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All Panama Tours & Cruises

Explore the colors and natural beauty of Panama - a land between the seas. Travel via dugout canoe to meet the indigenous Emberá people, visit gorgeous islands, snorkel the Caribbean and cruise through the world-famous Panama Canal. Choose from 767 cruises, small group tours and adventures to Panama traveling with the world's leading tour operators.
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2 Days
171 Days
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368 Trips (767 Trip Departures)
6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operated By: Globus
Departures: Jun 2025 to Mar 2026
Trip Styles: Short Break, Scenic
Countries Visited: Panama
Flash Sale
Save (per person) 56
From (per person) 1,709
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ships: Jewel of the Seas, Serenade of the Seas
Departures: Apr 2026 to Apr 2027
Countries Visited: Panama, Colombia
Bonus Onboard CreditLatest Offer
INSIDE
$156
OCEANVIEW
$186
BALCONY
$205
SUITE
$306
Save (per person) 56
From (per person) 156
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (2)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 15 January 2027
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,300
SUITE
$8,950
From (per person) 5,300
View Trip
11 Day Secrets of Central America with Ponant
Cruise
 (2)

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 05 January 2027
Countries Visited: Costa Rica, Panama
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$7,560
SUITE
$12,770
From (per person) 7,560
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise
 (2)

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 26 February 2027
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,300
SUITE
$8,950
From (per person) 5,300
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 February 2026
Countries Visited: Panama, Costa Rica
INSIDE
-
OCEANVIEW
-
BALCONY
$6,820
SUITE
$11,410
From (per person) 6,820
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ships: Le Bellot, Le Laperouse
Departures: Nov 2026 to Jan 2027
Countries Visited: Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$7,560
SUITE
$12,770
From (per person) 7,560
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Dec 2025 to Jan 2026
Countries Visited: Costa Rica, Panama
INSIDE
-
OCEANVIEW
-
BALCONY
$6,640
SUITE
$10,430
From (per person) 6,640
View Trip
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: May 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Costa Rica, Panama
Exclusive Deal
Save (per person) 210
From (per person) 1,827
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 15 March 2026
Countries Visited: Costa Rica, Panama
INSIDE
-
OCEANVIEW
-
BALCONY
$11,290
SUITE
$17,390
From (per person) 11,290
View Trip
12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) San Jose to Panama City
Operated By: Tauck
Departures: Jan 2026 to Feb 2026
Countries Visited: Costa Rica, Panama
Complimentary Hotel Night
From (per person) 8,990
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ships: Le Champlain, Le Laperouse
Departures: Feb 2026 to Feb 2027
Countries Visited: Costa Rica, Panama
INSIDE
-
OCEANVIEW
-
BALCONY
$6,420
SUITE
$10,700
From (per person) 6,420
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Bellot
Departures: Dec 2026 to Mar 2027
Countries Visited: Costa Rica, Panama
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$7,560
SUITE
$12,770
From (per person) 7,560
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Dec 2025 to Jan 2026
Countries Visited: Panama, Costa Rica
INSIDE
-
OCEANVIEW
-
BALCONY
$6,070
SUITE
$9,270
From (per person) 6,070
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Countries Visited: Panama, Chile
2 for 1 Fares + Pay in Full Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$7,980
SUITE
$9,180
Save (per person) 11,010
From (per person) 7,980
View Trip
12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 03 February 2026
Countries Visited: Panama, Costa Rica
Complimentary Hotel Night
From (per person) 9,390
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Costa Rica
INSIDE
-
OCEANVIEW
-
BALCONY
$11,280
SUITE
$16,560
From (per person) 11,280
View Trip
8 Day Panama City to Fort Lauderdale with Silversea
Cruise

8 Days (7 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 20 May 2025
Countries Visited: Panama, Colombia, USA
Port-to-Port
INSIDE
-
OCEANVIEW
$5,100
BALCONY
-
SUITE
-
From (per person) 5,100
View Trip
14 Day Chile, Peru & Panama Voyage with Azamara Cruises
Cruise
 (2)

