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Sicily Cruises

Are you looking for a cruise to Sicily? Choose from 338 unique cruise itineraries to Sicily, departing from Amalfi, Antalya, Athens, Barcelona, Bologna and more. October is the most popular month to cruise to Sicily and we have over 2,220 departures available from twenty of the world's leading cruise lines.
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338 Cruises (2,220 Cruise Departures)
9 Day Mind and Taste Buds Awake with the Mucem in the Mediterranean with Ponant
Cruise
 (2)

9 Days (8 Nights) Rome to Athens
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 09 October 2025
Visit: Italy, Sicily, Greece
Inside
-
Oceanview
-
Balcony
-
Suite
$16,210
From
US$16,210
Per Person
View Trip
10 Day Malta, Sicily & Amalfi Coast with Emerald Cruises
New ReleaseCruise

10 Days (9 Nights) Valletta to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departures: May 2026 to Jul 2026
Visit: Malta, Sicily, Italy
Fly Free Economy
Fly Free Premium Economy
Exclusive Savings
Inside
-
Oceanview
$7,013
Balcony
-
Suite
$9,584
From
US$7,013
Save 10,824
Per Person
View Trip
9 Day Cruising Southern Italy and Sicily - with Smithsonian Journeys with Ponant
Cruise

9 Days (8 Nights) Valletta to Livorno
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departure: 06 September 2026
Visit: Malta, Sicily, Italy
Inside
-
Oceanview
-
Balcony
$9,460
Suite
$21,190
From
US$9,460
Per Person
View Trip
11 Day Rome, Florence, Mykonos & More with Virgin Voyages
Cruise
 (1)

11 Days (10 Nights) Rome to Athens
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 31 August 2026
Visit: Italy, Sicily, Greece
Set, Sail and Save Offer
Inside
$2,850
Oceanview
$3,251
Balcony
$3,350
Suite
$5,990
From
US$2,850
Per Person
View Trip
12 Day Italy Intensive Cruise: Bologna, Sicily & Amalfi with Azamara Cruises
Cruise
 (8)

12 Days (11 Nights) Venice to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 16 May 2027
Visit: Italy, Montenegro, Sicily
Azamara Always Included
Exclusive Savings
Inside
$3,289
Oceanview
$3,783
Balcony
$4,744
Suite
$7,169
From
US$3,289
Save 70
Per Person
View Trip
8 Day Iberian Peninsula & Sicily with Ponant
Cruise
 (1)

8 Days (7 Nights) Malaga to Valletta
Cruise Line: Ponant
Ship: Le Bougainville
Departure: 28 April 2026
Visit: Spain, Sicily, Malta
Inside
-
Oceanview
-
Balcony
$5,920
Suite
$11,040
From
US$5,920
Per Person
View Trip
11 Day Mediterranean Crossroads with Emerald Cruises
New ReleaseCruise
 (3)

11 Days (10 Nights) Athens to Valletta
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 09 November 2025
Visit: Greece, Sicily, Malta
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$22,228
From
US$22,228
Save 662
Per Person
View Trip
8 Day Italian Sojourn with Viking Cruises
Cruise
 (8)

8 Days (7 Nights) Rome to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+8 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Mar 2026 to Jul 2028
Visit: Italy, Sicily, Croatia
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,723
Suite
$5,389
From
US$3,723
Save 300
Per Person
View Trip
6 Day Italian Escape with Ponant
Cruise
 (2)

6 Days (5 Nights) Valletta to Amalfi
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 17 November 2025
Visit: Malta, Sicily, Italy
Inside
-
Oceanview
-
Balcony
$4,020
Suite
-
From
US$4,020
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (2)

4 Days (3 Nights) Messina to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 05 November 2025
Visit: Sicily, Italy, Spain
Inside
$219
Oceanview
$269
Balcony
$359
Suite
$709
From
US$219
Per Person
View Trip
11 Day Yachting Sicily to Elba via the Amalfi Coast with Emerald Cruises
New ReleaseCruise

11 Days (10 Nights) Rome to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departure: 30 June 2027
Visit: Italy, Sicily, Malta
Fly Free Economy
Fly Free Premium Economy
Exclusive Savings
Inside
-
Oceanview
$9,226
Balcony
-
Suite
$12,233
From
US$9,226
Save 9,764
Per Person
View Trip
9 Day A Circumnavigation of Sicily - with Smithsonian Journeys with Ponant
Cruise
 (1)

9 Days (8 Nights) Valletta to Valletta
Cruise Line: Ponant
Ships: Le Bougainville, Le Dumont d’Urville
Departures: May 2026 to Aug 2026
Visit: Malta, Sicily, Tunisia
Inside
-
Oceanview
-
Balcony
$8,910
Suite
$14,980
From
US$8,910
Per Person
View Trip
11 Day Italy Intensive Cruise: Venice, Sicily & Amalfi with Azamara Cruises
Cruise
 (2)

11 Days (10 Nights) Venice to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 05 May 2027
Visit: Italy, Montenegro, Sicily
Azamara Always Included
Inside
$2,539
Oceanview
$2,859
Balcony
$3,713
Suite
$5,633
From
US$2,539
Per Person
View Trip
11 Day 5th Opera Festival at Sea with Ponant
Cruise

11 Days (10 Nights) Venice to Nice
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departure: 22 June 2026
Visit: Italy, Sicily, France
Inside
-
Oceanview
-
Balcony
$13,640
Suite
$24,390
From
US$13,640
Per Person
View Trip
8 Day Island Odyssey: Malta, Sicily & the Greek Isles with Scenic
New ReleaseCruise

