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Panama Tours & Cruises Starting In October 2025

If you're looking at joining a tour to Panama in October 2025, we have 30 unique cruises, small group tours and adventures with 340 departures from the world's leading tour operators departing in October.
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Departures (October 2025)
< September 2025 November 2025 >
Duration
6 Days
58 Days
Types
Budget
Start & End Cities
Operators
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Price
$100pp
$232,995pp
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30 Trips (340 Trip Departures)
6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operated By: Globus
Departures: Mar 2025 to Mar 2026
Trip Styles: Short Break, Scenic
Countries Visited: Panama
From (per person) 1,709
View Trip
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: Mar 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Costa Rica, Panama
Exclusive Deal
Save (per person) 211
From (per person) 1,899
View Trip
14 Day Cycle Nicaragua to the Panama Canal with Explore!
Tour

14 Days Granada to Panama City
Operated By: Explore!
Departures: Oct 2025 to Nov 2026
Trip Styles: Adventure, Small Group, Cycling
Countries Visited: Costa Rica, Panama, Nicaragua
Exclusive DealSolo Traveller Offer
Save (per person) 760
From (per person) 4,150
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Apr 2026
Countries Visited: Colombia, Curacao, Aruba, Panama
Exclusive DealExclusive Solo Offer
INSIDE
$1,088
OCEANVIEW
$1,119
BALCONY
$1,218
SUITE
$1,386
Save (per person) 712
From (per person) 1,088
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Apr 2026
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive Deal
INSIDE
$941
OCEANVIEW
$1,039
BALCONY
$1,039
SUITE
$1,189
Save (per person) 585
From (per person) 941
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Nov 2025
Countries Visited: Colombia, Aruba, Curacao, Panama
Exclusive DealExclusive Solo Offer
INSIDE
$1,186
OCEANVIEW
$1,187
BALCONY
$1,256
SUITE
$1,386
Save (per person) 695
From (per person) 1,186
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Nov 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$940
OCEANVIEW
$940
BALCONY
$939
SUITE
$1,189
Save (per person) 554
From (per person) 939
View Trip
16 Day Panama Canal Repositioning Cruise From Los Angeles To Miami with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Los Angeles to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Joy
Departure: 05 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
INSIDE
$1,846
OCEANVIEW
$2,346
BALCONY
$2,946
SUITE
$3,196
From (per person) 1,846
View Trip
28 Day Amazing Central America with Intrepid Travel
Tour

28 Days Antigua to Panama City
Operated By: Intrepid Travel
Departures: Mar 2025 to Dec 2026
Trip Styles: Adventure, Small Group
Countries Visited: Guatemala, Honduras, El Salvador, Nicaragua (+2 more), Costa Rica, Panama
From (per person) 4,230
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11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (7)

11 Days (10 Nights) Fort Lauderdale to Panama City
Operated By: Viking Cruises
Ship: Viking Mars
Departures: Oct 2025 to Dec 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
INSIDE
-
OCEANVIEW
-
BALCONY
$3,399
SUITE
$6,049
From (per person) 3,399
View Trip
19 Day Panama Canal Repositioning Cruise From San Francisco To Miami with Norwegian Cruise Line
Cruise

19 Days (18 Nights) San Francisco to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Joy
Departure: 02 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
INSIDE
$1,944
OCEANVIEW
$2,444
BALCONY
$3,044
SUITE
$3,294
From (per person) 1,944
View Trip
21 Day Panama Canal Repositioning Cruise From Seattle To Miami with Norwegian Cruise Line
Cruise

21 Days (20 Nights) Seattle to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Encore
Departure: 19 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
INSIDE
$1,988
OCEANVIEW
$2,498
BALCONY
$3,038
SUITE
$3,438
From (per person) 1,988
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise
 (1)

