Cruises from Italy to USA

Are you looking for a cruise from Italy to USA? October is the most popular month to cruise between Italy and USA and there are 37 departures available from twelve of the world's leading cruise lines.
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14 Days
58 Days
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$1,700pp
$43,980pp
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37 Cruises (37 Cruise Departures)
Cruise
 (2)

27 Days (26 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Sun Princess
Departure: 21 October 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+3 more), Spain, Gibraltar, USA
Exclusive Deal
INSIDE
$5,248
OCEANVIEW
$6,308
BALCONY
$8,090
SUITE
$10,743
From (per person) 5,248
Cruise
 (1)

17 Days (16 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Departure: 17 November 2026
Countries Visited: Italy, Spain, Gibraltar, Morocco (+1 more), USA
Exclusive Deal
INSIDE
$1,737
OCEANVIEW
$2,785
BALCONY
$2,410
SUITE
$3,260
From (per person) 1,737
Cruise
 (5)

22 Days (21 Nights) Rome to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Sky
Departure: 28 November 2025
Countries Visited: Italy, Monaco, France, Spain (+3 more), Portugal, Sint Maarten, USA
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$12,370
SUITE
$18,211
Save (per person) 925
From (per person) 12,370
Cruise
 (3)

34 Days (33 Nights) Rome to Boston
Cruise Line: Princess
Departure: 30 June 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+7 more), Spain, Gibraltar, England, Scotland, Iceland, Canada, USA
Exclusive Deal
INSIDE
$9,659
OCEANVIEW
-
BALCONY
$9,952
SUITE
$14,878
From (per person) 9,659
Cruise
 (3)

16 Days (15 Nights) Rome to New York
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 20 April 2025
Countries Visited: Italy, Sardinia, Spain, England (+2 more), France, USA
Experience Like No Other
INSIDE
$3,815
OCEANVIEW
-
BALCONY
$6,845
SUITE
-
From (per person) 3,815
Cruise
 (1)

24 Days (23 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Departure: 10 November 2026
Countries Visited: Italy, Greece, Turkey, Spain (+3 more), Gibraltar, Morocco, USA
Exclusive Deal
INSIDE
$3,463
OCEANVIEW
$5,603
BALCONY
$5,071
SUITE
$6,395
From (per person) 3,463
Cruise
 (4)

22 Days (21 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Departure: 11 April 2025
Countries Visited: Italy, Corsica, France, Spain (+2 more), Morocco, USA
Exclusive Deal
INSIDE
$4,049
OCEANVIEW
$4,069
BALCONY
$4,376
SUITE
$6,217
From (per person) 4,049
Cruise
 (2)

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Holland America
Departure: 15 November 2025
Countries Visited: Italy, Spain, Gibraltar, Portugal (+1 more), USA
Exclusive Deal
INSIDE
$1,843
OCEANVIEW
$2,140
BALCONY
$2,437
SUITE
$4,070
From (per person) 1,843
Cruise

18 Days (17 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Countries Visited: Italy, France, Spain, Portugal (+3 more), Saint Martin, Bahamas, USA
Early Booking Offer
INSIDE
$1,865
OCEANVIEW
$2,172
BALCONY
$2,558
SUITE
$5,419
From (per person) 1,865
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Seabourn
Departure: 11 November 2025
Countries Visited: Italy, Corsica, Sardinia, Spain (+3 more), Portugal, Bermuda, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,482
SUITE
$44,172
From (per person) 13,482
Cruise

23 Days (22 Nights) Naples to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 25 October 2025
Countries Visited: Italy, France, Spain, Morocco (+5 more), Barbados, Grenada, Sint Maarten, Puerto Rico, USA
Early Booking Offer
INSIDE
$3,301
OCEANVIEW
$3,598
BALCONY
$4,361
SUITE
$6,578
From (per person) 3,301
Cruise

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Departure: 15 November 2026
Countries Visited: Italy, Sicily, Malta, Tunisia (+6 more), Sardinia, Spain, Portugal, Puerto Rico, Bahamas, USA
Exclusive Deal
INSIDE
$9,959
OCEANVIEW
$12,207
BALCONY
$14,167
SUITE
$19,127
Save (per person) 2,071
From (per person) 9,959
Cruise

22 Days (21 Nights) Livorno to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 26 October 2025
Countries Visited: Italy, France, Spain, Morocco (+5 more), Barbados, Grenada, Sint Maarten, Puerto Rico, USA
Early Booking Offer
INSIDE
$2,996
OCEANVIEW
$3,442
BALCONY
$4,164
SUITE
$6,313
From (per person) 2,996
Cruise

21 Days (20 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 17 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Early Booking Offer
INSIDE
$2,780
OCEANVIEW
$3,067
BALCONY
$3,503
SUITE
$6,037
From (per person) 2,780
Cruise

