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Panama Cruises

Are you looking for a cruise to Panama? Choose from 96 unique cruise itineraries to Panama, departing from Cartagena, Colon, Fort Lauderdale, London, Los Angeles and more. January is the most popular month to cruise to Panama and we have over 231 departures available from sixteen of the world's leading cruise lines.
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96 Cruises (231 Cruise Departures)
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Costa Rica
INSIDE
-
OCEANVIEW
-
BALCONY
$9,710
SUITE
$14,900
From (per person) 9,710
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Dec 2025 to Jan 2026
Countries Visited: Costa Rica, Panama
INSIDE
-
OCEANVIEW
-
BALCONY
$5,480
SUITE
$9,270
From (per person) 5,480
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 February 2026
Countries Visited: Panama, Costa Rica
INSIDE
-
OCEANVIEW
-
BALCONY
$6,420
SUITE
$10,700
From (per person) 6,420
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Dec 2025 to Jan 2026
Countries Visited: Panama, Costa Rica
INSIDE
-
OCEANVIEW
-
BALCONY
$5,480
SUITE
$9,270
From (per person) 5,480
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 15 March 2026
Countries Visited: Costa Rica, Panama
INSIDE
-
OCEANVIEW
-
BALCONY
$9,710
SUITE
$14,900
From (per person) 9,710
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 26 February 2026
Countries Visited: Costa Rica, Panama
INSIDE
-
OCEANVIEW
-
BALCONY
$6,420
SUITE
$10,700
From (per person) 6,420
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ships: Jewel of the Seas, Serenade of the Seas
Departures: Apr 2026 to Apr 2027
Countries Visited: Panama, Colombia
Exclusive DealExclusive Solo Offer
INSIDE
$106
OCEANVIEW
$136
BALCONY
$118
SUITE
$143
Save (per person) 156
From (per person) 106
View Trip
12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) San Jose to Panama City
Operated By: Tauck
Departures: Jan 2026 to Feb 2026
Countries Visited: Costa Rica, Panama
Complimentary Hotel Night
From (per person) 8,990
View Trip
12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 03 February 2026
Countries Visited: Panama, Costa Rica
Complimentary Hotel Night
From (per person) 9,390
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Countries Visited: Panama, Chile
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$9,480
SUITE
$12,180
Save (per person) 9,510
From (per person) 9,480
View Trip
14 Day Chile, Peru & Panama Voyage with Azamara Cruises
Cruise
 (1)

14 Days (13 Nights) San Antonio to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 March 2026
Countries Visited: Chile, Peru, Panama
INSIDE
$5,309
OCEANVIEW
$5,819
BALCONY
$6,699
SUITE
$9,639
From (per person) 5,309
View Trip
8 Day Natural Sanctuaries & Heritage of the Caribbean with Ponant
Cruise

8 Days (7 Nights) Willemstad to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 26 November 2025
Countries Visited: Curacao, Colombia, Panama
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$4,840
SUITE
$7,660
From (per person) 4,840
View Trip
20 Day Treasures of French Polynesia & the Marquesas Islands with Scenic
New ReleaseCruise

20 Days (19 Nights) Papeete to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 25 March 2026
Countries Visited: French Polynesia, Costa Rica, Panama
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$16,345
SUITE
$20,145
Save (per person) 16,445
From (per person) 16,345
View Trip
11 Day Pristine islands of the Bahamas & the Panama Canal with Scenic
New ReleaseCruise

11 Days (10 Nights) Nassau to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 16 October 2026
Countries Visited: Bahamas, Colombia, Panama
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$11,470
SUITE
$14,470
Save (per person) 11,520
From (per person) 11,470
View Trip
8 Day Panama City to Fort Lauderdale with Silversea
Cruise

8 Days (7 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 20 May 2025
Countries Visited: Panama, Colombia, USA
Port-to-Port
INSIDE
-
OCEANVIEW
-
BALCONY
$6,400
SUITE
$12,200
From (per person) 6,400
View Trip
12 Day San Diego to Panama City with Silversea
Cruise

