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Spain Cruises Starting In September 2025

If you're looking at joining a cruise to Spain in September 2025, we have 43 unique cruise itineraries and 464 departures available, operated by thirteen of the world's leading cruise lines departing in September.
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Departures (September 2025)
< August 2025 October 2025 >
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8 Days
18 Days
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43 Cruises (464 Cruise Departures)
9 Day Cruising Southern Spain and Portugal - with Smithsonian Journeys with Ponant
Cruise
 (2)

9 Days (8 Nights) Barcelona to Lisbon
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 16 September 2025
Countries Visited: Spain, Portugal
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$10,576
SUITE
$17,916
Save (per person) 204
From (per person) 10,576
View Trip
9 Day Civitavecchia to Barcelona with Silversea
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 23 September 2025
Countries Visited: Italy, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$10,098
Save (per person) 2,602
From (per person) 10,098
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Barcelona
Cruise Line: Royal Caribbean
Ships: Allure of the Seas, Harmony of the Seas
Departures: Apr 2025 to Jul 2026
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
$1,462
OCEANVIEW
$1,756
BALCONY
$1,734
SUITE
$2,508
Save (per person) 1,088
From (per person) 1,462
View Trip
14 Day Mediterranean with P&O Cruises Worldwide
Cruise

14 Days (13 Nights) London to London
Cruise Line: P&O Cruises Worldwide
Ship: Arvia
Departure: 28 September 2025
Countries Visited: England, Spain
Latest Offer
INSIDE
$2,042
OCEANVIEW
$2,517
BALCONY
$3,079
SUITE
$4,198
From (per person) 2,042
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Rome to Rome
Cruise Line: Royal Caribbean
Ship: Allure of the Seas
Departures: May 2025 to Oct 2025
Countries Visited: Italy, Spain
Exclusive Deal
INSIDE
$1,503
OCEANVIEW
$1,826
BALCONY
$1,923
SUITE
$3,049
Save (per person) 1,206
From (per person) 1,503
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Barcelona
Cruise Line: Royal Caribbean
Ships: Allure of the Seas, Harmony of the Seas
Departures: Apr 2025 to Jun 2026
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$1,610
OCEANVIEW
$1,842
BALCONY
$1,958
SUITE
$2,777
Save (per person) 1,142
From (per person) 1,610
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: May 2025 to Oct 2025
Countries Visited: Italy, Spain, France
Seasational Sale
INSIDE
$1,395
OCEANVIEW
$1,643
BALCONY
$1,890
SUITE
$2,643
From (per person) 1,395
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+8 more), Viking Mira, Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Vesta
Departures: Feb 2025 to Sep 2027
Countries Visited: Italy, Monaco, France, Spain
Companion Fly Free
INSIDE
-
OCEANVIEW
-
BALCONY
$5,341
SUITE
$7,321
Save (per person) 659
From (per person) 5,341
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Barcelona to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departures: May 2025 to Oct 2025
Countries Visited: Spain, Italy, France
Early Booking Offer
INSIDE
$1,386
OCEANVIEW
$1,633
BALCONY
$1,732
SUITE
$2,465
From (per person) 1,386
View Trip
15 Day Canary Islands with P&O Cruises Worldwide
Cruise
 (1)

15 Days (14 Nights) London to London
Cruise Line: P&O Cruises Worldwide
Ships: Britannia, Ventura
Departures: Apr 2025 to Oct 2026
Countries Visited: England, Portugal, Spain
Latest Offer
INSIDE
$2,270
OCEANVIEW
$2,696
BALCONY
$3,129
SUITE
$5,546
From (per person) 2,270
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Genoa to Genoa
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: May 2025 to Oct 2025
Countries Visited: Italy, Spain, France
Seasational Sale
INSIDE
$1,603
OCEANVIEW
$1,782
BALCONY
$2,029
SUITE
$2,781
From (per person) 1,603
View Trip
15 Day Portugal And Canary Islands with P&O Cruises Worldwide
Cruise
 (1)

15 Days (14 Nights) London to London
Cruise Line: P&O Cruises Worldwide
Ship: Iona
Departures: Sep 2025 to Nov 2026
Countries Visited: England, Portugal, Spain
Latest Offer
INSIDE
$1,924
OCEANVIEW
$2,586
BALCONY
$3,297
SUITE
$4,694
From (per person) 1,924
View Trip
12 Day Canaries & Portugal Cruise with Celebrity Cruises
Cruise
 (1)

12 Days (11 Nights) London to London
Cruise Line: Celebrity Cruises
Ship: Celebrity Apex
Departures: Sep 2025 to Oct 2026
Countries Visited: England, Portugal, Spain
Exclusive DealNew Year Sale
INSIDE
$2,838
OCEANVIEW
$3,128
BALCONY
$3,790
SUITE
$8,112
Save (per person) 2,389
From (per person) 2,838
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Barcelona to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: May 2025 to Oct 2025
Countries Visited: Spain, France, Italy
Seasational SaleSeasational Sale With Drinks
INSIDE
$1,475
OCEANVIEW
$1,722
BALCONY
$1,940
SUITE
$2,692
From (per person) 1,475
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Palma de Mallorca to Palma de Mallorca
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: May 2025 to Oct 2025
Countries Visited: Spain, France, Italy
Seasational Sale
INSIDE
$1,603
OCEANVIEW
$1,821
BALCONY
$2,019
SUITE
$2,772
From (per person) 1,603
View Trip
8 Day Mediterranean with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Cannes to Cannes
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: May 2025 to Oct 2025
Countries Visited: France, Italy, Spain
Seasational Sale
INSIDE
$1,445
OCEANVIEW
$1,742
BALCONY
$1,940
SUITE
$2,692
From (per person) 1,445
View Trip
11 Day Flamenco & Jaleo with Regent Seven Seas
Cruise

