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Panama Tours & Cruises Starting In April 2025

If you're looking at joining a tour to Panama in April 2025, we have 10 unique cruises, small group tours and adventures with 242 departures from the world's leading tour operators departing in April.
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Departures (April 2025)
May 2025 >
Duration
6 Days
58 Days
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Price
$100pp
$214,598pp
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10 Trips (242 Trip Departures)
6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operated By: Globus
Departures: May 2025 to Mar 2026
Trip Styles: Short Break, Scenic
Countries Visited: Panama
Exclusive Savings
Save (per person) 38
From (per person) 1,675
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12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: Apr 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Costa Rica, Panama
Exclusive Deal
Save (per person) 432
From (per person) 1,726
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28 Day Amazing Central America with Intrepid Travel
Tour

28 Days Antigua to Panama City
Operated By: Intrepid Travel
Departures: Apr 2025 to Dec 2026
Trip Styles: Adventure, Small Group
Countries Visited: Guatemala, Honduras, El Salvador, Nicaragua (+2 more), Costa Rica, Panama
Exclusive Deal
Save (per person) 423
From (per person) 3,807
View Trip
20 Day Panama Canal Passage with Seabourn
Cruise

20 Days (19 Nights) Los Angeles to Miami
Cruise Line: Seabourn
Ships: Seabourn Encore, Seabourn Quest
Departures: Apr 2025 to Apr 2026
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
Exclusive DealA Sail Beyond Event
INSIDE
-
OCEANVIEW
$8,499
BALCONY
$7,999
SUITE
$17,499
From (per person) 7,999
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12 Day Panama Canal & Southern Caribbean with Celebrity Cruises
Cruise

12 Days (11 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ships: Celebrity Ascent, Celebrity Beyond
Departures: Apr 2025 to Mar 2027
Countries Visited: USA, Colombia, Panama, Aruba (+2 more), Curacao, Bonaire
Exclusive Deal
INSIDE
$2,847
OCEANVIEW
$3,325
BALCONY
$4,201
SUITE
$13,776
Save (per person) 50
From (per person) 2,847
View Trip
25 Day Central American Explorer with Explore!
Tour

25 Days Panama City to Antigua
Operated By: Explore!
Departures: Apr 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Panama, Costa Rica, Nicaragua, El Salvador (+2 more), Honduras, Guatemala
Great Europe Getaway SaleSolo Traveller Offer
Save (per person) 330
From (per person) 5,870
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17 Day Panama Canal Westward Cruise with Celebrity Cruises
Cruise

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Celebrity Cruises
Ship: Celebrity Summit
Departure: 17 April 2025
Countries Visited: USA, Cayman Islands, Colombia, Panama (+3 more), Costa Rica, Guatemala, Mexico
Exciting Deals
INSIDE
$1,290
OCEANVIEW
$1,690
BALCONY
$2,390
SUITE
-
Save (per person) 668
From (per person) 1,290
View Trip
44 Day Best of Central America with Intrepid Travel
Tour
 (1)

44 Days Playa del Carmen to Panama City
Operated By: Intrepid Travel
Departures: Apr 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Deal
Save (per person) 648
From (per person) 5,836
View Trip
58 Day Ultimate Central America with Intrepid Travel
Tour

58 Days Mexico City to Panama City
Operated By: Intrepid Travel
Departures: Apr 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Deal
Save (per person) 1,369
From (per person) 7,756
View Trip
45 Day Epic Central America with Intrepid Travel
Tour

45 Days Mexico City to San Jose
Operated By: Intrepid Travel
Departures: May 2025 to Dec 2025
Trip Styles: Adventure, Small Group, 18-30's
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Deal
Save (per person) 554
From (per person) 4,775
View Trip
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