Home > Cruises > South America Cruises > Chile > Cruises From Santiago

Cruises From Santiago

Choose from 57 unique expeditions and cruises starting in Santiago, and travelling to Broome, Buenos Aires, Cape Town, Darwin, Fort Lauderdale and more. February is the most popular month to join a cruise from Santiago and you can select from 165 departures available from fourteen leading cruise lines.
Filter Results
Departures
Show More...
Duration
7 Days
58 Days
Countries Visited
End City
Ship Features
Operators
Show More...
Price
$2,200pp
$93,270pp
Countries
Show More...
Filter Results
57 Cruises (165 Cruise Departures)
15 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (2)

15 Days (14 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 23 February 2027
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$3,457
OCEANVIEW
$3,853
BALCONY
$5,289
SUITE
$6,972
From (per person) 3,457
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2025 to Mar 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Mexico, USA
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$15,871
SUITE
$22,731
Save (per person) 324
From (per person) 15,871
View Trip
20 Day Southern America & Panama Canal Cruise: Lima, Panama City & Cozumel with Azamara Cruises
Cruise
 (1)

20 Days (19 Nights) Santiago to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 10 March 2027
Countries Visited: Chile, Peru, Panama, Costa Rica (+3 more), Colombia, Mexico, USA
INSIDE
$7,355
OCEANVIEW
$8,177
BALCONY
$10,592
SUITE
$16,117
From (per person) 7,355
View Trip
16 Day South America Pathways: Chilean Fjords & Glaciers with Holland America
Cruise
 (2)

16 Days (15 Nights) Santiago to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departure: 04 December 2026
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$3,552
OCEANVIEW
$3,938
BALCONY
$5,384
SUITE
$6,869
From (per person) 3,552
View Trip
17 Day Inca & Panama Canal Discovery: Lima Overnight with Holland America
Cruise
 (2)

17 Days (16 Nights) Santiago to Fort Lauderdale
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 March 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Cayman Islands, USA
Exclusive Deal
INSIDE
$4,099
OCEANVIEW
$4,544
BALCONY
$5,584
SUITE
$7,861
From (per person) 4,099
View Trip
18 Day South America & the Chilean Fjords with Viking Cruises
Cruise
 (4)

18 Days (17 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Jupiter
Departures: Feb 2025 to Feb 2027
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$10,775
SUITE
$19,791
Save (per person) 356
From (per person) 10,775
View Trip
13 Day Chilean Fjords & Scenic Shores with Viking Cruises
Cruise
 (1)

13 Days (12 Nights) Santiago to Buenos Aires
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2025 to Nov 2026
Countries Visited: Chile, Argentina
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$12,568
SUITE
$17,815
Save (per person) 2,427
From (per person) 12,568
View Trip
18 Day Antarctic Voyage with Chile with APT
Tour + Cruise

18 Days Santiago to Buenos Aires
Operated By: APT
Ship: Seabourn Venture
Departure: 14 February 2026
Trip Styles: Cruise, Scenic
Countries Visited: Chile, Argentina, Antarctica
Exclusive DealBusiness Class Included + Save
INSIDE
-
OCEANVIEW
-
BALCONY
$26,460
SUITE
$27,499
Save (per person) 2,635
From (per person) 26,460
View Trip
34 Day San Antonio To Southampton with Cunard
Cruise

34 Days (33 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+4 more), Aruba, USA, Portugal, England
Exclusive Deal
INSIDE
$9,317
OCEANVIEW
$13,871
BALCONY
$15,653
SUITE
$28,226
From (per person) 9,317
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 21 December 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$29,799
BALCONY
$35,343
SUITE
$52,074
Save (per person) 2,801
From (per person) 29,799
View Trip
16 Day Puerto Williams to Puerto Williams with Silversea
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Silversea
Ships: Silver Cloud, Silver Endeavour, Silver Wind
Departures: Dec 2025 to Feb 2027
Countries Visited: Chile, South Georgia Island, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$22,572
BALCONY
$22,572
SUITE
$33,858
Save (per person) 2,755
From (per person) 22,572
View Trip
7 Day King George Island to King George Island with Silversea
Cruise

7 Days (6 Nights) Santiago to Santiago
Cruise Line: Silversea
Ships: Silver Cloud, Silver Wind
Departures: Jan 2026 to Feb 2026
Countries Visited: Chile, Antarctica
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$22,671
BALCONY
$22,671
SUITE
$37,323
Save (per person) 4,278
From (per person) 22,671
View Trip
29 Day Ultimate Journey: Patagonia, Argentina, Brazil & Antarctica - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

