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Cruises From Colon

Choose from 22 unique cruises starting in Colon, and travelling to Cancun, Cartagena, Fort-de-France, Los Angeles and Puntarenas. January is the most popular month to join a cruise from Colon and you can select from 40 departures available from three leading cruise lines.
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22 Cruises (40 Cruise Departures)
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America - with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Bellot
Departure: 06 January 2025
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$23,403
Save (per person) 467
From (per person) 23,403
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 February 2026
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$8,174
SUITE
$13,779
Save (per person) 156
From (per person) 8,174
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 28 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Exclusive Deal
INSIDE
$1,665
OCEANVIEW
$1,816
BALCONY
$2,076
SUITE
$2,901
Save (per person) 960
From (per person) 1,665
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Apr 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,251
OCEANVIEW
$1,324
BALCONY
$1,497
SUITE
$2,268
Save (per person) 872
From (per person) 1,251
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Colon to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 14 November 2025
Countries Visited: Panama, Costa Rica, Nicaragua, Guatemala (+2 more), Mexico, USA
New Year Sale
INSIDE
$5,584
OCEANVIEW
$5,584
BALCONY
$6,713
SUITE
$12,801
From (per person) 5,584
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Costa Rica
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$11,157
SUITE
$19,174
Save (per person) 238
From (per person) 11,157
View Trip
13 Day Panama, Colombia & Caribbean Islands with Ponant
Cruise

13 Days (12 Nights) Colon to Fort-de-France
Cruise Line: Ponant
Ship: Le Bellot
Departure: 15 March 2025
Countries Visited: Panama, Colombia, Holland, Saint Vincent (+3 more), Saint Lucia, Guadeloupe, Martinique
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$12,973
SUITE
$18,804
Save (per person) 247
From (per person) 12,973
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Apr 2026
Countries Visited: Panama, Colombia, Curacao, Aruba
Exclusive Deal
INSIDE
$1,251
OCEANVIEW
$1,360
BALCONY
$1,444
SUITE
$1,974
Save (per person) 824
From (per person) 1,251
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 06 December 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,255
OCEANVIEW
$1,371
BALCONY
$1,543
SUITE
$2,251
Save (per person) 769
From (per person) 1,255
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Dec 2025 to Feb 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Exclusive Deal
INSIDE
$1,197
OCEANVIEW
$1,273
BALCONY
$1,457
SUITE
$2,245
Save (per person) 1,014
From (per person) 1,197
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Oct 2025 to Nov 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,272
OCEANVIEW
$1,334
BALCONY
$1,466
SUITE
$1,974
Save (per person) 877
From (per person) 1,272
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Dec 2025 to Jan 2026
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$6,527
SUITE
$11,153
Save (per person) 123
From (per person) 6,527
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Exclusive Deal
INSIDE
$1,252
OCEANVIEW
$1,392
BALCONY
$1,641
SUITE
$2,356
Save (per person) 778
From (per person) 1,252
View Trip
13 Day Panama, Colombia & Caribbean Islands with Ponant
Cruise

13 Days (12 Nights) Colon to Fort-de-France
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departure: 16 January 2026
Countries Visited: Panama, Colombia, Curacao, Saint Vincent (+3 more), Saint Lucia, Guadeloupe, Martinique
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$9,573
SUITE
$15,325
Save (per person) 177
From (per person) 9,573
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Bellot
Departures: Feb 2025 to Feb 2025
Countries Visited: Panama, Costa Rica
Holiday Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$13,428
SUITE
$27,987
Save (per person) 1,552
From (per person) 13,428
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 18 April 2026
Countries Visited: Panama, Colombia
Exclusive Deal
INSIDE
$155
OCEANVIEW
$199
BALCONY
$223
SUITE
$321
Save (per person) 188
From (per person) 155
View Trip
9 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

9 Days (8 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 12 December 2025
Countries Visited: Panama, Colombia, Bonaire, Aruba (+1 more), Curacao
Exclusive Deal
INSIDE
$1,529
OCEANVIEW
$1,580
BALCONY
$1,786
SUITE
$2,332
Save (per person) 887
From (per person) 1,529
View Trip
11 Day A Tropical Odyssey in Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Cancun
Cruise Line: Ponant
Ship: Le Champlain
Departure: 03 December 2025
Countries Visited: Panama, Costa Rica, Colombia, Honduras (+3 more), Guatemala, Belize, Mexico
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$10,328
SUITE
$15,904
Save (per person) 192
From (per person) 10,328
View Trip
11 Day Panama Canal Westward Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Colon to Los Angeles
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 25 April 2026
Countries Visited: Panama, Costa Rica, Mexico, USA
Exclusive Deal
INSIDE
$2,033
OCEANVIEW
$2,507
BALCONY
$3,079
SUITE
$4,083
Save (per person) 913
From (per person) 2,033
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Feb 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Exclusive Deal
INSIDE
$1,126
OCEANVIEW
$1,240
BALCONY
$1,485
SUITE
$2,320
Save (per person) 778
From (per person) 1,126
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 17 January 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Exclusive Deal
INSIDE
$1,434
OCEANVIEW
$1,425
BALCONY
$1,492
SUITE
$2,292
Save (per person) 847
From (per person) 1,425
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Nov 2025
Countries Visited: Panama, Colombia, Bonaire, Curacao
Exclusive Deal
INSIDE
$1,269
OCEANVIEW
$1,339
BALCONY
$1,498
SUITE
$2,047
Save (per person) 779
From (per person) 1,269
View Trip
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