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Panama Tours & Cruises Starting In April 2025

If you're looking at joining a tour to Panama in April 2025, we have 21 unique cruises, small group tours and adventures with 313 departures from the world's leading tour operators departing in April.
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Departures (April 2025)
< March 2025 May 2025 >
Duration
6 Days
58 Days
Types
Budget
Start & End Cities
Operators
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Price
$100pp
$232,995pp
Countries
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21 Trips (313 Trip Departures)
6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operated By: Globus
Departures: Mar 2025 to Mar 2026
Trip Styles: Short Break, Scenic
Countries Visited: Panama
From (per person) 1,709
View Trip
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: Mar 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Costa Rica, Panama
Exclusive Deal
Save (per person) 211
From (per person) 1,899
View Trip
15 Day Pacific Latin America — Diverse Landscapes And Cultures with HX Hurtigruten Expeditions
Cruise

15 Days (14 Nights) Valparaiso to Panama City
Ship: MS Fram
Departure: 06 April 2025
Countries Visited: Chile, Peru, Ecuador, Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
$5,828
BALCONY
-
SUITE
$7,916
Save (per person) 3,984
From (per person) 5,828
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise
 (5)

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ships: Coral Princess, Crown Princess (+2 more), Grand Princess, Island Princess
Departures: Apr 2025 to Apr 2027
Countries Visited: USA, Aruba, Panama, Costa Rica (+1 more), Mexico
Exclusive Deal
INSIDE
$1,368
OCEANVIEW
$1,299
BALCONY
$2,447
SUITE
$3,059
From (per person) 1,299
View Trip
18 Day Panama Canal & the Pacific Coast with Viking Cruises
Cruise

18 Days (17 Nights) Los Angeles to Fort Lauderdale
Operated By: Viking Cruises
Ship: Viking Neptune
Departure: 05 April 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+1 more), Colombia
INSIDE
-
OCEANVIEW
-
BALCONY
$7,099
SUITE
$14,349
From (per person) 7,099
View Trip
18 Day Pacific Latin America — Ancient Wonders And National Parks with HX Hurtigruten Expeditions
Cruise

18 Days (17 Nights) Valparaiso to Puntarenas
Ship: MS Roald Amundsen
Departure: 04 April 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+1 more), Costa Rica
Exclusive Deal
INSIDE
-
OCEANVIEW
$5,466
BALCONY
-
SUITE
$8,035
Save (per person) 4,349
From (per person) 5,466
View Trip
24 Day Panama Canal & Pacific Coast with Princess
Cruise
 (2)

24 Days (23 Nights) Fort Lauderdale to Vancouver
Cruise Line: Princess
Ship: Coral Princess
Departure: 10 April 2025
Countries Visited: USA, Aruba, Panama, Costa Rica (+2 more), Mexico, Canada
Exclusive Deal
INSIDE
$1,763
OCEANVIEW
$2,798
BALCONY
$3,528
SUITE
$4,308
From (per person) 1,763
View Trip
28 Day Amazing Central America with Intrepid Travel
Tour

28 Days Antigua to Panama City
Operated By: Intrepid Travel
Departures: Mar 2025 to Dec 2026
Trip Styles: Adventure, Small Group
Countries Visited: Guatemala, Honduras, El Salvador, Nicaragua (+2 more), Costa Rica, Panama
From (per person) 4,230
View Trip
12 Day Panama Canal & Southern Caribbean with Celebrity Cruises
Cruise

12 Days (11 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ships: Celebrity Ascent, Celebrity Beyond
Departures: Apr 2025 to Mar 2027
Countries Visited: USA, Colombia, Panama, Aruba (+2 more), Curacao, Bonaire
Exclusive DealExclusive Solo Offer
INSIDE
$2,124
OCEANVIEW
$2,482
BALCONY
$2,776
SUITE
$7,086
Save (per person) 18,133
From (per person) 2,124
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Orlando to Los Angeles
Cruise Line: Princess
Ship: Caribbean Princess
Departure: 14 April 2025
Countries Visited: USA, Bahamas, Colombia, Panama (+2 more), Costa Rica, Mexico
Exclusive Deal
INSIDE
$999
OCEANVIEW
$1,159
BALCONY
$1,900
SUITE
$2,059
From (per person) 999
View Trip
26 Day Panama Canal Repositioning Cruise From Tampa To Anchorage with Norwegian Cruise Line
Cruise

