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Panama Tours & Cruises Starting In April 2026

If you're looking at joining a tour to Panama in April 2026, we have 30 unique cruises, small group tours and adventures with 127 departures from the world's leading tour operators departing in April.
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Departures (April 2026)
< March 2026 May 2026 >
Duration
2 Days
43 Days
Types
Budget
Start & End Cities
Operators
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Price
$100pp
$232,995pp
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30 Trips (127 Trip Departures)
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 18 April 2026
Countries Visited: Panama, Colombia
Exclusive Deal
INSIDE
$106
OCEANVIEW
$159
BALCONY
$162
SUITE
$197
Save (per person) 100
From (per person) 106
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Apr 2026
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive Deal
INSIDE
$941
OCEANVIEW
$1,039
BALCONY
$1,039
SUITE
$1,189
Save (per person) 585
From (per person) 941
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Apr 2026
Countries Visited: Colombia, Curacao, Aruba, Panama
Exclusive DealExclusive Solo Offer
INSIDE
$1,088
OCEANVIEW
$1,119
BALCONY
$1,218
SUITE
$1,386
Save (per person) 712
From (per person) 1,088
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Apr 2026
Countries Visited: Colombia, Aruba, Curacao, Panama
Exclusive DealExclusive Solo Offer
INSIDE
$1,028
OCEANVIEW
$1,068
BALCONY
$1,184
SUITE
$1,434
Save (per person) 575
From (per person) 1,028
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Apr 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$939
OCEANVIEW
$939
BALCONY
$938
SUITE
$1,388
Save (per person) 554
From (per person) 938
View Trip
11 Day Panama Canal Westward Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Colon to Los Angeles
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 25 April 2026
Countries Visited: Panama, Costa Rica, Mexico, USA
Exclusive DealExclusive Solo Offer
INSIDE
$1,273
OCEANVIEW
$1,594
BALCONY
$1,993
SUITE
$2,704
Save (per person) 502
From (per person) 1,273
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Cartagena to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 19 April 2026
Countries Visited: Colombia, Curacao, Aruba, Panama
Exclusive DealExclusive Solo Offer
INSIDE
$1,070
OCEANVIEW
$1,171
BALCONY
$1,370
SUITE
$1,945
Save (per person) 553
From (per person) 1,070
View Trip
21 Day Panama Canal - Ocean to Ocean with Princess
Cruise

21 Days (20 Nights) Fort Lauderdale to Seattle
Cruise Line: Princess
Ship: Star Princess
Departure: 13 April 2026
Countries Visited: USA, Aruba, Panama, Mexico
Exclusive Deal
INSIDE
$2,228
OCEANVIEW
$2,828
BALCONY
$3,748
SUITE
$5,048
From (per person) 2,228
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (5)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ships: Coral Princess, Crown Princess (+2 more), Grand Princess, Island Princess
Departures: Apr 2025 to Apr 2027
Countries Visited: USA, Aruba, Panama, Costa Rica (+1 more), Mexico
Exclusive Deal
INSIDE
$1,368
OCEANVIEW
$1,299
BALCONY
$2,447
SUITE
$3,059
From (per person) 1,299
View Trip
21 Day Miami To Seattle with Cunard
Cruise
 (11)

21 Days (20 Nights) Miami to Seattle
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 14 April 2026
Countries Visited: USA, Colombia, Panama, Costa Rica (+1 more), Mexico
Exclusive Deal
INSIDE
$4,120
OCEANVIEW
$4,520
BALCONY
$5,220
SUITE
$13,620
From (per person) 4,120
View Trip
15 Day Los Angeles To Miami with Cunard
Cruise

15 Days (14 Nights) Los Angeles to Miami
Cruise Line: Cunard
Ship: Queen Anne
Departure: 05 April 2026
Countries Visited: USA, Guatemala, Panama, Curacao (+1 more), Aruba
Exclusive Deal
INSIDE
$2,859
OCEANVIEW
$3,979
BALCONY
$4,959
SUITE
$9,169
From (per person) 2,859
View Trip
11 Day Canal & Coral Isles with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 April 2026
Countries Visited: Panama, Colombia, Costa Rica, Honduras (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$3,099
OCEANVIEW
$3,399
BALCONY
$4,999
SUITE
$6,899
Save (per person) 3,099
From (per person) 3,099
View Trip
20 Day Panama Canal Passage with Seabourn
Cruise

