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Cruises from USA to Italy

Are you looking for a cruise from USA to Italy? April is the most popular month to cruise between USA and Italy and there are 24 departures available from ten of the world's leading cruise lines.
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15 Days
128 Days
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$600pp
$214,598pp
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23 Cruises (24 Cruise Departures)
21 Day Western Mediterranean Grand Adventure with Princess
Cruise
 (2)

21 Days (20 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 05 March 2026
Countries Visited: USA, Spain, Gibraltar, France (+1 more), Italy
Exclusive Deal
INSIDE
$2,181
OCEANVIEW
$2,378
BALCONY
$2,684
SUITE
$3,358
From (per person) 2,181
View Trip
15 Day Western Mediterranean Passage with Princess
Cruise
 (1)

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Countries Visited: USA, Portugal, Gibraltar, Corsica (+1 more), Italy
Exclusive Deal
INSIDE
$738
OCEANVIEW
$1,168
BALCONY
$979
SUITE
$1,548
From (per person) 738
View Trip
22 Day MSC Grand Voyages with MSC Cruises
Cruise

22 Days (21 Nights) New York to Florence
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 19 April 2026
Countries Visited: USA, Canada, Portugal, Spain (+5 more), Gibraltar, France, Tunisia, Sicily, Italy
Escape To Sea - Cruise OnlyDrinks and Wi-Fi Included
INSIDE
$1,648
OCEANVIEW
$2,034
BALCONY
$2,222
SUITE
$6,885
From (per person) 1,648
View Trip
17 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

17 Days (16 Nights) Tampa to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 12 April 2025
Countries Visited: USA, Bermuda, Gibraltar, Spain (+1 more), Italy
Bonus Onboard Credit + SaveExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$10,085
From (per person) 16,478
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) New York to Amalfi
Cruise Line: MSC Cruises
Ship: MSC Meraviglia
Departure: 19 April 2026
Countries Visited: USA, Canada, Portugal, Spain (+5 more), Gibraltar, France, Tunisia, Sicily, Italy
Escape To Sea - Cruise OnlyDrinks and Wi-Fi Included
INSIDE
$1,554
OCEANVIEW
$1,931
BALCONY
$2,119
SUITE
$8,375
From (per person) 1,554
View Trip
16 Day Transatlantic Repositioning Cruise From New York to Rome with Norwegian Cruise Line
Cruise
 (1)

16 Days (15 Nights) New York to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 31 March 2025
Countries Visited: USA, Portugal, Spain, France (+1 more), Italy
INSIDE
$782
OCEANVIEW
-
BALCONY
$1,032
SUITE
$1,332
From (per person) 782
View Trip
15 Day Italy, Spain, Azores Transatlantic with Royal Caribbean
Cruise

15 Days (14 Nights) New York to Rome
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 27 April 2025
Countries Visited: USA, Portugal, Spain, Italy
Exclusive DealExclusive Solo Offer
INSIDE
$1,399
OCEANVIEW
$1,804
BALCONY
$1,871
SUITE
-
Save (per person) 618
From (per person) 1,399
View Trip
20 Day Western Mediterranean & Adriatic Grand Adventure with Princess
Cruise
 (1)

20 Days (19 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Countries Visited: USA, Portugal, Gibraltar, Corsica (+3 more), Italy, Montenegro, Greece
Exclusive Deal
INSIDE
$1,661
OCEANVIEW
-
BALCONY
$2,064
SUITE
$3,001
From (per person) 1,661
View Trip
22 Day Mediterranean Grand Adventure with Princess
Cruise
 (2)

22 Days (21 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 22 March 2025
Countries Visited: USA, Spain, Gibraltar, France (+1 more), Italy
Exclusive Deal
INSIDE
$1,485
OCEANVIEW
$1,729
BALCONY
-
SUITE
$11,067
From (per person) 1,485
View Trip
128 Day Navigate The World with Regent Seven Seas
Cruise

128 Days (127 Nights) Miami to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 11 January 2027
Countries Visited: USA, Mexico, Belize, Honduras (+33 more), Cayman Islands, Jamaica, Costa Rica, Colombia, Panama, Nicaragua, El Salvador, Guatemala, French Polynesia, American Samoa, Samoa, Fiji, Vanuatu, New Caledonia, Australia, Indonesia, Singapore, Malaysia, Thailand, Sri Lanka, Maldives, India, Oman, United Arab Emirates, Qatar, Saudi Arabia, Egypt, Jordan, Israel, Cyprus, Greece, Turkey, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$82,999
SUITE
$91,999
Save (per person) 131,599
From (per person) 82,999
View Trip
17 Day Treasures Of The Atlantic with Regent Seven Seas
Cruise

