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Cruises from Rome to Istanbul

Are you looking for a cruise from Rome to Istanbul? September is the most popular month to cruise between Rome and Istanbul and there are 39 departures available from four of the world's leading cruise lines.
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11 Cruises (39 Cruise Departures)
12 Day Eastern Mediterranean From Rome To Istanbul with Norwegian Cruise Line
Cruise
 (1)

12 Days (11 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 07 May 2025
Countries Visited: Italy, Sicily, Egypt, Cyprus (+2 more), Greece, Turkey
INSIDE
$2,092
OCEANVIEW
$2,292
BALCONY
$2,342
SUITE
$3,242
From (per person) 2,092
View Trip
15 Day Ancient Mediterranean Antiquities with Viking Cruises
Cruise

15 Days (14 Nights) Rome to Istanbul
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mira (+5 more), Viking Neptune, Viking Saturn, Viking Star, Viking Vela, Viking Vesta
Departures: Dec 2025 to Feb 2027
Countries Visited: Italy, Sicily, Greece, Turkey
INSIDE
-
OCEANVIEW
-
BALCONY
$5,598
SUITE
$10,098
From (per person) 5,598
View Trip
10 Day Greek Isles & Italy with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Rome to Istanbul
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: May 2026 to Jul 2026
Countries Visited: Italy, Sicily, Malta, Greece (+1 more), Turkey
INSIDE
$2,108
OCEANVIEW
$2,448
BALCONY
$2,978
SUITE
$3,828
From (per person) 2,108
View Trip
13 Day Italy & Ancient Isles with Oceania Cruises
Cruise

13 Days (12 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 04 October 2025
Countries Visited: Italy, Sicily, Malta, Greece (+1 more), Turkey
Exclusive DealFlash Sale + Prestige Beverage Package
INSIDE
$4,299
OCEANVIEW
$5,099
BALCONY
$4,425
SUITE
$6,075
Save (per person) 4,299
From (per person) 4,299
View Trip
8 Day Istanbul, Greek Isles And Italy with Cunard
Cruise

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 21 September 2026
Countries Visited: Italy, Greece, Turkey
Exclusive Deal
INSIDE
$1,099
OCEANVIEW
$1,229
BALCONY
$1,459
SUITE
$3,659
From (per person) 1,099
View Trip
8 Day Hellenic & Dalmatian Gems with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 05 November 2026
Countries Visited: Italy, Sicily, Malta, Greece (+1 more), Turkey
Exclusive Deal
INSIDE
$2,099
OCEANVIEW
$2,299
BALCONY
$3,399
SUITE
$4,699
Save (per person) 2,099
From (per person) 2,099
View Trip
12 Day Antiquity To Anatolia with Oceania Cruises
Cruise

12 Days (11 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 29 October 2025
Countries Visited: Italy, Sicily, Greece, Turkey
Flash Sale + Prestige Beverage PackageExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$3,840
SUITE
$5,760
Save (per person) 5,758
From (per person) 3,840
View Trip
22 Day Adriatic & Mediterranean Sojourn with Viking Cruises
Cruise
 (7)

22 Days (21 Nights) Rome to Istanbul
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+6 more), Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vesta
Departures: Apr 2025 to Jul 2027
Countries Visited: Italy, Sicily, Croatia, Montenegro (+2 more), Greece, Turkey
INSIDE
-
OCEANVIEW
-
BALCONY
$10,147
SUITE
$15,447
From (per person) 10,147
View Trip
13 Day Artifacts & Antiquities with Oceania Cruises
Cruise

13 Days (12 Nights) Rome to Istanbul
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 14 September 2026
Countries Visited: Italy, Sardinia, Sicily, Malta (+2 more), Greece, Turkey
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$5,499
SUITE
$8,899
Save (per person) 5,499
From (per person) 5,499
View Trip
8 Day Greece And Turkey with Cunard
Cruise

8 Days (7 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 12 May 2025
Countries Visited: Italy, Greece, Turkey
Exclusive Deal
INSIDE
$1,019
OCEANVIEW
$1,349
BALCONY
$1,489
SUITE
$3,049
From (per person) 1,019
View Trip
15 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise

15 Days (14 Nights) Rome to Istanbul
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 14 September 2026
Countries Visited: Italy, France, Greece, Turkey
Exclusive Deal
INSIDE
$2,339
OCEANVIEW
$2,609
BALCONY
$3,209
SUITE
$7,419
From (per person) 2,339
View Trip
Results: 11 results

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