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Panama Tours & Cruises Starting In October 2025

If you're looking at joining a tour to Panama in October 2025, we have 29 unique cruises, small group tours and adventures with 370 departures from the world's leading tour operators departing in October.
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Departures (October 2025)
< September 2025 November 2025 >
Duration
6 Days
58 Days
Types
Budget
Start & End Cities
Operators
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Price
$200pp
$257,000pp
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29 Trips (370 Trip Departures)
6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operated By: Globus
Departures: Feb 2025 to Mar 2026
Trip Styles: Short Break, Scenic
Countries Visited: Panama
Exclusive Savings
Save (per person) 56
From (per person) 2,518
View Trip
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: Jan 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Costa Rica, Panama
Big Sale
Save (per person) 471
From (per person) 2,268
View Trip
14 Day Cycle Nicaragua to the Panama Canal with Explore!
Tour

14 Days Granada to Panama City
Operated By: Explore!
Departures: Feb 2025 to Nov 2026
Trip Styles: Adventure, Small Group, Cycling
Countries Visited: Costa Rica, Panama, Nicaragua
Big Blue SaleSolo Traveller Offer
Save (per person) 828
From (per person) 6,732
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Apr 2026
Countries Visited: Colombia, Curacao, Aruba, Panama
Exclusive DealSingle Savings
INSIDE
$1,551
OCEANVIEW
$1,695
BALCONY
$2,029
SUITE
$2,538
Save (per person) 952
From (per person) 1,551
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Apr 2026
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive Deal
INSIDE
$1,422
OCEANVIEW
$1,555
BALCONY
$1,722
SUITE
$2,395
Save (per person) 652
From (per person) 1,422
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Nov 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,444
OCEANVIEW
$1,527
BALCONY
$1,745
SUITE
$2,395
Save (per person) 705
From (per person) 1,444
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Nov 2025
Countries Visited: Colombia, Aruba, Curacao, Panama
Exclusive Deal
INSIDE
$1,722
OCEANVIEW
$1,826
BALCONY
$2,070
SUITE
$2,538
Save (per person) 931
From (per person) 1,722
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Island Princess
Departure: 22 October 2025
Countries Visited: USA, Mexico, Nicaragua, Costa Rica (+2 more), Panama, Curacao
Exclusive Deal
INSIDE
$2,261
OCEANVIEW
$2,452
BALCONY
$3,380
SUITE
$4,667
From (per person) 2,261
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (7)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Oct 2025 to Dec 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$6,561
SUITE
$9,501
Save (per person) 144
From (per person) 6,561
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise

18 Days (17 Nights) Fort Lauderdale to Santiago
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2025 to Nov 2026
Countries Visited: USA, Mexico, Panama, Ecuador (+2 more), Peru, Chile
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$15,871
SUITE
$21,751
Save (per person) 324
From (per person) 15,871
View Trip
21 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

21 Days (20 Nights) Seattle to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Encore
Departure: 19 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
INSIDE
$5,275
OCEANVIEW
$6,024
BALCONY
$6,895
SUITE
$7,569
From (per person) 5,275
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ships: Caribbean Princess, Coral Princess, Island Princess
Departures: Sep 2025 to Feb 2026
Countries Visited: USA, Mexico, Nicaragua, Costa Rica (+2 more), Panama, Aruba
Exclusive Deal
INSIDE
$2,229
OCEANVIEW
$2,402
BALCONY
$3,281
SUITE
$5,090
From (per person) 2,229
View Trip
17 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

17 Days (16 Nights) Los Angeles to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Encore
Departure: 23 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
INSIDE
$4,556
OCEANVIEW
$5,366
BALCONY
$6,238
SUITE
$6,911
From (per person) 4,556
View Trip
28 Day Amazing Central America with Intrepid Travel
Tour

28 Days Antigua to Panama City
Operated By: Intrepid Travel
Departures: Feb 2025 to Dec 2026
Trip Styles: Adventure, Small Group
Countries Visited: Guatemala, Honduras, El Salvador, Nicaragua (+2 more), Costa Rica, Panama
Big Sale
Save (per person) 1,400
From (per person) 4,447
View Trip
19 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

19 Days (18 Nights) San Francisco to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Encore
Departure: 21 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
INSIDE
$4,826
OCEANVIEW
$5,637
BALCONY
$6,509
SUITE
$7,181
From (per person) 4,826
View Trip
16 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Los Angeles to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Joy
Departure: 05 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
INSIDE
$4,984
OCEANVIEW
$6,116
BALCONY
$6,804
SUITE
$7,477
From (per person) 4,984
View Trip
19 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

19 Days (18 Nights) San Francisco to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Joy
Departure: 02 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
Exclusive Solo Offer
INSIDE
$5,426
OCEANVIEW
$6,557
BALCONY
$7,245
SUITE
$7,919
From (per person) 5,426
View Trip
13 Day Panama Canal Sunfarer with Holland America
Cruise
 (2)

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Rotterdam
Departures: Oct 2025 to Mar 2026
Countries Visited: USA, Bahamas, Curacao, Colombia (+3 more), Panama, Costa Rica, Cayman Islands
Exclusive Deal
INSIDE
$1,826
OCEANVIEW
$2,717
BALCONY
$3,014
SUITE
$4,945
From (per person) 1,826
View Trip
24 Day Panama Canal & Pacific Coast with Princess
Cruise
 (2)

