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Cruises From Panama City

Choose from 20 unique cruises starting in Panama City, and travelling to Bridgetown, Fort Lauderdale, Hong Kong, Honolulu, Los Angeles and more. December is the most popular month to join a cruise from Panama City and you can select from 21 departures available from eight leading cruise lines.
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8 Days
38 Days
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20 Cruises (21 Cruise Departures)
11 Day Captivating Panama Canal with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 April 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+3 more), Bonaire, Jamaica, USA
Bonus SavingsExclusive Deal
INSIDE
$4,314
OCEANVIEW
$4,778
BALCONY
$6,854
SUITE
$9,331
Save (per person) 2,506
From (per person) 4,314
View Trip
12 Day Caribbean Quest Voyage with Azamara Cruises
Cruise
 (1)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 15 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire (+3 more), Curacao, Dominican Republic, USA
INSIDE
$5,308
OCEANVIEW
$6,664
BALCONY
$7,882
SUITE
-
From (per person) 5,308
View Trip
10 Day Panama Canal Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 13 December 2024
Countries Visited: Panama, Costa Rica, Honduras, Guatemala (+2 more), Mexico, USA
INSIDE
$1,923
OCEANVIEW
$2,012
BALCONY
$3,428
SUITE
-
From (per person) 1,923
View Trip
11 Day Canal & Caribbean Discovery with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 January 2026
Countries Visited: Panama, Colombia, Bonaire, Curacao (+3 more), Aruba, Jamaica, USA
Exclusive Deal
INSIDE
$4,484
OCEANVIEW
$4,940
BALCONY
$7,316
SUITE
$10,147
Save (per person) 2,026
From (per person) 4,484
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (7)

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2025 to Dec 2025
Countries Visited: Panama, Costa Rica, Honduras, Belize (+2 more), Mexico, USA
Limited Time Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,836
SUITE
$9,103
Save (per person) 859
From (per person) 5,836
View Trip
12 Day Classic Panama Canal with Oceania Cruises
Cruise
 (3)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 February 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+4 more), Bonaire, Jamaica, Bahamas, USA
Bonus SavingsExclusive Deal
INSIDE
$4,984
OCEANVIEW
-
BALCONY
-
SUITE
-
Save (per person) 2,586
From (per person) 4,984
View Trip
8 Day Panama City to Fort Lauderdale with Silversea
Cruise

8 Days (7 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 20 May 2025
Countries Visited: Panama, Colombia, USA
Port-to-Port
INSIDE
-
OCEANVIEW
$7,128
BALCONY
$8,019
SUITE
-
From (per person) 7,128
View Trip
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 January 2026
Countries Visited: Panama, Costa Rica, Nicaragua, Mexico (+1 more), USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,064
SUITE
$10,658
Save (per person) 6,286
From (per person) 10,064
View Trip
11 Day Canal & Coral Isles with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 April 2026
Countries Visited: Panama, Colombia, Costa Rica, Honduras (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$4,483
OCEANVIEW
$4,938
BALCONY
$7,314
SUITE
$10,145
Save (per person) 2,027
From (per person) 4,483
View Trip
12 Day Panama Canal & the Alluring Islands of the Caribbean with Scenic
New ReleaseCruise

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 13 April 2026
Countries Visited: Panama, Colombia, Aruba, Curacao (+2 more), Saint Vincent, Barbados
Super EarlybirdReduced Single Supplement
INSIDE
-
OCEANVIEW
-
BALCONY
$13,172
SUITE
$14,568
Save (per person) 3,603
From (per person) 13,172
View Trip
38 Day Central America, Hawaiian Nights & Pacific Crossing with Seabourn
Cruise

38 Days (37 Nights) Panama City to Hong Kong
Cruise Line: Seabourn
Ship: Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA (+3 more), Japan, Taiwan, China
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$20,329
SUITE
$35,872
From (per person) 20,329
View Trip
18 Day Costa Rica, Mexico & Hawaiian Nights with Seabourn
Cruise

18 Days (17 Nights) Panama City to Honolulu
Cruise Line: Seabourn
Ship: Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,825
SUITE
$16,151
From (per person) 8,825
View Trip
10 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Panama City to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Gem
Departure: 11 December 2024
Countries Visited: Panama, Costa Rica, Jamaica, Cayman Islands (+3 more), Mexico, Bahamas, USA
INSIDE
$1,597
OCEANVIEW
$1,627
BALCONY
$1,734
SUITE
$2,539
From (per person) 1,597
View Trip
12 Day Panama City to Los Angeles with Silversea
Cruise

12 Days (11 Nights) Panama City to Los Angeles
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 24 December 2024
Countries Visited: Panama, Costa Rica, Mexico, USA
Port-to-Port
INSIDE
-
OCEANVIEW
$7,623
BALCONY
-
SUITE
$22,572
From (per person) 7,623
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 04 April 2026
Countries Visited: Panama, Colombia, Curacao, Aruba (+3 more), Jamaica, Cayman Islands, USA
Exclusive Deal
INSIDE
$4,641
OCEANVIEW
$5,086
BALCONY
$7,462
SUITE
$10,293
Save (per person) 2,029
From (per person) 4,641
View Trip
11 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Panama City to Tampa
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 19 January 2025
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
Exclusive Solo Offer
INSIDE
$2,011
OCEANVIEW
$2,164
BALCONY
$3,235
SUITE
$3,999
From (per person) 2,011
View Trip
23 Day Journey To The Amazon with Regent Seven Seas
Cruise

23 Days (22 Nights) Panama City to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 March 2027
Countries Visited: Panama, Aruba, Trinidad and Tobago, Brazil (+2 more), Grenada, Curacao
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$16,299
SUITE
$18,517
Save (per person) 8,871
From (per person) 16,299
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Countries Visited: Panama, Chile
Super EarlybirdReduced Single Supplement
INSIDE
-
OCEANVIEW
-
BALCONY
$8,343
SUITE
$10,778
Save (per person) 3,052
From (per person) 8,343
View Trip
12 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Panama City to Miami
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Jade
Departure: 09 February 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+4 more), Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
INSIDE
$2,437
OCEANVIEW
$2,743
BALCONY
$4,348
SUITE
$5,266
From (per person) 2,437
View Trip
30 Day Pacific Crossing & Treasures Of Japan with Seabourn
Cruise

30 Days (29 Nights) Panama City to Tokyo
Cruise Line: Seabourn
Ship: Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA (+1 more), Japan
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,389
SUITE
$23,883
From (per person) 13,389
View Trip
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