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Italy Cruises Starting In April 2025

If you're looking at joining a cruise to Italy in April 2025, we have 72 unique cruise itineraries and 562 departures available, operated by seventeen of the world's leading cruise lines departing in April.
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Departures (April 2025)
< March 2025 May 2025 >
Duration
2 Days
26 Days
Countries Visited
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$200pp
$53,820pp
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72 Cruises (562 Cruise Departures)
3 Day Mediterranean with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 16 April 2025
Countries Visited: Italy, Spain
Exclusive Deal
INSIDE
$433
OCEANVIEW
$512
BALCONY
$621
SUITE
$1,017
From (per person) 433
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (1)

6 Days (5 Nights) Rome to Rome
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 16 April 2025
Countries Visited: Italy, Spain
Seasational Sale
INSIDE
$1,220
OCEANVIEW
$1,378
BALCONY
$1,507
SUITE
$2,378
From (per person) 1,220
View Trip
3 Day Mediterranean with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Marseille to Naples
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 24 April 2025
Countries Visited: France, Italy
Exclusive Deal
INSIDE
$532
OCEANVIEW
$621
BALCONY
$671
SUITE
$1,017
From (per person) 532
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (1)

6 Days (5 Nights) Genoa to Genoa
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 17 April 2025
Countries Visited: Italy, Spain
Seasational Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$1,656
SUITE
-
From (per person) 1,656
View Trip
12 Day Venice and Croatian Islands Cruise with Collette
Tour + Cruise

12 Days Split to Venice or Venice to Split
Operated By: Collette
Departures: Apr 2025 to May 2026
Trip Styles: Coach, Cruise, Island Hopping, Scenic
Countries Visited: Croatia, Italy
Latest Offer
Save (per person) 316
From (per person) 5,830
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Marseille to Marseille
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 21 April 2025
Countries Visited: France, Italy
Early Booking Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$463
SUITE
$760
From (per person) 463
View Trip
8 Day Sublime Mediterranean with Regent Seven Seas
Cruise

8 Days (7 Nights) Barcelona to Monte Carlo
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 13 April 2025
Countries Visited: Spain, Italy, Monaco
Gift Of TravelExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$5,025
SUITE
$5,464
Save (per person) 9,165
From (per person) 5,025
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Barcelona
Cruise Line: Royal Caribbean
Ships: Allure of the Seas, Harmony of the Seas
Departures: Apr 2025 to Jul 2026
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
$1,447
OCEANVIEW
$1,722
BALCONY
$1,711
SUITE
$2,483
Save (per person) 1,103
From (per person) 1,447
View Trip
5 Day Mediterranean with MSC Cruises
Cruise

5 Days (4 Nights) Venice to Athens
Cruise Line: MSC Cruises
Ship: MSC Armonia
Departure: 20 April 2025
Countries Visited: Italy, Greece
Exclusive Deal
INSIDE
$657
OCEANVIEW
$756
BALCONY
$1,122
SUITE
$1,350
From (per person) 657
View Trip
2 Day Mediterranean with MSC Cruises
Cruise

2 Days (1 Nights) Genoa to Marseille
Cruise Line: MSC Cruises
Ships: MSC Divina, MSC Magnifica, MSC Musica
Departures: Jan 2025 to Oct 2025
Countries Visited: Italy, France
Exclusive Deal
INSIDE
$267
OCEANVIEW
$306
BALCONY
$355
SUITE
$653
From (per person) 267
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Barcelona
Cruise Line: Royal Caribbean
Ships: Allure of the Seas, Harmony of the Seas
Departures: Apr 2025 to Jun 2026
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$1,595
OCEANVIEW
$1,793
BALCONY
$1,935
SUITE
$2,752
Save (per person) 1,155
From (per person) 1,595
View Trip
8 Day Mediterranean with Greek Isles & Turkey with Princess
Cruise
 (2)

8 Days (7 Nights) Rome to Athens
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2025 to Sep 2025
Countries Visited: Italy, Greece, Turkey
Exclusive Deal
INSIDE
$1,901
OCEANVIEW
$2,582
BALCONY
$3,089
SUITE
$3,495
From (per person) 1,901
View Trip
26 Day Northern Italy, Slovenia & Croatia with Bunnik Tours
Tour + Cruise
 (5)

26 Days Milan to Dubrovnik
Operated By: Bunnik Tours
Departures: Apr 2025 to Sep 2025
Trip Styles: Coach, Small Group, Cruise, Island Hopping, Scenic
Countries Visited: Italy, Slovenia, Croatia
Exclusive Savings
Save (per person) 347
From (per person) 17,256
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Genoa to Malaga
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 16 April 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$580
OCEANVIEW
-
BALCONY
$837
SUITE
-
From (per person) 580
View Trip
5 Day Mediterranean with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Genoa to Genoa
Cruise Line: MSC Cruises
Ships: MSC Fantasia, MSC Splendida
Departures: Apr 2025 to Nov 2025
Countries Visited: Italy, Spain, France
Early Booking OfferSeasational Sale
INSIDE
$608
OCEANVIEW
$736
BALCONY
$806
SUITE
$1,221
From (per person) 608
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Istanbul to Bari
Cruise Line: MSC Cruises
Ships: MSC Fantasia, MSC Sinfonia
Departures: Apr 2025 to May 2025
Countries Visited: Turkey, Greece, Italy
Exclusive Deal
INSIDE
$431
OCEANVIEW
$560
BALCONY
$837
SUITE
$995
From (per person) 431
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (2)

