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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 300 departures available from seventeen of the world's leading cruise lines.
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145 Cruises (300 Cruise Departures)
8 Day Mediterranean with France & Italy with Princess
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2025 to Oct 2026
Countries Visited: Spain, Gibraltar, France, Italy
Exclusive Deal
INSIDE
$1,731
OCEANVIEW
$1,952
BALCONY
$2,128
SUITE
$2,427
From (per person) 1,731
View Trip
10 Day Greece, Malta & Turkey Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 30 August 2025
Countries Visited: Spain, Malta, Greece, Turkey (+1 more), Italy
New Year SaleExclusive Deal
INSIDE
$2,933
OCEANVIEW
$3,319
BALCONY
$3,684
SUITE
$6,403
Save (per person) 1,873
From (per person) 2,933
View Trip
13 Day Mediterranean Odyssey with Viking Cruises
Cruise

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+5 more), Viking Saturn, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Jun 2025 to Jul 2027
Countries Visited: Spain, France, Italy, Greece (+1 more), Croatia
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$10,971
SUITE
$16,361
Save (per person) 310
From (per person) 10,971
View Trip
10 Day Italy & Spain Cruise: Florence, Portofino & Barcelona with Azamara Cruises
Cruise
 (3)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 13 August 2026
Countries Visited: Spain, France, Monaco, Italy
INSIDE
$2,930
OCEANVIEW
$3,692
BALCONY
$4,514
SUITE
$7,167
From (per person) 2,930
View Trip
12 Day Italy Cruise: Florence, Rome & Sorrento with Azamara Cruises
Cruise
 (1)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 13 September 2026
Countries Visited: Spain, France, Monaco, Italy (+3 more), Sicily, Montenegro, Slovenia
INSIDE
$4,743
OCEANVIEW
$5,535
BALCONY
$6,921
SUITE
$9,327
From (per person) 4,743
View Trip
9 Day Spain & Italy Cruise: Barcelona, Portofino & Florence with Azamara Cruises
Cruise
 (1)

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 09 April 2026
Countries Visited: Spain, France, Italy
INSIDE
$2,671
OCEANVIEW
$3,186
BALCONY
$4,097
SUITE
$5,691
From (per person) 2,671
View Trip
8 Day Mediterranean with France & Italy with Princess
Cruise
 (2)

8 Days (7 Nights) Barcelona to Naples
Cruise Line: Princess
Ship: Sun Princess
Departures: Jun 2025 to Sep 2025
Countries Visited: Spain, Gibraltar, France, Italy
Exclusive Deal
INSIDE
$1,621
OCEANVIEW
$2,017
BALCONY
$2,215
SUITE
$2,710
From (per person) 1,621
View Trip
3 Day Mediterranean with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Barcelona to Genoa
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Feb 2025 to Apr 2025
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$314
OCEANVIEW
$393
BALCONY
$492
SUITE
-
From (per person) 314
View Trip
8 Day Costa Brave & Italy with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 29 October 2026
Countries Visited: Spain, France, Corsica, Italy (+1 more), Sardinia
Exclusive Deal
INSIDE
$3,169
OCEANVIEW
$3,476
BALCONY
$5,129
SUITE
$7,080
Save (per person) 2,021
From (per person) 3,169
View Trip
8 Day Mediterranean Cruise: Spain, France & Italy with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 28 November 2026
Countries Visited: Spain, France, Italy
INSIDE
$2,504
OCEANVIEW
$2,870
BALCONY
$3,682
SUITE
$5,751
From (per person) 2,504
View Trip
10 Day France Intensive Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 April 2025
Countries Visited: Spain, France, Corsica, Italy
INSIDE
$3,039
OCEANVIEW
$3,247
BALCONY
$4,366
SUITE
$7,049
From (per person) 3,039
View Trip
7 Day Mediterranean with France & Italy with Princess
Cruise
 (2)

7 Days (6 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 19 March 2026
Countries Visited: Spain, Gibraltar, France, Italy
Exclusive Deal
INSIDE
$1,549
OCEANVIEW
$1,811
BALCONY
$1,964
SUITE
$2,130
From (per person) 1,549
View Trip
27 Day Ramblas To Renaissance with Oceania Cruises
Cruise
 (1)

27 Days (26 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 09 December 2026
Countries Visited: Spain, Gibraltar, Morocco, Portugal (+3 more), France, Italy, Corsica
Exclusive Deal
INSIDE
$10,865
OCEANVIEW
$11,914
BALCONY
$18,082
SUITE
$25,141
Save (per person) 2,075
From (per person) 10,865
View Trip
8 Day Mediterranean with Total Solar Eclipse with Princess
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 08 August 2026
Countries Visited: Spain, Gibraltar, Italy
Exclusive Deal
INSIDE
$3,289
OCEANVIEW
$4,566
BALCONY
$5,764
SUITE
$6,397
From (per person) 3,289
View Trip
12 Day Around Italy's Boot: Venice Overnight with Holland America
Cruise
 (2)

