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Cruises from Barcelona to Rome

Are you looking for a cruise from Barcelona to Rome? September is the most popular month to cruise between Barcelona and Rome and there are 216 departures available from seventeen of the world's leading cruise lines.
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96 Cruises (216 Cruise Departures)
8 Day A Journey of Iconic Islands & Coastal Wonders with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departures: May 2027 to Oct 2027
Visit: Spain, Tunisia, Malta, Sicily, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$4,450
From
US$4,450
Per Person
View Trip
10 Day Italy & Spain Cruise: Florence, Portofino & Barcelona with Azamara Cruises
Cruise
 (8)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 13 August 2026
Visit: Spain, France, Monaco, Italy
Azamara Always Included
Exclusive Savings
Inside
$2,445
Oceanview
$2,881
Balcony
$3,512
Suite
$4,210
From
US$2,445
Save 54
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2026 to Oct 2027
Visit: Spain, France, Italy, Sicily
Inside
$729
Oceanview
$1,079
Balcony
$1,129
Suite
$1,349
From
US$729
Per Person
View Trip
12 Day Spain & Italy Cruise: Barcelona, Salerno & Rome with Azamara Cruises
Cruise
 (8)

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 20 February 2027
Visit: Spain, Sardinia, Tunisia, Malta, Sicily, Italy
Azamara Always Included
Exclusive Savings
Inside
$3,129
Oceanview
$3,653
Balcony
$4,186
Suite
$6,495
From
US$3,129
Save 70
Per Person
View Trip
8 Day Mediterranean Holiday with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 10 June 2026
Visit: Spain, France, Italy, Corsica, Sardinia, Sicily
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
$2,689
Oceanview
$2,980
Balcony
$3,998
Suite
$5,065
From
US$2,689
Save 2,809
Per Person
View Trip
8 Day A Journey Through Sparkling Bays & Riviera Radiance with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departures: May 2027 to Sep 2027
Visit: Spain, Sardinia, France, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$4,450
From
US$4,450
Per Person
View Trip
9 Day Italy, France & Spain Cruise with Royal Caribbean
Cruise

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Odyssey of the Seas
Departure: 16 April 2026
Visit: Spain, France, Italy, Sicily
Exclusive Savings
Inside
$922
Oceanview
$1,045
Balcony
$1,288
Suite
-
From
US$922
Save 490
Per Person
View Trip
8 Day Culinary Towns & Villages with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 13 November 2027
Visit: Spain, France, Italy
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$15,299
Suite
$17,259
From
US$15,299
Save 299
Per Person
View Trip
22 Day Italy, Spain, Greece And Adriatic with Cunard
Cruise
 (13)

22 Days (21 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 11 June 2027
Visit: Spain, Corsica, Italy, Malta (+4 more), Montenegro, Croatia, Greece, Sicily
Bonus Onboard Credit
Inside
$3,029
Oceanview
$3,629
Balcony
$4,109
Suite
$8,562
From
US$3,029
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 13 June 2027
Visit: Spain, France, Italy, Sicily
Inside
$1,339
Oceanview
$1,887
Balcony
$1,887
Suite
$2,071
From
US$1,339
Per Person
View Trip
8 Day Spain, France & Italy with Seabourn
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 25 September 2027
Visit: Spain, France, Corsica, Sardinia, Italy
Yours to Explore
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,462
Suite
$11,774
From
US$7,462
Save 137
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 02 May 2027
Visit: Spain, Malta, Tunisia, Sicily, Italy
Inside
$1,179
Oceanview
-
Balcony
$1,679
Suite
$1,799
From
US$1,179
Per Person
View Trip
12 Day Epicurean Spotlight On Wine with Regent Seven Seas
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 18 September 2026
Visit: Spain, Monaco, Italy
Elevate Your Experience
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$27,853
Suite
$30,793
From
US$27,853
Save 545
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2026 to Sep 2027
Visit: Spain, France, Italy, Sicily
Inside
$719
Oceanview
$1,579
Balcony
$999
Suite
$1,249
From
US$719
Per Person
View Trip
5 Day A Journey Through Europe's Timeless Charm & Cultural Richness with Explora Journeys
Cruise