20 Days (19 Nights) Los Angeles to Miami
Cruise Line: Seabourn
Ships: Seabourn Encore, Seabourn Quest, Seabourn Sojourn
Departures: Apr 2025 to May 2026
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
Sail Of The Year Offer
INSIDE
-
OCEANVIEW
$7,139
BALCONY
$5,999
SUITE
$13,599
From (per person) 5,999
View Trip
12 Day Panama Canal & the Alluring Islands of the Caribbean with Scenic
New ReleaseCruise

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 13 April 2026
Countries Visited: Panama, Colombia, Aruba, Curacao (+2 more), Saint Vincent, Barbados
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$12,225
SUITE
$15,525
Save (per person) 12,365
From (per person) 12,225
View Trip
31 Day Miami To Seattle with Cunard
Cruise
 (11)

31 Days (30 Nights) Miami to Seattle
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 14 April 2026
Countries Visited: USA, Colombia, Panama, Costa Rica (+2 more), Mexico, Canada
Exclusive Deal
INSIDE
$5,509
OCEANVIEW
$6,159
BALCONY
$7,459
SUITE
$19,159
From (per person) 5,509
View Trip
11 Day Vivid Western Caribbean with Oceania Cruises
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 April 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$3,099
OCEANVIEW
$3,399
BALCONY
$4,999
SUITE
$6,899
Save (per person) 3,099
From (per person) 3,099
View Trip
28 Day Amazing Central America with Intrepid Travel
Tour

28 Days Antigua to Panama City
Operated By: Intrepid Travel
Departures: Mar 2025 to Dec 2026
Trip Styles: Adventure, Small Group
Countries Visited: Guatemala, Honduras, El Salvador, Nicaragua (+2 more), Costa Rica, Panama
From (per person) 4,230
View Trip
19 Day Panama Canal From Miami To Miami with Norwegian Cruise Line
Cruise

19 Days (18 Nights) Miami to San Francisco
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Encore
Departure: 11 April 2026
Countries Visited: USA, Colombia, Panama, Costa Rica (+2 more), Guatemala, Mexico
INSIDE
$2,847
OCEANVIEW
$3,737
BALCONY
$4,707
SUITE
$5,397
From (per person) 2,847
View Trip
34 Day Grand World Voyage with Holland America
Cruise

34 Days (33 Nights) Tokyo to Fort Lauderdale
Cruise Line: Holland America
Ship: Volendam
Departure: 14 April 2026
Countries Visited: Japan, USA, Mexico, El Salvador (+2 more), Panama, Colombia
Exclusive Deal
INSIDE
$8,329
OCEANVIEW
$8,969
BALCONY
$15,809
SUITE
-
From (per person) 8,329
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 04 April 2026
Countries Visited: Panama, Colombia, Curacao, Aruba (+3 more), Jamaica, Cayman Islands, USA
Exclusive Deal
INSIDE
$3,099
OCEANVIEW
$3,499
BALCONY
$4,999
SUITE
$7,099
Save (per person) 3,099
From (per person) 3,099
View Trip
18 Day Panama Canal with Holland America
Cruise
 (2)

18 Days (17 Nights) Fort Lauderdale to San Diego
Cruise Line: Holland America
Ship: Koningsdam
Departure: 10 April 2026
Countries Visited: USA, Colombia, Panama, Costa Rica (+3 more), El Salvador, Guatemala, Mexico
Exclusive Deal
INSIDE
$2,550
OCEANVIEW
$3,650
BALCONY
$3,650
SUITE
$4,725
From (per person) 2,550
View Trip
26 Day Los Angeles To Southampton with Cunard
Cruise

26 Days (25 Nights) Los Angeles to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 05 April 2026
Countries Visited: USA, Guatemala, Panama, Curacao (+3 more), Aruba, Portugal, England
Exclusive Deal
INSIDE
$3,429
OCEANVIEW
$4,869
BALCONY
$5,929
SUITE
$12,199
From (per person) 3,429
View Trip
18 Day Panama Canal Westward Cruise with Celebrity Cruises
Cruise

