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Cruises from Panama to USA

Are you looking for a cruise from Panama to USA? February and April are the most popular months to cruise between Panama and USA and there are 24 departures available from nine of the world's leading cruise lines.
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37 Days
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19 Cruises (24 Cruise Departures)
12 Day Caribbean Quest Voyage with Azamara Cruises
Cruise
 (1)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 15 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire (+3 more), Curacao, Dominican Republic, USA
INSIDE
$5,476
OCEANVIEW
$6,902
BALCONY
$8,506
SUITE
$11,674
From (per person) 5,476
View Trip
11 Day Canal & Caribbean Discovery with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 January 2026
Countries Visited: Panama, Colombia, Bonaire, Curacao (+3 more), Aruba, Jamaica, USA
Flex FaresExclusive Deal
INSIDE
$4,308
OCEANVIEW
$4,732
BALCONY
$7,017
SUITE
$9,736
Save (per person) 2,252
From (per person) 4,308
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (7)

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2025 to Dec 2026
Countries Visited: Panama, Costa Rica, Honduras, Belize (+2 more), Mexico, USA
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$6,561
SUITE
$9,991
Save (per person) 144
From (per person) 6,561
View Trip
11 Day Captivating Panama Canal with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 April 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+3 more), Bonaire, Jamaica, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
$5,356
BALCONY
-
SUITE
-
Save (per person) 2,034
From (per person) 5,356
View Trip
20 Day San Antonio To Fort Lauderdale with Cunard
Cruise

20 Days (19 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Aruba, USA
Experience Like No Other
INSIDE
$6,490
OCEANVIEW
$9,609
BALCONY
$10,797
SUITE
$18,459
From (per person) 6,490
View Trip
18 Day Costa Rica, Mexico & Hawaiian Nights with Seabourn
Cruise

18 Days (17 Nights) Panama City to Honolulu
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,825
SUITE
$16,151
From (per person) 8,825
View Trip
8 Day Panama City to Fort Lauderdale with Silversea
Cruise

8 Days (7 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 20 May 2025
Countries Visited: Panama, Colombia, USA
Port-to-Port
INSIDE
-
OCEANVIEW
$7,128
BALCONY
$8,019
SUITE
-
From (per person) 7,128
View Trip
12 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Panama City to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 09 February 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+4 more), Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
INSIDE
$2,361
OCEANVIEW
$2,666
BALCONY
$4,272
SUITE
$7,649
From (per person) 2,361
View Trip
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 January 2026
Countries Visited: Panama, Costa Rica, Nicaragua, Mexico (+1 more), USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,064
SUITE
$10,658
Save (per person) 6,286
From (per person) 10,064
View Trip
11 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Panama City to Tampa
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 19 January 2025
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
INSIDE
$1,996
OCEANVIEW
$2,088
BALCONY
$3,311
SUITE
$3,770
From (per person) 1,996
View Trip
37 Day San Antonio To Hamburg with Cunard
Cruise

37 Days (36 Nights) Santiago to Hamburg
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+6 more), Aruba, USA, Portugal, England, Belgium, Germany
Experience Like No Other
INSIDE
$10,011
OCEANVIEW
$14,367
BALCONY
$16,545
SUITE
$29,316
From (per person) 10,011
View Trip
18 Day San Antonio To Fort Lauderdale with Cunard
Cruise

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 February 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+3 more), Aruba, Bahamas, USA
Exclusive Deal
INSIDE
$5,252
OCEANVIEW
$6,192
BALCONY
$8,321
SUITE
$17,577
From (per person) 5,252
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 04 April 2026
Countries Visited: Panama, Colombia, Curacao, Aruba (+3 more), Jamaica, Cayman Islands, USA
Exclusive Deal
INSIDE
$4,682
OCEANVIEW
$5,138
BALCONY
$7,543
SUITE
$10,395
Save (per person) 2,028
From (per person) 4,682
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2025 to Mar 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Mexico, USA
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$15,871
SUITE
$22,731
Save (per person) 1,065
From (per person) 15,871
View Trip
11 Day Canal & Coral Isles with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 April 2026
Countries Visited: Panama, Colombia, Costa Rica, Honduras (+2 more), Mexico, USA
Flex FaresExclusive Deal
INSIDE
$4,308
OCEANVIEW
$4,732
BALCONY
$7,017
SUITE
$9,736
Save (per person) 2,252
From (per person) 4,308
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Colon to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 14 November 2025
Countries Visited: Panama, Costa Rica, Nicaragua, Guatemala (+2 more), Mexico, USA
New Year Sale
INSIDE
$5,584
OCEANVIEW
$5,584
BALCONY
$6,713
SUITE
$12,801
From (per person) 5,584
View Trip
32 Day San Antonio To Southampton with Cunard
Cruise

32 Days (31 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 February 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+6 more), Aruba, Bahamas, USA, Bermuda, Portugal, England
Exclusive Deal
INSIDE
$7,237
OCEANVIEW
$8,722
BALCONY
$11,395
SUITE
$26,047
From (per person) 7,237
View Trip
11 Day Panama Canal Westward Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Colon to Los Angeles
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 25 April 2026
Countries Visited: Panama, Costa Rica, Mexico, USA
Exclusive Deal
INSIDE
$2,033
OCEANVIEW
$2,507
BALCONY
$3,079
SUITE
$4,083
Save (per person) 913
From (per person) 2,033
View Trip
34 Day San Antonio To Southampton with Cunard
Cruise

34 Days (33 Nights) Santiago to London
Cruise Line: Cunard
Ship: Queen Anne
Departure: 28 February 2027
Countries Visited: Chile, Peru, Ecuador, Panama (+4 more), Aruba, USA, Portugal, England
Experience Like No Other
INSIDE
$8,921
OCEANVIEW
$13,475
BALCONY
$15,158
SUITE
$26,246
From (per person) 8,921
View Trip
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