Home > Operators > MSC Cruises > South America Cruises
MSC South America Cruises

MSC South America Cruises

Join MSC on one of 85 cruises visiting the coastal ports and cities of South America this season. December is the most popular month to begin your cruise and MSC have 229 cruises departing between February 2025 and April 2026.
Filter Results
Departures
Show More...
Duration
4 Days
27 Days
Start & End Cities
Ship Name
Show More...
Price
$200pp
$6,977pp
Countries
Show More...
Filter Results
85 Cruises (229 Cruise Departures)
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 22 February 2026
Countries Visited: Brazil, Argentina, Uruguay
Escape To Sea - Cruise Only
INSIDE
$759
OCEANVIEW
$909
BALCONY
$1,029
SUITE
$1,609
From (per person) 759
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Santos to Oslo
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Countries Visited: Brazil, Portugal, Spain, England (+4 more), France, Belgium, Denmark, Norway
Escape To Sea - Cruise Only
INSIDE
$1,655
OCEANVIEW
$1,955
BALCONY
$2,455
SUITE
-
From (per person) 1,655
View Trip
25 Day MSC Grand Voyages with MSC Cruises
Cruise

25 Days (24 Nights) Santos to Hamburg
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Countries Visited: Brazil, Portugal, Spain, England (+5 more), France, Belgium, Denmark, Norway, Germany
Escape To Sea - Cruise Only
INSIDE
$1,789
OCEANVIEW
$2,039
BALCONY
$2,299
SUITE
$7,639
From (per person) 1,789
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seaview
Departures: Mar 2025 to Apr 2026
Countries Visited: Brazil
Escape To Sea - Cruise Only
INSIDE
$709
OCEANVIEW
$869
BALCONY
$1,049
SUITE
$1,529
From (per person) 709
View Trip
8 Day South America with MSC Cruises
Cruise

8 Days (7 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departures: Jan 2026 to Mar 2026
Countries Visited: Brazil
Escape To Sea - Cruise Only
INSIDE
$734
OCEANVIEW
-
BALCONY
-
SUITE
-
From (per person) 734
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Santos to Copenhagen
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Countries Visited: Brazil, Portugal, Spain, England (+3 more), France, Belgium, Denmark
Escape To Sea - Cruise Only
INSIDE
-
OCEANVIEW
$1,883
BALCONY
$2,393
SUITE
$6,693
From (per person) 1,883
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

16 Days (15 Nights) Rio de Janeiro to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 09 March 2025
Countries Visited: Brazil, Cape Verde, Spain, Morocco
Escape To Sea - Cruise Only
INSIDE
-
OCEANVIEW
-
BALCONY
$1,592
SUITE
-
From (per person) 1,592
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Jan 2026 to Mar 2026
Countries Visited: Uruguay, Argentina, Brazil
Escape To Sea - Cruise Only
INSIDE
$1,108
OCEANVIEW
$1,384
BALCONY
$1,672
SUITE
$2,452
From (per person) 1,108
View Trip
10 Day South America with MSC Cruises
Cruise
 (1)

10 Days (9 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Jan 2026 to Mar 2026
Countries Visited: Argentina, Brazil, Uruguay
Escape To Sea - Cruise Only
INSIDE
$1,099
OCEANVIEW
$1,375
BALCONY
$1,519
SUITE
$2,443
From (per person) 1,099
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

21 Days (20 Nights) Montevideo to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 22 March 2026
Countries Visited: Uruguay, Argentina, Brazil, Spain (+1 more), Morocco
Escape To Sea - Cruise Only
INSIDE
$1,971
OCEANVIEW
$2,235
BALCONY
$2,751
SUITE
$4,503
From (per person) 1,971
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Sao Paulo to Marseille
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 18 April 2025
Countries Visited: Brazil, Spain, France
Escape To Sea - Cruise Only
INSIDE
$1,064
OCEANVIEW
-
BALCONY
-
SUITE
-
From (per person) 1,064
View Trip
15 Day MSC Grand Voyages with MSC Cruises
Cruise

15 Days (14 Nights) Santos to Santiago De Compostela
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Countries Visited: Brazil, Portugal, Spain
Escape To Sea - Cruise Only
INSIDE
$1,081
OCEANVIEW
$1,231
BALCONY
$1,381
SUITE
-
From (per person) 1,081
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

19 Days (18 Nights) Sao Paulo to Genoa
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 18 April 2025
Countries Visited: Brazil, Spain, France, Italy
Escape To Sea - Cruise Only
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$6,977
From (per person) 6,977
View Trip
11 Day South America with MSC Cruises
Cruise
 (1)

11 Days (10 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 26 December 2025
Countries Visited: Argentina, Brazil, Uruguay
Escape To Sea - Cruise Only
INSIDE
$1,662
OCEANVIEW
$1,902
BALCONY
$2,162
SUITE
$2,882
From (per person) 1,662
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departures: Nov 2025 to Dec 2025
Countries Visited: Brazil
Escape To Sea - Cruise Only
INSIDE
$465
OCEANVIEW
$545
BALCONY
$605
SUITE
$955
From (per person) 465
View Trip
11 Day South America with MSC Cruises
Cruise
 (1)

