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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? October is the most popular month to cruise between Italy and Spain and there are 296 departures available from fifteen of the world's leading cruise lines.
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139 Cruises (296 Cruise Departures)
13 Day Mediterranean Odyssey with Viking Cruises
Cruise
 (6)

13 Days (12 Nights) Venice to Barcelona
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+5 more), Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vesta
Departures: Jun 2025 to Aug 2027
Countries Visited: Italy, Croatia, Greece, Monaco (+2 more), France, Spain
INSIDE
-
OCEANVIEW
-
BALCONY
$5,499
SUITE
$7,749
From (per person) 5,499
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise
 (5)

8 Days (7 Nights) Rome to Barcelona
Operated By: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+8 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Jul 2025 to Sep 2027
Countries Visited: Italy, Monaco, France, Spain
INSIDE
-
OCEANVIEW
-
BALCONY
$2,799
SUITE
$5,049
From (per person) 2,799
View Trip
11 Day Italy, Greece, & France: Mediterranean Jewels with Norwegian Cruise Line
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Breakaway
Departures: May 2025 to Oct 2025
Countries Visited: Italy, Croatia, Greece, Sicily (+2 more), France, Spain
INSIDE
$2,941
OCEANVIEW
$3,441
BALCONY
$4,091
SUITE
$4,491
From (per person) 2,941
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2025 to May 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$3,111
OCEANVIEW
$3,951
BALCONY
$4,751
SUITE
$5,351
From (per person) 3,111
View Trip
8 Day Amalfi Coast, Africa & Iberia with Viking Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Operated By: Viking Cruises
Ships: Viking Saturn, Viking Star, Viking Vesta
Departures: Oct 2026 to Jun 2027
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+1 more), Spain
INSIDE
-
OCEANVIEW
-
BALCONY
$2,999
SUITE
$5,549
From (per person) 2,999
View Trip
10 Day Classic Mediterranean From Bologna To Barcelona with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Bologna to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departures: Aug 2026 to Oct 2026
Countries Visited: Italy, Croatia, Montenegro, France (+1 more), Spain
INSIDE
$2,149
OCEANVIEW
$2,549
BALCONY
$3,139
SUITE
$4,020
From (per person) 2,149
View Trip
8 Day Essential Mediterranean with Oceania Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 09 June 2026
Countries Visited: Italy, Monaco, France, Spain
Exclusive Deal
INSIDE
$2,199
OCEANVIEW
$2,399
BALCONY
$3,599
SUITE
$4,999
Save (per person) 2,199
From (per person) 2,199
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2026 to Aug 2026
Countries Visited: Italy, Greece, Montenegro, Croatia (+2 more), Malta, Spain
Exclusive Deal
INSIDE
$2,299
OCEANVIEW
$2,469
BALCONY
$2,959
SUITE
$6,889
From (per person) 2,299
View Trip
11 Day Spanish Sapphire Shores with Regent Seven Seas
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 24 March 2027
Countries Visited: Italy, France, Spain
Exclusive DealUpgrade Your Horizon
INSIDE
-
OCEANVIEW
-
BALCONY
$7,999
SUITE
$11,199
Save (per person) 13,599
From (per person) 7,999
View Trip
21 Day An Extended Journey To Castaway Canaries, Cadiz And Casablanca with Explora Journeys
Cruise