26 Days (25 Nights) Tampa to Anchorage
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 03 April 2025
Countries Visited: USA, Colombia, Panama, Costa Rica (+2 more), Guatemala, Mexico
INSIDE
$1,755
OCEANVIEW
$2,005
BALCONY
$3,205
SUITE
-
From (per person) 1,755
View Trip
20 Day Panama Canal Passage with Seabourn
Cruise

20 Days (19 Nights) Los Angeles to Miami
Cruise Line: Seabourn
Ships: Seabourn Encore, Seabourn Quest, Seabourn Sojourn
Departures: Apr 2025 to May 2026
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
Sail Of The Year Offer
INSIDE
-
OCEANVIEW
$7,139
BALCONY
$5,999
SUITE
$13,599
From (per person) 5,999
View Trip
25 Day Central American Explorer with Explore!
Tour

25 Days Panama City to Antigua
Operated By: Explore!
Departures: Mar 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Panama, Costa Rica, Nicaragua, El Salvador (+2 more), Honduras, Guatemala
From (per person) 6,070
View Trip
17 Day Panama Canal Westward Cruise with Royal Caribbean
Cruise

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 13 April 2025
Countries Visited: USA, Cayman Islands, Colombia, Panama (+2 more), Guatemala, Mexico
Exclusive Deal
INSIDE
$3,023
OCEANVIEW
-
BALCONY
-
SUITE
-
Save (per person) 1,191
From (per person) 3,023
View Trip
16 Day Panama Canal Cruise with Royal Caribbean
Cruise

16 Days (15 Nights) Tampa to Los Angeles
Cruise Line: Royal Caribbean
Ship: Radiance of the Seas
Departure: 19 April 2025
Countries Visited: USA, Cayman Islands, Colombia, Panama (+2 more), Guatemala, Mexico
Exclusive DealExclusive Solo Offer
INSIDE
$2,217
OCEANVIEW
-
BALCONY
$6,538
SUITE
$18,692
Save (per person) 864
From (per person) 2,217
View Trip
11 Day Captivating Panama Canal with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 April 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+3 more), Bonaire, Jamaica, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
$5,999
BALCONY
-
SUITE
-
Save (per person) 5,999
From (per person) 5,999
View Trip
32 Day Panama Canal & Atlantic Ocean Passage with Seabourn
Cruise

32 Days (31 Nights) Los Angeles to Lisbon
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 09 April 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+3 more), Panama, Colombia, Portugal
Sail Of The Year Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$8,774
SUITE
-
From (per person) 8,774
View Trip
22 Day Panama Canal & Pacific Coast with Princess
Cruise

22 Days (21 Nights) Orlando to Vancouver
Cruise Line: Princess
Ship: Caribbean Princess
Departure: 14 April 2025
Countries Visited: USA, Bahamas, Colombia, Panama (+3 more), Costa Rica, Mexico, Canada
Exclusive Deal
INSIDE
$1,411
OCEANVIEW
$1,550
BALCONY
$2,379
SUITE
$2,749
From (per person) 1,411
View Trip
44 Day Best of Central America with Intrepid Travel
Tour
 (1)

44 Days Playa del Carmen to Panama City
Operated By: Intrepid Travel
Departures: Mar 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Deal
Save (per person) 680
From (per person) 6,116
View Trip
45 Day Epic Central America with Intrepid Travel
Tour

45 Days Mexico City to San Jose
Operated By: Intrepid Travel
Departures: Mar 2025 to Dec 2025
Trip Styles: Adventure, Small Group, 18-30's
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Deal
Save (per person) 549
From (per person) 4,640
View Trip
58 Day Ultimate Central America with Intrepid Travel
Tour

58 Days Mexico City to Panama City
Operated By: Intrepid Travel
Departures: Mar 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Deal
Save (per person) 976
From (per person) 8,788
View Trip
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