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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? September is the most popular month to cruise between Spain and Italy and there are 304 departures available from seventeen of the world's leading cruise lines.
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147 Cruises (304 Cruise Departures)
8 Day Mediterranean with France & Italy with Princess
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2025 to Oct 2026
Countries Visited: Spain, Gibraltar, France, Italy
Exclusive Deal
INSIDE
$1,671
OCEANVIEW
$1,952
BALCONY
$2,226
SUITE
$2,427
From (per person) 1,671
View Trip
10 Day Greece, Malta & Turkey Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 30 August 2025
Countries Visited: Spain, Malta, Greece, Turkey (+1 more), Italy
Exclusive DealSummer Sale
INSIDE
$2,969
OCEANVIEW
$4,484
BALCONY
$4,175
SUITE
$6,462
From (per person) 4,613
View Trip
13 Day Mediterranean Odyssey with Viking Cruises
Cruise

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+5 more), Viking Saturn, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Apr 2025 to Jul 2027
Countries Visited: Spain, France, Italy, Greece (+1 more), Croatia
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$10,971
SUITE
$16,361
Save (per person) 310
From (per person) 10,971
View Trip
8 Day Mediterranean with France & Italy with Princess
Cruise
 (2)

8 Days (7 Nights) Barcelona to Naples
Cruise Line: Princess
Ship: Sun Princess
Departures: Jun 2025 to Sep 2025
Countries Visited: Spain, Gibraltar, France, Italy
Exclusive Deal
INSIDE
$1,704
OCEANVIEW
$1,997
BALCONY
$2,215
SUITE
$2,710
From (per person) 1,704
View Trip
8 Day Southern France and the Italian Riviera by Sea - with Smithsonian Journeys with Ponant
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 02 October 2025
Countries Visited: Spain, France, Italy
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$8,791
SUITE
$14,769
Save (per person) 169
From (per person) 8,791
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Barcelona to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 24 March 2025
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$778
SUITE
-
From (per person) 778
View Trip
11 Day Charmed Rivieras with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 21 April 2026
Countries Visited: Spain, France, Corsica, Sardinia (+1 more), Italy
Flex FaresExclusive Deal
INSIDE
$4,585
OCEANVIEW
$5,084
BALCONY
$7,228
SUITE
$10,012
Save (per person) 2,275
From (per person) 4,585
View Trip
8 Day Europe - Western Mediterranean with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2026 to Oct 2026
Countries Visited: Spain, France, Italy, Sicily
Exclusive Solo Offer
INSIDE
$2,537
OCEANVIEW
-
BALCONY
$3,149
SUITE
$3,455
From (per person) 2,537
View Trip
23 Day Italy, Greece & Dalmatian Coast Collectors' Voyage with Holland America
Cruise
 (2)

23 Days (22 Nights) Barcelona to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 22 April 2026
Countries Visited: Spain, France, Italy, Sicily (+4 more), Greece, Turkey, Albania, Croatia
Have It All Offer
INSIDE
$5,788
OCEANVIEW
$6,530
BALCONY
$8,560
SUITE
$11,777
From (per person) 5,788
View Trip
8 Day Yachting Havens with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 05 May 2026
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$3,318
OCEANVIEW
$3,625
BALCONY
$5,426
SUITE
$7,535
Save (per person) 2,022
From (per person) 3,318
View Trip
10 Day Europe - Western Mediterranean with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Barcelona to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: Apr 2026 to Aug 2026
Countries Visited: Spain, France, Italy, Sicily (+3 more), Greece, Montenegro, Croatia
INSIDE
$4,097
OCEANVIEW
$4,633
BALCONY
$5,703
SUITE
$6,865
From (per person) 4,097
View Trip
27 Day Ramblas To Renaissance with Oceania Cruises
Cruise
 (1)

27 Days (26 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 09 December 2026
Countries Visited: Spain, Gibraltar, Morocco, Portugal (+3 more), France, Italy, Corsica
Exclusive Deal
INSIDE
$10,865
OCEANVIEW
$11,914
BALCONY
$18,082
SUITE
$25,141
Save (per person) 2,075
From (per person) 10,865
View Trip
12 Day Around Italy's Boot: Italy, Dalmatia & Venice with Holland America
Cruise
 (2)

12 Days (11 Nights) Barcelona to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 12 September 2026
Countries Visited: Spain, France, Italy, Sicily (+3 more), Greece, Croatia, Montenegro
Have It All Offer
INSIDE
$3,165
OCEANVIEW
$3,363
BALCONY
$4,501
SUITE
$6,333
From (per person) 3,165
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departures: May 2026 to Sep 2026
Countries Visited: Spain, France, Corsica, Italy (+1 more), Sicily
Exclusive Deal
INSIDE
$1,549
OCEANVIEW
$1,791
BALCONY
$2,409
SUITE
$3,216
Save (per person) 994
From (per person) 1,549
View Trip
12 Day Around Italy's Boot: Venice Overnight with Holland America
Cruise
 (2)

