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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? April and September are the most popular months to cruise between Spain and Italy and there are 215 departures available from sixteen of the world's leading cruise lines.
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113 Cruises (215 Cruise Departures)
31 Day Jewels Of Spain, Italy & France with Seabourn
Cruise

31 Days (30 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 11 July 2025
Countries Visited: Spain, Sardinia, France, Italy (+4 more), Monaco, Sicily, Malta, Corsica
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$24,263
SUITE
$43,029
From 24,263
View Trip
11 Day Hadrian's Homecoming with Oceania Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 03 October 2024
Countries Visited: Spain, France, Monaco, Italy (+4 more), Corsica, Sardinia, Sicily, Malta
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,903
SUITE
-
Save 2,127
From 13,903
View Trip
8 Day Florence, Rome, Palma & More with Virgin Voyages
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 29 June 2025
Countries Visited: Spain, France, Corsica, Italy
Up to 80% Off Second Sailor + Free Upgrade
INSIDE
$2,288
OCEANVIEW
$2,679
BALCONY
$2,951
SUITE
$6,552
From 2,288
View Trip
21 Day Spain, Morocco & Mediterranean Overture with Seabourn
Cruise

21 Days (20 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departures: May 2025 to Oct 2025
Countries Visited: Spain, France, Gibraltar, Morocco (+4 more), Monaco, Italy, Corsica, Sardinia
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$15,418
SUITE
$28,714
From 15,418
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Valencia to Venice
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 27 March 2025
Countries Visited: Spain, Sicily, Greece, Italy (+1 more), Croatia
Early Booking Offer
INSIDE
$1,405
OCEANVIEW
$1,751
BALCONY
$2,682
SUITE
$4,088
From 1,405
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departures: May 2026 to Jun 2026
Countries Visited: Spain, Corsica, Sicily, Italy
INSIDE
$1,387
OCEANVIEW
$1,585
BALCONY
$1,783
SUITE
$3,763
From 1,387
View Trip
12 Day Europe - Western Mediterranean - Barcelona with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Barcelona to Venice
Ships: Norwegian Breakaway, Norwegian Escape
Departures: Sep 2024 to Sep 2025
Countries Visited: Spain, France, Italy, Sicily (+3 more), Malta, Greece, Croatia
Exclusive Solo Offer
INSIDE
$3,685
OCEANVIEW
$4,297
BALCONY
$5,367
SUITE
$5,673
From 3,685
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 17 August 2026
Countries Visited: Spain, Sardinia, Sicily, Italy (+3 more), Greece, Montenegro, Croatia
INSIDE
$3,172
OCEANVIEW
$3,518
BALCONY
$4,112
SUITE
$8,518
From 3,172
View Trip
11 Day Mediterranean Overture with Seabourn
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departures: May 2025 to Oct 2025
Countries Visited: Spain, France, Monaco, Italy (+2 more), Corsica, Sardinia
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$8,424
SUITE
$15,913
From 8,424
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Countries Visited: Spain, Corsica, Sicily, Italy (+1 more), France
INSIDE
$2,974
OCEANVIEW
$3,320
BALCONY
$3,766
SUITE
$7,924
From 2,974
View Trip
8 Day Spain, France & Italy Cruise with Celebrity Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 17 August 2024
Countries Visited: Spain, France, Italy
Exclusive Offer
INSIDE
$1,888
OCEANVIEW
$2,130
BALCONY
$2,420
SUITE
$5,677
Save 2,367
From 1,888
View Trip
25 Day Mediterranean Autumn with Oceania Cruises
Cruise

25 Days (24 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 02 October 2024
Countries Visited: Spain, France, Corsica, Italy (+5 more), Sicily, Greece, Montenegro, Croatia, Malta
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$15,559
SUITE
$22,499
Save 2,131
From 15,559
View Trip
11 Day Art De Vivre Experience with Regent Seven Seas
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 22 July 2025
Countries Visited: Spain, France, Monaco, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,238
SUITE
$14,198
Save 7,572
From 13,238
View Trip
13 Day Barcelona to Rome with Silversea
Cruise

