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Cruises from Rome to Barcelona

Are you looking for a cruise from Rome to Barcelona? September is the most popular month to cruise between Rome and Barcelona and there are 208 departures available from fifteen of the world's leading cruise lines.
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102 Cruises (208 Cruise Departures)
11 Day Grand Mediterranean with Princess
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Majestic Princess
Departure: 30 June 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Exclusive Deal
INSIDE
$3,090
OCEANVIEW
-
BALCONY
$3,595
SUITE
$4,357
From (per person) 3,090
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+8 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: May 2025 to Sep 2027
Countries Visited: Italy, Monaco, France, Spain
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$5,341
SUITE
$7,321
Save (per person) 2,262
From (per person) 5,341
View Trip
3 Day Mediterranean with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 16 April 2025
Countries Visited: Italy, Spain
Exclusive Deal
INSIDE
$433
OCEANVIEW
$512
BALCONY
$621
SUITE
$1,017
From (per person) 433
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Sep 2026 to Oct 2026
Countries Visited: Italy, Sicily, Greece, Montenegro (+2 more), Turkey, Spain
Exclusive Deal
INSIDE
$3,907
OCEANVIEW
$4,501
BALCONY
$6,386
SUITE
$7,079
From (per person) 3,907
View Trip
8 Day Mediterranean Passage with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 02 December 2026
Countries Visited: Italy, Corsica, France, Spain
Exclusive Deal
INSIDE
$3,020
OCEANVIEW
$3,317
BALCONY
$4,822
SUITE
$6,782
Save (per person) 2,020
From (per person) 3,020
View Trip
8 Day Europe - Mediterranean with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2026 to Oct 2026
Countries Visited: Italy, Sicily, France, Spain
Exclusive Solo Offer
INSIDE
$2,643
OCEANVIEW
-
BALCONY
$3,255
SUITE
$3,561
From (per person) 2,643
View Trip
12 Day Grand Western Mediterranean with Princess
Cruise
 (2)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 29 July 2025
Countries Visited: Italy, Sicily, France, Gibraltar (+1 more), Spain
Exclusive Deal
INSIDE
$2,302
OCEANVIEW
$2,770
BALCONY
$3,062
SUITE
$3,492
From (per person) 2,302
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 06 September 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$5,722
OCEANVIEW
$6,573
BALCONY
$7,207
SUITE
$7,919
From (per person) 5,722
View Trip
8 Day Western Mediterranean Cruise: Italy, France & Spain with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 31 October 2026
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$2,917
OCEANVIEW
$3,451
BALCONY
$4,006
SUITE
$5,520
From (per person) 2,917
View Trip
9 Day Western Mediterranean Cruise: Italy, France & Spain with Azamara Cruises
Cruise
 (2)

