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All Panama Tours & Cruises

Explore the colors and natural beauty of Panama - a land between the seas. Travel via dugout canoe to meet the indigenous Emberá people, visit gorgeous islands, snorkel the Caribbean and cruise through the world-famous Panama Canal. Choose from 803 cruises, small group tours and adventures to Panama traveling with the world's leading tour operators.
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2 Days
171 Days
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341 Trips (803 Trip Departures)
6 Day Independent Panama with Globus
New ReleaseTour

6 Days Panama City to Panama City
Operated By: Globus
Departures: May 2025 to Mar 2026
Trip Styles: Short Break, Scenic
Countries Visited: Panama
Exclusive Savings
Save (per person) 38
From (per person) 1,675
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Dec 2025 to Jan 2026
Countries Visited: Panama, Costa Rica
INSIDE
-
OCEANVIEW
-
BALCONY
$5,480
SUITE
$9,270
From (per person) 5,480
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 26 February 2026
Countries Visited: Costa Rica, Panama
INSIDE
-
OCEANVIEW
-
BALCONY
$6,420
SUITE
$10,700
From (per person) 6,420
View Trip
8 Day Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys with Ponant
Cruise

8 Days (7 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departure: 19 February 2026
Countries Visited: Panama, Costa Rica
INSIDE
-
OCEANVIEW
-
BALCONY
$6,820
SUITE
$11,410
From (per person) 6,820
View Trip
10 Day Wellness Retreat - Panama City to Valparaiso with Scenic
New ReleaseCruise

10 Days (9 Nights) Panama City to Santiago
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 26 October 2026
Countries Visited: Panama, Chile
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$9,480
SUITE
$12,180
Save (per person) 9,510
From (per person) 9,480
View Trip
8 Day Central America Jewels & Panama Canal with Ponant
Cruise

8 Days (7 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Dumont d’Urville
Departures: Dec 2025 to Jan 2026
Countries Visited: Costa Rica, Panama
INSIDE
-
OCEANVIEW
-
BALCONY
$5,810
SUITE
$9,850
From (per person) 5,810
View Trip
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: Apr 2025 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Costa Rica, Panama
Exclusive Deal
Save (per person) 432
From (per person) 1,726
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Puntarenas to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 15 March 2026
Countries Visited: Costa Rica, Panama
INSIDE
-
OCEANVIEW
-
BALCONY
$10,730
SUITE
$15,730
From (per person) 10,730
View Trip
2 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

2 Days (1 Nights) Colon to Cartagena
Cruise Line: Royal Caribbean
Ships: Jewel of the Seas, Serenade of the Seas
Departures: Apr 2026 to Apr 2027
Countries Visited: Panama, Colombia
Latest Offer
INSIDE
$119
OCEANVIEW
$135
BALCONY
$118
SUITE
$142
Save (per person) 156
From (per person) 118
View Trip
12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) San Jose to Panama City
Operated By: Tauck
Departures: Jan 2026 to Feb 2026
Countries Visited: Costa Rica, Panama
Complimentary Hotel Night
From (per person) 8,990
View Trip
12 Day The Panama Canal & Costa Rica with Tauck
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 03 February 2026
Countries Visited: Panama, Costa Rica
Complimentary Hotel Night
From (per person) 9,390
View Trip
11 Day Secrets of Central America with Ponant
Cruise

11 Days (10 Nights) Colon to Puntarenas
Cruise Line: Ponant
Ship: Le Champlain
Departures: Jan 2026 to Mar 2026
Countries Visited: Panama, Costa Rica
INSIDE
-
OCEANVIEW
-
BALCONY
$10,240
SUITE
$15,730
From (per person) 10,240
View Trip
20 Day Treasures of French Polynesia & the Marquesas Islands with Scenic
New ReleaseCruise

20 Days (19 Nights) Papeete to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse II
Departure: 25 March 2026
Countries Visited: French Polynesia, Costa Rica, Panama
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$16,345
SUITE
$20,145
Save (per person) 16,445
From (per person) 16,345
View Trip
8 Day Natural Sanctuaries & Heritage of the Caribbean with Ponant
Cruise

8 Days (7 Nights) Willemstad to Colon
Cruise Line: Ponant
Ship: Le Champlain
Departure: 26 November 2025
Countries Visited: Curacao, Colombia, Panama
Exclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$4,840
SUITE
$7,660
From (per person) 4,840
View Trip
14 Day Chile, Peru & Panama Voyage with Azamara Cruises
Cruise
 (1)

14 Days (13 Nights) San Antonio to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 March 2026
Countries Visited: Chile, Peru, Panama
Azamara Circle Loyalty Quarterly Savings
INSIDE
$3,529
OCEANVIEW
$3,889
BALCONY
$4,469
SUITE
$7,039
From (per person) 3,529
View Trip
11 Day Pristine islands of the Bahamas & the Panama Canal with Scenic
New ReleaseCruise

