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South America Short Break Cruises

Explore the best short cruise breaks around South America. Choose from 15 unique cruise itineraries from 1 leading cruise lines. December is the most popular month to join a short cruise break around South America with 58 departures starting between December 2025 and March 2027.
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2 Days
5 Days
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15 Cruises (58 Cruise Departures)
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Buenos Aires to Santos
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 11 March 2027
Visit: Argentina, Brazil
Inside
$289
Oceanview
$379
Balcony
$439
Suite
$719
From
US$289
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Nov 2026 to Mar 2027
Visit: Brazil
Inside
$363
Oceanview
$393
Balcony
$463
Suite
$703
From
US$363
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 November 2026
Visit: Brazil
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$855
From
US$475
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 19 December 2025
Visit: Brazil
Inside
$1,047
Oceanview
$1,204
Balcony
$1,333
Suite
-
From
US$1,047
Per Person
View Trip
2 Day MSC Grand Voyages with MSC Cruises
Cruise

2 Days (1 Nights) Santos to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil
Drinks & WiFi Package
Inside
$175
Oceanview
$196
Balcony
$238
Suite
$406
From
US$175
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Preziosa, MSC Sinfonia
Departures: Jan 2026 to Mar 2027
Visit: Brazil
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$855
From
US$475
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Sinfonia
Departures: Jan 2026 to Dec 2026
Visit: Brazil
Inside
$475
Oceanview
$505
Balcony
$575
Suite
$855
From
US$475
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Santos to Maceio
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departures: Dec 2026 to Jan 2027
Visit: Brazil
Inside
$569
Oceanview
$649
Balcony
$739
Suite
$1,179
From
US$569
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Sinfonia
Departures: Mar 2026 to Mar 2027
Visit: Brazil
Inside
$475
Oceanview
$505
Balcony
$565
Suite
$855
From
US$475
Per Person
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise

5 Days (4 Nights) Santos to Salvador
Cruise Line: MSC Cruises
Ship: MSC Preziosa
Departure: 02 April 2026
Visit: Brazil
Inside
-
Oceanview
-
Balcony
$579
Suite
$1,379
From
US$579
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Sao Paulo to Salvador
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 05 December 2026
Visit: Brazil
Inside
$439
Oceanview
$509
Balcony
$569
Suite
$909
From
US$439
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Maceio to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departures: Dec 2026 to Mar 2027
Visit: Brazil
Inside
$359
Oceanview
$429
Balcony
$489
Suite
$829
From
US$359
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ships: MSC Musica, MSC Sinfonia, MSC Virtuosa
Departures: Feb 2026 to Mar 2027
Visit: Brazil
Inside
$363
Oceanview
$393
Balcony
$453
Suite
$703
From
US$363
Per Person
View Trip
4 Day South America with MSC Cruises
Cruise

4 Days (3 Nights) Santos to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Lirica
Departure: 06 December 2026
Visit: Brazil
Inside
$319
Oceanview
$379
Balcony
$579
Suite
$699
From
US$319
Per Person
View Trip
5 Day South America with MSC Cruises
Cruise

5 Days (4 Nights) Salvador to Santos
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 30 March 2027
Visit: Brazil
Inside
$469
Oceanview
$549
Balcony
$649
Suite
$1,079
From
US$469
Per Person
View Trip
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