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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? September is the most popular month to cruise between Italy and Spain and there are 301 departures available from fifteen of the world's leading cruise lines.
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141 Cruises (301 Cruise Departures)
13 Day Mediterranean Odyssey with Viking Cruises
Cruise

13 Days (12 Nights) Venice to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+5 more), Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vesta
Departures: Mar 2025 to Aug 2027
Countries Visited: Italy, Croatia, Greece, Monaco (+2 more), France, Spain
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$8,227
SUITE
$11,461
Save (per person) 324
From (per person) 8,227
View Trip
11 Day Grand Mediterranean with Princess
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Majestic Princess
Departure: 30 June 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$3,419
SUITE
$4,377
From (per person) 3,419
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+8 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: May 2025 to Sep 2027
Countries Visited: Italy, Monaco, France, Spain
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$5,341
SUITE
$7,321
Save (per person) 2,262
From (per person) 5,341
View Trip
11 Day Italy, Greece, & France: Mediterranean Jewels with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Breakaway
Departures: May 2025 to Oct 2025
Countries Visited: Italy, Croatia, Greece, Sicily (+2 more), France, Spain
INSIDE
$4,201
OCEANVIEW
$4,879
BALCONY
$5,628
SUITE
$6,331
From (per person) 4,201
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 27 July 2026
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$1,900
OCEANVIEW
$1,958
BALCONY
$2,866
SUITE
$3,535
Save (per person) 1,019
From (per person) 1,900
View Trip
15 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

15 Days (14 Nights) Genoa to Santa Cruz De Tenerife
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 02 November 2025
Countries Visited: Italy, France, Spain, Gibraltar (+2 more), Portugal, Morocco
Early Booking Offer
INSIDE
$2,127
OCEANVIEW
$2,394
BALCONY
$3,067
SUITE
-
From (per person) 2,127
View Trip
8 Day Mediterranean Cruise: Itlay, France & Spain with Azamara Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 07 November 2026
Countries Visited: Italy, France, Spain
INSIDE
$2,908
OCEANVIEW
$3,393
BALCONY
$3,809
SUITE
$6,036
From (per person) 2,908
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Bologna to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 26 October 2026
Countries Visited: Italy, Sicily, Corsica, France (+1 more), Spain
Exclusive Deal
INSIDE
$1,588
OCEANVIEW
$1,732
BALCONY
$2,256
SUITE
$3,050
Save (per person) 837
From (per person) 1,588
View Trip
12 Day Grand Western Mediterranean with Princess
Cruise
 (2)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 29 July 2025
Countries Visited: Italy, Sicily, France, Gibraltar (+1 more), Spain
Exclusive Deal
INSIDE
$2,330
OCEANVIEW
$2,770
BALCONY
$3,215
SUITE
$3,522
From (per person) 2,330
View Trip
13 Day Canary Islands And Madeira with MSC Cruises
Cruise
 (1)

13 Days (12 Nights) Genoa to Las Palmas de Gran Canaria
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 02 November 2025
Countries Visited: Italy, France, Spain, Gibraltar (+2 more), Portugal, Morocco
Early Booking Offer
INSIDE
$1,813
OCEANVIEW
$2,061
BALCONY
$2,645
SUITE
$4,496
From (per person) 1,813
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2025 to Aug 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$3,834
OCEANVIEW
$4,765
BALCONY
$6,250
SUITE
$6,745
From (per person) 3,834
View Trip
12 Day Rivieras & Yacht Havens Voyage with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 26 August 2025
Countries Visited: Italy, Monaco, France, Spain
Circle Club Voyage
INSIDE
$5,031
OCEANVIEW
$5,536
BALCONY
$6,328
SUITE
$7,318
From (per person) 5,031
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Naples to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 27 September 2025
Countries Visited: Italy, Sicily, Greece, Turkey (+2 more), Montenegro, Spain
Exclusive Deal
INSIDE
$4,749
OCEANVIEW
$5,690
BALCONY
$5,947
SUITE
$6,977
From (per person) 4,749
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2026 to Sep 2026
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$3,797
OCEANVIEW
$4,593
BALCONY
$5,678
SUITE
$6,242
From (per person) 3,797
View Trip
8 Day Western Mediterranean: Italy, France & Gibraltar with Holland America
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departures: Jun 2026 to Jul 2026
Countries Visited: Italy, France, Gibraltar, Spain
Have It All Offer
INSIDE
$1,865
OCEANVIEW
$2,162
BALCONY
$2,608
SUITE
$4,093
From (per person) 1,865
View Trip
9 Day Western Mediterranean Cruise: Italy, France & Spain with Azamara Cruises
Cruise
 (2)

