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Cruises from USA to Italy

Are you looking for a cruise from USA to Italy? April is the most popular month to cruise between USA and Italy and there are 25 departures available from ten of the world's leading cruise lines.
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15 Days
128 Days
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$1,300pp
$162,190pp
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24 Cruises (25 Cruise Departures)
21 Day Atlantic & Mediterranean Horizons with Viking Cruises
Cruise
 (7)

21 Days (20 Nights) Fort Lauderdale to Rome
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Mar 2025 to Feb 2026
Countries Visited: USA, Sint Maarten, Portugal, Spain (+3 more), France, Monaco, Italy
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$12,073
SUITE
$19,498
Save (per person) 965
From (per person) 12,073
View Trip
21 Day Western Mediterranean Grand Adventure with Princess
Cruise
 (2)

21 Days (20 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 05 March 2026
Countries Visited: USA, Spain, Gibraltar, France (+1 more), Italy
Exclusive Deal
INSIDE
$3,178
OCEANVIEW
$3,674
BALCONY
$4,356
SUITE
$5,565
From (per person) 3,178
View Trip
22 Day Mediterranean Grand Adventure with Princess
Cruise
 (2)

22 Days (21 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 22 March 2025
Countries Visited: USA, Spain, Gibraltar, France (+1 more), Italy
Exclusive Deal
INSIDE
$2,565
OCEANVIEW
$2,704
BALCONY
$2,961
SUITE
$3,654
From (per person) 2,565
View Trip
22 Day Western Mediterranean Grand Adventure with Princess
Cruise
 (3)

22 Days (21 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Majestic Princess
Departure: 18 February 2025
Countries Visited: USA, Portugal, Spain, Gibraltar (+2 more), Corsica, Italy
Exclusive Deal
INSIDE
$2,820
OCEANVIEW
-
BALCONY
$3,485
SUITE
$4,406
From (per person) 2,820
View Trip
16 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise
 (1)

16 Days (15 Nights) New York to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 31 March 2025
Countries Visited: USA, Portugal, Spain, France (+1 more), Italy
INSIDE
$2,411
OCEANVIEW
-
BALCONY
$3,329
SUITE
$3,787
From (per person) 2,411
View Trip
15 Day Western Mediterranean Passage with Princess
Cruise
 (1)

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Countries Visited: USA, Portugal, Gibraltar, Corsica (+1 more), Italy
Exclusive Deal
INSIDE
$1,772
OCEANVIEW
$2,613
BALCONY
$1,934
SUITE
$3,494
From (per person) 1,772
View Trip
36 Day Crossing To Antiquity with Oceania Cruises
Cruise
 (1)

36 Days (35 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 March 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+6 more), Morocco, Gibraltar, France, Corsica, Sardinia, Italy
Exclusive Deal
INSIDE
$13,580
OCEANVIEW
$14,937
BALCONY
$20,649
SUITE
$28,618
Save (per person) 2,090
From (per person) 13,580
View Trip
20 Day Western Mediterranean & Adriatic Grand Adventure with Princess
Cruise
 (1)

20 Days (19 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Countries Visited: USA, Portugal, Gibraltar, Corsica (+3 more), Italy, Montenegro, Greece
Exclusive Deal
INSIDE
$2,607
OCEANVIEW
-
BALCONY
$3,267
SUITE
$4,656
From (per person) 2,607
View Trip
17 Day Treasures Of The Atlantic with Regent Seven Seas
Cruise

17 Days (16 Nights) Miami to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 15 April 2027
Countries Visited: USA, Bermuda, Spain, Corsica (+1 more), Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$14,798
SUITE
$16,570
Save (per person) 7,382
From (per person) 14,798
View Trip
17 Day Transoceanic Salute with Oceania Cruises
Cruise

17 Days (16 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 14 April 2026
Countries Visited: USA, Bahamas, Bermuda, Portugal (+2 more), Spain, Italy
Flex FaresExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$6,598
SUITE
$9,815
Save (per person) 2,392
From (per person) 6,598
View Trip
17 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

17 Days (16 Nights) Tampa to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 12 April 2025
Countries Visited: USA, Bermuda, Gibraltar, Spain (+1 more), Italy
Exclusive DealSummer Sale
INSIDE
$2,094
OCEANVIEW
$2,416
BALCONY
$3,259
SUITE
$8,253
From (per person) 3,184
View Trip
16 Day Spanish Passage with Princess
Cruise