17 Days (16 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Departure: 19 November 2025
Countries Visited: Italy, France, Spain, Puerto Rico (+2 more), Virgin Islands, USA
Early Booking Offer
INSIDE
$2,153
OCEANVIEW
$2,480
BALCONY
$2,836
SUITE
$5,222
From (per person) 2,153
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Departure: 08 November 2026
Countries Visited: Italy, Spain, Gibraltar, Portugal (+5 more), Bermuda, USA, Honduras, Belize, Mexico
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$15,989
SUITE
$17,474
Save (per person) 8,881
From (per person) 15,989
Cruise

33 Days (32 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Departure: 23 October 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+6 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA
Exclusive Deal
INSIDE
$12,380
OCEANVIEW
$13,875
BALCONY
$19,438
SUITE
$26,358
Save (per person) 2,080
From (per person) 12,380
Cruise

23 Days (22 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 18 October 2025
Countries Visited: Italy, France, Spain, Portugal (+5 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA, Bahamas
Early Booking Offer
INSIDE
$2,856
OCEANVIEW
$3,301
BALCONY
$3,737
SUITE
-
From (per person) 2,856
Cruise

26 Days (25 Nights) Venice to Miami
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 18 October 2025
Countries Visited: Italy, Croatia, Montenegro, Monaco (+6 more), Spain, Portugal, Antigua and Barbuda, Virgin Islands, Puerto Rico, USA
INSIDE
-
OCEANVIEW
-
BALCONY
$27,225
SUITE
$29,205
From (per person) 18,087
Cruise

22 Days (21 Nights) Naples to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 16 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Early Booking Offer
INSIDE
$2,897
OCEANVIEW
$3,145
BALCONY
$4,164
SUITE
-
From (per person) 2,897
Cruise

15 Days (14 Nights) Rome to New York
Cruise Line: Royal Caribbean
Departure: 22 October 2025
Countries Visited: Italy, Spain, Gibraltar, Portugal (+1 more), USA
Exclusive Deal
INSIDE
$2,576
OCEANVIEW
$3,651
BALCONY
-
SUITE
-
Save (per person) 1,322
From (per person) 2,576
Cruise

20 Days (19 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 18 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Early Booking Offer
INSIDE
$2,535
OCEANVIEW
$2,940
BALCONY
$3,317
SUITE
$5,297
From (per person) 2,535
Cruise

35 Days (34 Nights) Rome to Miami
Cruise Line: Seabourn
Departure: 15 November 2026
Countries Visited: Italy, Corsica, Sardinia, Sicily (+7 more), Malta, Tunisia, Spain, Gibraltar, Morocco, Portugal, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
$21,415
BALCONY
$24,682
SUITE
$42,799
From (per person) 21,415
Cruise

57 Days (56 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Departure: 04 October 2025
Countries Visited: Italy, Sicily, Malta, Greece (+12 more), Turkey, Cyprus, Croatia, Montenegro, Tunisia, Spain, Morocco, Portugal, Barbados, Antigua and Barbuda, Puerto Rico, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$31,946
SUITE
$46,074
Save (per person) 2,254
From (per person) 31,946
Cruise

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Departure: 07 November 2026
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Spain, Morocco, Puerto Rico, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,208
SUITE
$18,831
Save (per person) 2,092
From (per person) 12,208
Cruise

58 Days (57 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Departure: 23 October 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+14 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin
Exclusive Deal
INSIDE
$22,337
OCEANVIEW
$24,436
BALCONY
$34,514
SUITE
$48,047
Save (per person) 2,143
From (per person) 22,337
Cruise

35 Days (34 Nights) Genoa to Seattle
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 07 April 2026
Countries Visited: Italy, France, Spain, Portugal (+7 more), Saint Martin, Bahamas, USA, Colombia, Panama, Costa Rica, Mexico
Early Booking Offer
INSIDE
-
OCEANVIEW
$5,220
BALCONY
$6,477
SUITE
-
From (per person) 5,220
Cruise

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Departure: 30 October 2026
Countries Visited: Italy, Sardinia, Spain, Portugal (+2 more), Bermuda, USA
Summer SaleExclusive Deal
INSIDE
$2,437
OCEANVIEW
$2,866
BALCONY
$3,587
SUITE
$8,870
Save (per person) 1,410
From (per person) 2,437
Cruise

26 Days (25 Nights) Rome to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Ray
Departure: 07 November 2025
Countries Visited: Italy, France, Spain, Portugal (+2 more), Bermuda, USA
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$17,622
From (per person) 17,622
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Seabourn
Departure: 01 November 2026
Countries Visited: Italy, Corsica, Sardinia, Spain (+2 more), Portugal, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
$13,384
BALCONY
$15,859
SUITE
$24,076
From (per person) 13,384
Results: 1-30 of 37

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