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Cruises from Italy to USA

Are you looking for a cruise from Italy to USA? October is the most popular month to cruise between Italy and USA and there are 40 departures available from twelve of the world's leading cruise lines.
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58 Days
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40 Cruises (40 Cruise Departures)
22 Day Riviera Gems & Atlantic Crossing with Seabourn
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 11 November 2025
Countries Visited: Italy, Corsica, Sardinia, Spain (+3 more), Portugal, Bermuda, USA
Exclusive DealA Sail Beyond Event
INSIDE
-
OCEANVIEW
-
BALCONY
$8,499
SUITE
$32,799
From (per person) 8,499
View Trip
20 Day MSC Grand Voyages with MSC Cruises
Cruise

20 Days (19 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 18 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Escape To Sea
INSIDE
$1,419
OCEANVIEW
$1,659
BALCONY
$1,819
SUITE
$3,249
From (per person) 1,419
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 19 November 2025
Countries Visited: Italy, France, Spain, Puerto Rico (+2 more), Virgin Islands, USA
Escape To Sea
INSIDE
$1,053
OCEANVIEW
$1,240
BALCONY
$1,444
SUITE
$2,804
From (per person) 1,053
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 07 April 2026
Countries Visited: Italy, France, Spain, Portugal (+3 more), Saint Martin, Bahamas, USA
Escape To Sea
INSIDE
$990
OCEANVIEW
$1,179
BALCONY
$1,475
SUITE
$3,623
From (per person) 990
View Trip
15 Day Splendid Atlantic Sojourn with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to New York
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 18 May 2027
Countries Visited: Italy, Spain, Morocco, Bermuda (+1 more), USA
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$9,099
SUITE
$9,999
Save (per person) 15,699
From (per person) 9,099
View Trip
26 Day Allura Autumn Crossing with Oceania Cruises
Cruise

26 Days (25 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 07 November 2026
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Spain, Morocco, Puerto Rico, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,399
SUITE
$12,699
Save (per person) 9,399
From (per person) 9,399
View Trip
22 Day Transatlantic with MSC Cruises
Cruise

22 Days (21 Nights) Naples to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 16 October 2025
Countries Visited: Italy, France, Spain, Portugal (+4 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA
Escape To Sea
INSIDE
$1,641
OCEANVIEW
$1,771
BALCONY
$2,131
SUITE
$3,831
From (per person) 1,641
View Trip
15 Day Spain & Portugal Transatlantic with Royal Caribbean
Cruise

15 Days (14 Nights) Rome to New York
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 25 October 2026
Countries Visited: Italy, Spain, Portugal, USA
Latest OfferExclusive Solo Offer
INSIDE
$1,316
OCEANVIEW
$1,584
BALCONY
$1,785
SUITE
-
Save (per person) 614
From (per person) 1,316
View Trip
22 Day Mediterranean with MSC Cruises
Cruise

22 Days (21 Nights) Livorno to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 26 October 2025
Countries Visited: Italy, France, Spain, Morocco (+5 more), Barbados, Grenada, Sint Maarten, Puerto Rico, USA
Escape To Sea
INSIDE
$1,455
OCEANVIEW
$1,701
BALCONY
$2,109
SUITE
$3,316
From (per person) 1,455
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Florence to New York
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 18 October 2026
Countries Visited: Italy, France, Spain, Gibraltar (+2 more), Portugal, USA
Escape To Sea
INSIDE
$1,693
OCEANVIEW
$1,893
BALCONY
$2,183
SUITE
-
From (per person) 1,693
View Trip
17 Day Moroccan Passage with Princess
Cruise
 (1)

17 Days (16 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 17 November 2026
Countries Visited: Italy, Spain, Gibraltar, Morocco (+1 more), USA
Exclusive DealSpring Swing Offer
INSIDE
$964
OCEANVIEW
-
BALCONY
$1,668
SUITE
$1,905
From (per person) 964
View Trip
14 Day Italy & Bermuda Transatlantic with Celebrity Cruises
Cruise

