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Mediterranean Luxury Cruises

Explore the best luxury cruises in the Mediterranean. Choose from 451 unique cruise itineraries from 10 leading cruise lines. September is the most popular month to join a luxury cruise in the Mediterranean with 542 departures starting between May 2024 and April 2027.
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451 Cruises (542 Cruise Departures)
8 Day Southern France and the Italian Riviera by Sea - with Smithsonian Journeys with Ponant
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 02 October 2025
Countries Visited: Spain, France, Italy
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$8,301
SUITE
$13,907
Save 159
From 8,301
View Trip
8 Day Mediterranean Spring with Oceania Cruises
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 06 May 2025
Countries Visited: Spain, France, Monaco, Italy
Exclusive Deal
INSIDE
$4,129
OCEANVIEW
$4,357
BALCONY
$6,109
SUITE
$12,287
Save 2,031
From 4,129
View Trip
12 Day Spain Intensive Voyage with Azamara Cruises
Cruise
 (1)

12 Days (11 Nights) Barcelona to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 06 November 2025
Countries Visited: Spain, Gibraltar, Portugal
INSIDE
$4,625
OCEANVIEW
$5,087
BALCONY
$5,777
SUITE
$7,500
From 4,625
View Trip
8 Day France Intensive Voyage with Azamara Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Nice
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 21 September 2024
Countries Visited: Spain, France, Corsica
Circle Club Voyage
INSIDE
$2,796
OCEANVIEW
$2,913
BALCONY
$4,170
SUITE
$5,731
From 2,796
View Trip
6 Day Grand Prix Voyage with Azamara Cruises
Cruise
 (1)

6 Days (5 Nights) Barcelona to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 22 May 2025
Countries Visited: Spain, France
INSIDE
$2,629
OCEANVIEW
$2,774
BALCONY
$3,492
SUITE
$5,576
From 2,629
View Trip
13 Day Iconic Med Voyage with Azamara Cruises
Cruise
 (1)

13 Days (12 Nights) Athens to Lisbon
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 21 September 2024
Countries Visited: Greece, Sicily, Italy, France (+3 more), Spain, Gibraltar, Portugal
INSIDE
$4,539
OCEANVIEW
$5,049
BALCONY
$6,829
SUITE
$10,397
From 4,539
View Trip
13 Day Arc Of History with Oceania Cruises
Cruise
 (1)

13 Days (12 Nights) Barcelona to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 08 November 2025
Countries Visited: Spain, France, Italy, Sicily (+2 more), Greece, Turkey
Exclusive Deal
INSIDE
$4,620
OCEANVIEW
$5,085
BALCONY
$7,986
SUITE
$11,303
Save 2,030
From 4,620
View Trip
8 Day Mediterranean Highlights with Cunard
Cruise
 (2)

8 Days (7 Nights) Rome to London
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 20 April 2025
Countries Visited: Italy, Sardinia, Spain, England
INSIDE
$1,962
OCEANVIEW
-
BALCONY
$2,674
SUITE
$5,169
From 1,962
View Trip
14 Day Iberian Spring with Regent Seven Seas
Cruise

14 Days (13 Nights) Barcelona to Lisbon
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 18 May 2025
Countries Visited: Spain, France, Italy, Malta (+2 more), Sicily, Portugal
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$16,271
SUITE
$18,043
Save 6,499
From 16,271
View Trip
17 Day Barcelona to Civitavecchia with Silversea
Cruise

17 Days (16 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 06 July 2025
Countries Visited: Spain, France, Monaco, Italy (+1 more), Sicily
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$18,513
From 18,513
View Trip
8 Day A Journey From Montecarlo To Barcelona with Explora Journeys
Cruise

8 Days (7 Nights) Monte Carlo to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 26 May 2025
Countries Visited: France, Italy, Sicily, Sardinia (+1 more), Spain
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$6,192
SUITE
$7,529
From 6,192
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 July 2025
Countries Visited: Spain, Corsica, France, Italy (+2 more), Sardinia, Sicily
INSIDE
$2,855
OCEANVIEW
$3,033
BALCONY
$3,568
SUITE
$7,399
From 2,855
View Trip
31 Day Malta, Morocco & Mediterranean with Seabourn
Cruise

31 Days (30 Nights) Barcelona to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 01 July 2025
Countries Visited: Spain, France, Gibraltar, Morocco (+5 more), Sardinia, Italy, Sicily, Malta, Corsica
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$24,767
SUITE
$43,028
From 24,767
View Trip
11 Day Mediterranean Hideaways with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 26 October 2024
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Corsica, Monaco, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,111
SUITE
$19,268
Save 2,069
From 8,111
View Trip
11 Day Flair, Flavor & Culture with Regent Seven Seas
Cruise

