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Cruises From Santiago

Choose from 58 unique expeditions and cruises starting in Santiago, and travelling to Barcelona, Broome, Buenos Aires, Cape Town, Darwin and more. February is the most popular month to join a cruise from Santiago and you can select from 160 departures available from fourteen leading cruise lines.
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7 Days
64 Days
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58 Cruises (160 Cruise Departures)
33 Day Highlights of South America and Chilean Fjords Cruise with Travelmarvel
Tour + Cruise
 (1)

33 Days Santiago to Lima
Operated By: Travelmarvel
Departure: 20 February 2026
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay (+2 more), Brazil, Peru
Exclusive Deal
Save (per person) 1,546
From (per person) 17,649
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2025 to Mar 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Mexico, USA
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$15,871
SUITE
$22,731
Save (per person) 1,065
From (per person) 15,871
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (3)

18 Days (17 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Jupiter
Departures: Feb 2025 to Feb 2027
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$10,579
SUITE
$19,791
Save (per person) 344
From (per person) 10,579
View Trip
20 Day Ushuaia & The White Continent with Regent Seven Seas
Cruise

20 Days (19 Nights) Santiago to Buenos Aires
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 12 February 2025
Countries Visited: Chile, Argentina, Antarctica, Falkland Islands (+1 more), Uruguay
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$20,864
SUITE
$22,785
Save (per person) 8,036
From (per person) 20,864
View Trip
16 Day In the Wake of Jean-Baptiste Charcot with Ponant
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departures: Dec 2025 to Jan 2026
Countries Visited: Chile, Argentina, Antarctica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$38,625
SUITE
$41,290
Save (per person) 794
From (per person) 38,625
View Trip
22 Day Treasures of South America with Chilean Fjords - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

22 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Argentina, Brazil
Super Earlybird
INSIDE
-
OCEANVIEW
-
BALCONY
$28,579
SUITE
$38,498
Save (per person) 6,746
From (per person) 28,579
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 21 December 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$29,799
BALCONY
$35,343
SUITE
$52,074
Save (per person) 2,801
From (per person) 29,799
View Trip
14 Day The Emperor Penguins of Weddell Sea with Ponant
Cruise

14 Days (13 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departures: Oct 2025 to Nov 2025
Countries Visited: Chile, Argentina, Antarctica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$39,974
SUITE
$42,463
Save (per person) 796
From (per person) 39,974
View Trip
32 Day San Antonio To Southampton with Cunard
Cruise

32 Days (31 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 February 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+6 more), Aruba, Bahamas, USA, Bermuda, Portugal, England
Exclusive Deal
INSIDE
$7,237
OCEANVIEW
$8,722
BALCONY
$11,395
SUITE
$26,047
From (per person) 7,237
View Trip
23 Day In-depth Antarctica & Patagonia Expedition (Northbound) with HX Hurtigruten Expeditions
Cruise

23 Days (22 Nights) Santiago to Valparaiso
Ship: MS Fram
Departure: 15 March 2025
Countries Visited: Chile, Antarctica
Exclusive Deal
INSIDE
$22,137
OCEANVIEW
$26,208
BALCONY
-
SUITE
$32,639
Save (per person) 3,853
From (per person) 22,137
View Trip
11 Day Puerto Williams to Ushuaia with Silversea
Cruise

11 Days (10 Nights) Santiago to Ushuaia
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 09 March 2025
Countries Visited: Chile, Antarctica, Argentina
Port-to-Port
INSIDE
-
OCEANVIEW
$17,919
BALCONY
$21,384
SUITE
$29,799
From (per person) 17,919
View Trip
23 Day Puerto Williams to Valparaiso with Silversea
Cruise

23 Days (22 Nights) Santiago to Valparaiso
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 09 March 2025
Countries Visited: Chile, Antarctica, Argentina
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$25,245
BALCONY
$28,314
SUITE
$44,451
Save (per person) 4,255
From (per person) 25,245
View Trip
22 Day Puerto Williams to Buenos Aires with Silversea
Cruise

22 Days (21 Nights) Santiago to Buenos Aires
Cruise Line: Silversea
Ship: Silver Endeavour
Departure: 04 March 2027
Countries Visited: Chile, Antarctica, South Georgia Island, Falkland Islands (+1 more), Argentina
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$33,462
From (per person) 33,462
View Trip
27 Day Antarctica & Falklands - From Punta Arenas To Buenos Aires (Flights Included) with HX Hurtigruten Expeditions
Cruise

27 Days (26 Nights) Santiago to Buenos Aires
Ship: MS Fram
Departure: 19 March 2026
Countries Visited: Chile, Antarctica, Falkland Islands, Argentina
Wave Offer
INSIDE
-
OCEANVIEW
$28,268
BALCONY
-
SUITE
$34,130
Save (per person) 5,909
From (per person) 28,268
View Trip
23 Day Patagonian Adventure and the Weddell Sea - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

23 Days Santiago to Buenos Aires
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 26 November 2026
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Argentina, Antarctica
Super Earlybird
INSIDE
-
OCEANVIEW
-
BALCONY
$58,013
SUITE
$65,438
Save (per person) 7,052
From (per person) 58,013
View Trip
20 Day Easter & Pitcairn Islands: Marooned, Moai & Mutineers with Seabourn
Cruise

