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Cruises from Rome to Barcelona

Are you looking for a cruise from Rome to Barcelona? June and September are the most popular months to cruise between Rome and Barcelona and there are 242 departures available from fifteen of the world's leading cruise lines.
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90 Cruises (242 Cruise Departures)
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise
 (5)

8 Days (7 Nights) Rome to Barcelona
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Libra (+9 more), Viking Mars, Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Jul 2025 to Sep 2027
Countries Visited: Italy, Monaco, France, Spain
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$2,599
SUITE
$3,799
Save (per person) 1,000
From (per person) 2,599
View Trip
13 Day Roman Holiday To Toulon & Beyond with Regent Seven Seas
Cruise

13 Days (12 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 14 November 2025
Countries Visited: Italy, France, Spain, Corsica (+1 more), Sardinia
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$9,099
SUITE
$17,399
Save (per person) 16,499
From (per person) 9,099
View Trip
11 Day Riviera & Mediterranean Jewels with Seabourn
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departures: May 2025 to Aug 2025
Countries Visited: Italy, Malta, Tunisia, France (+1 more), Spain
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$5,699
SUITE
$12,299
From (per person) 5,699
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 04 August 2025
Countries Visited: Italy, France, Sardinia, Sicily (+2 more), Corsica, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
$1,805
BALCONY
$2,065
SUITE
$4,455
From (per person) 1,805
View Trip
8 Day Amalfi Coast, Africa & Iberia with Viking Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Operated By: Viking Cruises
Ships: Viking Astrea, Viking Saturn (+2 more), Viking Star, Viking Vesta
Departures: Oct 2026 to Jun 2027
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+1 more), Spain
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$3,149
SUITE
$4,799
From (per person) 3,149
View Trip
8 Day Mediterranean Passage with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 December 2026
Countries Visited: Italy, Corsica, France, Spain
Exclusive Deal
INSIDE
$1,999
OCEANVIEW
$2,199
BALCONY
$3,199
SUITE
$4,499
Save (per person) 1,999
From (per person) 1,999
View Trip
3 Day Mediterranean with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 16 April 2025
Countries Visited: Italy, Spain
One Way Cruise Offer
INSIDE
$181
OCEANVIEW
$241
BALCONY
$331
SUITE
$591
From (per person) 181
View Trip
10 Day Tyrrhenian Yacht Treasures with Seabourn
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Venture
Departure: 05 May 2026
Countries Visited: Italy, Sicily, Sardinia, Corsica (+2 more), France, Spain
Exclusive DealA Sail Beyond Event
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$8,699
From (per person) 8,699
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 27 July 2026
Countries Visited: Italy, France, Spain
Latest Offer
INSIDE
$1,345
OCEANVIEW
$1,359
BALCONY
$2,055
SUITE
$2,603
Save (per person) 66
From (per person) 1,928
View Trip
21 Day Am Extended Journey To Moroccan Medinas And Flavourful Andalusia with Explora Journeys
Cruise

21 Days (20 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 23 April 2025
Countries Visited: Italy, Spain, Morocco, Gibraltar (+1 more), Portugal
Upgrade Your Ocean OfferBest Available Fare
INSIDE
-
OCEANVIEW
-
BALCONY
$10,085
SUITE
$15,485
From (per person) 10,085
View Trip
4 Day MSC Grand Voyages with MSC Cruises
Cruise

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 04 May 2025
Countries Visited: Italy, France, Spain
One Way Cruise Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$709
From (per person) 709
View Trip
4 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