29 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ships: Scenic Eclipse I
Departures: Feb 2026 to Jan 2027
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Argentina, Antarctica, Brazil
Super Earlybird
INSIDE
-
OCEANVIEW
-
BALCONY
$61,143
SUITE
$72,056
Save (per person) 5,594
From (per person) 61,143
View Trip
21 Day Easter & Pitcairn Islands: Marooned, Moai & Mutineers with Seabourn
Cruise

21 Days (20 Nights) Santiago to Tahiti
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 18 March 2025
Countries Visited: Chile, Easter Island, Pitcairn Islands, French Polynesia
Sail Of The Year
INSIDE
-
OCEANVIEW
-
BALCONY
$18,617
SUITE
$36,343
From (per person) 18,617
View Trip
20 Day Wonders of Patagonia and Antarctica - Cruise & Land Journey with Scenic
Tour + Cruise

20 Days Santiago to Buenos Aires
Operated By: Scenic
Ships: Scenic Eclipse I, Scenic Eclipse II
Departures: Feb 2026 to Feb 2027
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Antarctica, Argentina
Super Earlybird
INSIDE
-
OCEANVIEW
-
BALCONY
$51,660
SUITE
$61,622
Save (per person) 5,499
From (per person) 51,660
View Trip
22 Day Puerto Williams to Buenos Aires with Silversea
Cruise

22 Days (21 Nights) Santiago to Buenos Aires
Cruise Line: Silversea
Ship: Silver Endeavour
Departure: 10 March 2025
Countries Visited: Chile, Argentina, Falkland Islands, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$37,125
Save (per person) 2,875
From (per person) 37,125
View Trip
32 Day Across Oceanic Cultures: Chilean Coast To Fiji with Seabourn
Cruise

32 Days (31 Nights) Santiago to Lautoka
Cruise Line: Seabourn
Ship: Seabourn Pursuit
Departure: 02 April 2026
Countries Visited: Chile, Easter Island, Pitcairn Islands, French Polynesia (+4 more), Cook Islands, Samoa, Tonga, Fiji
Sail Of The Year
INSIDE
-
OCEANVIEW
-
BALCONY
$37,228
SUITE
$51,365
From (per person) 37,228
View Trip
20 Day Panama Canal & the Americas with Viking Cruises
Cruise

20 Days (19 Nights) Santiago to New York
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2026 to Apr 2027
Countries Visited: Chile, Peru, Panama, Jamaica (+1 more), Bahamas
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$18,811
SUITE
$25,671
Save (per person) 384
From (per person) 18,811
View Trip
19 Day Andes & South America with Princess
Cruise

19 Days (18 Nights) Santiago to Los Angeles
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 21 March 2025
Countries Visited: Chile, Peru, Ecuador, Costa Rica (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$2,255
OCEANVIEW
$2,397
BALCONY
$3,235
SUITE
$4,225
From (per person) 2,255
View Trip
17 Day Edge Of The World Expedition with Regent Seven Seas
Cruise

17 Days (16 Nights) Santiago to Buenos Aires
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 01 February 2026
Countries Visited: Chile, Argentina, Uruguay
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$18,793
SUITE
$19,387
Save (per person) 6,967
From (per person) 18,793
View Trip
13 Day Puerto Williams to Puerto Williams with Silversea
Cruise

13 Days (12 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 09 December 2026
Countries Visited: Chile, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$25,839
BALCONY
$29,304
SUITE
$37,719
Save (per person) 2,761
From (per person) 25,839
View Trip
17 Day Cape Horn & Strait of Magellan with Princess
Cruise

17 Days (16 Nights) Santiago to Buenos Aires
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 06 December 2025
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Exclusive Deal
INSIDE
$5,211
OCEANVIEW
$5,257
BALCONY
$7,633
SUITE
$9,200
From (per person) 5,211
View Trip
24 Day Antarctica & Falklands - From Punta Arenas To Buenos Aires with HX Hurtigruten Expeditions
Cruise

24 Days (23 Nights) Santiago to Buenos Aires
Ship: MS Fram
Departure: 20 March 2026
Countries Visited: Chile, Antarctica, Falkland Islands, Argentina
Wave Offer
INSIDE
-
OCEANVIEW
$23,648
BALCONY
-
SUITE
$31,628
Save (per person) 5,862
From (per person) 23,648
View Trip
23 Day Puerto Williams to Cape Town with Silversea
Cruise

