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Royal Caribbean Cruises from San Diego

Start your journey from San Diego with 15 unique Royal Caribbean cruise itineraries to choose from. March is the most popular month to begin your cruise from San Diego and Royal Caribbean have 46 trips departing this season.
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3 Days
17 Days
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15 Cruises (46 Cruise Departures)
8 Day Ensenada, Cabo & La Paz Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2026 to Nov 2026
Countries Visited: USA, Mexico
Bonus Onboard Credit
INSIDE
$801
OCEANVIEW
$1,011
BALCONY
$1,208
SUITE
$2,144
Save (per person) 273
From (per person) 801
View Trip
17 Day Panama Canal Cruise with Royal Caribbean
Cruise

17 Days (16 Nights) San Diego to Fort Lauderdale
Cruise Line: Royal Caribbean
Ship: Radiance of the Seas
Departure: 04 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+3 more), Panama, Colombia, Cayman Islands
Bonus Onboard Credit
INSIDE
$2,246
OCEANVIEW
-
BALCONY
$5,017
SUITE
-
Save (per person) 720
From (per person) 2,246
View Trip
5 Day Catalina & Ensenada Cruise with Royal Caribbean
Cruise

5 Days (4 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2026 to Apr 2027
Countries Visited: USA, Mexico
Bonus Onboard Credit
INSIDE
$515
OCEANVIEW
$615
BALCONY
$712
SUITE
$887
Save (per person) 188
From (per person) 515
View Trip
3 Day Ensenada Cruise with Royal Caribbean
Cruise

3 Days (2 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 02 October 2026
Countries Visited: USA, Mexico
Bonus Onboard Credit
INSIDE
$356
OCEANVIEW
$406
BALCONY
$524
SUITE
$879
Save (per person) 94
From (per person) 356
View Trip
14 Day Panama Canal Eastward Cruise with Royal Caribbean
Cruise

14 Days (13 Nights) San Diego to Miami
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 19 September 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+1 more), Colombia
Bonus Onboard Credit
INSIDE
$1,623
OCEANVIEW
$1,964
BALCONY
-
SUITE
-
Save (per person) 474
From (per person) 1,623
View Trip
4 Day Ensenada Cruise with Royal Caribbean
Cruise

4 Days (3 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Dec 2026 to Apr 2027
Countries Visited: USA, Mexico
Bonus Onboard Credit
INSIDE
$466
OCEANVIEW
$565
BALCONY
$663
SUITE
$869
Save (per person) 162
From (per person) 466
View Trip
8 Day Ensenada, Cabo & La Paz Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2026 to Mar 2027
Countries Visited: USA, Mexico
Bonus Onboard Credit
INSIDE
$794
OCEANVIEW
$991
BALCONY
$1,159
SUITE
$1,984
Save (per person) 316
From (per person) 794
View Trip
8 Day Ensenada, Cabo & Mazatlan with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2026 to Feb 2027
Countries Visited: USA, Mexico
Bonus Onboard Credit
INSIDE
$819
OCEANVIEW
$1,017
BALCONY
$1,164
SUITE
$2,511
Save (per person) 281
From (per person) 819
View Trip
8 Day Cabo, Mazatlan & La Paz with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 28 January 2027
Countries Visited: USA, Mexico
Bonus Onboard Credit
INSIDE
$800
OCEANVIEW
$1,010
BALCONY
$1,158
SUITE
$2,622
Save (per person) 273
From (per person) 800
View Trip
4 Day Ensenada Cruise with Royal Caribbean
Cruise

4 Days (3 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2026 to Mar 2027
Countries Visited: USA, Mexico
Bonus Onboard Credit
INSIDE
$467
OCEANVIEW
$566
BALCONY
$684
SUITE
$869
Save (per person) 150
From (per person) 467
View Trip
8 Day Cabo, Mazatlan & La Paz Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 27 December 2026
Countries Visited: USA, Mexico
Bonus Onboard Credit
INSIDE
$1,240
OCEANVIEW
$1,380
BALCONY
$1,737
SUITE
$3,373
Save (per person) 457
From (per person) 1,240
View Trip
5 Day Catalina & Ensenada Cruise with Royal Caribbean
Cruise

5 Days (4 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 07 March 2027
Countries Visited: USA, Mexico
Bonus Onboard Credit
INSIDE
$554
OCEANVIEW
$654
BALCONY
$761
SUITE
$986
Save (per person) 166
From (per person) 554
View Trip
5 Day Catalina & Ensenada Cruise with Royal Caribbean
Cruise

5 Days (4 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Feb 2027 to Mar 2027
Countries Visited: USA, Mexico
Bonus Onboard Credit
INSIDE
$514
OCEANVIEW
$614
BALCONY
$731
SUITE
$916
Save (per person) 166
From (per person) 514
View Trip
8 Day Cabo Overnight, Catalina & Ensenada with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 13 December 2026
Countries Visited: USA, Mexico
Bonus Onboard Credit
INSIDE
$815
OCEANVIEW
$1,025
BALCONY
$1,222
SUITE
$2,407
Save (per person) 273
From (per person) 815
View Trip
8 Day Cabo, Mazatlan & La Paz Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) San Diego to San Diego
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2026 to Dec 2026
Countries Visited: USA, Mexico
Bonus Onboard Credit
INSIDE
$998
OCEANVIEW
$1,218
BALCONY
$1,365
SUITE
$2,660
Save (per person) 423
From (per person) 998
View Trip
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