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MSC Cruises from Rome

Start your journey from Rome with 33 unique MSC cruise itineraries to choose from. October is the most popular month to begin your cruise from Rome and MSC Cruises have 325 trips departing this season.
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21 Days
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33 Cruises (325 Cruise Departures)
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ships: MSC Grandiosa, MSC Seaview
Departures: May 2025 to Oct 2026
Countries Visited: Italy, Spain, France
Escape To Sea - Cruise OnlyDrinks and Wi-Fi Included
INSIDE
$901
OCEANVIEW
$925
BALCONY
$1,164
SUITE
$1,654
From (per person) 901
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

18 Days (17 Nights) Rome to Doha
Cruise Line: MSC Cruises
Ship: MSC Euribia
Departure: 23 October 2025
Countries Visited: Italy, Egypt, Jordan, Oman (+2 more), Qatar, United Arab Emirates
Escape To Sea - Cruise Only
INSIDE
$1,505
OCEANVIEW
$1,825
BALCONY
$2,095
SUITE
-
From (per person) 1,505
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

19 Days (18 Nights) Rome to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 06 November 2025
Countries Visited: Italy, Spain, Morocco, Brazil (+2 more), Uruguay, Argentina
Escape To Sea - Cruise OnlyDrinks and Wi-Fi Included
INSIDE
$1,287
OCEANVIEW
$1,477
BALCONY
$1,867
SUITE
$3,747
From (per person) 1,287
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Rome to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 12 December 2025
Countries Visited: Italy, France
Escape To Sea - Cruise Only
INSIDE
$221
OCEANVIEW
$281
BALCONY
$341
SUITE
$651
From (per person) 221
View Trip
13 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

13 Days (12 Nights) Rome to Hamburg
Cruise Line: MSC Cruises
Ship: MSC Euribia
Departure: 20 April 2026
Countries Visited: Italy, Spain, Portugal, France (+2 more), England, Germany
Escape To Sea - Cruise Only
INSIDE
$1,024
OCEANVIEW
$1,224
BALCONY
$1,324
SUITE
$2,494
From (per person) 1,024
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

17 Days (16 Nights) Rome to Dubai
Cruise Line: MSC Cruises
Ship: MSC Euribia
Departure: 23 October 2025
Countries Visited: Italy, Egypt, Jordan, Oman (+2 more), Qatar, United Arab Emirates
Escape To Sea - Cruise Only
INSIDE
$1,393
OCEANVIEW
$1,703
BALCONY
$1,863
SUITE
-
From (per person) 1,393
View Trip
9 Day Mediterranean with MSC Cruises
Cruise

9 Days (8 Nights) Rome to Genoa
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 10 October 2025
Countries Visited: Italy, Greece, Turkey
Escape To Sea - Cruise OnlyDrinks and Wi-Fi Included
INSIDE
$1,009
OCEANVIEW
$1,229
BALCONY
$1,319
SUITE
$1,979
From (per person) 1,009
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departures: Apr 2025 to Nov 2025
Countries Visited: Italy, France, Spain, Sardinia
Escape To Sea - Cruise Only
INSIDE
$730
OCEANVIEW
$860
BALCONY
$1,080
SUITE
$1,770
From (per person) 730
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 19 August 2025
Countries Visited: Italy, France, Spain
Escape To Sea - Cruise OnlyDrinks and Wi-Fi Included
INSIDE
-
OCEANVIEW
-
BALCONY
$1,238
SUITE
$1,910
From (per person) 1,238
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (1)

6 Days (5 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 16 April 2025
Countries Visited: Italy, Spain
Escape To Sea - Cruise Only
INSIDE
$721
OCEANVIEW
$831
BALCONY
$991
SUITE
$1,481
From (per person) 721
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (1)

6 Days (5 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Apr 2026 to Apr 2026
Countries Visited: Italy, Spain, France
Escape To Sea - Cruise OnlyDrinks and Wi-Fi Included
INSIDE
$804
OCEANVIEW
$864
BALCONY
$934
SUITE
$1,324
From (per person) 804
View Trip
3 Day Mediterranean with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 16 April 2025
Countries Visited: Italy, Spain
One Way Cruise Offer
INSIDE
-
OCEANVIEW
$251
BALCONY
$351
SUITE
$591
From (per person) 251
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