18 Days (17 Nights) Fort Lauderdale to Santiago
Operated By: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2025 to Nov 2026
Countries Visited: USA, Mexico, Panama, Ecuador (+2 more), Peru, Chile
INSIDE
-
OCEANVIEW
-
BALCONY
$9,495
SUITE
$13,995
From (per person) 9,495
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ships: Caribbean Princess, Coral Princess, Island Princess
Departures: Sep 2025 to Feb 2026
Countries Visited: USA, Mexico, Nicaragua, Costa Rica (+2 more), Panama, Aruba
Exclusive Deal
INSIDE
$1,379
OCEANVIEW
$1,518
BALCONY
$2,149
SUITE
$3,229
From (per person) 1,379
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (4)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Island Princess
Departure: 22 October 2025
Countries Visited: USA, Mexico, Nicaragua, Costa Rica (+2 more), Panama, Curacao
Exclusive Deal
INSIDE
$1,508
OCEANVIEW
$1,393
BALCONY
$2,238
SUITE
$2,898
From (per person) 1,393
View Trip
19 Day Panama Canal Repositioning Cruise From San Francisco To Miami with Norwegian Cruise Line
Cruise

19 Days (18 Nights) San Francisco to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Encore
Departure: 21 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
INSIDE
$1,853
OCEANVIEW
$2,153
BALCONY
$2,603
SUITE
$2,943
From (per person) 1,853
View Trip
17 Day Panama Canal Repositioning Cruise From Los Angeles To Miami with Norwegian Cruise Line
Cruise

17 Days (16 Nights) Los Angeles to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Encore
Departure: 23 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
INSIDE
$1,553
OCEANVIEW
$1,953
BALCONY
$2,353
SUITE
$2,653
From (per person) 1,553
View Trip
24 Day Panama Canal & Pacific Coast with Princess
Cruise
 (2)

24 Days (23 Nights) Vancouver to Fort Lauderdale
Cruise Line: Princess
Ship: Coral Princess
Departure: 21 October 2025
Countries Visited: Canada, USA, Mexico, Nicaragua (+3 more), Costa Rica, Panama, Aruba
Exclusive Deal
INSIDE
$2,447
OCEANVIEW
$2,518
BALCONY
$2,875
SUITE
$4,737
From (per person) 2,447
View Trip
13 Day Panama Canal Sunfarer with Holland America
Cruise
 (2)

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Rotterdam
Departures: Oct 2025 to Mar 2026
Countries Visited: USA, Bahamas, Curacao, Colombia (+3 more), Panama, Costa Rica, Cayman Islands
Exclusive Deal
INSIDE
$1,279
OCEANVIEW
$1,979
BALCONY
$1,979
SUITE
$3,179
From (per person) 1,279
View Trip
17 Day Panama Canal Cruise with Royal Caribbean
Cruise

17 Days (16 Nights) San Diego to Fort Lauderdale
Cruise Line: Royal Caribbean
Ship: Radiance of the Seas
Departure: 04 October 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+3 more), Panama, Colombia, Cayman Islands
Exclusive Deal
INSIDE
$2,605
OCEANVIEW
-
BALCONY
$5,726
SUITE
-
Save (per person) 999
From (per person) 2,605
View Trip
13 Day Panama Canal with Costa Rica & Caribbean From Fort Lauderdale with Princess
Cruise

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Princess
Ships: Caribbean Princess, Emerald Princess
Departures: Mar 2025 to Mar 2026
Countries Visited: USA, Aruba, Curacao, Colombia (+3 more), Panama, Costa Rica, Cayman Islands
Exclusive Deal
INSIDE
$1,339
OCEANVIEW
$1,386
BALCONY
$2,289
SUITE
$2,609
From (per person) 1,339
View Trip
44 Day Best of Central America with Intrepid Travel
Tour
 (1)

44 Days Playa del Carmen to Panama City
Operated By: Intrepid Travel
Departures: Mar 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Deal
Save (per person) 680
From (per person) 6,116
View Trip
41 Day The Americas & Antarctic Explorer with Viking Cruises
Cruise
 (1)

