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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? June is the most popular month to cruise between Italy and Spain and there are 326 departures available from sixteen of the world's leading cruise lines.
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127 Cruises (326 Cruise Departures)
8 Day Western Mediterranean with Cunard
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 10 August 2026
Visit: Italy, Spain, France
Inside
$1,609
Oceanview
$1,769
Balcony
$2,839
Suite
$5,299
From
US$1,609
Per Person
View Trip
8 Day Italy And France with Cunard
Cruise
 (13)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 24 September 2027
Visit: Italy, France, Corsica, Spain
Inside
$1,059
Oceanview
$1,149
Balcony
$1,299
Suite
$3,079
From
US$1,059
Per Person
View Trip
8 Day Rome To Romance with Oceania Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 10 April 2028
Visit: Italy, Corsica, Monaco, France, Spain
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$2,099
Oceanview
$2,785
Balcony
$3,415
Suite
$4,676
From
US$2,099
Save 2,099
Per Person
View Trip
8 Day Rome to Barcelona with Silversea
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Nova
Departure: 23 November 2026
Visit: Italy, Sicily, Tunisia, Sardinia, Spain
All-Inclusive Fare
Inside
-
Oceanview
-
Balcony
$5,700
Suite
$7,560
From
US$5,700
Per Person
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departures: May 2027 to Sep 2027
Visit: Italy, France, Spain
Bonus Onboard Credit
Exclusive Savings
Inside
$947
Oceanview
$1,197
Balcony
$1,467
Suite
$2,187
From
US$947
Save 576
Per Person
View Trip
10 Day Pasta To Paella with Oceania Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 15 April 2028
Visit: Italy, Sardinia, Monaco, France, Spain
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$3,613
Suite
$6,135
From
US$3,613
Save 3,785
Per Person
View Trip
8 Day Italy & France Cruise with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Bologna to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 26 October 2026
Visit: Italy, Corsica, France, Spain
Bonus Onboard Credit
Exclusive Savings
Inside
$1,029
Oceanview
$1,109
Balcony
$1,432
Suite
$3,646
From
US$1,029
Save 511
Per Person
View Trip
11 Day Southern European Gems with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 23 October 2026
Visit: Italy, Croatia, Montenegro, Greece, Sicily, Spain
Black Friday Sale + Your World Included
Your World Inclusions
Exclusive Savings
Inside
$3,086
Oceanview
$3,231
Balcony
$4,977
Suite
$6,917
From
US$3,086
Save 3,212
Per Person
View Trip
29 Day Mediterranean Medley: Greece, Ephesus & Spain with Seabourn
Cruise

29 Days (28 Nights) Venice to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 09 October 2027
Visit: Italy, Slovenia, Croatia, Montenegro (+6 more), Greece, Turkey, Malta, Sicily, Sardinia, Spain
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$17,308
Suite
$29,553
From
US$17,308
Save 286
Per Person
View Trip
8 Day Western Mediterranean: Italy, France & Gibraltar with Holland America
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departures: Jun 2026 to Jun 2027
Visit: Italy, France, Gibraltar, Spain
Fare Saver
Book Early & Have It All Fare Option
Inside
$1,269
Oceanview
$1,419
Balcony
$1,684
Suite
$2,264
From
US$1,269
Per Person
View Trip
10 Day Classic Mediterranean From Bologna To Barcelona with Norwegian Cruise Line
Cruise
 (1)

10 Days (9 Nights) Bologna to Barcelona
Cruise Line: Norwegian Cruise Line
Ship: Norwegian Viva
Departure: 15 June 2026
Visit: Italy, Montenegro, Croatia, France, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
-
Suite
$7,840
From
US$7,840
Save 229
Per Person
View Trip
15 Day Mediterranean with Greece, Turkey, & Adriatic with Princess
Cruise
 (6)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2026 to Oct 2027
Visit: Italy, Greece, Turkey, Montenegro, Sicily, Spain
Princess Standard
Sanctuary Collection
Princess Premier
Inside
$2,053
Oceanview
$2,521
Balcony
$2,826
Suite
$3,095
From
US$2,053
Per Person
View Trip
8 Day Riviera Reverie with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 30 September 2027
Visit: Italy, France, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$6,090
Suite
$6,384
From
US$6,090
Save 11,308
Per Person
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 07 September 2026
Visit: Italy, France, Spain
Bonus Onboard Credit
Exclusive Savings
Inside
$1,148
Oceanview
$1,409
Balcony
$1,821
Suite
$2,841
From
US$1,148
Save 588
Per Person
View Trip
11 Day Antiquities & Ancients with Regent Seven Seas
Cruise

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Prestige
Departure: 21 August 2027
Visit: Italy, Greece, Spain
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$8,746
Suite
$9,236
From
US$8,746
Save 15,052
Per Person
View Trip
8 Day Monaco, Italy, France & Spain with Seabourn
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Seabourn Ovation
Departure: 18 September 2027
Visit: Italy, Monaco, France, Spain
Explore More
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$5,010
Suite
$8,592
From
US$5,010
Save 89
Per Person
View Trip
8 Day Civitavecchia (Rome) to Barcelona with Silversea
Cruise
 (1)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Nova
Departure: 07 November 2027
Visit: Italy, France, Spain
All-Inclusive Fare
Exclusive Savings
Inside
-
Oceanview
-
Balcony
$7,300
Suite
$6,720
From
US$6,720
Save 1,680
Per Person
View Trip
21 Day Adriatic & Iberia Discovery with Oceania Cruises
Cruise
 (1)