18 Days (17 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Celebrity Cruises
Ship: Celebrity Summit
Departure: 13 April 2026
Countries Visited: USA, Cayman Islands, Colombia, Panama (+3 more), Costa Rica, Guatemala, Mexico
Exclusive Deal
INSIDE
$2,699
OCEANVIEW
$3,032
BALCONY
$3,623
SUITE
-
Save (per person) 1,444
From (per person) 2,699
View Trip
23 Day Panama Canal Repositioning Cruise From Miami to Seattle with Norwegian Cruise Line
Cruise

23 Days (22 Nights) Miami to Seattle
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Encore
Departure: 11 April 2026
Countries Visited: USA, Colombia, Panama, Costa Rica (+3 more), Guatemala, Mexico, Canada
INSIDE
$2,956
OCEANVIEW
$3,846
BALCONY
$4,816
SUITE
$5,506
From (per person) 2,956
View Trip
23 Day Panama Canal with Holland America
Cruise
 (2)

23 Days (22 Nights) Fort Lauderdale to Vancouver
Cruise Line: Holland America
Ship: Koningsdam
Departure: 10 April 2026
Countries Visited: USA, Colombia, Panama, Costa Rica (+4 more), El Salvador, Guatemala, Mexico, Canada
Exclusive Deal
INSIDE
$2,924
OCEANVIEW
$4,124
BALCONY
$4,124
SUITE
$5,424
From (per person) 2,924
View Trip
33 Day Miami To Seattle with Cunard
Cruise
 (11)

33 Days (32 Nights) Miami to Seattle
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 02 April 2026
Countries Visited: USA, Puerto Rico, Antigua and Barbuda, Saint Lucia (+7 more), Barbados, Saint Martin, Virgin Islands, Colombia, Panama, Costa Rica, Mexico
Exclusive Deal
INSIDE
$5,359
OCEANVIEW
$5,959
BALCONY
$6,959
SUITE
$18,859
From (per person) 5,359
View Trip
27 Day Panama Canal & Eastern Caribbean with Holland America
Cruise
 (2)

27 Days (26 Nights) Fort Lauderdale to San Diego
Cruise Line: Holland America
Ship: Koningsdam
Departure: 01 April 2026
Countries Visited: USA, Virgin Islands, Antigua and Barbuda, Puerto Rico (+7 more), Bahamas, Colombia, Panama, Costa Rica, El Salvador, Guatemala, Mexico
Exclusive Deal
INSIDE
$3,485
OCEANVIEW
$4,915
BALCONY
$4,915
SUITE
$6,580
From (per person) 3,485
View Trip
28 Day Panama Canal and Caribbean Adventurer with Princess
Cruise
 (5)

28 Days (27 Nights) San Juan to Los Angeles
Cruise Line: Princess
Ship: Grand Princess
Departure: 05 April 2026
Countries Visited: Puerto Rico, Virgin Islands, Saint Kitts and Nevis, Aruba (+8 more), Curacao, Bonaire, Dominican Republic, Turks and Caicos Islands, USA, Panama, Costa Rica, Mexico
Exclusive Deal
INSIDE
$2,757
OCEANVIEW
$3,033
BALCONY
$4,407
SUITE
$5,508
From (per person) 2,757
View Trip
43 Day Miami To Seattle with Cunard
Cruise
 (11)

43 Days (42 Nights) Miami to Seattle
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 02 April 2026
Countries Visited: USA, Puerto Rico, Antigua and Barbuda, Saint Lucia (+8 more), Barbados, Saint Martin, Virgin Islands, Colombia, Panama, Costa Rica, Mexico, Canada
Exclusive Deal
INSIDE
$6,649
OCEANVIEW
$7,649
BALCONY
$9,349
SUITE
$24,449
From (per person) 6,649
View Trip
32 Day Panama Canal & Eastern Caribbean with Holland America
Cruise
 (2)

32 Days (31 Nights) Fort Lauderdale to Vancouver
Cruise Line: Holland America
Ship: Koningsdam
Departure: 01 April 2026
Countries Visited: USA, Virgin Islands, Antigua and Barbuda, Puerto Rico (+8 more), Bahamas, Colombia, Panama, Costa Rica, El Salvador, Guatemala, Mexico, Canada
Exclusive Deal
INSIDE
$3,839
OCEANVIEW
$5,369
BALCONY
$5,369
SUITE
$7,259
From (per person) 3,839
View Trip
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