41 Days (40 Nights) Fort Lauderdale to Buenos Aires
Operated By: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2025 to Nov 2026
Countries Visited: USA, Mexico, Panama, Ecuador (+4 more), Peru, Chile, Argentina, Antarctica
INSIDE
-
OCEANVIEW
-
BALCONY
$33,485
SUITE
$49,495
From (per person) 33,485
View Trip
45 Day Epic Central America with Intrepid Travel
Tour

45 Days Mexico City to San Jose
Operated By: Intrepid Travel
Departures: Mar 2025 to Dec 2025
Trip Styles: Adventure, Small Group, 18-30's
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Deal
Save (per person) 549
From (per person) 4,640
View Trip
58 Day Ultimate Central America with Intrepid Travel
Tour

58 Days Mexico City to Panama City
Operated By: Intrepid Travel
Departures: Mar 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Deal
Save (per person) 976
From (per person) 8,788
View Trip
22 Day Panama Canal & Southern Caribbean: ABC Islands with Holland America
Cruise
 (2)

22 Days (21 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Rotterdam
Departures: Oct 2025 to Mar 2026
Countries Visited: USA, Bahamas, Curacao, Colombia (+5 more), Panama, Costa Rica, Cayman Islands, Bonaire, Aruba
Exclusive Deal
INSIDE
$2,040
OCEANVIEW
$2,960
BALCONY
$2,960
SUITE
$4,480
From (per person) 2,040
View Trip
47 Day The Americas, Chile & Antarctica with Viking Cruises
Cruise

47 Days (46 Nights) Fort Lauderdale to Buenos Aires
Operated By: Viking Cruises
Ship: Viking Octantis
Departure: 13 October 2025
Countries Visited: USA, Mexico, Panama, Ecuador (+6 more), Peru, Chile, Argentina, Antarctica, South Georgia Island, Falkland Islands
INSIDE
-
OCEANVIEW
-
BALCONY
$38,985
SUITE
$53,885
From (per person) 38,985
View Trip
25 Day Panama Canal & Eastern Caribbean with Holland America
Cruise

25 Days (24 Nights) San Diego to Fort Lauderdale
Cruise Line: Holland America
Ship: Eurodam
Departure: 09 October 2025
Countries Visited: USA, Mexico, Guatemala, El Salvador (+7 more), Costa Rica, Panama, Aruba, Turks and Caicos Islands, Puerto Rico, Virgin Islands, Bahamas
Exclusive Deal
INSIDE
$2,665
OCEANVIEW
$4,290
BALCONY
$4,290
SUITE
$7,589
From (per person) 2,665
View Trip
29 Day Panama Canal & Eastern Caribbean with Holland America
Cruise

29 Days (28 Nights) Vancouver to Fort Lauderdale
Cruise Line: Holland America
Ship: Eurodam
Departure: 05 October 2025
Countries Visited: Canada, USA, Mexico, Guatemala (+8 more), El Salvador, Costa Rica, Panama, Aruba, Turks and Caicos Islands, Puerto Rico, Virgin Islands, Bahamas
Exclusive Deal
INSIDE
$2,930
OCEANVIEW
$4,660
BALCONY
$4,660
SUITE
$8,154
From (per person) 2,930
View Trip
30 Day Panama Canal & Eastern Caribbean with Holland America
Cruise

30 Days (29 Nights) Seattle to Fort Lauderdale
Cruise Line: Holland America
Ship: Eurodam
Departure: 04 October 2025
Countries Visited: USA, Canada, Mexico, Guatemala (+8 more), El Salvador, Costa Rica, Panama, Aruba, Turks and Caicos Islands, Puerto Rico, Virgin Islands, Bahamas
Exclusive Deal
INSIDE
$3,114
OCEANVIEW
$4,864
BALCONY
$4,864
SUITE
$8,424
From (per person) 3,114
View Trip
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