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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? April is the most popular month to cruise between Spain and Italy and there are 327 departures available from seventeen of the world's leading cruise lines.
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152 Cruises (327 Cruise Departures)
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 19 September 2026
Visit: Spain, Corsica, France, Italy
Princess Standard
Sanctuary Collection
Inside
$1,504
Oceanview
$1,904
Balcony
$2,359
Suite
$2,669
From
US$1,504
Per Person
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (2)

6 Days (5 Nights) Barcelona to Bari
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 27 April 2026
Visit: Spain, Malta, Greece, Italy
Inside
$579
Oceanview
$709
Balcony
$789
Suite
$1,239
From
US$579
Per Person
View Trip
10 Day Under The Tuscan Sunset with Regent Seven Seas
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 17 June 2027
Visit: Spain, Corsica, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,151
Suite
$8,543
From
US$8,151
Save 13,447
Per Person
View Trip
10 Day Spring In Southern Europe with Oceania Cruises
Cruise
 (3)

10 Days (9 Nights) Barcelona to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 26 April 2027
Visit: Spain, Sardinia, Sicily, Greece, Italy, Croatia
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$2,546
Oceanview
$2,789
Balcony
$4,292
Suite
$6,135
From
US$2,546
Save 2,652
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 05 September 2027
Visit: Spain, France, Italy, Corsica
Princess Standard
Sanctuary Collection
Inside
$1,313
Oceanview
$1,424
Balcony
$1,589
Suite
$1,939
From
US$1,313
Per Person
View Trip
8 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Lanzarote to Rome
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 13 April 2026
Visit: Spain, Morocco, Italy
Inside
-
Oceanview
-
Balcony
$925
Suite
-
From
US$925
Per Person
View Trip
11 Day Riviera Yacht Harbors with Seabourn
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Seabourn Venture
Departure: 25 April 2026
Visit: Spain, France, Monaco, Italy
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$11,433
From
US$11,433
Save 211
Per Person
View Trip
8 Day Mediterranean with Total Solar Eclipse with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 08 August 2026
Visit: Spain, Gibraltar, Italy
Princess Standard
Sanctuary Collection
Inside
$2,244
Oceanview
$3,004
Balcony
$3,591
Suite
$4,423
From
US$2,244
Per Person
View Trip
5 Day Mediterranean with MSC Cruises
Cruise
 (2)

5 Days (4 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 25 April 2026
Visit: Spain, Italy
Inside
-
Oceanview
-
Balcony
$463
Suite
$923
From
US$463
Per Person
View Trip
25 Day Greek Isles, Malta & Croatia With History Channel with Holland America
Cruise
 (2)

25 Days (24 Nights) Barcelona to Trieste
Cruise Line: Holland America
Ship: Oosterdam
Departure: 28 August 2027
Visit: Spain, Malta, Greece, Turkey (+4 more), Montenegro, Sicily, Italy, Croatia
Book Early & Have It All Fare Option
Exclusive Savings
Inside
$4,354
Oceanview
$4,874
Balcony
$5,971
Suite
$9,195
From
US$4,354
Per Person
View Trip
12 Day Cultures of the Mediterranean Barcelona to Civitavecchia with Emerald Cruises
New ReleaseCruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departures: May 2027 to Sep 2027
Visit: Italy, Sicily, Malta, Tunisia, Sardinia, Spain
Fly Free Economy
Wave Offer
Early Payment Discount
Exclusive Savings
Inside
-
Oceanview
$8,527
Balcony
-
Suite
$11,825
From
US$8,527
Save 11,463
Per Person
View Trip
15 Day Maritime Memories In The Med with Oceania Cruises
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 17 January 2028
Visit: Spain, Morocco, Sardinia, Tunisia, Sicily, Malta, Italy
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$4,398
Suite
$7,696
From
US$4,398
Save 4,600
Per Person
View Trip
16 Day Barcelona to Civitavecchia with Silversea
Cruise

16 Days (15 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 27 June 2026
Visit: Spain, France, Monaco, Italy
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$8,200
Suite
$13,500
From
US$8,200
Per Person
View Trip
8 Day Malta, Croatia And Montenegro with Cunard
Cruise
 (13)

