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Cruises From Santiago

Choose from 45 unique expeditions and cruises starting in Santiago, and traveling to Broome, Buenos Aires, Cape Town, Darwin, Fort Lauderdale and more. February is the most popular month to join a cruise from Santiago and you can select from 106 departures available from twelve leading cruise lines.
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7 Days
58 Days
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45 Cruises (106 Cruise Departures)
34 Day San Antonio To Southampton with Cunard
Cruise

34 Days (33 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+4 more), Aruba, USA, Portugal, England
Exclusive Deal
INSIDE
$6,359
OCEANVIEW
$9,059
BALCONY
$10,059
SUITE
$20,159
From (per person) 6,359
View Trip
43 Day Grand World Voyage with Holland America
Cruise

43 Days (42 Nights) Santiago to Singapore
Cruise Line: Holland America
Ship: Volendam
Departure: 10 February 2026
Countries Visited: Chile, Easter Island, Pitcairn Islands, French Polynesia (+5 more), Tonga, New Zealand, Australia, Indonesia, Singapore
Exclusive Deal
INSIDE
$9,482
OCEANVIEW
$10,185
BALCONY
$19,025
SUITE
$35,360
From (per person) 9,482
View Trip
14 Day The Emperor Penguins of Weddell Sea with Ponant
Cruise

14 Days (13 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departures: Oct 2025 to Nov 2025
Countries Visited: Chile, Argentina, Antarctica
INSIDE
-
OCEANVIEW
-
BALCONY
$32,410
SUITE
$34,420
From (per person) 32,410
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (2)

17 Days (16 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 March 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Cayman Islands, USA
Exclusive Deal
INSIDE
$2,791
OCEANVIEW
$3,088
BALCONY
$3,781
SUITE
$5,266
From (per person) 2,791
View Trip
20 Day Southern America & Panama Canal Cruise: Lima, Panama City & Cozumel with Azamara Cruises
Cruise
 (1)

20 Days (19 Nights) Santiago to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 March 2027
Countries Visited: Chile, Peru, Panama, Costa Rica (+3 more), Colombia, Mexico, USA
INSIDE
$5,309
OCEANVIEW
$5,919
BALCONY
$7,679
SUITE
$11,709
From (per person) 5,309
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise
 (1)

20 Days (19 Nights) Santiago to New York
Operated By: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2026 to Apr 2027
Countries Visited: Chile, Peru, Panama, Jamaica (+1 more), Bahamas
FLY FREE With VikingViking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$11,995
SUITE
$16,995
Save (per person) 500
From (per person) 11,995
View Trip
13 Day Chilean Fjords & Scenic Shores with Viking Cruises
Cruise
 (1)

13 Days (12 Nights) Santiago to Buenos Aires
Operated By: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2025 to Nov 2026
Countries Visited: Chile, Argentina
FLY FREE With VikingViking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,995
SUITE
$12,995
Save (per person) 1,500
From (per person) 7,995
View Trip
7 Day King George Island to King George Island with Silversea
Cruise

7 Days (6 Nights) Santiago to Santiago
Cruise Line: Silversea
Ships: Silver Cloud, Silver Wind
Departures: Jan 2026 to Feb 2026
Countries Visited: Chile, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$19,400
BALCONY
$22,000
SUITE
$28,300
From (per person) 19,400
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Wind
Departures: Nov 2026 to Nov 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$21,900
BALCONY
$25,900
SUITE
$38,200
From (per person) 21,900
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Santiago to Fort Lauderdale
Operated By: Viking Cruises
Ship: Viking Polaris
Departure: 22 March 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Mexico, USA
Viking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,995
SUITE
$14,995
From (per person) 9,995
View Trip
13 Day Puerto Williams to Puerto Williams with Silversea
Cruise

13 Days (12 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Endeavour
Departure: 24 January 2026
Countries Visited: Chile, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$24,700
From (per person) 24,700
View Trip
16 Day Puerto Williams to Puerto Williams with Silversea
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Silversea
Ships: Silver Cloud, Silver Endeavour, Silver Wind
Departures: Dec 2025 to Feb 2027
Countries Visited: Chile, South Georgia Island, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$18,400
BALCONY
$23,300
SUITE
$26,800
From (per person) 18,400
View Trip
29 Day Ultimate Journey: Patagonia, Argentina, Brazil & Antarctica - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

29 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 30 January 2027
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Argentina, Antarctica, Brazil
2 for 1 Fares + Fly Free Premium Economy2 for 1 Cruise Fares
INSIDE
-
OCEANVIEW
-
BALCONY
$44,388
SUITE
$52,638
Save (per person) 20,032
From (per person) 44,388
View Trip
13 Day Puerto Williams to Puerto Williams with Silversea
Cruise

13 Days (12 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 09 December 2026
Countries Visited: Chile, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$17,400
BALCONY
$19,900
SUITE
$26,400
From (per person) 17,400
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (2)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 04 December 2026
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$2,425
OCEANVIEW
$2,673
BALCONY
$3,613
SUITE
$4,603
From (per person) 2,425
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (4)