24 Days (23 Nights) Vancouver to Fort Lauderdale
Cruise Line: Princess
Ship: Coral Princess
Departure: 21 October 2025
Countries Visited: Canada, USA, Mexico, Nicaragua (+3 more), Costa Rica, Panama, Aruba
Exclusive Deal
INSIDE
$3,801
OCEANVIEW
$3,910
BALCONY
$5,185
SUITE
$7,547
From (per person) 3,801
View Trip
13 Day Panama Canal with Costa Rica & Caribbean From Fort Lauderdale with Princess
Cruise

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Princess
Ships: Caribbean Princess, Emerald Princess
Departures: Mar 2025 to Mar 2026
Countries Visited: USA, Aruba, Curacao, Colombia (+3 more), Panama, Costa Rica, Cayman Islands
Exclusive Deal
INSIDE
$2,091
OCEANVIEW
$2,147
BALCONY
$3,674
SUITE
$4,330
From (per person) 2,091
View Trip
44 Day Best of Central America with Intrepid Travel
Tour
 (1)

44 Days Playa del Carmen to Panama City
Operated By: Intrepid Travel
Departures: Feb 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Big Sale
Save (per person) 2,123
From (per person) 6,748
View Trip
45 Day Epic Central America with Intrepid Travel
Tour

45 Days Mexico City to San Jose
Operated By: Intrepid Travel
Departures: Feb 2025 to Dec 2025
Trip Styles: Adventure, Small Group, 18-30's
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Big Sale
Save (per person) 443
From (per person) 5,958
View Trip
41 Day The Americas & Antarctic Explorer with Viking Cruises
Cruise

41 Days (40 Nights) Fort Lauderdale to Buenos Aires
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2025 to Nov 2026
Countries Visited: USA, Mexico, Panama, Ecuador (+4 more), Peru, Chile, Argentina, Antarctica
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$46,251
SUITE
$64,871
Save (per person) 968
From (per person) 46,251
View Trip
58 Day Ultimate Central America with Intrepid Travel
Tour

58 Days Mexico City to Panama City
Operated By: Intrepid Travel
Departures: Feb 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Big Sale
Save (per person) 2,278
From (per person) 10,186
View Trip
22 Day Panama Canal & Southern Caribbean: ABC Islands with Holland America
Cruise
 (2)

22 Days (21 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Rotterdam
Departures: Oct 2025 to Mar 2026
Countries Visited: USA, Bahamas, Curacao, Colombia (+5 more), Panama, Costa Rica, Cayman Islands, Bonaire, Aruba
Exclusive Deal
INSIDE
$2,896
OCEANVIEW
$3,980
BALCONY
$4,499
SUITE
$6,757
From (per person) 2,896
View Trip
47 Day The Americas, Chile & Antarctica with Viking Cruises
Cruise

47 Days (46 Nights) Fort Lauderdale to Buenos Aires
Cruise Line: Viking Cruises
Ship: Viking Octantis
Departure: 13 October 2025
Countries Visited: USA, Mexico, Panama, Ecuador (+6 more), Peru, Chile, Argentina, Antarctica, South Georgia Island, Falkland Islands
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$54,346
SUITE
$77,512
Save (per person) 2,649
From (per person) 54,346
View Trip
25 Day Panama Canal & Eastern Caribbean with Holland America
Cruise

25 Days (24 Nights) San Diego to Fort Lauderdale
Cruise Line: Holland America
Ship: Eurodam
Departure: 09 October 2025
Countries Visited: USA, Mexico, Guatemala, El Salvador (+7 more), Costa Rica, Panama, Aruba, Turks and Caicos Islands, Puerto Rico, Virgin Islands, Bahamas
Exclusive Deal
INSIDE
$3,891
OCEANVIEW
$4,337
BALCONY
$6,319
SUITE
$10,975
From (per person) 3,891
View Trip
30 Day Panama Canal & Eastern Caribbean with Holland America
Cruise

30 Days (29 Nights) Seattle to Fort Lauderdale
Cruise Line: Holland America
Ship: Eurodam
Departure: 04 October 2025
Countries Visited: USA, Canada, Mexico, Guatemala (+8 more), El Salvador, Costa Rica, Panama, Aruba, Turks and Caicos Islands, Puerto Rico, Virgin Islands, Bahamas
Exclusive Deal
INSIDE
$4,552
OCEANVIEW
$4,997
BALCONY
$7,158
SUITE
$12,125
From (per person) 4,552
View Trip
29 Day Panama Canal & Eastern Caribbean with Holland America
Cruise

29 Days (28 Nights) Vancouver to Fort Lauderdale
Cruise Line: Holland America
Ship: Eurodam
Departure: 05 October 2025
Countries Visited: Canada, USA, Mexico, Guatemala (+8 more), El Salvador, Costa Rica, Panama, Aruba, Turks and Caicos Islands, Puerto Rico, Virgin Islands, Bahamas
Exclusive Deal
INSIDE
$4,263
OCEANVIEW
$4,708
BALCONY
$6,869
SUITE
$11,747
From (per person) 4,263
View Trip
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