14 Days (13 Nights) Rome to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 31 October 2025
Countries Visited: Italy, Sardinia, Gibraltar, Bermuda (+1 more), USA
Exclusive DealExclusive Solo Offer
INSIDE
$1,483
OCEANVIEW
$2,395
BALCONY
$3,263
SUITE
-
Save (per person) 907
From (per person) 1,483
View Trip
18 Day MSC Grand Voyages with MSC Cruises
Cruise

18 Days (17 Nights) Rome to Miami
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 06 April 2026
Countries Visited: Italy, France, Spain, Portugal (+3 more), Saint Martin, Bahamas, USA
Escape To Sea
INSIDE
$1,064
OCEANVIEW
$1,263
BALCONY
$1,734
SUITE
$3,862
From (per person) 1,064
View Trip
34 Day Mediterranean, Iceland & British Isles Grand Adventure with Princess
Cruise
 (3)

34 Days (33 Nights) Rome to Boston
Cruise Line: Princess
Ship: Majestic Princess
Departure: 30 June 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+6 more), Spain, Gibraltar, England, Iceland, Canada, USA
Exclusive DealSpring Swing Offer
INSIDE
$4,020
OCEANVIEW
-
BALCONY
$4,940
SUITE
$7,614
From (per person) 4,020
View Trip
22 Day Atlantic Crossing & Mediterranean with Viking Cruises
Cruise
 (5)

22 Days (21 Nights) Rome to Fort Lauderdale
Operated By: Viking Cruises
Ship: Viking Sky
Departure: 28 November 2025
Countries Visited: Italy, Monaco, France, Spain (+3 more), Portugal, Sint Maarten, USA
Viking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$6,348
SUITE
$9,498
Save (per person) 950
From (per person) 6,348
View Trip
31 Day A Journey Of Sun And Sea with Regent Seven Seas
Cruise

31 Days (30 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 25 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+7 more), Corsica, Monaco, Spain, Portugal, Bermuda, Bahamas, USA
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$21,899
SUITE
$22,799
Save (per person) 37,299
From (per person) 21,899
View Trip
26 Day A Grand Journey Of European Gems And Tropical Idylls with Explora Journeys
Cruise

26 Days (25 Nights) Venice to Miami
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 18 October 2025
Countries Visited: Italy, Croatia, Montenegro, Monaco (+6 more), Spain, Portugal, Antigua and Barbuda, Virgin Islands, Puerto Rico, USA
Upgrade Your Ocean OfferBest Available Fare
INSIDE
-
OCEANVIEW
-
BALCONY
$12,365
SUITE
$16,320
From (per person) 12,365
View Trip
24 Day Mediterranean, Aegean & Moroccan Passage with Princess
Cruise
 (1)

24 Days (23 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 10 November 2026
Countries Visited: Italy, Greece, Turkey, Spain (+3 more), Gibraltar, Morocco, USA
Exclusive DealSpring Swing Offer
INSIDE
$2,528
OCEANVIEW
$4,062
BALCONY
$3,835
SUITE
$4,359
From (per person) 2,528
View Trip
57 Day Antiquity To America with Oceania Cruises
Cruise

57 Days (56 Nights) Rome to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 04 October 2025
Countries Visited: Italy, Sicily, Malta, Greece (+12 more), Turkey, Cyprus, Croatia, Montenegro, Tunisia, Spain, Morocco, Portugal, Barbados, Antigua and Barbuda, Puerto Rico, USA
Exclusive Deal
INSIDE
$15,499
OCEANVIEW
-
BALCONY
$21,499
SUITE
$31,799
Save (per person) 15,499
From (per person) 15,499
View Trip
15 Day Transatlantic Repositioning Cruise From Rome To Jacksonville with Norwegian Cruise Line
Cruise

15 Days (14 Nights) Rome to Jacksonville
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Gem
Departure: 01 November 2026
Countries Visited: Italy, France, Spain, Portugal (+1 more), USA
INSIDE
$1,217
OCEANVIEW
$1,415
BALCONY
$2,405
SUITE
$2,504
From (per person) 1,217
View Trip
15 Day Cultural Crossing With Andalusia And Azores with Holland America
Cruise
 (2)