17 Days (16 Nights) Miami to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 15 April 2027
Countries Visited: USA, Bermuda, Spain, Corsica (+1 more), Italy
Exclusive DealUpgrade Your Horizon
INSIDE
-
OCEANVIEW
-
BALCONY
$10,199
SUITE
$13,849
Save (per person) 16,799
From (per person) 10,199
View Trip
36 Day Crossing To Antiquity with Oceania Cruises
Cruise
 (1)

36 Days (35 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 27 March 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+6 more), Morocco, Gibraltar, France, Corsica, Sardinia, Italy
Exclusive Deal
INSIDE
$8,999
OCEANVIEW
$9,899
BALCONY
$13,699
SUITE
$18,999
Save (per person) 8,999
From (per person) 8,999
View Trip
17 Day Transoceanic Salute with Oceania Cruises
Cruise

17 Days (16 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 14 April 2026
Countries Visited: USA, Bahamas, Bermuda, Portugal (+2 more), Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$4,599
SUITE
$7,049
Save (per person) 4,599
From (per person) 4,599
View Trip
21 Day Atlantic & Mediterranean Horizons with Viking Cruises
Cruise
 (7)

21 Days (20 Nights) Fort Lauderdale to Rome
Operated By: Viking Cruises
Ship: Viking Mars
Departures: Mar 2025 to Feb 2026
Countries Visited: USA, Sint Maarten, Portugal, Spain (+3 more), France, Monaco, Italy
INSIDE
-
OCEANVIEW
-
BALCONY
$7,898
SUITE
$13,398
From (per person) 7,898
View Trip
15 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 20 April 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+1 more), Italy
Exclusive DealExclusive Solo Offer
INSIDE
$1,662
OCEANVIEW
$1,912
BALCONY
$2,174
SUITE
$5,546
Save (per person) 957
From (per person) 1,662
View Trip
16 Day Spanish Passage with Princess
Cruise

16 Days (15 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Emerald Princess
Departure: 24 March 2025
Countries Visited: USA, Portugal, Gibraltar, Spain (+2 more), Corsica, Italy
Exclusive Deal
INSIDE
$678
OCEANVIEW
$727
BALCONY
$829
SUITE
$2,157
From (per person) 678
View Trip
16 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

16 Days (15 Nights) Tampa to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 12 April 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+1 more), Italy
Exclusive Deal
INSIDE
$1,158
OCEANVIEW
$1,358
BALCONY
$1,583
SUITE
$4,896
Save (per person) 631
From (per person) 1,158
View Trip
21 Day Atlantic Crossing: Miami To The Mediterranean with Seabourn
Cruise

21 Days (20 Nights) Miami to Rome
Cruise Line: Seabourn
Ship: Seabourn Encore
Departure: 28 April 2025
Countries Visited: USA, Portugal, Gibraltar, Corsica (+1 more), Italy
Sail Of The Year Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$7,649
SUITE
-
From (per person) 7,649
View Trip
25 Day Atlantic Crossing & Spain's Southern Coast with Seabourn
Cruise

25 Days (24 Nights) Miami to Genoa
Cruise Line: Seabourn
Ship: Seabourn Quest
Departure: 26 April 2026
Countries Visited: USA, Portugal, Morocco, Gibraltar (+3 more), Spain, France, Italy
Sail Of The Year Offer
INSIDE
-
OCEANVIEW
$8,244
BALCONY
$9,519
SUITE
$16,064
From (per person) 8,244
View Trip
16 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

16 Days (15 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 20 April 2025
Countries Visited: USA, Bermuda, Gibraltar, Spain (+1 more), Italy
Bonus Onboard Credit + SaveExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$14,519
From (per person) 23,584
View Trip
25 Day Miami to Rome with Silversea
Cruise

25 Days (24 Nights) Miami to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 31 May 2026
Countries Visited: USA, Portugal, Spain, France (+2 more), Monaco, Italy
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$15,400
From (per person) 15,400
View Trip
22 Day Atlantic & Italian Stars with Oceania Cruises
Cruise

22 Days (21 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 07 April 2026
Countries Visited: USA, Bermuda, Portugal, Gibraltar (+5 more), Spain, France, Italy, Corsica, Sardinia
Exclusive Deal
INSIDE
$5,299
OCEANVIEW
$6,199
BALCONY
$6,999
SUITE
$10,099
Save (per person) 5,299
From (per person) 5,299
View Trip
16 Day MSC Grand Voyages with MSC Cruises
Cruise

16 Days (15 Nights) Miami to Rome
Cruise Line: MSC Cruises
Ship: MSC Divina
Departure: 09 April 2026
Countries Visited: USA, Virgin Islands, Spain, France (+1 more), Italy
Escape To Sea - Cruise OnlyDrinks and Wi-Fi Included
INSIDE
$1,384
OCEANVIEW
$1,582
BALCONY
$1,711
SUITE
$2,928
From (per person) 1,384
View Trip
Results: 23 results

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Cruises from USA to Italy

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