5 Days (4 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 25 March 2026
Visit: Spain, France, Corsica, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$3,185
From
US$3,185
Per Person
View Trip
8 Day Relaxing Rivieras with Oceania Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 08 June 2027
Visit: Spain, France, Italy, Corsica
Your World Included Credit
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,368
Suite
$5,405
From
US$3,368
Save 3,530
Per Person
View Trip
12 Day Picturesque Panoramas with Regent Seven Seas
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 22 August 2027
Visit: Spain, France, Monaco, Italy, Corsica, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$24,912
Suite
$27,852
From
US$24,912
Save 486
Per Person
View Trip
8 Day Western Mediterranean with Italy with Princess
Cruise
 (6)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 02 May 2027
Visit: Spain, France, Corsica, Italy
Princess Standard
Inside
$1,189
Oceanview
$1,409
Balcony
$1,759
Suite
$1,809
From
US$1,189
Per Person
View Trip
8 Day Mediterranean Cruise: Spain, France & Italy with Azamara Cruises
Cruise
 (8)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 28 November 2026
Visit: Spain, France, Italy
Azamara Always Included
Inside
$1,699
Oceanview
$1,949
Balcony
$2,249
Suite
$3,735
From
US$1,699
Per Person
View Trip
15 Day Mediterranean, Greece And Turkey with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 01 October 2027
Visit: Spain, Sicily, Greece, Turkey, Italy
Bonus Onboard Credit
Inside
$2,399
Oceanview
$2,699
Balcony
$2,859
Suite
$5,539
From
US$2,399
Per Person
View Trip
15 Day Greek Isles: Mykonos & Naples with Holland America
Cruise
 (3)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Holland America
Ship: Oosterdam
Departures: Jun 2027 to Aug 2027
Visit: Spain, Malta, Greece, Turkey, Montenegro, Sicily, Italy
Book Early & Have It All Fare Option
Inside
$2,569
Oceanview
$2,919
Balcony
$3,424
Suite
$5,345
From
US$2,569
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 15 June 2026
Visit: Spain, France, Italy, Sardinia, Corsica, Sicily
Inside
$2,309
Oceanview
$2,389
Balcony
$2,709
Suite
$4,689
From
US$2,309
Per Person
View Trip
10 Day Western Med: Barcelona to Rome with Virgin Voyages
Cruise
 (5)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Resilient Lady
Departure: 08 August 2027
Visit: Spain, France, Italy, Sicily, Malta
Limited Time Offer
Inside
$2,406
Oceanview
$2,706
Balcony
$2,877
Suite
-
From
US$2,406
Per Person
View Trip
11 Day Spain, Portugal & France Cruise with Celebrity Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 24 July 2027
Visit: Spain, Gibraltar, Portugal, Corsica, Italy
Exclusive Savings
Inside
$2,324
Oceanview
$2,610
Balcony
$2,718
Suite
$6,815
From
US$2,757
Save 943
Per Person
View Trip
5 Day A Journey Through Riviera Elegance & Coastal Splendour with Explora Journeys
Cruise
 (1)

5 Days (4 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 25 April 2026
Visit: Spain, Monaco, Italy
Inside
-
Oceanview
-
Balcony
-
Suite
$3,040
From
US$3,040
Per Person
View Trip
15 Day Italy, Greece And Turkey with Cunard
Cruise
 (13)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 14 May 2027
Visit: Spain, Sicily, Greece, Turkey, Italy
Bonus Onboard Credit
Inside
$2,539
Oceanview
$2,719
Balcony
$2,939
Suite
$6,085
From
US$2,539
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 18 May 2026
Visit: Spain, France, Italy, Corsica, Sicily
Inside
$2,639
Oceanview
$2,969
Balcony
$3,679
Suite
$5,866
From
US$2,639
Per Person
View Trip
8 Day Western Mediterranean From Barcelona To Rome with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departure: 17 October 2027
Visit: Spain, Tunisia, Malta, Sicily, Italy
Inside
$1,149
Oceanview
-
Balcony
$1,589
Suite
$1,857
From
US$1,149
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Visit: Spain, Corsica, Sicily, Italy, France
Bonus Onboard Credit
Inside
$3,049
Oceanview
$2,869
Balcony
$4,699
Suite
-
From
US$2,869
Per Person
View Trip
10 Day Toast To Toulon with Regent Seven Seas
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 31 August 2027
Visit: Spain, France, Italy, Sardinia
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$20,793
Suite
$21,577
From
US$20,793
Save 405
Per Person
View Trip
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