11 Days (10 Nights) Monte Carlo to Athens
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 20 April 2025
Countries Visited: Monaco, Italy, Turkey, Greece
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,545
SUITE
$11,396
Save 7,685
From 9,545
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Rome to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 09 June 2025
Countries Visited: Italy, Corsica, Spain, France (+2 more), Sardinia, Sicily
INSIDE
$2,588
OCEANVIEW
$2,855
BALCONY
$3,340
SUITE
$7,043
From 2,588
View Trip
8 Day Italy And Spain with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 17 August 2026
Countries Visited: Spain, Sardinia, Sicily, Italy
INSIDE
$1,684
OCEANVIEW
$1,882
BALCONY
$2,080
SUITE
$4,654
From 1,684
View Trip
12 Day Treasures of the Mediterranean Isles - Northbound with Tauck
Cruise

12 Days (11 Nights) Valletta to Marseille
Operated By: Tauck
Departures: May 2025 to Sep 2025
Trip Styles: Group, Cruise
Countries Visited: Malta, Sicily, Sardinia, Corsica (+2 more), Italy, France
From 16,650
View Trip
10 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 13 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+2 more), Sardinia, Spain
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$7,049
SUITE
$8,593
From 7,049
View Trip
20 Day Iberian Coast, Riviera Gems & The Calanques with Seabourn
Cruise

20 Days (19 Nights) Lisbon to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 27 March 2025
Countries Visited: Portugal, Spain, France, Corsica (+3 more), Italy, Monaco, Sardinia
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$16,344
SUITE
$22,908
From 16,344
View Trip
8 Day Mediterranean Rivieras with Azamara Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Pursuit
Departure: 18 August 2024
Countries Visited: Italy, France, Spain
Circle Club Voyage
INSIDE
$1,858
OCEANVIEW
$2,079
BALCONY
$3,065
SUITE
$3,910
From 1,857
View Trip
9 Day Monte Carlo to Rome with Silversea
Cruise

9 Days (8 Nights) Monte Carlo to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 07 September 2025
Countries Visited: Monaco, France, Spain, Italy
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$11,286
From 11,286
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Rome to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 13 July 2026
Countries Visited: Italy, France, Corsica, Spain (+3 more), Sicily, Greece, Montenegro
INSIDE
$4,610
OCEANVIEW
$4,956
BALCONY
$5,847
SUITE
$12,381
From 4,610
View Trip
12 Day Barcelona to Rome with Silversea
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 26 April 2025
Countries Visited: Spain, France, Monaco, Italy
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$14,553
From 14,553
View Trip
8 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+1 more), Spain
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,197
SUITE
$6,341
From 5,197
View Trip
21 Day Spain, Morocco & Mediterranean Overture with Seabourn
Cruise

21 Days (20 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departures: May 2025 to Oct 2025
Countries Visited: Spain, France, Gibraltar, Morocco (+4 more), Monaco, Italy, Corsica, Sardinia
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$15,418
SUITE
$28,714
From 15,418
View Trip
11 Day Greco-roman Echoes with Oceania Cruises
Cruise

11 Days (10 Nights) Athens to Monte Carlo
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 03 October 2025
Countries Visited: Greece, Sicily, Italy, France (+1 more), Monaco
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$6,983
SUITE
$10,438
Save 2,057
From 6,983
View Trip
31 Day Riviera, Mediterranean & Tyrrhenian Treasures with Seabourn
Cruise

31 Days (30 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 August 2025
Countries Visited: Italy, Malta, Tunisia, France (+5 more), Spain, Sardinia, Monaco, Sicily, Corsica
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$22,411
SUITE
$42,860
From 22,411
View Trip
8 Day Riviera Gems & The Calanques with Seabourn
Cruise

8 Days (7 Nights) Monte Carlo to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 08 April 2025
Countries Visited: Monaco, Italy, Sardinia, France (+1 more), Spain
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$8,422
SUITE
$11,030
From 8,422
View Trip
13 Day Glorious Roman Empire with Oceania Cruises
Cruise

13 Days (12 Nights) Barcelona to Athens
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 11 July 2024
Countries Visited: Spain, France, Italy, Sardinia (+3 more), Sicily, Turkey, Greece
Exclusive DealSingles Special Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$9,916
SUITE
$13,539
Save 2,084
From 9,916
View Trip
Results: 31-60 of 451

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