11 Days (10 Nights) Nassau to Panama City
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 16 October 2026
Countries Visited: Bahamas, Colombia, Panama
2 for 1 Fares + Fly Free Premium Economy2 for 1 Fares + Fly Free Business Class
INSIDE
-
OCEANVIEW
-
BALCONY
$12,470
SUITE
$14,770
Save (per person) 12,520
From (per person) 12,470
View Trip
8 Day Panama City to Fort Lauderdale with Silversea
Cruise

8 Days (7 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 20 May 2025
Countries Visited: Panama, Colombia, USA
Port-to-Port
INSIDE
-
OCEANVIEW
-
BALCONY
$6,400
SUITE
$12,200
From (per person) 6,400
View Trip
14 Day Cycle Nicaragua to the Panama Canal with Explore!
Tour

14 Days Granada to Panama City
Operated By: Explore!
Departures: Nov 2025 to Nov 2026
Trip Styles: Adventure, Small Group, Cycling
Countries Visited: Costa Rica, Panama, Nicaragua
From (per person) 5,010
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Jewel of the Seas
Departures: Nov 2026 to Dec 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire
Latest Offer
INSIDE
$918
OCEANVIEW
$957
BALCONY
$1,078
SUITE
$1,420
Save (per person) 527
From (per person) 918
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departures: Nov 2025 to Apr 2026
Countries Visited: Panama, Colombia, Aruba, Curacao
Latest Offer
INSIDE
$934
OCEANVIEW
$1,044
BALCONY
$1,131
SUITE
$1,419
Save (per person) 659
From (per person) 934
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 07 December 2025
Countries Visited: Colombia, Aruba, Curacao, Panama
Latest OfferExclusive Solo Offer
INSIDE
$1,325
OCEANVIEW
$1,356
BALCONY
$1,424
SUITE
$1,573
Save (per person) 671
From (per person) 1,325
View Trip
19 Day New York To San Francisco with Cunard
Cruise
 (3)

19 Days (18 Nights) New York to San Francisco
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 19 January 2026
Countries Visited: USA, Curacao, Panama, Mexico
Exclusive Deal
INSIDE
$4,629
OCEANVIEW
$7,099
BALCONY
$7,139
SUITE
-
From (per person) 4,629
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 29 March 2026
Countries Visited: Colombia, Aruba, Bonaire, Panama
Latest OfferExclusive Solo Offer
INSIDE
$1,175
OCEANVIEW
$1,224
BALCONY
$1,422
SUITE
$1,809
Save (per person) 605
From (per person) 1,175
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ship: Jewel of the Seas
Departures: Nov 2026 to Dec 2026
Countries Visited: Colombia, Aruba, Bonaire, Panama
Latest Offer
INSIDE
$985
OCEANVIEW
$1,034
BALCONY
$1,165
SUITE
$1,537
Save (per person) 580
From (per person) 985
View Trip
8 Day Southern Caribbean Holiday with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 20 December 2025
Countries Visited: Panama, Colombia, Curacao, Aruba
Latest Offer
INSIDE
$1,204
OCEANVIEW
$1,244
BALCONY
$1,372
SUITE
$1,619
Save (per person) 618
From (per person) 1,204
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Cartagena to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 19 April 2026
Countries Visited: Colombia, Curacao, Aruba, Panama
Latest OfferExclusive Solo Offer
INSIDE
$1,062
OCEANVIEW
$1,162
BALCONY
$1,359
SUITE
$1,928
Save (per person) 561
From (per person) 1,062
View Trip
7 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

7 Days (6 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 06 December 2025
Countries Visited: Panama, Colombia, Aruba, Curacao
Latest Offer
INSIDE
$1,061
OCEANVIEW
$1,091
BALCONY
$1,229
SUITE
$1,526
Save (per person) 552
From (per person) 1,061
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Colon to Colon
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 17 January 2026
Countries Visited: Panama, Colombia, Bonaire, Aruba
Latest Offer
INSIDE
$1,127
OCEANVIEW
$1,157
BALCONY
$1,206
SUITE
$1,394
Save (per person) 584
From (per person) 1,127
View Trip
8 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Cartagena to Cartagena
Cruise Line: Royal Caribbean
Ships: Jewel of the Seas, Serenade of the Seas
Departures: Oct 2025 to Jan 2027
Countries Visited: Colombia, Curacao, Aruba, Panama
Latest OfferExclusive Solo Offer
INSIDE
$970
OCEANVIEW
$1,021
BALCONY
$1,141
SUITE
$1,503
Save (per person) 930
From (per person) 970
View Trip
21 Day Panama Canal - Ocean to Ocean with Princess
Cruise

21 Days (20 Nights) Fort Lauderdale to Seattle
Cruise Line: Princess
Ship: Star Princess
Departure: 13 April 2026
Countries Visited: USA, Aruba, Panama, Mexico
Exclusive DealSpring Swing Offer
INSIDE
$1,892
OCEANVIEW
$2,535
BALCONY
$3,426
SUITE
$4,713
From (per person) 1,892
View Trip
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