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Cruises From Panama City

Choose from 16 unique cruises starting in Panama City, and traveling to Bridgetown, Fort Lauderdale, Hong Kong, Honolulu, Los Angeles and more. December is the most popular month to join a cruise from Panama City and you can select from 19 departures available from eight leading cruise lines.
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Duration
8 Days
38 Days
Countries Visited
End City
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$3,000pp
$49,598pp
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16 Cruises (19 Cruise Departures)
8 Day Panama City to Fort Lauderdale with Silversea
Cruise

8 Days (7 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 20 May 2025
Countries Visited: Panama, Colombia, USA
Port-to-Port
INSIDE
-
OCEANVIEW
-
BALCONY
$5,800
SUITE
-
From (per person) 5,800
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Countries Visited: Panama, Chile
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$9,480
SUITE
$12,180
Save (per person) 9,510
From (per person) 9,480
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 04 April 2026
Countries Visited: Panama, Colombia, Curacao, Aruba (+3 more), Jamaica, Cayman Islands, USA
Exclusive Deal
INSIDE
$3,099
OCEANVIEW
$3,499
BALCONY
$4,999
SUITE
$7,099
Save (per person) 3,099
From (per person) 3,099
View Trip
11 Day Captivating Panama Canal with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 April 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+3 more), Bonaire, Jamaica, USA
Exclusive Deal
INSIDE
-
OCEANVIEW
$5,999
BALCONY
-
SUITE
-
Save (per person) 5,999
From (per person) 5,999
View Trip
18 Day Costa Rica, Mexico & Hawaiian Nights with Seabourn
Cruise

18 Days (17 Nights) Panama City to Honolulu
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA
Sail Of The Year Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,099
SUITE
$9,349
From (per person) 5,099
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (7)

11 Days (10 Nights) Panama City to Fort Lauderdale
Operated By: Viking Cruises
Ship: Viking Mars
Departures: Nov 2025 to Dec 2026
Countries Visited: Panama, Costa Rica, Honduras, Belize (+2 more), Mexico, USA
INSIDE
-
OCEANVIEW
-
BALCONY
$3,499
SUITE
$6,249
From (per person) 3,499
View Trip
12 Day Caribbean Quest Voyage with Azamara Cruises
Cruise
 (1)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 15 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire (+3 more), Curacao, Dominican Republic, USA
INSIDE
$3,799
OCEANVIEW
$4,789
BALCONY
$5,899
SUITE
$8,109
From (per person) 3,799
View Trip
11 Day Canal & Caribbean Discovery with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 January 2026
Countries Visited: Panama, Colombia, Bonaire, Curacao (+3 more), Aruba, Jamaica, USA
Exclusive Deal
INSIDE
$3,099
OCEANVIEW
$3,399
BALCONY
$4,999
SUITE
$6,999
Save (per person) 3,099
From (per person) 3,099
View Trip
30 Day Pacific Crossing & Treasures Of Japan with Seabourn
Cruise

30 Days (29 Nights) Panama City to Tokyo
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA (+1 more), Japan
Sail Of The Year Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$7,139
SUITE
$13,429
From (per person) 7,139
View Trip
23 Day Journey To The Amazon with Regent Seven Seas
Cruise

23 Days (22 Nights) Panama City to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 March 2027
Countries Visited: Panama, Aruba, Trinidad and Tobago, Brazil (+2 more), Grenada, Curacao
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,249
SUITE
$13,299
Save (per person) 19,849
From (per person) 12,249
View Trip
11 Day Canal & Coral Isles with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 April 2026
Countries Visited: Panama, Colombia, Costa Rica, Honduras (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$3,099
OCEANVIEW
$3,399
BALCONY
$4,999
SUITE
$6,899
Save (per person) 3,099
From (per person) 3,099
View Trip
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 January 2026
Countries Visited: Panama, Costa Rica, Nicaragua, Mexico (+1 more), USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,099
SUITE
$7,499
Save (per person) 12,099
From (per person) 7,099
View Trip
12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 03 February 2026
Countries Visited: Panama, Costa Rica
Complimentary Hotel Night
From (per person) 9,390
View Trip
12 Day Panama Canal & the Alluring Islands of the Caribbean with Scenic
New ReleaseCruise

12 Days (11 Nights) Panama City to Bridgetown
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 13 April 2026
Countries Visited: Panama, Colombia, Aruba, Curacao (+2 more), Saint Vincent, Barbados
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$13,325
SUITE
$15,525
Save (per person) 13,465
From (per person) 13,325
View Trip
38 Day Central America, Hawaiian Nights & Pacific Crossing with Seabourn
Cruise

38 Days (37 Nights) Panama City to Hong Kong
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 12 December 2025
Countries Visited: Panama, Costa Rica, Mexico, USA (+3 more), Japan, Taiwan, China
Sail Of The Year Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$10,709
SUITE
$20,654
From (per person) 10,709
View Trip
29 Day Canal To Coral Reefs with Regent Seven Seas
Cruise

29 Days (28 Nights) Panama City to Tahiti
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 26 January 2027
Countries Visited: Panama, Costa Rica, Nicaragua, El Salvador (+4 more), Guatemala, Mexico, USA, French Polynesia
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$20,499
SUITE
$21,699
Save (per person) 29,099
From (per person) 20,499
View Trip
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