12 Days (11 Nights) Barcelona to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 10 September 2025
Countries Visited: Spain, France, Italy, Sicily (+2 more), Montenegro, Croatia
Exclusive Deal
INSIDE
$3,264
OCEANVIEW
$3,412
BALCONY
$4,650
SUITE
$6,432
From (per person) 3,264
View Trip
8 Day Costa Brave & Italy with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 29 October 2026
Countries Visited: Spain, France, Corsica, Italy (+1 more), Sardinia
Exclusive Deal
INSIDE
$3,169
OCEANVIEW
$3,476
BALCONY
$5,129
SUITE
$7,080
Save (per person) 2,021
From (per person) 3,169
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 23 April 2025
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$738
OCEANVIEW
$906
BALCONY
$966
SUITE
$1,382
From (per person) 738
View Trip
28 Day Solar Eclipse Collectors' Voyage: Iberia & Italy with Holland America
Cruise
 (2)

28 Days (27 Nights) Barcelona to Rome
Cruise Line: Holland America
Ship: Oosterdam
Departure: 02 August 2026
Countries Visited: Spain, Morocco, Portugal, Corsica (+4 more), Italy, Montenegro, Greece, Sicily
Have It All Offer
INSIDE
$7,224
OCEANVIEW
$8,115
BALCONY
-
SUITE
-
From (per person) 7,224
View Trip
15 Day Iberia Celebration with Oceania Cruises
Cruise
 (1)

15 Days (14 Nights) Bilbao to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 30 August 2026
Countries Visited: Spain, Portugal, France, Italy
Exclusive Deal
INSIDE
$6,791
OCEANVIEW
$7,385
BALCONY
$11,147
SUITE
$15,355
Save (per person) 2,049
From (per person) 6,791
View Trip
10 Day Italy & Spain Cruise: Florence, Portofino & Barcelona with Azamara Cruises
Cruise
 (3)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 13 August 2026
Countries Visited: Spain, France, Monaco, Italy
INSIDE
$2,930
OCEANVIEW
$3,692
BALCONY
$4,514
SUITE
$7,167
From (per person) 2,930
View Trip
15 Day Malta, Greece & Amalfi Coast Collectors' Voyage with Holland America
Cruise
 (2)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Holland America
Ship: Oosterdam
Departure: 12 July 2026
Countries Visited: Spain, Malta, Greece, Turkey (+3 more), Montenegro, Sicily, Italy
Have It All Offer
INSIDE
$3,633
OCEANVIEW
$4,227
BALCONY
$5,217
SUITE
$8,088
From (per person) 3,633
View Trip
10 Day France Intensive Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 April 2025
Countries Visited: Spain, France, Corsica, Italy
INSIDE
$4,197
OCEANVIEW
$4,405
BALCONY
$5,435
SUITE
$8,049
From (per person) 4,197
View Trip
11 Day Grand Mediterranean with Princess
Cruise
 (2)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 11 October 2025
Countries Visited: Spain, France, Italy, Montenegro (+1 more), Greece
Exclusive Deal
INSIDE
$2,706
OCEANVIEW
$3,339
BALCONY
$4,102
SUITE
$4,686
From (per person) 2,706
View Trip
3 Day Mediterranean with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Barcelona to Genoa
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 19 April 2025
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$591
SUITE
-
From (per person) 591
View Trip
7 Day Mediterranean with France & Italy with Princess
Cruise
 (2)

7 Days (6 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 19 March 2026
Countries Visited: Spain, Gibraltar, France, Italy
Exclusive Deal
INSIDE
$1,486
OCEANVIEW
$1,754
BALCONY
$1,833
SUITE
$2,130
From (per person) 1,486
View Trip
8 Day Mediterranean with France & Italy with Princess
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Majestic Princess
Departure: 04 March 2025
Countries Visited: Spain, Gibraltar, Corsica, Italy
Exclusive Deal
INSIDE
$1,383
OCEANVIEW
-
BALCONY
$1,750
SUITE
$1,868
From (per person) 1,383
View Trip
23 Day Scenic Strands & Havens with Oceania Cruises
Cruise
 (1)

23 Days (22 Nights) Malaga to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 07 October 2025
Countries Visited: Spain, Morocco, Portugal, Tunisia (+4 more), Malta, Greece, Sicily, Italy
Exclusive Deal
INSIDE
$9,205
OCEANVIEW
$9,651
BALCONY
$15,215
SUITE
$20,174
Save (per person) 2,065
From (per person) 9,205
View Trip
9 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santa Cruz De Tenerife to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 12 April 2026
Countries Visited: Spain, Morocco, Italy
Early Booking Offer
INSIDE
$1,335
OCEANVIEW
$1,503
BALCONY
$1,889
SUITE
-
From (per person) 1,335
View Trip
8 Day Southern France and the Italian Riviera by Sea – with Smithsonian Journeys with Ponant
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Ponant
Ship: Le Bougainville
Departure: 26 April 2025
Countries Visited: Spain, France, Italy
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$9,761
SUITE
$14,818
Save (per person) 189
From (per person) 9,761
View Trip
13 Day French & Italian Treasures with Oceania Cruises
Cruise
 (1)

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 30 September 2026
Countries Visited: Spain, France, Italy, Corsica (+3 more), Sardinia, Sicily, Malta
Exclusive Deal
INSIDE
$5,431
OCEANVIEW
$6,035
BALCONY
$9,342
SUITE
$12,945
Save (per person) 2,039
From (per person) 5,431
View Trip
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