11 Days (10 Nights) Lisbon to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 14 September 2025
Countries Visited: Portugal, Spain, France
Upgrade Your HorizonExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,644
SUITE
$9,286
Save (per person) 9,056
From (per person) 8,644
View Trip
8 Day A Journey to White Isle Bohemia & Italian Riviera Romance with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2025 to Sep 2025
Countries Visited: Spain, France, Italy
Unique Oceans Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,866
SUITE
$6,940
From (per person) 5,866
View Trip
18 Day Crossing the Equator: Portugal to Brazil with Scenic
Cruise

18 Days (17 Nights) Lisbon to Rio de Janeiro
Cruise Line: Scenic
Ship: Scenic Eclipse I
Departure: 24 September 2025
Countries Visited: Portugal, Spain, Brazil
Mutiple Deals Available
INSIDE
-
OCEANVIEW
-
BALCONY
$10,619
SUITE
$15,559
Save (per person) 13,101
From (per person) 10,619
View Trip
12 Day Lisbon to Monte Carlo with Silversea
Cruise

12 Days (11 Nights) Lisbon to Monte Carlo
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 24 September 2025
Countries Visited: Portugal, Gibraltar, Spain, Monaco
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
$12,177
SUITE
$20,295
Save (per person) 4,123
From (per person) 12,177
View Trip
8 Day Western Europe with MSC Cruises
Cruise

8 Days (7 Nights) London to London
Cruise Line: MSC Cruises
Ship: MSC Virtuosa
Departure: 27 September 2025
Countries Visited: England, Spain, France
Seasational Sale
INSIDE
$1,485
OCEANVIEW
$1,871
BALCONY
$2,019
SUITE
$3,128
From (per person) 1,485
View Trip
15 Day Mediterranean with P&O Cruises Worldwide
Cruise

15 Days (14 Nights) London to London
Cruise Line: P&O Cruises Worldwide
Ship: Arvia
Departures: Mar 2025 to Sep 2026
Countries Visited: England, Spain, France
Latest Offer
INSIDE
$2,171
OCEANVIEW
$2,696
BALCONY
$3,080
SUITE
$4,180
From (per person) 2,171
View Trip
10 Day Spanish Flair Cruise with Royal Caribbean
Cruise

10 Days (9 Nights) London to London
Cruise Line: Royal Caribbean
Ships: Independence of the Seas, Liberty of the Seas
Departures: Jun 2025 to Sep 2026
Countries Visited: England, Spain, Portugal
Exclusive Deal
INSIDE
$1,909
OCEANVIEW
$2,243
BALCONY
$2,758
SUITE
$4,283
Save (per person) 1,324
From (per person) 1,909
View Trip
11 Day Iberian Embrace with Oceania Cruises
Cruise

11 Days (10 Nights) Bilbao to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 04 September 2025
Countries Visited: Spain, Portugal, Morocco
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,586
SUITE
$11,438
Save (per person) 2,074
From (per person) 8,586
View Trip
17 Day Escapades In Iberia with Regent Seven Seas
Cruise

17 Days (16 Nights) Paris to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 September 2025
Countries Visited: France, Spain, Portugal
Exclusive DealUpgrade Your Horizon
INSIDE
-
OCEANVIEW
-
BALCONY
$21,887
SUITE
$22,778
Save (per person) 11,203
From (per person) 21,887
View Trip
15 Day Canary Islands with P&O Cruises Worldwide
Cruise

15 Days (14 Nights) London to London
Cruise Line: P&O Cruises Worldwide
Ship: Ventura
Departure: 20 September 2025
Countries Visited: England, Portugal, Spain
Latest Offer
INSIDE
$2,369
OCEANVIEW
$2,597
BALCONY
$3,298
SUITE
$5,397
From (per person) 2,369
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: May 2025 to Sep 2026
Countries Visited: Italy, France, Spain
Exclusive DealNew Year Sale
INSIDE
$2,019
OCEANVIEW
$2,018
BALCONY
$2,272
SUITE
$7,721
Save (per person) 1,883
From (per person) 2,018
View Trip
8 Day Spain & France Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) London to London
Cruise Line: Royal Caribbean
Ship: Independence of the Seas
Departure: 22 September 2025
Countries Visited: England, France, Spain
Exclusive Deal
INSIDE
$1,569
OCEANVIEW
$2,030
BALCONY
$2,126
SUITE
$3,572
Save (per person) 883
From (per person) 1,569
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Valencia to Valencia
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departures: May 2025 to Oct 2025
Countries Visited: Spain, Italy, France
Early Booking Offer
INSIDE
$1,376
OCEANVIEW
$1,653
BALCONY
$1,692
SUITE
$2,603
From (per person) 1,376
View Trip
9 Day Monte Carlo to Rome with Silversea
Cruise

9 Days (8 Nights) Monte Carlo to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 07 September 2025
Countries Visited: Monaco, France, Spain, Italy
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$10,098
Save (per person) 2,602
From (per person) 10,098
View Trip
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