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Cruises from Italy to Portugal

Are you looking for a cruise from Italy to Portugal? November is the most popular month to cruise between Italy and Portugal and there are 29 departures available from nine of the world's leading cruise lines.
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6 Days
43 Days
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$900pp
$19,190pp
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28 Cruises (29 Cruise Departures)
Cruise
 (1)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Norwegian Cruise Line
Departure: 18 November 2025
Countries Visited: Italy, France, Spain, Portugal
INSIDE
$4,232
OCEANVIEW
$4,691
BALCONY
$5,333
SUITE
$7,337
From (per person) 4,232
Cruise
 (2)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 24 May 2026
Countries Visited: Italy, Sicily, Sardinia, Spain (+2 more), Gibraltar, Portugal
Exclusive Deal
INSIDE
$2,728
OCEANVIEW
$2,976
BALCONY
$4,015
SUITE
$5,550
From (per person) 2,728
Cruise
 (1)

13 Days (12 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Departure: 20 May 2025
Countries Visited: Italy, Corsica, France, Spain (+2 more), Gibraltar, Portugal
INSIDE
$4,626
OCEANVIEW
$4,923
BALCONY
$5,339
SUITE
$11,437
From (per person) 4,626
Cruise
 (3)

18 Days (17 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Departure: 22 December 2026
Countries Visited: Italy, Spain, Morocco, Portugal
INSIDE
$5,555
OCEANVIEW
$6,377
BALCONY
$8,337
SUITE
$12,930
From (per person) 5,555
New ReleaseCruise
 (3)

12 Days (11 Nights) Rome to Lisbon
Cruise Line: Emerald Cruises
Departure: 27 October 2026
Countries Visited: Italy, Corsica, Spain, Morocco (+1 more), Portugal
Super Earlybird
INSIDE
-
OCEANVIEW
$12,238
BALCONY
-
SUITE
$16,644
Save (per person) 2,607
From (per person) 12,238
Cruise
 (2)

21 Days (20 Nights) Trieste to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 14 May 2026
Countries Visited: Italy, Croatia, Montenegro, Greece (+5 more), Sicily, Sardinia, Spain, Gibraltar, Portugal
Exclusive Deal
INSIDE
$5,160
OCEANVIEW
$5,606
BALCONY
$7,635
SUITE
$10,605
From (per person) 5,160
Cruise
 (3)

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Azamara Cruises
Departure: 22 May 2025
Countries Visited: Italy, France, Spain, Gibraltar (+1 more), Portugal
INSIDE
$3,931
OCEANVIEW
$4,416
BALCONY
$6,752
SUITE
$8,643
From (per person) 3,931
Cruise
 (1)

20 Days (19 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Departure: 02 December 2026
Countries Visited: Italy, Corsica, France, Spain (+3 more), Gibraltar, Morocco, Portugal
Exclusive Deal
INSIDE
$7,550
OCEANVIEW
$8,303
BALCONY
$12,362
SUITE
$17,322
Save (per person) 2,050
From (per person) 7,550
Cruise
 (2)

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 29 June 2025
Countries Visited: Italy, Sicily, Greece, Malta (+5 more), Tunisia, Sardinia, Spain, Morocco, Portugal
Exclusive Deal
INSIDE
$3,434
OCEANVIEW
$3,929
BALCONY
$4,424
SUITE
$6,701
From (per person) 3,434
Cruise
 (2)

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 26 July 2026
Countries Visited: Italy, France, Gibraltar, Spain (+2 more), Morocco, Portugal
Exclusive Deal
INSIDE
$3,582
OCEANVIEW
$4,176
BALCONY
-
SUITE
-
From (per person) 3,582
Cruise
 (2)

25 Days (24 Nights) Venice to Lisbon
Cruise Line: Holland America
Ship: Oosterdam
Departure: 19 June 2025
Countries Visited: Italy, Croatia, Montenegro, Greece (+7 more), Sicily, Malta, Tunisia, Sardinia, Spain, Morocco, Portugal
Exclusive Deal
INSIDE
-
OCEANVIEW
$6,499
BALCONY
-
SUITE
-
From (per person) 6,499
Cruise
 (3)

21 Days (20 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Departure: 18 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Monaco, France, Spain, Portugal, Morocco
Exclusive Deal
INSIDE
$7,994
OCEANVIEW
$8,450
BALCONY
$13,410
SUITE
$18,073
Save (per person) 2,056
From (per person) 7,994
Cruise
 (3)

43 Days (42 Nights) Venice to Lisbon
Cruise Line: Azamara Cruises
Departure: 06 October 2026
Countries Visited: Italy, Greece, Turkey, Egypt (+7 more), Malta, Sicily, Monaco, France, Spain, Gibraltar, Portugal
INSIDE
$13,282
OCEANVIEW
$15,361
BALCONY
$18,875
SUITE
$24,766
From (per person) 13,282
Cruise
 (1)

