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Cruises from USA to Italy

Are you looking for a cruise from USA to Italy? April is the most popular month to cruise between USA and Italy and there are 22 departures available from nine of the world's leading cruise lines.
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15 Days
128 Days
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$900pp
$214,598pp
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21 Cruises (22 Cruise Departures)
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Miami to Naples
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 06 April 2025
Countries Visited: USA, Sint Maarten, Antigua and Barbuda, Barbados (+4 more), Portugal, Spain, Sicily, Italy
Escape To Sea
INSIDE
-
OCEANVIEW
-
BALCONY
$1,929
SUITE
$4,919
From (per person) 1,929
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Miami to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 09 April 2026
Countries Visited: USA, Virgin Islands, Spain, France (+1 more), Italy
Escape To Sea
INSIDE
$1,337
OCEANVIEW
$1,537
BALCONY
$1,727
SUITE
$2,777
From (per person) 1,337
View Trip
16 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

16 Days (15 Nights) Tampa to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 12 April 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+1 more), Italy
Bonus Onboard Credit + SaveExclusive Deal
INSIDE
$1,127
OCEANVIEW
$1,311
BALCONY
$1,812
SUITE
$4,946
From (per person) 1,699
View Trip
22 Day Atlantic & Italian Stars with Oceania Cruises
Cruise

22 Days (21 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 07 April 2026
Countries Visited: USA, Bermuda, Portugal, Gibraltar (+5 more), Spain, France, Italy, Corsica, Sardinia
Exclusive Deal
INSIDE
$5,399
OCEANVIEW
$6,299
BALCONY
$6,999
SUITE
$10,199
Save (per person) 5,399
From (per person) 5,399
View Trip
36 Day Crossing To Antiquity with Oceania Cruises
Cruise
 (1)

36 Days (35 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 March 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+6 more), Morocco, Gibraltar, France, Corsica, Sardinia, Italy
Exclusive Deal
INSIDE
$8,999
OCEANVIEW
$9,899
BALCONY
$13,699
SUITE
$18,999
Save (per person) 8,999
From (per person) 8,999
View Trip
21 Day Western Mediterranean Grand Adventure with Princess
Cruise
 (2)

21 Days (20 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 05 March 2026
Countries Visited: USA, Spain, Gibraltar, France (+1 more), Italy
Exclusive DealSpring Swing Offer
INSIDE
$1,938
OCEANVIEW
$2,077
BALCONY
$2,671
SUITE
$3,166
From (per person) 1,938
View Trip
21 Day Atlantic & Mediterranean Horizons with Viking Cruises
Cruise
 (7)

21 Days (20 Nights) Fort Lauderdale to Rome
Operated By: Viking Cruises
Ship: Viking Mars
Departures: Feb 2026 to Feb 2026
Countries Visited: USA, Sint Maarten, Portugal, Spain (+3 more), France, Monaco, Italy
Viking $799 Air Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$6,798
SUITE
$13,398
From (per person) 6,798
View Trip
15 Day Italy, Spain, Azores Transatlantic with Royal Caribbean
Cruise

15 Days (14 Nights) New York to Rome
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 27 April 2025
Countries Visited: USA, Portugal, Spain, Italy
March Vacation SaleExclusive Solo Offer
INSIDE
$2,080
OCEANVIEW
$3,032
BALCONY
$2,899
SUITE
$6,390
Save (per person) 932
From (per person) 2,080
View Trip
15 Day Western Mediterranean Passage with Princess
Cruise
 (1)

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Countries Visited: USA, Portugal, Gibraltar, Corsica (+1 more), Italy
Exclusive DealSpring Swing Offer
INSIDE
$944
OCEANVIEW
$1,291
BALCONY
$1,291
SUITE
$1,459
From (per person) 944
View Trip
20 Day Western Mediterranean & Adriatic Grand Adventure with Princess
Cruise
 (1)

