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Cruises From Santiago

Choose from 54 unique expeditions and cruises starting in Santiago, and traveling to Broome, Buenos Aires, Cape Town, Darwin, Fort Lauderdale and more. February is the most popular month to join a cruise from Santiago and you can select from 121 departures available from twelve leading cruise lines.
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58 Days
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54 Cruises (121 Cruise Departures)
23 Day Puerto Williams to Valparaiso with Silversea
Cruise

23 Days (22 Nights) Santiago to Valparaiso
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 09 March 2025
Countries Visited: Chile, Antarctica, Argentina
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$21,100
BALCONY
$22,200
SUITE
$32,200
From (per person) 21,100
View Trip
22 Day Puerto Williams to Buenos Aires with Silversea
Cruise

22 Days (21 Nights) Santiago to Buenos Aires
Cruise Line: Silversea
Ship: Silver Endeavour
Departure: 04 March 2027
Countries Visited: Chile, Antarctica, South Georgia Island, Falkland Islands (+1 more), Argentina
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$26,000
Save (per person) 1,500
From (per person) 26,000
View Trip
13 Day Puerto Williams to Puerto Williams with Silversea
Cruise

13 Days (12 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Endeavour
Departure: 24 January 2026
Countries Visited: Chile, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$24,600
From (per person) 24,600
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (4)

18 Days (17 Nights) Santiago to Buenos Aires
Operated By: Viking Cruises
Ship: Viking Jupiter
Departures: Mar 2025 to Feb 2027
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
INSIDE
-
OCEANVIEW
-
BALCONY
$6,199
SUITE
$12,749
From (per person) 6,199
View Trip
11 Day Puerto Williams to Ushuaia with Silversea
Cruise

11 Days (10 Nights) Santiago to Ushuaia
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 09 March 2025
Countries Visited: Chile, Antarctica, Argentina
Port-to-Port
INSIDE
-
OCEANVIEW
$12,100
BALCONY
$14,400
SUITE
$20,300
From (per person) 12,100
View Trip
16 Day In the Wake of Jean-Baptiste Charcot with Ponant
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departures: Dec 2025 to Jan 2026
Countries Visited: Chile, Argentina, Antarctica
INSIDE
-
OCEANVIEW
-
BALCONY
$29,340
SUITE
$31,890
From (per person) 29,340
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Santiago to Fort Lauderdale
Operated By: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2025 to Mar 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Mexico, USA
INSIDE
-
OCEANVIEW
-
BALCONY
$9,995
SUITE
$15,995
From (per person) 9,995
View Trip
17 Day Cape Horn & Strait of Magellan with Princess
Cruise

17 Days (16 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 06 December 2025
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$3,158
OCEANVIEW
$3,087
BALCONY
$4,568
SUITE
$5,908
From (per person) 3,087
View Trip
29 Day Ultimate Journey: Patagonia, Argentina, Brazil & Antarctica - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

29 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ships: Scenic Eclipse I
Departures: Feb 2026 to Jan 2027
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Argentina, Antarctica, Brazil
2 for 1 Fares + Fly Free Premium Economy2 for 1 Cruise Fares
INSIDE
-
OCEANVIEW
-
BALCONY
$44,388
SUITE
$52,638
Save (per person) 22,405
From (per person) 44,388
View Trip
20 Day Wonders of Patagonia and Antarctica - Cruise & Land Journey with Scenic
Tour + Cruise

20 Days Santiago to Buenos Aires
Operated By: Scenic
Ships: Scenic Eclipse I, Scenic Eclipse II
Departures: Feb 2026 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Antarctica, Argentina
2 for 1 Fares + Fly Free Premium Economy2 for 1 Cruise Fares
INSIDE
-
OCEANVIEW
-
BALCONY
$37,623
SUITE
$45,873
Save (per person) 22,405
From (per person) 37,623
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise
 (1)

20 Days (19 Nights) Santiago to New York
Operated By: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2026 to Apr 2027
Countries Visited: Chile, Peru, Panama, Jamaica (+1 more), Bahamas
INSIDE
-
OCEANVIEW
-
BALCONY
$11,995
SUITE
$18,495
From (per person) 11,995
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (2)

17 Days (16 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 March 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Cayman Islands, USA
Exclusive Deal
INSIDE
$2,804
OCEANVIEW
$3,104
BALCONY
$3,804
SUITE
$5,304
From (per person) 2,804
View Trip
13 Day Chilean Fjords & The Glaciers of The Beagle Channel with Scenic
Cruise

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Countries Visited: Chile, Argentina
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$19,103
SUITE
$25,403
Save (per person) 19,287
From (per person) 19,103
View Trip
23 Day Antarctic Voyage with Chile and Brazil Highlights with APT
New ReleaseTour + Cruise

23 Days Santiago to Rio de Janeiro
Operated By: APT
Ship: Seabourn Venture
Departure: 14 February 2026
Trip Style: Cruise
Countries Visited: Chile, Argentina, Antarctica, Brazil
INSIDE
-
OCEANVIEW
-
BALCONY
$21,895
SUITE
$23,445
From (per person) 21,895
View Trip
19 Day Andes & South America with Princess
Cruise

19 Days (18 Nights) Santiago to Los Angeles
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 21 March 2025
Countries Visited: Chile, Peru, Ecuador, Costa Rica (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$1,589
OCEANVIEW
$1,698
BALCONY
$2,169
SUITE
$2,789
From (per person) 1,589
View Trip
34 Day San Antonio To Southampton with Cunard
Cruise