12 Days (11 Nights) San Diego to Panama City
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 09 May 2025
Countries Visited: USA, Mexico, Costa Rica, Panama
Port-to-Port
INSIDE
-
OCEANVIEW
-
BALCONY
$7,300
SUITE
$15,000
From (per person) 7,300
View Trip
11 Day Panama Canal Westward Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Colon to Los Angeles
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 25 April 2026
Countries Visited: Panama, Costa Rica, Mexico, USA
Exclusive DealExclusive Solo Offer
INSIDE
$1,273
OCEANVIEW
$1,594
BALCONY
$1,993
SUITE
$2,704
Save (per person) 502
From (per person) 1,273
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Nov 2025
Countries Visited: Colombia, Bonaire, Curacao, Panama
Exclusive DealExclusive Solo Offer
INSIDE
$1,034
OCEANVIEW
$1,084
BALCONY
$1,133
SUITE
$1,283
Save (per person) 597
From (per person) 1,034
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Mar 2026
Countries Visited: Colombia, Aruba, Curacao, Panama
Exclusive DealExclusive Solo Offer
INSIDE
$1,038
OCEANVIEW
$1,079
BALCONY
$1,228
SUITE
$1,526
Save (per person) 660
From (per person) 1,038
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ships: Jewel of the Seas, Serenade of the Seas
Departures: Dec 2025 to Feb 2027
Countries Visited: Colombia, Aruba, Bonaire, Panama
Exclusive DealExclusive Solo Offer
INSIDE
$943
OCEANVIEW
$994
BALCONY
$1,116
SUITE
$1,453
Save (per person) 768
From (per person) 943
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Jewel of the Seas
Departures: Nov 2026 to Dec 2026
Countries Visited: Colombia, Aruba, Bonaire, Panama
Exclusive Deal
INSIDE
$992
OCEANVIEW
$1,042
BALCONY
$1,174
SUITE
$1,550
Save (per person) 571
From (per person) 992
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ships: Jewel of the Seas, Serenade of the Seas
Departures: Dec 2025 to Feb 2027
Countries Visited: Panama, Colombia, Aruba, Bonaire
Exclusive Deal
INSIDE
$875
OCEANVIEW
$915
BALCONY
$1,037
SUITE
$1,362
Save (per person) 639
From (per person) 875
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Apr 2026
Countries Visited: Colombia, Aruba, Curacao, Panama
Exclusive DealExclusive Solo Offer
INSIDE
$1,028
OCEANVIEW
$1,068
BALCONY
$1,218
SUITE
$1,434
Save (per person) 609
From (per person) 1,028
View Trip
19 Day New York To San Francisco with Cunard
Cruise
 (3)

19 Days (18 Nights) New York to San Francisco
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 19 January 2026
Countries Visited: USA, Curacao, Panama, Mexico
Latest OfferExclusive Deal
INSIDE
$4,379
OCEANVIEW
$6,189
BALCONY
$6,549
SUITE
-
From (per person) 4,379
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 06 December 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$919
OCEANVIEW
$950
BALCONY
$1,089
SUITE
$1,389
Save (per person) 480
From (per person) 919
View Trip
16 Day New York To Los Angeles with Cunard
Cruise
 (3)

16 Days (15 Nights) New York to Los Angeles
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 19 January 2026
Countries Visited: USA, Curacao, Panama, Mexico
Exclusive DealLatest Offer
INSIDE
$3,689
OCEANVIEW
$5,169
BALCONY
$5,659
SUITE
$11,149
From (per person) 3,689
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 20 December 2025
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive Deal
INSIDE
$1,113
OCEANVIEW
$1,154
BALCONY
$1,283
SUITE
$1,683
Save (per person) 566
From (per person) 1,113
View Trip
21 Day Panama Canal - Ocean to Ocean with Princess
Cruise

21 Days (20 Nights) Fort Lauderdale to Seattle
Cruise Line: Princess
Ship: Star Princess
Departure: 13 April 2026
Countries Visited: USA, Aruba, Panama, Mexico
Exclusive DealSpring Swing Offer
INSIDE
$2,228
OCEANVIEW
$2,828
BALCONY
$3,748
SUITE
$5,048
From (per person) 2,228
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ships: Jewel of the Seas, Serenade of the Seas
Departures: Oct 2025 to Apr 2027
Countries Visited: Colombia, Aruba, Curacao, Panama
Exclusive DealExclusive Solo Offer
INSIDE
$887
OCEANVIEW
$927
BALCONY
$1,049
SUITE
$1,364
Save (per person) 695
From (per person) 887
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Apr 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$939
OCEANVIEW
$939
BALCONY
$938
SUITE
$1,388
Save (per person) 554
From (per person) 938
View Trip
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