13 Days (12 Nights) Rome to Lisbon
Cruise Line: Norwegian Cruise Line
Departure: 01 November 2025
Countries Visited: Italy, Sicily, Spain, Morocco (+1 more), Portugal
Exclusive Solo Offer
INSIDE
$3,257
OCEANVIEW
-
BALCONY
$4,607
SUITE
$5,115
From (per person) 3,257
Cruise
 (1)

12 Days (11 Nights) Genoa to Funchal
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 02 November 2025
Countries Visited: Italy, France, Spain, Gibraltar (+2 more), Portugal, Morocco
Exclusive Deal
INSIDE
$1,775
OCEANVIEW
$2,013
BALCONY
$2,537
SUITE
$4,151
From (per person) 1,775
Cruise
 (1)

6 Days (5 Nights) Genoa to Lisbon
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 26 April 2025
Countries Visited: Italy, France, Spain, Portugal
Exclusive Deal
INSIDE
$982
OCEANVIEW
$1,111
BALCONY
$1,359
SUITE
-
From (per person) 982
Cruise

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Oceania Cruises
Departure: 28 April 2026
Countries Visited: Italy, France, Spain, Morocco (+1 more), Portugal
Exclusive Deal
INSIDE
$7,165
OCEANVIEW
$8,661
BALCONY
$9,733
SUITE
$14,022
Save (per person) 2,435
From (per person) 7,165
Cruise

17 Days (16 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Nova
Departure: 23 November 2026
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+4 more), Spain, Gibraltar, Morocco, Portugal
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$15,147
From (per person) 15,147
Cruise

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Seabourn
Departures: Nov 2025 to Nov 2026
Countries Visited: Italy, Corsica, Sardinia, Spain (+1 more), Portugal
Sail Of The Year
INSIDE
-
OCEANVIEW
$6,068
BALCONY
$5,647
SUITE
$12,126
From (per person) 5,647
Cruise

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Norwegian Cruise Line
Departure: 14 October 2025
Countries Visited: Italy, France, Spain, Portugal
Exclusive Solo Offer
INSIDE
$3,106
OCEANVIEW
$3,706
BALCONY
$5,966
SUITE
$11,033
From (per person) 3,106
Cruise

13 Days (12 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Ray
Departure: 07 November 2025
Countries Visited: Italy, Monaco, France, Spain (+1 more), Portugal
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$10,791
Save (per person) 2,609
From (per person) 10,791
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Regent Seven Seas
Departure: 10 July 2026
Countries Visited: Italy, France, Spain, Gibraltar (+1 more), Portugal
Upgrade Your HorizonExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,876
SUITE
$13,608
Save (per person) 6,314
From (per person) 12,876
Cruise

21 Days (20 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Muse
Departure: 31 July 2026
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Spain, Gibraltar, Morocco, Portugal
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$18,216
BALCONY
$20,889
SUITE
$29,601
From (per person) 18,216
Cruise

21 Days (20 Nights) Rome to Lisbon
Cruise Line: Seabourn
Departure: 15 November 2026
Countries Visited: Italy, Corsica, Sardinia, Sicily (+6 more), Malta, Tunisia, Spain, Gibraltar, Morocco, Portugal
Sail Of The Year
INSIDE
-
OCEANVIEW
$11,886
BALCONY
$13,653
SUITE
$26,108
From (per person) 11,886
Cruise

18 Days (17 Nights) Rome to Lisbon
Cruise Line: Seabourn
Departure: 13 April 2025
Countries Visited: Italy, France, Spain, Morocco (+1 more), Portugal
Sail Of The Year
INSIDE
-
OCEANVIEW
-
BALCONY
$14,326
SUITE
$14,326
From (per person) 14,326
Cruise

11 Days (10 Nights) Rome to Lisbon
Cruise Line: Silversea
Departure: 17 May 2025
Countries Visited: Italy, France, Spain, Portugal
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$9,850
SUITE
$9,256
From (per person) 9,256
Cruise

15 Days (14 Nights) Rome to Lisbon
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 25 November 2026
Countries Visited: Italy, Malta, Sicily, Tunisia (+3 more), Sardinia, Spain, Portugal
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$10,098
BALCONY
$11,088
SUITE
$17,523
Save (per person) 4,102
From (per person) 10,098
Cruise

10 Days (9 Nights) Rome to Lisbon
Cruise Line: Norwegian Cruise Line
Departure: 25 June 2025
Countries Visited: Italy, France, Spain, Portugal
INSIDE
$3,564
OCEANVIEW
$4,589
BALCONY
$7,189
SUITE
$13,861
From (per person) 3,564
Results: 28 results

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