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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? April and September are the most popular months to cruise between Spain and Italy and there are 215 departures available from sixteen of the world's leading cruise lines.
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113 Cruises (215 Cruise Departures)
8 Day A Journey from Barcelona to Rome with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 09 September 2024
Countries Visited: Spain, France, Corsica, Italy
Exclusive DealUnique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$6,816
SUITE
$8,286
From 6,816
View Trip
8 Day A Journey From Barcelona To Civitavecchia with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 08 September 2025
Countries Visited: Spain, France, Italy, Corsica (+1 more), Sardinia
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$5,846
SUITE
$7,108
From 5,846
View Trip
15 Day Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 18 August 2025
Countries Visited: Spain, Malta, Italy, Croatia (+2 more), Montenegro, Greece
INSIDE
$2,766
OCEANVIEW
$3,212
BALCONY
$3,657
SUITE
$7,667
From 2,766
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Malaga to Genoa
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 10 November 2024
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$669
SUITE
-
From 669
View Trip
8 Day Western Mediterranean with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 30 September 2024
Countries Visited: Spain, France, Corsica, Italy
Exclusive Deal
INSIDE
$2,002
OCEANVIEW
$2,665
BALCONY
$3,073
SUITE
$4,410
Save 774
From 1,650
View Trip
8 Day Western Mediterranean with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 08 September 2025
Countries Visited: Spain, Sardinia, Corsica, Sicily (+1 more), Italy
INSIDE
$1,427
OCEANVIEW
$1,645
BALCONY
$1,873
SUITE
$3,833
From 1,427
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 11 July 2024
Countries Visited: Spain, Italy, France
Exclusive Offer
INSIDE
$2,169
OCEANVIEW
$2,278
BALCONY
$2,610
SUITE
-
Save 2,853
From 2,169
View Trip
11 Day Mediterranean Jewels & Malta with Seabourn
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 20 October 2024
Countries Visited: Spain, Tunisia, Italy, Malta
More Moments On Us Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$10,701
SUITE
$16,740
From 10,701
View Trip
5 Day Mediterranean with MSC Cruises
Cruise

5 Days (4 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 29 April 2025
Countries Visited: Spain, Tunisia, Sicily, Italy
Exclusive Deal
INSIDE
$717
OCEANVIEW
$855
BALCONY
$1,004
SUITE
$1,330
From 717
View Trip
8 Day A Journey From Barcelona To Civitavecchia with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2025 to Aug 2025
Countries Visited: Spain, France, Italy
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,940
SUITE
$7,247
From 5,940
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 25 October 2024
Countries Visited: Spain, Italy
Best Deal Offer
INSIDE
$362
OCEANVIEW
$490
BALCONY
$540
SUITE
-
From 362
View Trip
8 Day A Journey From Barcelona To Civitavecchia with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 16 June 2025
Countries Visited: Spain, France, Corsica, Italy (+1 more), Sardinia
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,846
SUITE
$7,108
From 5,846
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departures: Jun 2025 to Sep 2025
Countries Visited: Spain, France, Corsica, Italy
Exclusive Deal
INSIDE
$1,418
OCEANVIEW
$1,979
BALCONY
$2,489
SUITE
$3,491
Save 638
From 1,265
View Trip
12 Day Canary Islands And Madeira with MSC Cruises
Cruise

12 Days (11 Nights) Santa Cruz de Tenerife to Venice
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 23 March 2025
Countries Visited: Spain, Morocco, Sicily, Greece (+2 more), Italy, Croatia
Save And Sail Offer
INSIDE
$1,567
OCEANVIEW
$1,914
BALCONY
$2,844
SUITE
$4,280
From 1,567
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise

5 Days (4 Nights) Alicante to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 26 November 2024
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$600
BALCONY
$758
SUITE
$1,421
From 600
View Trip
11 Day Italian Riviera & France with Celebrity Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 08 June 2024
Countries Visited: Spain, Corsica, Italy, France (+3 more), Sardinia, Malta, Sicily
Exclusive Offer
INSIDE
$2,471
OCEANVIEW
$2,966
BALCONY
$4,742
SUITE
$10,967
Save 3,223
From 2,471
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise

4 Days (3 Nights) Barcelona to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 28 November 2024
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
$470
OCEANVIEW
$569
BALCONY
$678
SUITE
$1,093
From 470
View Trip
8 Day A Journey Of Riviera Reveries And Italian Icons with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 26 August 2024
Countries Visited: Spain, France, Corsica, Sardinia (+1 more), Italy
Exclusive DealUnique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$6,816
SUITE
$8,286
From 6,816
View Trip
8 Day Italy And Adriatic with Cunard
Cruise

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 27 July 2026
Countries Visited: Spain, Italy, Sicily, Greece (+1 more), Montenegro
INSIDE
$1,783
OCEANVIEW
$1,981
BALCONY
$2,179
SUITE
$4,951
From 1,783
View Trip
18 Day Canary Islands And Madeira with MSC Cruises
Cruise

18 Days (17 Nights) Las Palmas de Gran Canaria to Venice
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 17 March 2025
Countries Visited: Spain, Portugal, Morocco, Sicily (+3 more), Greece, Italy, Croatia
Save And Sail Offer
INSIDE
$3,191
OCEANVIEW
$4,032
BALCONY
$6,280
SUITE
-
From 3,191
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 22 June 2026
Countries Visited: Spain, Corsica, Sicily, Italy (+4 more), Greece, Montenegro, Croatia, Malta
INSIDE
$4,857
OCEANVIEW
$5,253
BALCONY
$6,095
SUITE
$12,876
From 4,857
View Trip
11 Day Grand Mediterranean with Princess
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 11 October 2025
Countries Visited: Spain, France, Italy, Montenegro (+1 more), Greece
INSIDE
$2,713
OCEANVIEW
$3,317
BALCONY
$4,238
SUITE
$5,089
From 2,713
View Trip
11 Day Mediterranean Overture with Seabourn
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 12 July 2024
Countries Visited: Spain, France, Monaco, Italy (+2 more), Corsica, Sardinia
More Moments On Us Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$11,394
SUITE
$19,809
From 11,394
View Trip
Results: 91-113 of 113

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