21 Days (20 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 13 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+4 more), Sardinia, Spain, Gibraltar, Morocco
Explora Extended Journey SavingUnique Oceans Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$11,920
SUITE
$14,295
From (per person) 11,920
View Trip
12 Day Rivieras & Yacht Havens Voyage with Azamara Cruises
Cruise
 (3)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 26 August 2025
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$2,959
OCEANVIEW
$3,179
BALCONY
$3,909
SUITE
$4,639
From (per person) 2,959
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Florence to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 29 September 2025
Countries Visited: Italy, Sicily, Malta, Spain
One Way Cruise Offer
INSIDE
$593
OCEANVIEW
$663
BALCONY
$772
SUITE
$1,326
From (per person) 593
View Trip
11 Day Rome to Barcelona with Silversea
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Muse
Departure: 14 January 2026
Countries Visited: Italy, Sicily, Malta, Tunisia (+2 more), Sardinia, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$4,400
BALCONY
$5,400
SUITE
$9,600
Save (per person) 1,500
From (per person) 4,400
View Trip
8 Day Western Mediterranean: Italy, France & Gibraltar with Holland America
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 29 August 2026
Countries Visited: Italy, Corsica, France, Gibraltar (+1 more), Spain
Exclusive Deal
INSIDE
$1,324
OCEANVIEW
$1,524
BALCONY
$1,874
SUITE
$2,874
From (per person) 1,324
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 13 July 2026
Countries Visited: Italy, France, Corsica, Spain
Exclusive Deal
INSIDE
$2,149
OCEANVIEW
$2,369
BALCONY
$2,879
SUITE
$6,849
From (per person) 2,149
View Trip
11 Day Mediterranean Melange with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 29 October 2025
Countries Visited: Italy, Sicily, Sardinia, Corsica (+3 more), Monaco, France, Spain
Exclusive Deal
INSIDE
$2,599
OCEANVIEW
$3,099
BALCONY
$5,099
SUITE
$6,399
Save (per person) 2,599
From (per person) 2,599
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 20 July 2026
Countries Visited: Italy, France, Corsica, Spain
Exclusive Deal
INSIDE
$1,109
OCEANVIEW
$1,239
BALCONY
$1,499
SUITE
$3,689
From (per person) 1,109
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: May 2025 to Aug 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$2,579
OCEANVIEW
$3,513
BALCONY
$4,622
SUITE
$4,822
From (per person) 2,579
View Trip
9 Day Italy, France & Spain Cruise with Celebrity Cruises
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 06 June 2025
Countries Visited: Italy, Sicily, France, Spain
Exclusive Deal
INSIDE
$1,789
OCEANVIEW
$1,989
BALCONY
$2,589
SUITE
$10,077
Save (per person) 1,069
From (per person) 1,789
View Trip
9 Day Springtime Rivieras with Oceania Cruises
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 18 May 2025
Countries Visited: Italy, Corsica, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$4,599
SUITE
-
Save (per person) 4,599
From (per person) 4,599
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise
 (2)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2026 to Sep 2026
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$2,373
OCEANVIEW
$2,886
BALCONY
$3,570
SUITE
$3,894
From (per person) 2,373
View Trip
29 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise

29 Days (28 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 15 September 2025
Countries Visited: Italy, Greece, Montenegro, Croatia (+3 more), Malta, Spain, Turkey
Exclusive Deal
INSIDE
$3,869
OCEANVIEW
$4,109
BALCONY
-
SUITE
$11,909
From (per person) 3,869
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 11 August 2025
Countries Visited: Italy, France, Corsica, Spain
Exclusive Deal
INSIDE
$1,139
OCEANVIEW
$1,159
BALCONY
$1,389
SUITE
$2,919
From (per person) 1,139
View Trip
11 Day Mediterranean with MSC Cruises
Cruise
 (1)

11 Days (10 Nights) Trieste to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 29 October 2025
Countries Visited: Italy, Croatia, Greece, Malta (+2 more), Sicily, Spain
Escape To Sea - Cruise Only
INSIDE
-
OCEANVIEW
-
BALCONY
$1,231
SUITE
$1,954
From (per person) 1,231
View Trip
11 Day Dalmatian & Italian Gems with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 10 August 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$3,199
OCEANVIEW
$3,549
BALCONY
$5,299
SUITE
$7,299
Save (per person) 3,199
From (per person) 3,199
View Trip
11 Day Autumnal Mediterranean with Oceania Cruises
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Monaco, France, Spain
Your World + Prestige Drinks PackageExclusive Deal
INSIDE
$2,700
OCEANVIEW
$2,880
BALCONY
$4,410
SUITE
$6,899
Save (per person) 3,298
From (per person) 2,700
View Trip
8 Day Mediterranean Holiday Cruise: Barcelona, Palma & Florence with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 22 December 2026
Countries Visited: Italy, Spain
INSIDE
$1,639
OCEANVIEW
$1,899
BALCONY
$2,459
SUITE
$3,899
From (per person) 1,639
View Trip
3 Day Mediterranean with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Genoa to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 21 April 2025
Countries Visited: Italy, Spain
One Way Cruise Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$280
SUITE
-
From (per person) 280
View Trip
11 Day Southern European Gems with Oceania Cruises
Cruise

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+2 more), Sicily, Spain
Exclusive Deal
INSIDE
$2,999
OCEANVIEW
$3,299
BALCONY
$5,099
SUITE
$7,099
Save (per person) 2,999
From (per person) 2,999
View Trip
8 Day Mediterranean Cruise: Itlay, France & Spain with Azamara Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 07 November 2026
Countries Visited: Italy, France, Spain
INSIDE
$2,079
OCEANVIEW
$2,409
BALCONY
$2,699
SUITE
$4,249
From (per person) 2,079
View Trip
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