23 Days (22 Nights) Santiago to Cape Town
Cruise Line: Silversea
Ship: Silver Wind
Departure: 12 March 2025
Countries Visited: Chile, Falkland Islands, South Georgia Island, Saint Helena (+1 more), South Africa
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$16,830
BALCONY
$17,325
SUITE
$24,651
Save (per person) 2,670
From (per person) 16,830
View Trip
16 Day The Emperor Penguins of Weddell Sea with Ponant
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Ponant
Ship: Le Commandant-Charcot
Departure: 19 December 2025
Countries Visited: Chile, Argentina, Antarctica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$41,780
Save (per person) 830
From (per person) 41,780
View Trip
22 Day Treasures of South America with Chilean Fjords - Cruise & Land Journey with Scenic
New ReleaseTour + Cruise

22 Days Santiago to Rio de Janeiro
Operated By: Scenic
Ship: Scenic Eclipse I
Departure: 04 November 2026
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Argentina, Brazil
Super Earlybird
INSIDE
-
OCEANVIEW
-
BALCONY
$32,558
SUITE
$38,498
Save (per person) 6,787
From (per person) 32,558
View Trip
43 Day Grand World Voyage with Holland America
Cruise

43 Days (42 Nights) Santiago to Singapore
Cruise Line: Holland America
Ship: Volendam
Departure: 10 February 2026
Countries Visited: Chile, Easter Island, Pitcairn Islands, French Polynesia (+5 more), Tonga, New Zealand, Australia, Indonesia, Singapore
Exclusive Deal
INSIDE
$14,088
OCEANVIEW
$15,138
BALCONY
$28,146
SUITE
$52,649
From (per person) 14,088
View Trip
18 Day San Antonio To Fort Lauderdale with Cunard
Cruise

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 February 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+3 more), Aruba, Bahamas, USA
Exclusive Deal
INSIDE
$5,252
OCEANVIEW
$6,192
BALCONY
$8,341
SUITE
$21,983
From (per person) 5,252
View Trip
16 Day Puerto Williams to King George Island with Silversea
Cruise

16 Days (15 Nights) Santiago to Santiago
Cruise Line: Silversea
Ship: Silver Cloud
Departure: 06 December 2025
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$32,274
BALCONY
$35,739
SUITE
$52,371
Save (per person) 2,826
From (per person) 32,274
View Trip
19 Day Puerto Williams to Puerto Williams with Silversea
Cruise

19 Days (18 Nights) Santiago to Santiago
Cruise Line: Silversea
Ships: Silver Cloud, Silver Endeavour, Silver Wind
Departures: Jan 2025 to Feb 2026
Countries Visited: Chile, Falkland Islands, South Georgia Island, Antarctica
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$24,849
BALCONY
$24,849
SUITE
$44,550
Save (per person) 4,268
From (per person) 24,849
View Trip
Results: 1-30 of 57

No Results found. Try changing your search filters.




Cruises found! Scroll up to view

South & Central America Cruises

Central America Cruises South America Cruises Mexico Cruises Galapagos Cruises Bermunda Cruises Bahamas Cruises Caribbean Cruises Amazon Cruises Patagonia Cruises Cape Horn Cruises Falkland Island Cruises Panama Cruises

Travel Styles

Luxury Cruises

Trip Lengths

1 Month

Departure Months

January 2025 February 2025 March 2025 April 2025 July 2025 September 2025 October 2025 November 2025 December 2025 January 2026 February 2026 March 2026 April 2026 May 2026 June 2026 July 2026 September 2026 October 2026 November 2026 December 2026 January 2027 February 2027 March 2027 April 2027

Cities

Puerto Williams San Antonio Santiago Valparaiso

Routes

Buenos Aires to San Antonio Buenos Aires to Santiago San Antonio to Buenos Aires Santiago to Buenos Aires Santiago to Santiago

Country Routes

Argentina to Chile Chile to USA Chile to Argentina USA to Chile

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

South America Tours

All South America Tours Amazon Tours Argentina Tours Brazil Tours Chile Tours Colombia Tours Ecuador Tours Galapagos Tours Patagonia Tours Peru Tours

© 2010-2025. Global Journeys. You're viewing our site in Australian dollars.

    

About Us | View Your Booking | Terms & Conditions | Site Map

Global Journeys Pty Ltd. Accredited Member of The Australian Travel Industry Association (AITA). No. A11351.

Travel Industry Associations