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Pursuit
Departure: 09 October 2025
Countries Visited: Italy, France, Spain
INSIDE
$3,166
OCEANVIEW
$3,404
BALCONY
$4,354
SUITE
$6,740
From (per person) 3,166
View Trip
5 Day Mediterranean with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Amalfi to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 04 February 2025
Countries Visited: Italy, Sicily, Tunisia, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$667
SUITE
$2,017
From (per person) 667
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 06 September 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$5,761
OCEANVIEW
$6,573
BALCONY
$7,207
SUITE
$7,949
From (per person) 5,761
View Trip
8 Day Mediterranean Passage with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 02 December 2026
Countries Visited: Italy, Corsica, France, Spain
Exclusive Deal
INSIDE
$3,020
OCEANVIEW
$3,317
BALCONY
$4,822
SUITE
$6,782
Save (per person) 2,020
From (per person) 3,020
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Genoa to Malaga
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 April 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$580
OCEANVIEW
-
BALCONY
$837
SUITE
-
From (per person) 580
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 15 June 2026
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$1,904
OCEANVIEW
$2,063
BALCONY
$3,086
SUITE
$4,299
Save (per person) 1,010
From (per person) 1,904
View Trip
11 Day Autumnal Mediterranean with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Monaco, France, Spain
Exclusive Deal
INSIDE
$4,379
OCEANVIEW
$4,676
BALCONY
$7,230
SUITE
$10,091
Save (per person) 2,031
From (per person) 4,379
View Trip
11 Day Mediterranean Melange with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 29 October 2025
Countries Visited: Italy, Sicily, Sardinia, Corsica (+3 more), Monaco, France, Spain
New Year Sale
INSIDE
$3,923
OCEANVIEW
$4,527
BALCONY
$7,082
SUITE
$9,636
From (per person) 3,923
View Trip
12 Day Grand Mediterranean with Princess
Cruise
 (2)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 21 October 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Exclusive Deal
INSIDE
$3,438
OCEANVIEW
$4,072
BALCONY
$5,616
SUITE
$7,280
From (per person) 3,438
View Trip
3 Day Mediterranean with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 16 April 2025
Countries Visited: Italy, Spain
Exclusive Deal
INSIDE
$433
OCEANVIEW
$512
BALCONY
$621
SUITE
$1,017
From (per person) 433
View Trip
21 Day Adriatic & Iberia Discovery with Oceania Cruises
Cruise
 (1)

21 Days (20 Nights) Venice to Bilbao
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 10 August 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+4 more), Sicily, Spain, Morocco, Portugal
Exclusive Deal
INSIDE
$9,208
OCEANVIEW
$10,257
BALCONY
$15,217
SUITE
$20,930
Save (per person) 2,062
From (per person) 9,208
View Trip
8 Day Europe - Mediterranean with Norwegian Cruise Line
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Epic
Departures: May 2026 to Oct 2026
Countries Visited: Italy, Sicily, France, Spain
Exclusive Solo Offer
INSIDE
$2,396
OCEANVIEW
-
BALCONY
$3,008
SUITE
$3,313
From (per person) 2,396
View Trip
12 Day Around Italy's Boot: Cote D'azur with Holland America
Cruise
 (2)

12 Days (11 Nights) Trieste to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 30 August 2025
Countries Visited: Italy, Montenegro, Greece, Sicily (+2 more), France, Spain
Exclusive Deal
INSIDE
$2,546
OCEANVIEW
$2,843
BALCONY
$3,808
SUITE
$5,095
From (per person) 2,546
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Sep 2026 to Oct 2026
Countries Visited: Italy, Sicily, Greece, Montenegro (+2 more), Turkey, Spain
Exclusive Deal
INSIDE
$3,907
OCEANVIEW
$4,521
BALCONY
$6,402
SUITE
$7,099
From (per person) 3,907
View Trip
8 Day Essential Mediterranean with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 09 June 2026
Countries Visited: Italy, Monaco, France, Spain
Flex FaresExclusive Deal
INSIDE
$3,152
OCEANVIEW
$3,444
BALCONY
$5,156
SUITE
$7,159
Save (per person) 2,188
From (per person) 3,152
View Trip
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