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Cruises from USA to Italy

Are you looking for a cruise from USA to Italy? April is the most popular month to cruise between USA and Italy and there are 21 departures available from ten of the world's leading cruise lines.
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20 Cruises (21 Cruise Departures)
21 Day Western Mediterranean Grand Adventure with Princess
Cruise
 (2)

21 Days (20 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 05 March 2026
Countries Visited: USA, Spain, Gibraltar, France (+1 more), Italy
Exclusive Deal
INSIDE
$2,927
OCEANVIEW
$3,583
BALCONY
$4,129
SUITE
$5,266
From (per person) 2,927
View Trip
22 Day Mediterranean Grand Adventure with Princess
Cruise
 (2)

22 Days (21 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 22 March 2025
Countries Visited: USA, Spain, Gibraltar, France (+1 more), Italy
Exclusive Deal
INSIDE
$2,554
OCEANVIEW
$2,811
BALCONY
$3,098
SUITE
$3,692
From (per person) 2,554
View Trip
22 Day Western Mediterranean Grand Adventure with Princess
Cruise
 (3)

22 Days (21 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Majestic Princess
Departure: 18 February 2025
Countries Visited: USA, Portugal, Spain, Gibraltar (+2 more), Corsica, Italy
Exclusive Deal
INSIDE
$2,752
OCEANVIEW
-
BALCONY
$3,330
SUITE
$4,197
From (per person) 2,752
View Trip
21 Day Atlantic & Mediterranean Horizons with Viking Cruises
Cruise
 (7)

21 Days (20 Nights) Fort Lauderdale to Rome
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Mar 2025 to Feb 2026
Countries Visited: USA, Sint Maarten, Portugal, Spain (+3 more), France, Monaco, Italy
Limited Time Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$11,875
SUITE
$19,300
Save (per person) 965
From (per person) 11,875
View Trip
16 Day Transatlantic Repositioning Cruise with Norwegian Cruise Line
Cruise
 (1)

16 Days (15 Nights) New York to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 31 March 2025
Countries Visited: USA, Bermuda, Portugal, Spain (+2 more), France, Italy
INSIDE
$2,411
OCEANVIEW
-
BALCONY
$3,787
SUITE
$4,323
From (per person) 2,411
View Trip
15 Day Western Mediterranean Passage with Princess
Cruise
 (1)

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Countries Visited: USA, Portugal, Gibraltar, Corsica (+1 more), Italy
Exclusive Deal
INSIDE
$1,772
OCEANVIEW
$2,613
BALCONY
$1,934
SUITE
$3,494
From (per person) 1,772
View Trip
20 Day Western Mediterranean & Adriatic Grand Adventure with Princess
Cruise
 (1)

20 Days (19 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Enchanted Princess
Departure: 27 March 2026
Countries Visited: USA, Portugal, Gibraltar, Corsica (+3 more), Italy, Montenegro, Greece
Exclusive Deal
INSIDE
$2,642
OCEANVIEW
-
BALCONY
$3,125
SUITE
$4,949
From (per person) 2,642
View Trip
16 Day Spanish Passage with Princess
Cruise

16 Days (15 Nights) Fort Lauderdale to Rome
Cruise Line: Princess
Ship: Emerald Princess
Departure: 24 March 2025
Countries Visited: USA, Portugal, Gibraltar, Spain (+2 more), Corsica, Italy
Exclusive Deal
INSIDE
$1,532
OCEANVIEW
$1,904
BALCONY
$2,106
SUITE
$3,492
From (per person) 1,532
View Trip
25 Day Atlantic Crossing & Spain's Southern Coast with Seabourn
Cruise

25 Days (24 Nights) Miami to Genoa
Cruise Line: Seabourn
Ship: Quest
Departure: 26 April 2026
Countries Visited: USA, Portugal, Morocco, Gibraltar (+3 more), Spain, France, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$13,387
BALCONY
$15,565
SUITE
$22,990
From (per person) 13,387
View Trip
21 Day MSC Grand Voyages with MSC Cruises
Cruise