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 18 May 2025
Countries Visited: Spain, France, Monaco, Italy
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$18,315
From 18,315
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Alicante to Genoa
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 07 November 2024
Countries Visited: Spain, Sardinia, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$698
SUITE
-
From 698
View Trip
11 Day Greece, Turkey & Malta with Celebrity Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 25 May 2024
Countries Visited: Spain, Malta, Greece, Turkey (+1 more), Italy
Exclusive Offer
INSIDE
$3,604
OCEANVIEW
-
BALCONY
-
SUITE
-
Save 3,924
From 3,604
View Trip
8 Day A Journey From Barcelona To Civitavecchia with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 06 October 2025
Countries Visited: Spain, France, Sardinia, Corsica (+1 more), Italy
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$5,504
SUITE
$6,692
From 5,504
View Trip
11 Day Europe - Western Mediterranean with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Barcelona to Venice
Ship: Norwegian Escape
Departure: 23 June 2024
Countries Visited: Spain, France, Italy, Sicily (+2 more), Greece, Croatia
INSIDE
$2,139
OCEANVIEW
$2,674
BALCONY
$2,750
SUITE
$3,546
From 2,139
View Trip
22 Day Barcelona to Venice with Silversea
Cruise

22 Days (21 Nights) Barcelona to Venice
Cruise Line: Silversea
Ship: Silver Moon
Departure: 16 August 2024
Countries Visited: Spain, France, Italy, Sardinia (+4 more), Sicily, Malta, Montenegro, Croatia
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$21,780
BALCONY
$23,562
SUITE
-
From 21,780
View Trip
8 Day France And Italy with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 16 June 2025
Countries Visited: Spain, France, Sardinia, Sicily (+1 more), Italy
INSIDE
$1,338
OCEANVIEW
$1,556
BALCONY
$1,783
SUITE
$3,744
From 1,338
View Trip
13 Day Barcelona to Cannes, Rome & Tuscany with Virgin Voyages
Cruise

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 25 September 2025
Countries Visited: Spain, France, Corsica, Sardinia (+1 more), Italy
INSIDE
$4,133
OCEANVIEW
$4,269
BALCONY
$4,699
SUITE
$10,498
From 4,133
View Trip
10 Day Italian Riviera & France Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departures: Sep 2024 to Oct 2024
Countries Visited: Spain, France, Corsica, Italy (+2 more), Malta, Sicily
Exclusive Offer
INSIDE
$2,734
OCEANVIEW
$3,791
BALCONY
$3,932
SUITE
$10,144
Save 3,548
From 2,734
View Trip
11 Day Europe - Western Mediterranean with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Barcelona to Venice
Ship: Norwegian Escape
Departure: 11 August 2024
Countries Visited: Spain, France, Italy, Sicily (+3 more), Malta, Greece, Croatia
INSIDE
$2,798
OCEANVIEW
$3,638
BALCONY
$3,716
SUITE
$4,175
From 2,798
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 23 April 2025
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$530
OCEANVIEW
$659
BALCONY
$758
SUITE
$1,104
From 530
View Trip
11 Day Europe with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Barcelona to Venice
Ship: Norwegian Dawn
Departure: 07 October 2024
Countries Visited: Spain, France, Italy, Sicily (+3 more), Greece, Montenegro, Croatia
INSIDE
$3,046
OCEANVIEW
$3,275
BALCONY
$4,193
SUITE
$4,729
From 3,046
View Trip
9 Day A Journey To Elegant Enclaves On Old European Shores with Explora Journeys
Cruise

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 11 August 2024
Countries Visited: Spain, France, Italy
Unique EscapesExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,331
SUITE
$10,182
From 8,331
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 July 2025
Countries Visited: Spain, Corsica, France, Italy
INSIDE
$1,516
OCEANVIEW
$1,645
BALCONY
$1,912
SUITE
$3,833
From 1,516
View Trip
13 Day Vita Est Bona with Regent Seven Seas
Cruise

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 24 August 2024
Countries Visited: Spain, France, Monaco, Italy (+1 more), Sardinia
Explore More OfferExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,579
SUITE
$11,723
Save 11,141
From 10,579
View Trip
8 Day Etruscan Waterways with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 21 April 2026
Countries Visited: Spain, France, Italy, Corsica (+1 more), Sardinia
Exclusive Deal
INSIDE
$3,872
OCEANVIEW
$4,714
BALCONY
$5,248
SUITE
$7,298
Save 2,028
From 3,872
View Trip
12 Day Barcelona to Civitavecchia with Virgin Voyages
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 03 November 2024
Countries Visited: Spain, France, Italy, Corsica (+1 more), Sardinia
INSIDE
$3,276
OCEANVIEW
$3,694
BALCONY
$4,204
SUITE
-
From 3,276
View Trip
Results: 61-90 of 113

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