15 Days (14 Nights) Rome to Fort Lauderdale
Cruise Line: Holland America
Ship: Nieuw Statendam
Departure: 15 November 2025
Countries Visited: Italy, Spain, Gibraltar, Portugal (+1 more), USA
Exclusive Deal
INSIDE
$1,029
OCEANVIEW
$1,128
BALCONY
$1,336
SUITE
$2,326
From (per person) 1,029
View Trip
35 Day Explorers Grand Crossing with Oceania Cruises
Cruise

35 Days (34 Nights) Rome to New York
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 27 August 2025
Countries Visited: Italy, Sicily, Malta, Spain (+7 more), France, Monaco, Gibraltar, Morocco, Portugal, Canada, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$15,999
SUITE
-
Save (per person) 15,999
From (per person) 15,999
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Amalfi to New York
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 17 October 2026
Countries Visited: Italy, France, Spain, Gibraltar (+2 more), Portugal, USA
Escape To Sea
INSIDE
$1,675
OCEANVIEW
$1,985
BALCONY
$2,275
SUITE
-
From (per person) 1,675
View Trip
27 Day Mediterranean Grand Adventure with Princess
Cruise
 (2)

27 Days (26 Nights) Rome to Fort Lauderdale
Cruise Line: Princess
Ship: Sun Princess
Departure: 21 October 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+3 more), Spain, Gibraltar, USA
Exclusive DealSpring Swing Offer
INSIDE
$2,685
OCEANVIEW
$3,467
BALCONY
$4,100
SUITE
$5,318
From (per person) 2,685
View Trip
15 Day New World Passage with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 November 2026
Countries Visited: Italy, Spain, Gibraltar, Portugal (+2 more), Bermuda, USA
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$7,099
SUITE
$8,199
Save (per person) 13,699
From (per person) 7,099
View Trip
22 Day Atlantic Ocean Isles with Regent Seven Seas
Cruise

22 Days (21 Nights) Rome to Miami
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 08 November 2026
Countries Visited: Italy, Spain, Gibraltar, Portugal (+5 more), Bermuda, USA, Honduras, Belize, Mexico
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$11,499
SUITE
$12,499
Save (per person) 19,499
From (per person) 11,499
View Trip
23 Day Mediterranean with MSC Cruises
Cruise

23 Days (22 Nights) Naples to Miami
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 25 October 2025
Countries Visited: Italy, France, Spain, Morocco (+5 more), Barbados, Grenada, Sint Maarten, Puerto Rico, USA
Escape To Sea
INSIDE
$1,758
OCEANVIEW
$2,048
BALCONY
$2,558
SUITE
$4,018
From (per person) 1,758
View Trip
15 Day Italy, Spain, Azores Transatlantic with Royal Caribbean
Cruise

15 Days (14 Nights) Rome to New York
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 22 October 2025
Countries Visited: Italy, Spain, Gibraltar, Portugal (+1 more), USA
Latest Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$17,807
Save (per person) 8,379
From (per person) 17,807
View Trip
58 Day Old & New World Discovery with Oceania Cruises
Cruise

58 Days (57 Nights) Venice to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+14 more), Sicily, Spain, Portugal, Puerto Rico, Bahamas, USA, Virgin Islands, Antigua and Barbuda, Saint Lucia, Trinidad and Tobago, Brazil, Barbados, Dominica, Saint Martin
Exclusive Deal
INSIDE
$14,799
OCEANVIEW
$16,299
BALCONY
$22,999
SUITE
$31,899
Save (per person) 14,799
From (per person) 14,799
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Genoa to Miami
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 18 October 2025
Countries Visited: Italy, France, Spain, Portugal (+5 more), Antigua and Barbuda, Sint Maarten, Puerto Rico, USA, Bahamas
Escape To Sea
INSIDE
$1,699
OCEANVIEW
$1,959
BALCONY
$2,149
SUITE
-
From (per person) 1,699
View Trip
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