Panama Tours & Cruises Starting In September 2025

If you're looking at joining a tour to Panama in September 2025, we have 18 unique cruises, small group tours and adventures with 300 departures from the world's leading tour operators departing in September.
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Departures (September 2025)
Duration
6 Days
87 Days
Types
Budget
Start & End Cities
Operators
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Price
$100pp
$232,995pp
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18 Trips (300 Trip Departures)
New ReleaseTour

6 Days Panama City to Panama City
Operated By: Globus
Departures: Mar 2025 to Mar 2026
Trip Styles: Short Break, Scenic
Countries Visited: Panama
From (per person) 1,709
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: Mar 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Costa Rica, Panama
Exclusive Deal
Save (per person) 211
From (per person) 1,899
Cruise
 (5)

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Departure: 15 September 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+1 more), Aruba
Exclusive Deal
INSIDE
$1,398
OCEANVIEW
$1,525
BALCONY
$2,198
SUITE
$3,258
From (per person) 1,398
Cruise

14 Days (13 Nights) San Diego to Miami
Cruise Line: Royal Caribbean
Departure: 19 September 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+1 more), Colombia
Exclusive DealExclusive Solo Offer
INSIDE
$1,536
OCEANVIEW
$1,876
BALCONY
$5,821
SUITE
-
Save (per person) 561
From (per person) 1,536
Cruise
 (11)

22 Days (21 Nights) Seattle to Miami
Cruise Line: Cunard
Departure: 25 September 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+2 more), Colombia, Aruba
Exclusive Deal
INSIDE
$1,999
OCEANVIEW
$2,499
BALCONY
$3,049
SUITE
$8,899
From (per person) 1,999
Cruise

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Departures: Sep 2025 to Feb 2026
Countries Visited: USA, Mexico, Nicaragua, Costa Rica (+2 more), Panama, Aruba
Exclusive Deal
INSIDE
$1,379
OCEANVIEW
$1,518
BALCONY
$2,149
SUITE
$3,229
From (per person) 1,379
Tour

28 Days Antigua to Panama City
Operated By: Intrepid Travel
Departures: Mar 2025 to Dec 2026
Trip Styles: Adventure, Small Group
Countries Visited: Guatemala, Honduras, El Salvador, Nicaragua (+2 more), Costa Rica, Panama
From (per person) 4,230
Cruise
 (11)

29 Days (28 Nights) Seattle to Miami
Cruise Line: Cunard
Departure: 18 September 2025
Countries Visited: USA, Canada, Mexico, Costa Rica (+3 more), Panama, Colombia, Aruba
Exclusive Deal
INSIDE
$3,037
OCEANVIEW
$3,699
BALCONY
$4,405
SUITE
$11,098
From (per person) 3,037
Cruise
 (4)

19 Days (18 Nights) New York to Los Angeles
Cruise Line: Princess
Departure: 18 September 2025
Countries Visited: USA, Turks and Caicos Islands, Aruba, Panama (+3 more), Costa Rica, Nicaragua, Mexico
Exclusive Deal
INSIDE
$2,058
OCEANVIEW
$2,078
BALCONY
$2,648
SUITE
$3,678
From (per person) 2,058
Cruise

22 Days (21 Nights) Seattle to Miami
Cruise Line: Norwegian Cruise Line
Departure: 29 September 2025
Countries Visited: USA, Canada, Mexico, Guatemala (+3 more), Costa Rica, Panama, Colombia
INSIDE
$2,098
OCEANVIEW
$2,598
BALCONY
$3,198
SUITE
$3,448
From (per person) 2,098
Cruise

24 Days (23 Nights) Vancouver to Fort Lauderdale
Cruise Line: Princess
Departure: 23 September 2025
Countries Visited: Canada, USA, Mexico, Nicaragua (+3 more), Costa Rica, Panama, Aruba
Exclusive Deal
INSIDE
$2,227
OCEANVIEW
$2,439
BALCONY
$3,237
SUITE
$4,587
From (per person) 2,227
Tour
 (1)

44 Days Playa del Carmen to Panama City
Operated By: Intrepid Travel
Departures: Mar 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Deal
Save (per person) 680
From (per person) 6,116
Tour

45 Days Mexico City to San Jose
Operated By: Intrepid Travel
Departures: Mar 2025 to Dec 2025
Trip Styles: Adventure, Small Group, 18-30's
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Deal
Save (per person) 549
From (per person) 4,640
Tour

58 Days Mexico City to Panama City
Operated By: Intrepid Travel
Departures: Mar 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Exclusive Deal
Save (per person) 976
From (per person) 8,788
Cruise
 (5)

28 Days (27 Nights) Los Angeles to San Juan
Cruise Line: Princess
Departure: 15 September 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+8 more), Aruba, Turks and Caicos Islands, Dominican Republic, Bonaire, Curacao, Saint Kitts and Nevis, Virgin Islands, Puerto Rico
Exclusive Deal
INSIDE
$1,978
OCEANVIEW
$2,222
BALCONY
$3,324
SUITE
$4,947
From (per person) 1,978
Cruise
 (11)

34 Days (33 Nights) Seattle to Miami
Cruise Line: Cunard
Departure: 25 September 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+8 more), Colombia, Aruba, Puerto Rico, Antigua and Barbuda, Saint Lucia, Barbados, Sint Maarten, Virgin Islands
Exclusive Deal
INSIDE
$3,159
OCEANVIEW
$3,759
BALCONY
$4,499
SUITE
$13,949
From (per person) 3,159
Cruise
 (11)

41 Days (40 Nights) Seattle to Miami
Cruise Line: Cunard
Departure: 18 September 2025
Countries Visited: USA, Canada, Mexico, Costa Rica (+9 more), Panama, Colombia, Aruba, Puerto Rico, Antigua and Barbuda, Saint Lucia, Barbados, Sint Maarten, Virgin Islands
INSIDE
$3,799
OCEANVIEW
$4,599
BALCONY
$5,549
SUITE
$16,199
From (per person) 3,799
Cruise

87 Days (86 Nights) Nuuk to Buenos Aires
Operated By: Viking Cruises
Departures: Sep 2025 to Sep 2026
Countries Visited: Greenland, Canada, USA, Bahamas (+9 more), Mexico, Jamaica, Panama, Peru, Chile, Antarctica, South Georgia Island, Falkland Islands, Argentina
INSIDE
-
OCEANVIEW
-
BALCONY
$77,495
SUITE
$112,995
From (per person) 77,495
Results: 18 results

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