20 Days (19 Nights) Santiago to Tahiti
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 02 April 2026
Countries Visited: Chile, Easter Island, Pitcairn Islands, French Polynesia
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$25,463
SUITE
$36,551
From (per person) 25,463
View Trip
31 Day Chilean Fjords, Glaciers & Antarctic Wildlife Explorer with Scenic
Cruise

31 Days (30 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Countries Visited: Chile, Argentina, Falkland Islands, South Georgia Island (+1 more), Antarctica
Super Earlybird
INSIDE
-
OCEANVIEW
-
BALCONY
$63,025
SUITE
$79,449
Save (per person) 16,085
From (per person) 63,025
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ships: Silver Cloud, Silver Endeavour, Silver Wind
Departures: Jan 2025 to Feb 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$22,869
BALCONY
$25,839
SUITE
$44,550
Save (per person) 4,268
From (per person) 22,869
View Trip
26 Day In-depth Antarctica, Falklands & South Georgia Expedition (Flights Included) with HX Hurtigruten Expeditions
Cruise

26 Days (25 Nights) Santiago to Santiago
Ship: MS Fram
Departures: Nov 2025 to Feb 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Wave Offer
INSIDE
-
OCEANVIEW
$31,828
BALCONY
-
SUITE
$38,662
Save (per person) 3,741
From (per person) 31,828
View Trip
58 Day Remote Islands Of The Pacific & Kimberley Expedition with Seabourn
Cruise

58 Days (57 Nights) Santiago to Broome
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 02 April 2026
Countries Visited: Chile, Pitcairn Islands, French Polynesia, Cook Islands (+7 more), Samoa, Tonga, Fiji, Vanuatu, Papua New Guinea, Indonesia, Australia
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$71,349
SUITE
$104,316
From (per person) 71,349
View Trip
23 Day Puerto Williams to Cape Town with Silversea
Cruise

23 Days (22 Nights) Santiago to Cape Town
Cruise Line: Silversea
Ship: Silver Wind
Departure: 12 March 2025
Countries Visited: Chile, Falkland Islands, South Georgia Island, Saint Helena (+1 more), South Africa
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$16,830
BALCONY
$17,325
SUITE
$22,176
Save (per person) 2,670
From (per person) 16,830
View Trip
29 Day Ultimate Journey: Patagonia, Argentina, Brazil & Antarctica - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

29 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ships: Scenic Eclipse I
Departures: Feb 2026 to Jan 2027
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Argentina, Antarctica, Brazil
Super Earlybird
INSIDE
-
OCEANVIEW
-
BALCONY
$61,143
SUITE
$72,056
Save (per person) 5,594
From (per person) 61,143
View Trip
10 Day Puerto Williams to King George Island with Silversea
Cruise

10 Days (9 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departures: Jan 2027 to Mar 2027
Countries Visited: Chile, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$22,572
BALCONY
$27,621
SUITE
$44,847
Save (per person) 2,743
From (per person) 22,572
View Trip
11 Day Puerto Williams to Puerto Williams with Silversea
Cruise

11 Days (10 Nights) Santiago to Santiago
Cruise Line: Silversea
Ships: Silver Cloud, Silver Endeavour, Silver Wind
Departures: Jan 2025 to Feb 2027
Countries Visited: Chile, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$20,196
BALCONY
$22,275
SUITE
$24,255
Save (per person) 4,229
From (per person) 20,196
View Trip
26 Day In-depth Antarctica & Patagonia Expedition (Northbound) (Flights Included) with HX Hurtigruten Expeditions
Cruise

26 Days (25 Nights) Santiago to Santiago
Ship: MS Fram
Departure: 14 March 2025
Countries Visited: Chile, Antarctica
Exclusive Deal
INSIDE
$26,749
OCEANVIEW
$30,820
BALCONY
-
SUITE
$37,251
Save (per person) 3,899
From (per person) 26,749
View Trip
41 Day Puerto Williams to Cape Town with Silversea
Cruise

41 Days (40 Nights) Santiago to Cape Town
Cruise Line: Silversea
Ship: Silver Wind
Departure: 22 February 2025
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica (+2 more), Saint Helena, South Africa
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$44,154
BALCONY
$47,223
SUITE
$71,973
From (per person) 44,154
View Trip
16 Day The Emperor Penguins of Weddell Sea with Ponant
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departure: 19 December 2025
Countries Visited: Chile, Argentina, Antarctica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$40,026
SUITE
$41,780
Save (per person) 794
From (per person) 40,026
View Trip
15 Day Cape Horn & Strait of Magellan with Princess
Cruise

15 Days (14 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 21 February 2025
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$4,065
OCEANVIEW
$4,248
BALCONY
$6,560
SUITE
$7,431
From (per person) 4,065
View Trip
30 Day Best of South America with Amazon and Galapagos Cruises with APT
Tour + Cruise

30 Days Santiago to Guayaquil
Operated By: APT
Ship: Delfin III
Departures: Aug 2025 to Sep 2025
Trip Styles: Coach, Cruise, River Cruise, Island Hopping, Scenic
Countries Visited: Chile, Argentina, Brazil, Peru (+2 more), Ecuador, Galapagos
Exclusive Deal
Save (per person) 2,343
From (per person) 40,052
View Trip
21 Day Easter & Pitcairn Islands: Marooned, Moai & Mutineers with Seabourn
Cruise

21 Days (20 Nights) Santiago to Tahiti
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 18 March 2025
Countries Visited: Chile, Easter Island, Pitcairn Islands, French Polynesia
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$22,790
SUITE
$39,224
From (per person) 22,790
View Trip
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