & Pacific Coast with Princess
Cruise

22 Days (21 Nights) Orlando to Vancouver
Cruise Line: Princess
Ship: Caribbean Princess
Departure: 14 April 2025
Countries Visited: USA, Bahamas, Colombia, Panama (+3 more), Costa Rica, Mexico, Canada
Exclusive Deal
INSIDE
$3,181
OCEANVIEW
-
BALCONY
-
SUITE
$6,726
From 3,181
View Trip
22 Day Panama Canal - Tampa with Norwegian Cruise Line
Cruise

22 Days (21 Nights) Seattle to Miami
Ship: Norwegian Encore
Departure: 13 October 2024
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+3 more), Panama, Colombia, Cayman Islands
Exclusive Solo Offer
INSIDE
$4,007
OCEANVIEW
$4,160
BALCONY
$5,262
SUITE
$5,689
From 4,007
View Trip
15 Day Caribbean with Norwegian Cruise Line
Cruise

15 Days (14 Nights) New Orleans to New Orleans
Ship: Norwegian Escape
Departure: 22 February 2026
Countries Visited: USA, Mexico, Belize, Honduras (+5 more), Costa Rica, Panama, Colombia, Jamaica, Cayman Islands
Exclusive Solo Offer
INSIDE
$3,125
OCEANVIEW
$3,614
BALCONY
$4,271
SUITE
$4,730
From 3,125
View Trip
11 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Panama City to Tampa
Ship: Norwegian Jade
Departure: 19 January 2025
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
INSIDE
$2,504
OCEANVIEW
$2,825
BALCONY
$4,217
SUITE
$4,492
From 2,504
View Trip
11 Day Vivid Western Caribbean with Oceania Cruises
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 April 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$5,028
OCEANVIEW
$5,483
BALCONY
$7,928
SUITE
$10,928
Save 2,032
From 5,028
View Trip
22 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

22 Days (21 Nights) Seattle to Miami
Ship: Norwegian Joy
Departure: 29 September 2025
Countries Visited: USA, Canada, Mexico, Guatemala (+3 more), Costa Rica, Panama, Colombia
INSIDE
$5,128
OCEANVIEW
$6,199
BALCONY
$6,810
SUITE
$7,805
From 5,128
View Trip
12 Day Southern Caribbean & Perfect Day with Royal Caribbean
Cruise

12 Days (11 Nights) Miami to Miami
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 05 January 2025
Countries Visited: USA, Costa Rica, Panama, Colombia (+2 more), Aruba, Bahamas
Exclusive Deal
INSIDE
$2,446
OCEANVIEW
$3,495
BALCONY
$3,633
SUITE
$11,335
Save 928
From 2,128
View Trip
Results: 121-150 of 234

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South & Central America Cruises

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Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises Hurtigruten South America Cruises MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

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