4 Days (3 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Allure of the Seas
Departures: Oct 2025 to Oct 2026
Countries Visited: Italy, Spain
Latest Offer
INSIDE
$725
OCEANVIEW
$800
BALCONY
$762
SUITE
$1,450
Save (per person) 361
From (per person) 725
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 16 August 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive DealSpring Swing Offer
INSIDE
$2,159
OCEANVIEW
$2,753
BALCONY
$5,982
SUITE
$6,041
From (per person) 2,159
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 18 June 2025
Countries Visited: Italy, Spain
One Way Cruise Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$1,238
From (per person) 1,238
View Trip
11 Day Mediterranean Isles with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 15 November 2026
Countries Visited: Italy, Sicily, Malta, Tunisia (+2 more), Sardinia, Spain
Exclusive Deal
INSIDE
$3,199
OCEANVIEW
$4,049
BALCONY
$4,699
SUITE
$6,799
Save (per person) 3,199
From (per person) 3,199
View Trip
11 Day Italy & France Spotlight with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 22 May 2026
Countries Visited: Italy, Sicily, Sardinia, Corsica (+2 more), France, Spain
Exclusive Deal
INSIDE
$3,199
OCEANVIEW
$3,549
BALCONY
$5,299
SUITE
$7,299
Save (per person) 3,199
From (per person) 3,199
View Trip
10 Day Pesto, Paella & Paradise with Regent Seven Seas
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 17 April 2026
Countries Visited: Italy, France, Spain
Early Booking Saving
INSIDE
-
OCEANVIEW
-
BALCONY
$6,499
SUITE
$8,049
Save (per person) 10,899
From (per person) 6,499
View Trip
15 Day Mediterranean with Greece, Turkey, & Italy with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 06 September 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive DealSpring Swing Offer
INSIDE
$2,839
OCEANVIEW
$3,235
BALCONY
$3,760
SUITE
$4,720
From (per person) 2,839
View Trip
8 Day A Journey Of Antique Treasures To Sumptuous Catalan with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 07 September 2026
Countries Visited: Italy, Monaco, France, Spain
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$5,285
SUITE
$6,095
From (per person) 5,285
View Trip
11 Day Autumnal Mediterranean with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Monaco, France, Spain
Exclusive Deal
INSIDE
$3,099
OCEANVIEW
$3,299
BALCONY
$4,999
SUITE
$6,899
Save (per person) 3,099
From (per person) 3,099
View Trip
8 Day Mediterranean Cruise: Itlay, France & Spain with Azamara Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 07 November 2026
Countries Visited: Italy, France, Spain
INSIDE
$2,079
OCEANVIEW
$2,409
BALCONY
$2,699
SUITE
$4,249
From (per person) 2,079
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 07 September 2026
Countries Visited: Italy, France, Spain
Latest Offer
INSIDE
$1,199
OCEANVIEW
$1,277
BALCONY
$1,785
SUITE
$2,691
Save (per person) 63
From (per person) 1,715
View Trip
11 Day Grand Mediterranean with Princess
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Majestic Princess
Departure: 30 June 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Spring Swing OfferExclusive Deal
INSIDE
$1,488
OCEANVIEW
-
BALCONY
$1,956
SUITE
$2,607
From (per person) 1,488
View Trip
9 Day Italy, France & Spain Cruise with Celebrity Cruises
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 06 June 2025
Countries Visited: Italy, Sicily, France, Spain
Mutiple Deals Available
INSIDE
$1,339
OCEANVIEW
$1,539
BALCONY
$1,839
SUITE
$7,074
Save (per person) 919
From (per person) 1,339
View Trip
8 Day Western Mediterranean: Italy, France & Gibraltar with Holland America
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departures: Jun 2026 to Jul 2026
Countries Visited: Italy, France, Gibraltar, Spain
Exclusive Deal
INSIDE
$1,205
OCEANVIEW
$1,403
BALCONY
$1,700
SUITE
$2,690
From (per person) 1,205
View Trip
8 Day A Journey of Volcanic Vistas & Catalonian Culture with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 29 September 2025
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+1 more), Spain
Upgrade Your Ocean OfferBest Available Fare
INSIDE
-
OCEANVIEW
-
BALCONY
$5,130
SUITE
$6,220
From (per person) 5,130
View Trip
8 Day Rome to Barcelona with Silversea
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Nova
Departure: 23 November 2026
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+1 more), Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$6,700
From (per person) 6,700
View Trip
15 Day Mediterranean with Greece, Turkey, & Italy with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2026 to Sep 2026
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive DealSpring Swing Offer
INSIDE
$2,156
OCEANVIEW
$2,731
BALCONY
$3,206
SUITE
$3,681
From (per person) 2,156
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 12 December 2025
Countries Visited: Italy, France, Spain
One Way Cruise Offer
INSIDE
$479
OCEANVIEW
$559
BALCONY
$679
SUITE
$1,099
From (per person) 479
View Trip
8 Day A Journey to Scintillating Sardinia & Surrealist Sunsets with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2025 to Jul 2025
Countries Visited: Italy, Sicily, Sardinia, Spain
Best Available FareUpgrade Your Ocean Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$4,725
SUITE
$7,065
From (per person) 4,725
View Trip
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