16 Days (15 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Emerald Princess
Departure: 24 March 2025
Countries Visited: USA, Portugal, Gibraltar, Spain (+2 more), Corsica, Italy
Exclusive Deal
INSIDE
$1,324
OCEANVIEW
$1,642
BALCONY
$1,978
SUITE
$2,908
From (per person) 1,324
View Trip
16 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

16 Days (15 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 20 April 2025
Countries Visited: USA, Bermuda, Gibraltar, Spain (+1 more), Italy
Exclusive DealSummer Sale
INSIDE
$2,347
OCEANVIEW
$2,774
BALCONY
$2,789
SUITE
$10,309
From (per person) 3,615
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Miami to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 09 April 2026
Countries Visited: USA, Virgin Islands, Spain, France (+1 more), Italy
Early Booking Offer
INSIDE
$2,398
OCEANVIEW
$2,695
BALCONY
$2,982
SUITE
$4,547
From (per person) 2,398
View Trip
16 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

16 Days (15 Nights) Tampa to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 12 April 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+1 more), Italy
Exclusive DealSummer Sale
INSIDE
$1,832
OCEANVIEW
$2,129
BALCONY
$2,576
SUITE
$7,804
From (per person) 2,679
View Trip
21 Day Atlantic Crossing: Miami To The Mediterranean with Seabourn
Cruise

21 Days (20 Nights) Miami to Rome
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 28 April 2025
Countries Visited: USA, Portugal, Gibraltar, Corsica (+1 more), Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$16,150
SUITE
-
From (per person) 16,150
View Trip
22 Day Atlantic & Italian Stars with Oceania Cruises
Cruise

22 Days (21 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 07 April 2026
Countries Visited: USA, Bermuda, Portugal, Gibraltar (+5 more), Spain, France, Italy, Corsica, Sardinia
Exclusive Deal
INSIDE
$7,997
OCEANVIEW
$9,353
BALCONY
$10,551
SUITE
$14,917
Save (per person) 2,053
From (per person) 7,997
View Trip
15 Day Italy, Spain, Azores Transatlantic with Royal Caribbean
Cruise

15 Days (14 Nights) New York to Rome
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 27 April 2025
Countries Visited: USA, Portugal, Spain, Italy
Exclusive Deal
INSIDE
$3,252
OCEANVIEW
$4,382
BALCONY
$4,286
SUITE
$25,731
Save (per person) 1,576
From (per person) 3,252
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) Miami to Florence
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 06 April 2025
Countries Visited: USA, Saint Martin, Antigua and Barbuda, Barbados (+4 more), Portugal, Spain, Sicily, Italy
Save And Sail Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$4,081
SUITE
$5,507
From (per person) 4,081
View Trip
25 Day Atlantic Crossing & Spain's Southern Coast with Seabourn
Cruise

25 Days (24 Nights) Miami to Genoa
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 26 April 2026
Countries Visited: USA, Portugal, Morocco, Gibraltar (+3 more), Spain, France, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$13,387
BALCONY
$15,565
SUITE
$22,990
From (per person) 13,387
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Miami to Naples
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 06 April 2025
Countries Visited: USA, Sint Maarten, Antigua and Barbuda, Barbados (+4 more), Portugal, Spain, Sicily, Italy
Save And Sail Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$5,236
From (per person) 5,236
View Trip
25 Day Miami to Rome with Silversea
Cruise

25 Days (24 Nights) Miami to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 31 May 2026
Countries Visited: USA, Portugal, Spain, France (+2 more), Monaco, Italy
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$22,473
From (per person) 22,473
View Trip
128 Day Navigate The World with Regent Seven Seas
Cruise

128 Days (127 Nights) Miami to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 11 January 2027
Countries Visited: USA, Mexico, Belize, Honduras (+33 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama, Nicaragua, El Salvador, Guatemala, French Polynesia, American Samoa, Samoa, Fiji, Vanuatu, New Caledonia, Australia, Indonesia, Singapore, Malaysia, Thailand, Sri Lanka, Maldives, India, Oman, United Arab Emirates, Qatar, Saudi Arabia, Egypt, Jordan, Israel, Cyprus, Greece, Turkey, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$121,028
SUITE
$134,324
Save (per person) 41,162
From (per person) 121,028
View Trip
15 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 20 April 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+1 more), Italy
Exclusive DealSummer Sale
INSIDE
$2,587
OCEANVIEW
$2,960
BALCONY
$3,461
SUITE
$8,703
From (per person) 3,956
View Trip
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Cruises from USA to Italy

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