12 Days (11 Nights) Barcelona to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 10 September 2025
Countries Visited: Spain, France, Italy, Sicily (+2 more), Montenegro, Croatia
Exclusive Deal
INSIDE
$3,174
OCEANVIEW
$3,412
BALCONY
$4,650
SUITE
$6,630
From (per person) 3,174
View Trip
15 Day Iberia Celebration with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Bilbao to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 30 August 2026
Countries Visited: Spain, Portugal, France, Italy
Exclusive Deal
INSIDE
$6,791
OCEANVIEW
$7,385
BALCONY
$11,147
SUITE
$15,355
Save (per person) 2,049
From (per person) 6,791
View Trip
8 Day Yachting Havens with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 May 2026
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$3,152
OCEANVIEW
$3,444
BALCONY
$5,156
SUITE
$7,159
Save (per person) 2,188
From (per person) 3,152
View Trip
12 Day Europe - Western Mediterranean - Barcelona with Norwegian Cruise Line
Cruise
 (1)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Breakaway
Departures: May 2025 to Sep 2025
Countries Visited: Spain, France, Italy, Sicily (+3 more), Malta, Greece, Croatia
Exclusive Solo Offer
INSIDE
$4,505
OCEANVIEW
$5,866
BALCONY
$6,952
SUITE
$7,411
From (per person) 4,505
View Trip
12 Day Spain & Italy Cruise: Barcelona, Salerno & Rome with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 20 February 2027
Countries Visited: Spain, Sardinia, Tunisia, Malta (+2 more), Sicily, Italy
INSIDE
$4,407
OCEANVIEW
$5,120
BALCONY
$6,387
SUITE
$9,485
From (per person) 4,407
View Trip
23 Day Italy, Greece & Dalmatian Coast Collectors' Voyage with Holland America
Cruise
 (2)

23 Days (22 Nights) Barcelona to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 22 April 2026
Countries Visited: Spain, France, Italy, Sicily (+4 more), Greece, Turkey, Albania, Croatia
Exclusive Deal
INSIDE
$5,788
OCEANVIEW
$6,530
BALCONY
$8,560
SUITE
$11,777
From (per person) 5,788
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departures: May 2026 to Sep 2026
Countries Visited: Spain, France, Corsica, Italy (+1 more), Sicily
Exclusive DealSingle Savings
INSIDE
$1,741
OCEANVIEW
$1,889
BALCONY
$2,435
SUITE
$3,332
Save (per person) 996
From (per person) 1,741
View Trip
13 Day Best Of The Mediterranean Voyage with Azamara Cruises
Cruise
 (3)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 06 September 2025
Countries Visited: Spain, France, Monaco, Italy (+3 more), Montenegro, Croatia, Slovenia
INSIDE
$6,509
OCEANVIEW
$6,915
BALCONY
$9,677
SUITE
$12,261
From (per person) 6,509
View Trip
11 Day Highlights of Spain, Morocco & Italy with Emerald Cruises
Cruise
 (3)

11 Days (10 Nights) Santa Cruz de Tenerife to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Azzurra
Departure: 08 April 2026
Countries Visited: Spain, Morocco, Corsica, Italy
Super Earlybird
INSIDE
-
OCEANVIEW
$10,205
BALCONY
-
SUITE
$14,165
Save (per person) 2,590
From (per person) 10,205
View Trip
8 Day Europe - Western Mediterranean with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2026 to Oct 2026
Countries Visited: Spain, France, Italy, Sicily
Exclusive Solo Offer
INSIDE
$2,537
OCEANVIEW
-
BALCONY
$3,149
SUITE
$3,455
From (per person) 2,537
View Trip
13 Day Best Of The Mediterranean Voyage with Azamara Cruises
Cruise
 (1)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 21 April 2025
Countries Visited: Spain, France, Italy, Montenegro (+2 more), Croatia, Slovenia
INSIDE
$5,301
OCEANVIEW
$5,638
BALCONY
-
SUITE
-
From (per person) 5,301
View Trip
8 Day Southern France and the Italian Riviera by Sea – with Smithsonian Journeys with Ponant
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Ponant
Ship: Le Bougainville
Departure: 26 April 2025
Countries Visited: Spain, France, Italy
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$9,761
SUITE
$14,818
Save (per person) 189
From (per person) 9,761
View Trip
8 Day Southern France and the Italian Riviera by Sea - with Smithsonian Journeys with Ponant
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 02 October 2025
Countries Visited: Spain, France, Italy
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$9,281
SUITE
$15,641
Save (per person) 179
From (per person) 9,281
View Trip
12 Day Around Italy's Boot: Italy, Dalmatia & Venice with Holland America
Cruise
 (2)

12 Days (11 Nights) Barcelona to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 12 September 2026
Countries Visited: Spain, France, Italy, Sicily (+3 more), Greece, Croatia, Montenegro
Exclusive Deal
INSIDE
$3,165
OCEANVIEW
$3,363
BALCONY
$4,501
SUITE
$6,333
From (per person) 3,165
View Trip
13 Day French & Italian Treasures with Oceania Cruises
Cruise
 (1)

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 30 September 2026
Countries Visited: Spain, France, Italy, Corsica (+3 more), Sardinia, Sicily, Malta
Exclusive Deal
INSIDE
$5,431
OCEANVIEW
$6,035
BALCONY
$9,342
SUITE
$12,945
Save (per person) 2,039
From (per person) 5,431
View Trip
23 Day Scenic Strands & Havens with Oceania Cruises
Cruise
 (1)

23 Days (22 Nights) Malaga to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 07 October 2025
Countries Visited: Spain, Morocco, Portugal, Tunisia (+4 more), Malta, Greece, Sicily, Italy
Exclusive Deal
INSIDE
$9,354
OCEANVIEW
$9,651
BALCONY
$15,670
SUITE
$20,323
Save (per person) 2,066
From (per person) 9,354
View Trip
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