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departures: Aug 2027 to Sep 2027
Visit: Spain, Malta, Montenegro, Croatia, Italy
Inside
$949
Oceanview
$1,049
Balcony
$1,199
Suite
$2,979
From
US$949
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ships: MSC Euribia, MSC Splendida
Departures: Feb 2026 to Oct 2026
Visit: Spain, France, Italy
Inside
$299
Oceanview
$349
Balcony
$409
Suite
$859
From
US$299
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: Oct 2026 to Oct 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Inside
$1,323
Oceanview
$1,424
Balcony
$1,519
Suite
$1,819
From
US$1,323
Per Person
View Trip
29 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise
 (1)

29 Days (28 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Visit: Spain, Corsica, Sicily, Italy, France, Greece, Turkey
Inside
$3,169
Oceanview
$3,519
Balcony
$4,209
Suite
$12,140
From
US$3,169
Per Person
View Trip
8 Day Italy And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 17 August 2026
Visit: Spain, Sardinia, Sicily, Italy
Inside
$1,029
Oceanview
$1,119
Balcony
$1,239
Suite
$3,559
From
US$1,029
Per Person
View Trip
10 Day Western Med: Barcelona to Rome with Virgin Voyages
Cruise
 (5)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Resilient Lady
Departure: 08 August 2027
Visit: Spain, France, Italy, Sicily, Malta
With Love From the World
Inside
$1,881
Oceanview
$2,364
Balcony
$2,331
Suite
$5,535
From
US$1,881
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departures: May 2027 to Sep 2027
Visit: Spain, France, Corsica, Italy, Sicily
Bonus Onboard Credit
Exclusive Savings
Inside
$954
Oceanview
$1,184
Balcony
$1,443
Suite
$2,113
From
US$954
Save 495
Per Person
View Trip
11 Day Barcelona to Rome with Silversea
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Muse
Departure: 24 January 2026
Visit: Spain, Sardinia, Malta, Tunisia, Sicily, Italy
Last Minute Fare
All-Inclusive Fare
Inside
-
Oceanview
$4,550
Balcony
$5,050
Suite
$10,200
From
US$4,550
Per Person
View Trip
13 Day Total Eclipse of the (Med) with Virgin Voyages
Cruise
 (1)

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 10 August 2026
Visit: Spain, France, Corsica, Italy, Sicily
With Love From the World
Inside
$3,228
Oceanview
$3,468
Balcony
$3,708
Suite
$8,748
From
US$3,228
Per Person
View Trip
12 Day A Journey Of Creative Spirit & Enchanting Canals with Explora Journeys
Cruise

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 02 April 2026
Visit: Spain, Italy, Malta, Sicily, Greece, Montenegro, Croatia
The Exclusive Invitation Offer
Sky & Sea
Inside
-
Oceanview
-
Balcony
$6,475
Suite
$7,455
From
US$6,475
Per Person
View Trip
13 Day Dalmatian Diversion with Oceania Cruises
Cruise
 (1)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 03 October 2027
Visit: Spain, France, Monaco, Italy, Corsica, Montenegro, Croatia
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$3,231
Oceanview
$3,571
Balcony
$5,656
Suite
$8,275
From
US$3,231
Save 3,367
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Bologna with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Bologna
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Pearl
Departure: 26 April 2026
Visit: Spain, Malta, Greece, Croatia, Montenegro, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$4,201
From
US$4,201
Save 118
Per Person
View Trip
22 Day Greece, Turkey, Italy And Adriatic with Cunard
Cruise
 (13)

22 Days (21 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 14 May 2027
Visit: Spain, Sicily, Greece, Turkey (+4 more), Italy, Malta, Montenegro, Croatia
Inside
$3,519
Oceanview
$3,969
Balcony
$4,359
Suite
$9,068
From
US$3,519
Per Person
View Trip
8 Day Italy, France And Spain with Cunard
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Visit: Spain, Corsica, Sicily, Italy
Inside
$1,109
Oceanview
$1,249
Balcony
$1,379
Suite
$4,899
From
US$1,109
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2026 to Apr 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Sanctuary Collection
Inside
$1,114
Oceanview
$1,474
Balcony
$1,639
Suite
$2,099
From
US$1,114
Per Person
View Trip
15 Day Italy, Greece And Adriatic with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 20 August 2027
Visit: Spain, Malta, Montenegro, Croatia, Italy, Greece, Sicily
Inside
$1,749
Oceanview
$1,949
Balcony
$2,199
Suite
$5,629
From
US$1,749
Per Person
View Trip
10 Day Seaside Splendor with Oceania Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 17 November 2027
Visit: Spain, Sardinia, Tunisia, Sicily, Malta, Italy
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,130
Suite
$5,652
From
US$3,130
Save 3,268
Per Person
View Trip
Results: 31-60 of 152

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