21 Days (20 Nights) Miami to Naples
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 06 April 2025
Countries Visited: USA, Sint Maarten, Antigua and Barbuda, Barbados (+4 more), Portugal, Spain, Sicily, Italy
Save And Sail Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$3,531
SUITE
$5,151
From (per person) 3,531
View Trip
22 Day Atlantic & Italian Stars with Oceania Cruises
Cruise

22 Days (21 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 07 April 2026
Countries Visited: USA, Bermuda, Portugal, Gibraltar (+5 more), Spain, France, Italy, Corsica, Sardinia
Exclusive Deal
INSIDE
$7,917
OCEANVIEW
$9,264
BALCONY
$10,452
SUITE
$14,768
Save (per person) 2,053
From (per person) 7,917
View Trip
21 Day Atlantic Crossing: Miami To The Mediterranean with Seabourn
Cruise

21 Days (20 Nights) Miami to Rome
Cruise Line: Seabourn
Ship: Encore
Departure: 28 April 2025
Countries Visited: USA, Portugal, Gibraltar, Corsica (+1 more), Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$16,150
SUITE
-
From (per person) 16,150
View Trip
16 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

16 Days (15 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 20 April 2025
Countries Visited: USA, Bermuda, Gibraltar, Spain (+1 more), Italy
Exclusive DealBlack Friday Cyber Sale
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$10,362
Save (per person) 6,844
From (per person) 10,360
View Trip
15 Day Italy, Spain, Azores Transatlantic with Royal Caribbean
Cruise

15 Days (14 Nights) New York to Rome
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 27 April 2025
Countries Visited: USA, Portugal, Spain, Italy
Exclusive Deal
INSIDE
$2,411
OCEANVIEW
$2,997
BALCONY
$4,035
SUITE
-
Save (per person) 1,195
From (per person) 2,411
View Trip
16 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

16 Days (15 Nights) Tampa to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 12 April 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+1 more), Italy
Black Friday Cyber SaleExclusive Deal
INSIDE
$1,540
OCEANVIEW
$1,824
BALCONY
$2,253
SUITE
$7,379
Save (per person) 3,701
From (per person) 1,540
View Trip
17 Day Bermuda & Spain Transatlantic with Celebrity Cruises
Cruise

17 Days (16 Nights) Tampa to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Constellation
Departure: 12 April 2025
Countries Visited: USA, Bermuda, Gibraltar, Spain (+1 more), Italy
Black Friday Cyber SaleExclusive Deal
INSIDE
$1,323
OCEANVIEW
$1,589
BALCONY
-
SUITE
$9,101
Save (per person) 2,848
From (per person) 1,323
View Trip
17 Day Treasures Of The Atlantic with Regent Seven Seas
Cruise

17 Days (16 Nights) Miami to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 15 April 2027
Countries Visited: USA, Bermuda, Spain, Corsica (+1 more), Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$14,798
SUITE
$16,570
Save (per person) 7,382
From (per person) 14,798
View Trip
15 Day Spain & Bermuda Transatlantic with Celebrity Cruises
Cruise

15 Days (14 Nights) Fort Lauderdale to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 20 April 2026
Countries Visited: USA, Bermuda, Portugal, Spain (+1 more), Italy
Mutiple Deals Available
INSIDE
$2,248
OCEANVIEW
$2,610
BALCONY
$3,093
SUITE
$8,241
Save (per person) 4,024
From (per person) 2,248
View Trip
25 Day Miami to Rome with Silversea
Cruise

25 Days (24 Nights) Miami to Rome
Cruise Line: Silversea
Ship: Silver Nova
Departure: 31 May 2026
Countries Visited: USA, Portugal, Spain, France (+2 more), Monaco, Italy
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$22,473
From (per person) 22,473
View Trip
17 Day Transoceanic Salute with Oceania Cruises
Cruise

17 Days (16 Nights) Miami to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 14 April 2026
Countries Visited: USA, Bahamas, Bermuda, Portugal (+2 more), Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$6,872
SUITE
$10,000
Save (per person) 2,048
From (per person) 6,872
View Trip
Results: 20 results

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Cruises from USA to Italy

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