18 Days (17 Nights) Santiago to Buenos Aires
Operated By: Viking Cruises
Ship: Viking Jupiter
Departures: Dec 2025 to Feb 2027
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Viking $1,799 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$6,199
SUITE
$11,999
From (per person) 6,199
View Trip
24 Day Antarctica & Falklands - From Punta Arenas To Buenos Aires with HX Hurtigruten Expeditions
Cruise

24 Days (23 Nights) Santiago to Buenos Aires
Ship: MS Fram
Departures: Mar 2026 to Mar 2027
Countries Visited: Chile, Antarctica, Falkland Islands, Argentina
Exclusive Deal
INSIDE
-
OCEANVIEW
$17,270
BALCONY
-
SUITE
$23,079
Save (per person) 10,808
From (per person) 17,270
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 21 December 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$23,000
BALCONY
$27,000
SUITE
$39,000
From (per person) 23,000
View Trip
31 Day Chilean Fjords, Glaciers & Antarctic Wildlife Explorer with Scenic
Cruise

31 Days (30 Nights) Santiago to Buenos Aires
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Countries Visited: Chile, Argentina, Falkland Islands, South Georgia Island (+1 more), Antarctica
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$50,271
SUITE
$65,271
Save (per person) 48,544
From (per person) 50,271
View Trip
22 Day Puerto Williams to Cape Town with Silversea
Cruise

22 Days (21 Nights) Santiago to Cape Town
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 06 March 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Saint Helena (+1 more), South Africa
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$16,700
BALCONY
$17,700
SUITE
$27,400
From (per person) 16,700
View Trip
15 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (2)

15 Days (14 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 23 February 2027
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$2,370
OCEANVIEW
$2,618
BALCONY
$3,608
SUITE
$4,697
From (per person) 2,370
View Trip
37 Day San Antonio To Hamburg with Cunard
Cruise

37 Days (36 Nights) Santiago to Hamburg
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+6 more), Aruba, USA, Portugal, England, Belgium, Germany
Exclusive Deal
INSIDE
$6,939
OCEANVIEW
$9,739
BALCONY
$11,039
SUITE
$22,439
From (per person) 6,939
View Trip
18 Day Antarctic Voyage with Chile with APT
Tour + Cruise

18 Days Santiago to Buenos Aires
Operated By: APT
Ship: Seabourn Venture
Departure: 14 February 2026
Trip Styles: Cruise, Scenic
Countries Visited: Chile, Argentina, Antarctica
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$17,995
SUITE
$20,445
Save (per person) 500
From (per person) 17,995
View Trip
17 Day Cape Horn & Strait of Magellan with Princess
Cruise

17 Days (16 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 06 December 2025
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Spring Swing Offer
INSIDE
$2,989
OCEANVIEW
$2,919
BALCONY
$4,583
SUITE
$6,029
From (per person) 2,919
View Trip
23 Day Antarctic Voyage with Chile and Brazil Highlights with APT
New ReleaseTour + Cruise

23 Days Santiago to Rio de Janeiro
Operated By: APT
Ship: Seabourn Venture
Departure: 14 February 2026
Trip Style: Cruise
Countries Visited: Chile, Argentina, Antarctica, Brazil
INSIDE
-
OCEANVIEW
-
BALCONY
$20,995
SUITE
$23,445
From (per person) 20,995
View Trip
22 Day Treasures of South America with Chilean Fjords - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

22 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Argentina, Brazil
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$25,868
SUITE
$32,168
Save (per person) 19,287
From (per person) 25,868
View Trip
22 Day Puerto Williams to Buenos Aires with Silversea
Cruise

22 Days (21 Nights) Santiago to Buenos Aires
Cruise Line: Silversea
Ship: Silver Endeavour
Departure: 04 March 2027
Countries Visited: Chile, Antarctica, South Georgia Island, Falkland Islands (+1 more), Argentina
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$27,500
From (per person) 27,500
View Trip
16 Day Puerto Williams to King George Island with Silversea
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 06 December 2025
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$24,700
BALCONY
$26,800
SUITE
$37,400
From (per person) 24,700
View Trip
20 Day Easter & Pitcairn Islands: Marooned, Moai & Mutineers with Seabourn
Cruise

20 Days (19 Nights) Santiago to Tahiti
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 02 April 2026
Countries Visited: Chile, Easter Island, Pitcairn Islands, French Polynesia
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$19,799
SUITE
$28,499
From (per person) 19,799
View Trip
32 Day Across Oceanic Cultures: Chilean Coast To Fiji with Seabourn
Cruise

32 Days (31 Nights) Santiago to Lautoka
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 02 April 2026
Countries Visited: Chile, Easter Island, Pitcairn Islands, French Polynesia (+4 more), Cook Islands, Samoa, Tonga, Fiji
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$30,099
SUITE
$41,899
From (per person) 30,099
View Trip
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