8 Days (7 Nights) Valletta to Athens
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 14 June 2026
Visit: Malta, Sicily, Greece
Fly Free Premium Economy
Fly Free Business Class
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$11,595
Suite
$14,582
From
US$11,595
Save 12,335
Per Person
View Trip
8 Day Greek Isles & Italy Cruise with Celebrity Cruises
Cruise

8 Days (7 Nights) Barcelona to Athens
Cruise Line: Celebrity Cruises
Ship: Celebrity Xcel
Departure: 17 July 2027
Visit: Spain, Sicily, Greece
Exclusive Savings
Inside
$1,467
Oceanview
$1,657
Balcony
$1,780
Suite
$4,440
From
US$1,467
Save 859
Per Person
View Trip
8 Day Mediterranean Cruise: Italy & Greece with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Rome to Athens
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 05 December 2026
Visit: Italy, Sicily, Greece
Azamara Always Included
Inside
$1,779
Oceanview
$2,039
Balcony
$2,375
Suite
$3,694
From
US$1,779
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Palermo to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 07 January 2026
Visit: Sicily, Tunisia, Spain
Inside
$219
Oceanview
$309
Balcony
$379
Suite
$669
From
US$219
Per Person
View Trip
7 Day Western Mediterranean From Rome To Rome with Norwegian Cruise Line
Cruise

7 Days (6 Nights) Rome to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Gem
Departure: 11 May 2026
Visit: Italy, France, Sicily
Inside
$748
Oceanview
$900
Balcony
$1,707
Suite
$1,821
From
US$748
Per Person
View Trip
8 Day Italian Sojourn with Viking Cruises
Cruise
 (8)

8 Days (7 Nights) Venice to Rome
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Jupiter (+9 more), Viking Lyra, Viking Mars, Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Vela, Viking Vesta
Departures: Apr 2026 to Sep 2028
Visit: Italy, Croatia, Sicily
Viking $1,299 Air Deal
Viking $1,499 Air Deal
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,919
Suite
$5,879
From
US$3,919
Save 587
Per Person
View Trip
12 Day Italy Cruise: Venice, Sicily & Rome with Azamara Cruises
Cruise
 (8)

12 Days (11 Nights) Rome to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 22 August 2026
Visit: Italy, Sicily, Montenegro
Azamara Always Included
Exclusive Savings
Inside
$4,050
Oceanview
$4,467
Balcony
$4,923
Suite
$7,707
From
US$4,050
Save 99
Per Person
View Trip
11 Day Ancient Civilisations, from Italy to Greece with Ponant
Cruise

11 Days (10 Nights) Rome to Athens
Cruise Line: Ponant
Ship: Le Champlain
Departure: 01 October 2026
Visit: Italy, Sicily, Greece
Inside
-
Oceanview
-
Balcony
$8,950
Suite
$16,710
From
US$8,950
Per Person
View Trip
9 Day A Celebration of Art Featuring the 61st Venice Biennale with Ponant
Cruise
 (1)

9 Days (8 Nights) Valletta to Venice
Cruise Line: Ponant
Ship: Le Bougainville
Departure: 01 July 2026
Visit: Malta, Sicily, Italy
Inside
-
Oceanview
-
Balcony
$8,990
Suite
$16,550
From
US$8,990
Per Person
View Trip
10 Day Authentic Mediterranean shores with Ponant
Cruise
 (1)

10 Days (9 Nights) Valletta to Valletta
Cruise Line: Ponant
Ship: Le Boreal
Departure: 01 October 2026
Visit: Malta, Sicily, Italy
Inside
-
Oceanview
$7,340
Balcony
$7,730
Suite
$16,010
From
US$7,340
Per Person
View Trip
12 Day Sicily, the Amalfi Coast & Rome with Tauck
Cruise

12 Days (11 Nights) Malta to Rome
Operated By: Tauck
Departures: Apr 2026 to Oct 2026
Visit: Malta, Sicily, Italy
Complimentary Hotel Night
From
US$12,490
Per Person
View Trip
8 Day Mystical Italy & Croatia with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Venice
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 20 June 2027
Visit: Italy, Sicily, Croatia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,091
Suite
$6,875
From
US$6,091
Save 11,307
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Palermo to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 29 April 2026
Visit: Sicily, Malta, Spain
Inside
$259
Oceanview
$369
Balcony
-
Suite
-
From
US$259
Per Person
View Trip
8 Day Greek Isles & Italy Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departures: Oct 2026 to Oct 2026
Visit: Italy, Sicily, Greece
Exclusive Savings
Inside
$1,144
Oceanview
$1,303
Balcony
$1,355
Suite
$2,367
From
US$1,144
Save 593
Per Person
View Trip
12 Day Rome, the Amalfi Coast & Sicily with Tauck
Cruise

12 Days (11 Nights) Rome to Malta
Operated By: Tauck
Departures: Apr 2026 to Oct 2026
Visit: Italy, Sicily, Malta
Complimentary Hotel Night
From
US$12,490
Per Person
View Trip
9 Day Epicurean Delights: The Food & Wine of Sicily with Ponant
Cruise

9 Days (8 Nights) Valletta to Valletta
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departure: 11 April 2026
Visit: Malta, Sicily, Italy
Inside
-
Oceanview
-
Balcony
$10,460
Suite
$19,420
From
US$10,460
Per Person
View Trip
Results: 1-30 of 338

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