21 Days (20 Nights) Venice to Bilbao
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 10 August 2026
Visit: Italy, Croatia, Montenegro, Greece (+4 more), Sicily, Spain, Morocco, Portugal
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$6,261
Oceanview
$6,601
Balcony
$10,141
Suite
$13,876
From
US$6,261
Save 6,537
Per Person
View Trip
7 Day Amalfi Coast, Cannes & Ibiza with Virgin Voyages
Cruise
 (1)

7 Days (6 Nights) Rome to Barcelona
Cruise Line: Virgin Voyages
Ship: Valiant Lady
Departure: 25 May 2026
Visit: Italy, France, Spain
With Love From the World
Inside
$1,633
Oceanview
$1,719
Balcony
$2,004
Suite
-
From
US$1,633
Per Person
View Trip
22 Day Mediterranean, Adriatic And Greece with Cunard
Cruise
 (13)

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Elizabeth
Departure: 30 July 2027
Visit: Italy, Malta, Croatia, Greece, Sicily, Corsica, Spain
Inside
$4,259
Oceanview
$4,849
Balcony
$5,809
Suite
$11,997
From
US$4,259
Per Person
View Trip
12 Day Treasures Through Time with Oceania Cruises
Cruise
 (1)

12 Days (11 Nights) Trieste to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 17 April 2027
Visit: Italy, Slovenia, Croatia, Montenegro (+4 more), Greece, Sicily, France, Spain
Your World Inclusions
Black Friday Sale + Your World Included
Exclusive Savings
Inside
$3,229
Oceanview
$4,248
Balcony
$5,169
Suite
$7,206
From
US$3,229
Save 3,369
Per Person
View Trip
15 Day Italy, France And Spain with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 13 July 2026
Visit: Italy, France, Corsica, Spain
Inside
$1,889
Oceanview
$2,099
Balcony
$2,349
Suite
$7,032
From
US$1,889
Per Person
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Rome to Valencia
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 05 October 2026
Visit: Italy, France, Spain
Inside
$289
Oceanview
$359
Balcony
$479
Suite
$849
From
US$289
Per Person
View Trip
15 Day Italy, Africa & Iberia Discovery with Viking Cruises
New ReleaseCruise

15 Days (14 Nights) Venice to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Astrea, Viking Vela
Departures: Jun 2027 to Jun 2028
Visit: Italy, Croatia, Sicily, Tunisia, Sardinia, Spain
Viking $1,499 Air Deal
Inside
-
Oceanview
-
Balcony
$9,298
Suite
$14,298
From
US$9,298
Per Person
View Trip
11 Day Italy & Spain Cruise: Florence, Marseille & Barcelona with Azamara Cruises
Cruise
 (8)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 03 March 2027
Visit: Italy, France, Spain
Azamara Always Included
Exclusive Savings
Inside
$2,646
Oceanview
$3,034
Balcony
$3,451
Suite
$5,294
From
US$2,646
Save 53
Per Person
View Trip
8 Day Italy, France & Spain Cruise: Rome, Nice & Barcelona with Azamara Cruises
Cruise
 (3)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 04 December 2027
Visit: Italy, France, Spain
Azamara Always Included
Inside
$1,609
Oceanview
$2,029
Balcony
$2,569
Suite
$3,859
From
US$1,609
Per Person
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise
 (1)

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 24 August 2026
Visit: Italy, Greece, Montenegro, Croatia, Malta, Spain
Inside
$1,779
Oceanview
$1,979
Balcony
$2,399
Suite
$7,856
From
US$1,779
Per Person
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise
 (1)

22 Days (21 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 06 July 2026
Visit: Italy, Croatia, Malta, France, Corsica, Spain
Inside
-
Oceanview
$2,759
Balcony
$2,989
Suite
$8,413
From
US$2,759
Per Person
View Trip
8 Day Italy, Spain & French Riviera with Royal Caribbean
Cruise
 (2)

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Brilliance of the Seas
Departure: 27 July 2026
Visit: Italy, France, Spain
Exclusive Savings
Inside
$1,315
Oceanview
$1,546
Balcony
$1,958
Suite
$3,876
From
US$1,315
Save 661
Per Person
View Trip
22 Day Antiquities of the Mediterranean with Viking Cruises
Cruise
 (5)

22 Days (21 Nights) Venice to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Sky
Departures: Oct 2026 to Oct 2027
Visit: Italy, Croatia, Montenegro, Greece (+5 more), Turkey, Sicily, Monaco, France, Spain
Viking $1,499 Air Deal
Inside
-
Oceanview
-
Balcony
$13,797
Suite
$21,097
From
US$13,797
Per Person
View Trip
Results: 61-90 of 127

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