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Cruises From Panama City

Choose from 17 unique cruises starting in Panama City, and traveling to Bridgetown, Fort Lauderdale, Hong Kong, Honolulu, Los Angeles and more. December is the most popular month to join a cruise from Panama City and you can select from 20 departures available from nine leading cruise lines.
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Duration
8 Days
38 Days
Countries Visited
End City
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$2,900pp
$49,598pp
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17 Cruises (20 Cruise Departures)
23 Day Journey To The Amazon with Regent Seven Seas
Cruise

23 Days (22 Nights) Panama City to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 March 2027
Countries Visited: Panama, Aruba, Trinidad and Tobago, Brazil (+2 more), Grenada, Curacao
Exclusive DealEarly Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$12,899
SUITE
$13,999
Save (per person) 19,299
From (per person) 12,899
View Trip
11 Day Canal & Coral Isles with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 April 2026
Countries Visited: Panama, Colombia, Costa Rica, Honduras (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$3,099
OCEANVIEW
$3,399
BALCONY
$4,999
SUITE
$6,899
Save (per person) 3,099
From (per person) 3,099
View Trip
30 Day Pacific Crossing & Treasures Of Japan with Seabourn
Cruise

30 Days (29 Nights) Panama City to Tokyo
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA (+1 more), Japan
Exclusive DealA Sail Beyond Event
INSIDE
-
OCEANVIEW
-
BALCONY
$8,399
SUITE
$15,799
From (per person) 8,399
View Trip
29 Day Canal To Coral Reefs with Regent Seven Seas
Cruise

29 Days (28 Nights) Panama City to Tahiti
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 26 January 2027
Countries Visited: Panama, Costa Rica, Nicaragua, El Salvador (+4 more), Guatemala, Mexico, USA, French Polynesia
Exclusive DealEarly Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$20,599
SUITE
$21,799
Save (per person) 28,999
From (per person) 20,599
View Trip
12 Day Caribbean Quest Voyage with Azamara Cruises
Cruise
 (1)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 15 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire (+3 more), Curacao, Dominican Republic, USA
Azamara Circle Loyalty Quarterly Savings
INSIDE
$2,909
OCEANVIEW
$3,499
BALCONY
$4,009
SUITE
$11,439
From (per person) 2,909
View Trip
18 Day Costa Rica, Mexico & Hawaiian Nights with Seabourn
Cruise

18 Days (17 Nights) Panama City to Honolulu
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA
Exclusive DealA Sail Beyond Event
INSIDE
-
OCEANVIEW
-
BALCONY
$5,999
SUITE
$10,999
From (per person) 5,999
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (7)

11 Days (10 Nights) Panama City to Fort Lauderdale
Operated By: Viking Cruises
Ship: Viking Mars
Departures: Nov 2025 to Dec 2026
Countries Visited: Panama, Costa Rica, Honduras, Belize (+2 more), Mexico, USA
Viking $999 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$3,299
SUITE
$5,499
Save (per person) 700
From (per person) 3,299
View Trip
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 January 2026
Countries Visited: Panama, Costa Rica, Nicaragua, Mexico (+1 more), USA
Exclusive DealEarly Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$7,449
SUITE
$7,849
Save (per person) 11,849
From (per person) 7,449
View Trip
11 Day Canal & Caribbean Discovery with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 January 2026
Countries Visited: Panama, Colombia, Bonaire, Curacao (+3 more), Aruba, Jamaica, USA
Exclusive Deal
INSIDE
$3,099
OCEANVIEW
$3,399
BALCONY
$4,999
SUITE
$6,999
Save (per person) 3,099
From (per person) 3,099
View Trip
11 Day Captivating Panama Canal with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 April 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+3 more), Bonaire, Jamaica, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
$5,999
BALCONY
$5,599
SUITE
-
Save (per person) 5,599
From (per person) 5,599
View Trip
12 Day Panama Canal & the Alluring Islands of the Caribbean with Scenic
New ReleaseCruise

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 13 April 2026
Countries Visited: Panama, Colombia, Aruba, Curacao (+2 more), Saint Vincent, Barbados
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$13,325
SUITE
$15,525
Save (per person) 13,465
From (per person) 13,325
View Trip
12 Day A Journey Of Mayan Discovery & Mexican Exploration with Explora Journeys
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Cruise Line: Explora Journeys
Ship: Explora III
Departure: 22 April 2027
Countries Visited: Panama, El Salvador, Guatemala, Mexico (+1 more), USA
Unique Oceans OfferExplora Early Booking Benefit
INSIDE
-
OCEANVIEW
-
BALCONY
$6,760
SUITE
$7,865
From (per person) 6,760
View Trip
12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 03 February 2026
Countries Visited: Panama, Costa Rica
Complimentary Hotel Night
From (per person) 9,390
View Trip
38 Day Central America, Hawaiian Nights & Pacific Crossing with Seabourn
Cruise

38 Days (37 Nights) Panama City to Hong Kong
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA (+3 more), Japan, Taiwan, China
Exclusive DealA Sail Beyond Event
INSIDE
-
OCEANVIEW
-
BALCONY
$12,499
SUITE
$24,299
From (per person) 12,499
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 04 April 2026
Countries Visited: Panama, Colombia, Curacao, Aruba (+3 more), Jamaica, Cayman Islands, USA
Exclusive Deal
INSIDE
$3,099
OCEANVIEW
$3,499
BALCONY
$4,999
SUITE
$7,099
Save (per person) 3,099
From (per person) 3,099
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Countries Visited: Panama, Chile
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$9,480
SUITE
$12,180
Save (per person) 9,510
From (per person) 9,480
View Trip
8 Day Panama City to Fort Lauderdale with Silversea
Cruise

8 Days (7 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 20 May 2025
Countries Visited: Panama, Colombia, USA
Port-to-Port
INSIDE
-
OCEANVIEW
$5,100
BALCONY
$6,400
SUITE
$12,200
From (per person) 5,100
View Trip
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