20 Days (19 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Countries Visited: USA, Portugal, Gibraltar, Corsica (+3 more), Italy, Montenegro, Greece
Exclusive DealSpring Swing Offer
INSIDE
$1,564
OCEANVIEW
$2,217
BALCONY
$1,990
SUITE
$2,505
From (per person) 1,564
View Trip
15 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 20 April 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+1 more), Italy
Mutiple Deals Available
INSIDE
$1,588
OCEANVIEW
$1,817
BALCONY
$2,224
SUITE
$5,596
From (per person) 2,461
View Trip
128 Day Navigate The World with Regent Seven Seas
Cruise

128 Days (127 Nights) Miami to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 11 January 2027
Countries Visited: USA, Mexico, Belize, Honduras (+33 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama, Nicaragua, El Salvador, Guatemala, French Polynesia, American Samoa, Samoa, Fiji, Vanuatu, New Caledonia, Australia, Indonesia, Singapore, Malaysia, Thailand, Sri Lanka, Maldives, India, Oman, United Arab Emirates, Qatar, Saudi Arabia, Egypt, Jordan, Israel, Cyprus, Greece, Turkey, Italy
Exclusive DealEarly Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$83,199
SUITE
-
Save (per person) 131,399
From (per person) 83,199
View Trip
16 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

16 Days (15 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 20 April 2025
Countries Visited: USA, Bermuda, Gibraltar, Spain (+1 more), Italy
Bonus Onboard Credit + SaveExclusive Deal
INSIDE
$1,512
OCEANVIEW
-
BALCONY
-
SUITE
$14,569
From (per person) 2,373
View Trip
23 Day MSC Grand Voyages with MSC Cruises
Cruise

23 Days (22 Nights) Miami to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 09 April 2026
Countries Visited: USA, Virgin Islands, Spain, France (+3 more), Italy, Greece, Turkey
Escape To Sea
INSIDE
$2,738
OCEANVIEW
$3,148
BALCONY
$3,448
SUITE
-
From (per person) 2,738
View Trip
17 Day MSC Grand Voyages with MSC Cruises
Cruise

17 Days (16 Nights) Orlando to Genoa
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 18 April 2026
Countries Visited: USA, Saint Martin, Portugal, Spain (+2 more), France, Italy
Escape To Sea
INSIDE
$1,193
OCEANVIEW
$1,413
BALCONY
$1,653
SUITE
$5,293
From (per person) 1,193
View Trip
17 Day Transoceanic Salute with Oceania Cruises
Cruise

17 Days (16 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 14 April 2026
Countries Visited: USA, Bahamas, Bermuda, Portugal (+2 more), Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$4,599
SUITE
-
Save (per person) 4,599
From (per person) 4,599
View Trip
25 Day Miami to Rome with Silversea
Cruise

25 Days (24 Nights) Miami to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 31 May 2026
Countries Visited: USA, Portugal, Spain, France (+2 more), Monaco, Italy
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$15,400
From (per person) 15,400
View Trip
19 Day MSC Grand Voyages with MSC Cruises
Cruise

19 Days (18 Nights) Orlando to Rome
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 18 April 2026
Countries Visited: USA, Saint Martin, Portugal, Spain (+2 more), France, Italy
Escape To Sea
INSIDE
$1,378
OCEANVIEW
$1,638
BALCONY
$1,888
SUITE
$5,948
From (per person) 1,378
View Trip
17 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

17 Days (16 Nights) Tampa to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 12 April 2025
Countries Visited: USA, Bermuda, Gibraltar, Spain (+1 more), Italy
Bonus Onboard Credit + SaveExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$2,526
SUITE
-
From (per person) 4,063
View Trip
17 Day Treasures Of The Atlantic with Regent Seven Seas
Cruise

17 Days (16 Nights) Miami to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 15 April 2027
Countries Visited: USA, Bermuda, Spain, Corsica (+1 more), Italy
Exclusive DealEarly Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$10,199
SUITE
$11,399
Save (per person) 16,799
From (per person) 10,199
View Trip
25 Day Atlantic Crossing & Spain's Southern Coast with Seabourn
Cruise

25 Days (24 Nights) Miami to Genoa
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 26 April 2026
Countries Visited: USA, Portugal, Morocco, Gibraltar (+3 more), Spain, France, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$10,799
BALCONY
$12,299
SUITE
$20,999
From (per person) 10,799
View Trip
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Cruises from USA to Italy

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