34 Days (33 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+4 more), Aruba, USA, Portugal, England
Exclusive Deal
INSIDE
$6,359
OCEANVIEW
$9,059
BALCONY
$10,059
SUITE
$20,159
From (per person) 6,359
View Trip
18 Day San Antonio To Fort Lauderdale with Cunard
Cruise

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 February 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+3 more), Aruba, Bahamas, USA
Exclusive Deal
INSIDE
$1,199
OCEANVIEW
$1,299
BALCONY
$1,699
SUITE
$20,009
From (per person) 1,199
View Trip
16 Day The Emperor Penguins of Weddell Sea with Ponant
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departure: 19 December 2025
Countries Visited: Chile, Argentina, Antarctica
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$32,270
From (per person) 32,270
View Trip
43 Day Grand World Voyage with Holland America
Cruise

43 Days (42 Nights) Santiago to Singapore
Cruise Line: Holland America
Ship: Volendam
Departure: 10 February 2026
Countries Visited: Chile, Easter Island, Pitcairn Islands, French Polynesia (+5 more), Tonga, New Zealand, Australia, Indonesia, Singapore
Exclusive Deal
INSIDE
$9,509
OCEANVIEW
$10,219
BALCONY
$19,149
SUITE
$35,649
From (per person) 9,509
View Trip
23 Day Patagonian Adventure and the Weddell Sea - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

23 Days Santiago to Buenos Aires
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 26 November 2026
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Argentina, Antarctica
2 for 1 Fares + Fly Free Premium Economy2 for 1 Cruise Fares
INSIDE
-
OCEANVIEW
-
BALCONY
$42,423
SUITE
$49,423
Save (per person) 24,832
From (per person) 42,423
View Trip
20 Day Southern America & Panama Canal Cruise: Lima, Panama City & Cozumel with Azamara Cruises
Cruise
 (1)

20 Days (19 Nights) Santiago to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 March 2027
Countries Visited: Chile, Peru, Panama, Costa Rica (+3 more), Colombia, Mexico, USA
INSIDE
$5,079
OCEANVIEW
$5,669
BALCONY
$7,349
SUITE
$11,189
From (per person) 5,079
View Trip
22 Day Treasures of South America with Chilean Fjords - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

22 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Argentina, Brazil
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$25,868
SUITE
$32,168
Save (per person) 19,287
From (per person) 25,868
View Trip
23 Day In-depth Antarctica, Falklands & South Georgia Expedition with HX Hurtigruten Expeditions
Cruise

23 Days (22 Nights) Santiago to Santiago
Ship: MS Fram
Departures: Nov 2025 to Jan 2027
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Exclusive Deal
INSIDE
-
OCEANVIEW
$20,400
BALCONY
-
SUITE
$27,105
Save (per person) 11,020
From (per person) 20,400
View Trip
22 Day Puerto Williams to Buenos Aires with Silversea
Cruise

22 Days (21 Nights) Santiago to Buenos Aires
Cruise Line: Silversea
Ship: Silver Endeavour
Departure: 10 March 2025
Countries Visited: Chile, Argentina, Falkland Islands, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$27,500
From (per person) 27,500
View Trip
15 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (2)

15 Days (14 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 23 February 2027
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$2,384
OCEANVIEW
$2,634
BALCONY
$3,634
SUITE
$4,734
From (per person) 2,384
View Trip
24 Day Antarctica & Falklands - From Punta Arenas To Buenos Aires with HX Hurtigruten Expeditions
Cruise

24 Days (23 Nights) Santiago to Buenos Aires
Ship: MS Fram
Departure: 20 March 2026
Countries Visited: Chile, Antarctica, Falkland Islands, Argentina
Exclusive Deal
INSIDE
-
OCEANVIEW
$17,097
BALCONY
-
SUITE
$22,848
Save (per person) 10,981
From (per person) 17,097
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 21 December 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$21,400
BALCONY
$25,400
SUITE
$37,400
Save (per person) 1,500
From (per person) 21,400
View Trip
14 Day The Emperor Penguins of Weddell Sea with Ponant
Cruise

14 Days (13 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departures: Oct 2025 to Nov 2025
Countries Visited: Chile, Argentina, Antarctica
INSIDE
-
OCEANVIEW
-
BALCONY
$30,850
SUITE
$32,750
From (per person) 30,850
View Trip
21 Day Easter & Pitcairn Islands: Marooned, Moai & Mutineers with Seabourn
Cruise

21 Days (20 Nights) Santiago to Tahiti
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 18 March 2025
Countries Visited: Chile, Easter Island, Pitcairn Islands, French Polynesia
Sail Of The Year Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$9,799
SUITE
$23,459
From (per person) 9,799
View Trip
23 Day In-depth Antarctica & Patagonia Expedition (Northbound) with HX Hurtigruten Expeditions
Cruise

23 Days (22 Nights) Santiago to Valparaiso
Ship: MS Fram
Departure: 15 March 2025
Countries Visited: Chile, Antarctica
Exclusive Deal
INSIDE
-
OCEANVIEW
$20,199
BALCONY
-
SUITE
$26,953
Save (per person) 8,363
From (per person) 20,199
View Trip
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