14 Days (13 Nights) San Antonio to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 March 2026
Countries Visited: Chile, Peru, Panama
Azamara Circle Loyalty Quarterly Savings
INSIDE
$2,949
OCEANVIEW
$3,249
BALCONY
$3,719
SUITE
$5,789
From (per person) 2,949
View Trip
20 Day Treasures of French Polynesia & the Marquesas Islands with Scenic
New ReleaseCruise

20 Days (19 Nights) Papeete to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 25 March 2026
Countries Visited: French Polynesia, Costa Rica, Panama
2 for 1 Fares + Pay in Full Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$14,845
SUITE
$17,145
Save (per person) 17,945
From (per person) 14,845
View Trip
11 Day Pristine islands of the Bahamas & the Panama Canal with Scenic
New ReleaseCruise

11 Days (10 Nights) Nassau to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 16 October 2026
Countries Visited: Bahamas, Colombia, Panama
2 for 1 Fares + Pay in Full Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$11,020
SUITE
$11,770
Save (per person) 14,070
From (per person) 11,020
View Trip
14 Day Cycle Nicaragua to the Panama Canal with Explore!
Tour

14 Days Granada to Panama City
Operated By: Explore!
Departures: Nov 2025 to Nov 2026
Trip Styles: Adventure, Small Group, Cycling
Countries Visited: Costa Rica, Panama, Nicaragua
Sign Up Savings
Save (per person) 625
From (per person) 4,419
View Trip
8 Day Natural Sanctuaries & Heritage of the Caribbean with Ponant
Cruise

8 Days (7 Nights) Willemstad to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 26 November 2025
Countries Visited: Curacao, Colombia, Panama
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,120
SUITE
$8,130
From (per person) 5,120
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Cartagena to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 19 April 2026
Countries Visited: Colombia, Curacao, Aruba, Panama
Bonus Onboard CreditLatest Offer + Bonus Onboard Credit
INSIDE
$1,157
OCEANVIEW
$1,258
BALCONY
$1,495
SUITE
$2,345
Save (per person) 466
From (per person) 1,157
View Trip
10 Day Natural Sanctuaries & Heritage of the Caribbean with Ponant
Cruise

10 Days (9 Nights) Willemstad to Colon
Cruise Line: Ponant
Ship: Le Bellot
Departure: 12 November 2026
Countries Visited: Curacao, Colombia, Panama, Costa Rica
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,970
SUITE
$9,410
From (per person) 5,970
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 28 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Bonus Onboard CreditLatest Offer + Bonus Onboard Credit
INSIDE
$1,324
OCEANVIEW
$1,375
BALCONY
$1,562
SUITE
$2,226
Save (per person) 530
From (per person) 1,324
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Mar 2026
Countries Visited: Colombia, Bonaire, Aruba, Panama
Bonus Onboard CreditLatest Offer + Bonus Onboard Credit
INSIDE
$1,111
OCEANVIEW
$1,162
BALCONY
$1,349
SUITE
$1,893
Save (per person) 616
From (per person) 1,111
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Jan 2026 to Feb 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Bonus Onboard CreditLatest Offer + Bonus Onboard Credit
INSIDE
$1,024
OCEANVIEW
$1,065
BALCONY
$1,191
SUITE
$1,826
Save (per person) 423
From (per person) 1,024
View Trip
16 Day New York To Los Angeles with Cunard
Cruise
 (3)

16 Days (15 Nights) New York to Los Angeles
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 19 January 2026
Countries Visited: USA, Curacao, Panama, Mexico
Exclusive Deal
INSIDE
$3,389
OCEANVIEW
$4,869
BALCONY
$5,359
SUITE
-
From (per person) 3,389
View Trip
19 Day New York To San Francisco with Cunard
Cruise
 (3)

19 Days (18 Nights) New York to San Francisco
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 19 January 2026
Countries Visited: USA, Curacao, Panama, Mexico
Exclusive Deal
INSIDE
$3,809
OCEANVIEW
$5,809
BALCONY
$5,899
SUITE
-
From (per person) 3,809
View Trip
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