4 Days (3 Nights) Genoa to Valletta
Cruise Line: MSC Cruises
Ship: MSC World Europa
Departure: 13 April 2025
Countries Visited: Italy, Sicily, Malta
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$2,380
From (per person) 2,380
View Trip
7 Day Mediterranean with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Barcelona to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 18 April 2025
Countries Visited: Spain, Italy, France
Seasational Sale
INSIDE
$1,397
OCEANVIEW
$1,595
BALCONY
$1,823
SUITE
$2,793
From (per person) 1,397
View Trip
13 Day Italy Intensive Voyage with Azamara Cruises
Cruise
 (1)

13 Days (12 Nights) Rome to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 11 April 2025
Countries Visited: Italy, Sicily, Montenegro
INSIDE
$5,685
OCEANVIEW
$6,120
BALCONY
$6,853
SUITE
$11,852
From (per person) 5,685
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (1)

6 Days (5 Nights) Genoa to Amalfi
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 21 April 2025
Countries Visited: Italy, Spain, France
Seasational Sale
INSIDE
$1,111
OCEANVIEW
$1,210
BALCONY
$1,309
SUITE
$2,755
From (per person) 1,111
View Trip
5 Day Mediterranean with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Barcelona to Barcelona
Cruise Line: MSC Cruises
Ships: MSC Fantasia, MSC Splendida
Departures: Apr 2025 to Nov 2025
Countries Visited: Spain, France, Italy
Early Booking OfferSave And Sail Offer
INSIDE
$608
OCEANVIEW
$736
BALCONY
$806
SUITE
$1,221
From (per person) 608
View Trip
9 Day Croatia Intensive Voyage with Azamara Cruises
Cruise
 (1)

9 Days (8 Nights) Venice to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 23 April 2025
Countries Visited: Italy, Croatia, Montenegro
INSIDE
$4,079
OCEANVIEW
$4,762
BALCONY
$5,524
SUITE
$11,583
From (per person) 4,079
View Trip
5 Day Mediterranean with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Marseille to Marseille
Cruise Line: MSC Cruises
Ships: MSC Fantasia, MSC Splendida
Departures: Apr 2025 to Nov 2025
Countries Visited: France, Italy, Spain
Early Booking OfferSeasational Sale
INSIDE
$608
OCEANVIEW
$736
BALCONY
$806
SUITE
$1,320
From (per person) 608
View Trip
3 Day Mediterranean with MSC Cruises
Cruise
 (1)

3 Days (2 Nights) Barcelona to Genoa
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 19 April 2025
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$591
SUITE
-
From (per person) 591
View Trip
4 Day Mediterranean with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 23 April 2025
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$738
OCEANVIEW
$906
BALCONY
$966
SUITE
$1,382
From (per person) 738
View Trip
8 Day Southern France and the Italian Riviera by Sea – with Smithsonian Journeys with Ponant
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Ponant
Ship: Le Bougainville
Departure: 26 April 2025
Countries Visited: Spain, France, Italy
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$9,761
SUITE
$14,818
Save (per person) 189
From (per person) 9,761
View Trip
6 Day Mediterranean with MSC Cruises
Cruise
 (1)

6 Days (5 Nights) Amalfi to Istanbul
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 26 April 2025
Countries Visited: Italy, Greece, Turkey
Exclusive Deal
INSIDE
-
OCEANVIEW
$992
BALCONY
$1,131
SUITE
$1,636
From (per person) 992
View Trip
7 Day Mediterranean with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Genoa to Istanbul
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 25 April 2025
Countries Visited: Italy, Greece, Turkey
Exclusive Deal
INSIDE
-
OCEANVIEW
$1,001
BALCONY
$1,209
SUITE
$1,852
From (per person) 1,001
View Trip
8 Day Mediterranean Highlights with Cunard
Cruise
 (3)

8 Days (7 Nights) London to Rome
Cruise Line: Cunard
Ship: Queen Mary 2
Departure: 13 April 2025
Countries Visited: England, Spain, Italy
Experience Like No Other
INSIDE
$2,130
OCEANVIEW
$2,724
BALCONY
$2,922
SUITE
$5,922
From (per person) 2,130
View Trip
5 Day Mediterranean with MSC Cruises
Cruise

5 Days (4 Nights) Barcelona to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Splendida
Departure: 20 April 2025
Countries Visited: Spain, France, Italy
Early Booking Offer
INSIDE
$756
OCEANVIEW
$885
BALCONY
$954
SUITE
$1,370
From (per person) 756
View Trip
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