11 Days (10 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 25 December 2025
Countries Visited: Uruguay, Argentina, Brazil
Escape To Sea - Cruise Only
INSIDE
$1,652
OCEANVIEW
$1,902
BALCONY
$2,162
SUITE
$2,882
From (per person) 1,652
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 09 March 2025
Countries Visited: Brazil
Escape To Sea - Cruise Only
INSIDE
-
OCEANVIEW
$1,064
BALCONY
$1,364
SUITE
$1,880
From (per person) 1,064
View Trip
7 Day South America with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 13 December 2025
Countries Visited: Brazil
Escape To Sea - Cruise Only
INSIDE
$811
OCEANVIEW
$951
BALCONY
$1,101
SUITE
$1,531
From (per person) 811
View Trip
13 Day MSC Grand Voyages with MSC Cruises
Cruise

13 Days (12 Nights) Santos to Funchal
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Countries Visited: Brazil, Portugal
Escape To Sea - Cruise Only
INSIDE
$934
OCEANVIEW
$1,064
BALCONY
$1,374
SUITE
-
From (per person) 934
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 06 February 2026
Countries Visited: Brazil
Escape To Sea - Cruise Only
INSIDE
$485
OCEANVIEW
-
BALCONY
-
SUITE
$965
From (per person) 485
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 29 December 2025
Countries Visited: Brazil
Escape To Sea - Cruise Only
INSIDE
$1,594
OCEANVIEW
$1,764
BALCONY
$1,964
SUITE
-
From (per person) 1,594
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

19 Days (18 Nights) Rome to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 06 November 2025
Countries Visited: Italy, Spain, Morocco, Brazil (+2 more), Uruguay, Argentina
Escape To Sea - Cruise OnlyDrinks and Wi-Fi Included
INSIDE
$1,287
OCEANVIEW
$1,477
BALCONY
$1,867
SUITE
$3,747
From (per person) 1,287
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Rio de Janeiro to Brugge
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 03 April 2026
Countries Visited: Brazil, Portugal, Spain, England (+2 more), France, Belgium
Escape To Sea - Cruise Only
INSIDE
$1,327
OCEANVIEW
$1,537
BALCONY
$2,047
SUITE
-
From (per person) 1,327
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Hamburg to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 05 October 2025
Countries Visited: Germany, England, France, Spain (+2 more), Portugal, Brazil
Escape To Sea - Cruise Only
INSIDE
$1,489
OCEANVIEW
$1,719
BALCONY
$1,949
SUITE
$3,579
From (per person) 1,489
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Honfleur to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 08 October 2025
Countries Visited: France, Spain, Portugal, Brazil
Escape To Sea - Cruise Only
INSIDE
-
OCEANVIEW
-
BALCONY
$1,997
SUITE
$3,197
From (per person) 1,997
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 20 March 2025
Countries Visited: Brazil
Escape To Sea - Cruise Only
INSIDE
$880
OCEANVIEW
-
BALCONY
$1,139
SUITE
$1,892
From (per person) 880
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 26 December 2025
Countries Visited: Brazil
Escape To Sea - Cruise Only
INSIDE
$1,584
OCEANVIEW
$1,764
BALCONY
$1,964
SUITE
$2,494
From (per person) 1,584
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Sao Paulo to São Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 16 March 2025
Countries Visited: Brazil
Escape To Sea - Cruise Only
INSIDE
-
OCEANVIEW
-
BALCONY
$1,146
SUITE
-
From (per person) 1,146
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Rio de Janeiro to Copenhagen
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 03 April 2026
Countries Visited: Brazil, Portugal, Spain, England (+3 more), France, Belgium, Denmark
Escape To Sea - Cruise Only
INSIDE
$1,539
OCEANVIEW
$1,729
BALCONY
$2,289
SUITE
$3,589
From (per person) 1,539
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 02 March 2025
Countries Visited: Brazil
Escape To Sea - Cruise Only
INSIDE
-
OCEANVIEW
$1,250
BALCONY
$1,616
SUITE
$2,422
From (per person) 1,250
View Trip
Results: 1-30 of 85

No Results found. Try changing your search filters.




Cruises found! Scroll up to view

MSC Cruises

MSC Cruises All MSC Cruises MSC Cruises Reviews

Regions

MSC African Cruises MSC Asia Cruises MSC Caribbean Cruises MSC Europe & Med Cruises MSC Greece Cruises MSC Japan Cruises MSC Northern Europe Cruises MSC South America Cruises MSC Transatlantic Cruises MSC Worldwide Cruises

MSC Cruises Ships

MSC Armonia MSC Bellissima MSC Divina MSC Euribia MSC Fantasia MSC Grandiosa MSC Lirica MSC Magnifica MSC Meraviglia MSC Musica MSC Opera MSC Orchestra MSC Poesia MSC Preziosa MSC Seascape MSC Seashore MSC Seaside MSC Seaview MSC Sinfonia MSC Splendida MSC Virtuosa MSC World Europa

Cities

From Abu Dhabi From Athens From Barcelona From Bari From Berlin From Bridgetown From Brugge From Buenos Aires From Cape Town From Copenhagen From Dubai From Durban From Fort-de-France From Genoa From Hamburg From Istanbul From Kiel From Las Palmas de Gran Canaria From London From Malaga From Marseille From Miami From Montevideo From Naples From New York From Orlando From Palermo From Paris From Pointe-A-Pitre From Rio de Janeiro From Rome From Rotterdam From Santa Cruz de Tenerife From Santos From Sao Paulo From Stockholm From Valencia From Venice

© 2010-2025. Global Journeys. You're viewing our site in US dollars.

    

About Us | View Your Booking | Terms & Conditions | Site Map

Global Journeys Travel Inc. Member of American Society of Travel Advisors (ASTA No: 900374670) & TICO Accredited (No. 50027921).

Travel Industry Associations