21 Days (20 Nights) Rome to Abu Dhabi
Cruise Line: MSC Cruises
Ship: MSC Euribia
Departure: 23 October 2025
Countries Visited: Italy, Egypt, Jordan, Oman (+3 more), Qatar, United Arab Emirates, Bahrain
Escape To Sea - Cruise Only
INSIDE
$1,749
OCEANVIEW
-
BALCONY
-
SUITE
-
From (per person) 1,749
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ships: MSC Orchestra, MSC Splendida
Departures: May 2025 to Oct 2026
Countries Visited: Italy, France, Spain
Escape To Sea - Cruise OnlyDrinks and Wi-Fi Included
INSIDE
$573
OCEANVIEW
$830
BALCONY
$884
SUITE
$1,394
From (per person) 573
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: May 2026 to Nov 2026
Countries Visited: Italy, Sicily, Spain, France
Escape To Sea - Cruise OnlyDrinks and Wi-Fi Included
INSIDE
$916
OCEANVIEW
$1,046
BALCONY
$1,176
SUITE
$1,656
From (per person) 916
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 09 May 2025
Countries Visited: Italy, Greece, Turkey
Escape To Sea - Cruise OnlyDrinks and Wi-Fi Included
INSIDE
-
OCEANVIEW
$1,200
BALCONY
$1,380
SUITE
$1,882
From (per person) 1,200
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Rome to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 28 November 2025
Countries Visited: Italy, Spain, Morocco, Brazil
Escape To Sea - Cruise Only
INSIDE
-
OCEANVIEW
$1,363
BALCONY
-
SUITE
-
From (per person) 1,363
View Trip
7 Day Mediterranean with MSC Cruises
Cruise
 (2)

7 Days (6 Nights) Rome to Genoa
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 07 April 2025
Countries Visited: Italy, Sicily, Malta, Spain (+1 more), France
One Way Cruise Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$2,574
From (per person) 2,574
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Rome to Naples
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 07 April 2025
Countries Visited: Italy, Sicily, Malta, Spain (+1 more), France
Escape To Sea - Cruise OnlyDrinks and Wi-Fi Included
INSIDE
-
OCEANVIEW
$1,352
BALCONY
-
SUITE
$3,298
From (per person) 1,352
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (2)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departures: Mar 2025 to Apr 2026
Countries Visited: Italy, Sicily, Malta, Spain (+1 more), France
Escape To Sea - Cruise OnlyDrinks and Wi-Fi Included
INSIDE
$687
OCEANVIEW
$877
BALCONY
$987
SUITE
$1,717
From (per person) 687
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departures: May 2025 to Oct 2026
Countries Visited: Italy, Greece, Turkey
Escape To Sea - Cruise OnlyDrinks and Wi-Fi Included
INSIDE
$957
OCEANVIEW
$1,127
BALCONY
$1,257
SUITE
$1,797
From (per person) 957
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departures: Apr 2026 to Oct 2026
Countries Visited: Italy, France, Spain, Sardinia
Escape To Sea - Cruise Only
INSIDE
$761
OCEANVIEW
$861
BALCONY
-
SUITE
-
From (per person) 761
View Trip
3 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Rome to Marseille
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 21 April 2025
Countries Visited: Italy, France
One Way Cruise Offer
INSIDE
$135
OCEANVIEW
$185
BALCONY
$235
SUITE
$505
From (per person) 135
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departures: Nov 2025 to Apr 2026
Countries Visited: Italy, Spain, France
Escape To Sea - Cruise Only
INSIDE
$534
OCEANVIEW
$654
BALCONY
$884
SUITE
-
From (per person) 534
View Trip
9 Day Mediterranean with MSC Cruises
Cruise

9 Days (8 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departures: Dec 2025 to Dec 2025
Countries Visited: Italy, France, Spain
Escape To Sea - Cruise Only
INSIDE
$1,084
OCEANVIEW
$1,214
BALCONY
$1,364
SUITE
-
From (per person) 1,084
View Trip
7 Day Mediterranean with MSC Cruises
Cruise

7 Days (6 Nights) Rome to Genoa
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 09 November 2025
Countries Visited: Italy, Sicily, Spain, France
One Way Cruise Offer
INSIDE
$498
OCEANVIEW
$678
BALCONY
$768
SUITE
$1,348
From (per person) 498
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Rome to Kusadasi
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 09 May 2025
Countries Visited: Italy, Greece, Turkey
One Way Cruise Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$564
SUITE
-
From (per person) 564
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Countries Visited: Italy, France, Spain, Portugal (+3 more), Saint Martin, Bahamas, USA
Escape To Sea - Cruise Only
INSIDE
$1,188
OCEANVIEW
$1,367
BALCONY
$2,034
SUITE
-
From (per person) 1,188
View Trip
21 Day Transatlantic with MSC Cruises
Cruise

21 Days (20 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 17 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Cruise Only
INSIDE
$1,389
OCEANVIEW
$1,679
BALCONY
$2,169
SUITE
$3,679
From (per person) 1,389
View Trip
7 Day Mediterranean with MSC Cruises
Cruise

7 Days (6 Nights) Rome to Amalfi
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 09 May 2025
Countries Visited: Italy, Greece, Turkey
One Way Cruise Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$1,099
SUITE
$2,329
From (per person) 1,099
View Trip
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