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Pursuit
Departure: 09 October 2025
Countries Visited: Italy, France, Spain
INSIDE
$3,166
OCEANVIEW
$3,404
BALCONY
$4,166
SUITE
$6,433
From (per person) 3,166
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 15 June 2026
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$1,904
OCEANVIEW
$2,063
BALCONY
$3,086
SUITE
$4,299
Save (per person) 1,010
From (per person) 1,904
View Trip
11 Day Italy & France Spotlight with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 22 May 2026
Countries Visited: Italy, Sicily, Sardinia, Corsica (+2 more), France, Spain
Exclusive Deal
INSIDE
$4,824
OCEANVIEW
$5,349
BALCONY
$7,982
SUITE
$10,992
Save (per person) 2,036
From (per person) 4,824
View Trip
11 Day Autumnal Mediterranean with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Monaco, France, Spain
Exclusive Deal
INSIDE
$4,379
OCEANVIEW
$4,676
BALCONY
$7,230
SUITE
$10,091
Save (per person) 2,031
From (per person) 4,379
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2026 to Sep 2026
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$3,758
OCEANVIEW
$4,573
BALCONY
$5,639
SUITE
$6,143
From (per person) 3,758
View Trip
12 Day Rivieras & Yacht Havens Voyage with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 26 August 2025
Countries Visited: Italy, Monaco, France, Spain
Circle Club Voyage
INSIDE
$5,031
OCEANVIEW
$5,536
BALCONY
$6,328
SUITE
$7,318
From (per person) 5,031
View Trip
8 Day Essential Mediterranean with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 09 June 2026
Countries Visited: Italy, Monaco, France, Spain
Flex FaresExclusive Deal
INSIDE
$3,152
OCEANVIEW
$3,444
BALCONY
$5,156
SUITE
$7,159
Save (per person) 2,188
From (per person) 3,152
View Trip
11 Day Mediterranean Melange with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 29 October 2025
Countries Visited: Italy, Sicily, Sardinia, Corsica (+3 more), Monaco, France, Spain
New Year Sale
INSIDE
$3,923
OCEANVIEW
$4,527
BALCONY
$7,082
SUITE
$9,636
From (per person) 3,923
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 07 September 2026
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$1,744
OCEANVIEW
$1,825
BALCONY
$2,528
SUITE
$3,521
Save (per person) 941
From (per person) 1,744
View Trip
8 Day Western Mediterranean: Italy, France & Gibraltar with Holland America
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departures: Jun 2026 to Jul 2026
Countries Visited: Italy, France, Gibraltar, Spain
Have It All Offer
INSIDE
$1,865
OCEANVIEW
$2,162
BALCONY
$2,608
SUITE
$4,093
From (per person) 1,865
View Trip
8 Day Mediterranean Cruise: Itlay, France & Spain with Azamara Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 07 November 2026
Countries Visited: Italy, France, Spain
INSIDE
$2,908
OCEANVIEW
$3,393
BALCONY
$3,809
SUITE
$6,036
From (per person) 2,908
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 27 July 2026
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$1,900
OCEANVIEW
$1,958
BALCONY
$2,866
SUITE
$3,535
Save (per person) 1,019
From (per person) 1,900
View Trip
8 Day Western Mediterranean: Italy, France & Gibraltar with Holland America
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 29 August 2026
Countries Visited: Italy, Corsica, France, Gibraltar (+1 more), Spain
Have It All Offer
INSIDE
$1,914
OCEANVIEW
$2,211
BALCONY
$2,706
SUITE
$4,191
From (per person) 1,914
View Trip
12 Day Grand Mediterranean with Princess
Cruise
 (2)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 21 October 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Exclusive Deal
INSIDE
$3,438
OCEANVIEW
$4,072
BALCONY
$5,616
SUITE
$7,200
From (per person) 3,438
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2025 to Aug 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$3,795
OCEANVIEW
$4,765
BALCONY
$6,250
SUITE
$6,448
From (per person) 3,795
View Trip
31 Day Solar Eclipse, French Riviera & Iberian Coast with Seabourn
Cruise

31 Days (30 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Sojourn
Departure: 18 July 2026
Countries Visited: Italy, Albania, Sicily, Sardinia (+4 more), Corsica, Monaco, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
$25,078
BALCONY
$28,543
SUITE
$50,719
From (per person) 25,078
View Trip
16 Day Civitavecchia to Barcelona with Silversea
Cruise

16 Days (15 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 30 May 2025
Countries Visited: Italy, Sicily, France, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$18,315
From (per person) 18,315
View Trip
10 Day A Journey to UNESCO Malta & Balearic Bliss with Explora Journeys
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 13 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+2 more), Sardinia, Spain
INSIDE
-
OCEANVIEW
-
BALCONY
$8,811
SUITE
$10,593
From (per person) 8,370
View Trip
8 Day Rome To Barcelona with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 01 September 2025
Countries Visited: Italy, France, Spain
Experience Like No Other
INSIDE
$1,744
OCEANVIEW
$1,882
BALCONY
$2,120
SUITE
$4,100
From (per person) 1,744
View Trip
8 Day A Journey Of Treasured Secrets & Chic Promenades with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 10 August 2026
Countries Visited: Italy, Monaco, France, Spain
INSIDE
-
OCEANVIEW
-
BALCONY
$9,058
SUITE
$10,395
From (per person) 6,450
View Trip
8 Day Azure Summer with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 31 May 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$16,053
SUITE
$9,766
Save (per person) 7,184
From (per person) 9,766
View Trip
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