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All South America Cruises

All aboard for a spectacular cruising adventure discovering the treasures of South America, Argentina, Chile & Patagonia. Click here if you are interested in an Antarctic cruise departing from South America. Choose from 2,219 expeditions and cruises around South America travelling with the world's leading cruise lines.
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134 Days
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410 Cruises (2,219 Cruise Departures)
30 Day Ultimate South America with Brazil's Amazon & Galapagos Cruise with Cosmos
Tour + Cruise
 (3)

30 Days Manaus to Guayaquil
Operated By: Cosmos
Departures: Apr 2025 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador (+1 more), Galapagos
Exclusive Savings
Save (per person) 264
From (per person) 16,983
View Trip
10 Day Complete Galapagos (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Jan 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Cyber Sale
Save (per person) 3,118
From (per person) 7,360
View Trip
7 Day Galapagos Explorer: Southern Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

7 Days (6 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Dec 2024 to Dec 2025
Countries Visited: Ecuador, Galapagos
Cyber Sale
Save (per person) 1,073
From (per person) 5,744
View Trip
33 Day Highlights of South America and Chilean Fjords Cruise with Travelmarvel
Tour + Cruise
 (1)

33 Days Rio de Janeiro to Lima
Operated By: Travelmarvel
Departure: 01 March 2026
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Brazil, Argentina, Uruguay, Falkland Islands (+2 more), Chile, Peru
Exclusive Deal
Save (per person) 1,544
From (per person) 17,851
View Trip
33 Day Highlights of South America and Chilean Fjords Cruise with Travelmarvel
Tour + Cruise
 (1)

33 Days Santiago to Lima
Operated By: Travelmarvel
Departure: 20 February 2026
Trip Styles: Coach, Cruise, Scenic
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay (+2 more), Brazil, Peru
Exclusive Deal
Save (per person) 1,546
From (per person) 17,649
View Trip
13 Day Treasures of Galapagos: Western & Central Islands (Grand Queen Beatriz) with Intrepid Travel
Cruise
 (1)

13 Days (12 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Feb 2025 to Dec 2025
Countries Visited: Ecuador, Galapagos
Exclusive Savings
Save (per person) 287
From (per person) 14,041
View Trip
10 Day Ultimate Galapagos: Central Islands (Grand Daphne) with Intrepid Travel
Cruise
 (1)

10 Days (9 Nights) Quito to Quito
Operated By: Intrepid Travel
Departures: Dec 2024 to Dec 2025
Countries Visited: Ecuador, Galapagos
Cyber Sale
Save (per person) 1,599
From (per person) 8,799
View Trip
26 Day Ultimate South America with a Galapagos Cruise with Cosmos
Tour + Cruise
 (1)

26 Days Rio de Janeiro to Guayaquil
Operated By: Cosmos
Departures: Apr 2025 to Nov 2026
Trip Styles: Coach, Cruise, Island Hopping, Wildlife, Scenic
Countries Visited: Brazil, Argentina, Peru, Ecuador (+1 more), Galapagos
Exclusive Savings
Save (per person) 227
From (per person) 14,607
View Trip
18 Day Panama Canal & Inca Discovery with Holland America
Cruise
 (2)

18 Days (17 Nights) Fort Lauderdale to San Antonio
Cruise Line: Holland America
Ship: Oosterdam
Departure: 17 November 2025
Countries Visited: USA, Cayman Islands, Panama, Ecuador (+2 more), Peru, Chile
Have It All Offer
INSIDE
$5,439
OCEANVIEW
$5,835
BALCONY
$6,924
SUITE
$9,300
From (per person) 5,439
View Trip
8 Day South America with MSC Cruises
Cruise
 (1)

8 Days (7 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 08 February 2025
Countries Visited: Brazil
Save And Sail Offer
INSIDE
$1,054
OCEANVIEW
$1,252
BALCONY
$1,529
SUITE
$2,826
From (per person) 1,054
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Santos to Santos
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 26 December 2025
Countries Visited: Brazil
Early Booking Offer
INSIDE
$2,454
OCEANVIEW
$2,820
BALCONY
$3,117
SUITE
$3,899
From (per person) 2,454
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 28 December 2024
Countries Visited: Brazil
Save And Sail Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$3,255
SUITE
-
From (per person) 3,255
View Trip
15 Day South America Passage with Holland America
Cruise
 (2)

15 Days (14 Nights) Buenos Aires to San Antonio
Cruise Line: Holland America
Ship: Oosterdam
Departures: Mar 2025 to Mar 2026
Countries Visited: Argentina, Uruguay, Falkland Islands, Chile
Have It All OfferFlash Deal
INSIDE
$2,884
OCEANVIEW
$2,953
BALCONY
$4,765
SUITE
$5,824
From (per person) 2,884
View Trip
11 Day South America with MSC Cruises
Cruise
 (1)

11 Days (10 Nights) Buenos Aires to Buenos Aires
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 26 December 2025
Countries Visited: Argentina, Brazil, Uruguay
Early Booking Offer
INSIDE
$2,589
OCEANVIEW
$3,074
BALCONY
$3,262
SUITE
$4,292
From (per person) 2,589
View Trip
14 Day Chile, Peru & Panama Voyage with Azamara Cruises
Cruise
 (1)

14 Days (13 Nights) San Antonio to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 March 2026
Countries Visited: Chile, Peru, Panama
Circle Club Voyage
INSIDE
$6,559
OCEANVIEW
$7,182
BALCONY
$9,073
SUITE
$11,796
From (per person) 6,559
View Trip
15 Day Chilean Fjords — Discovering The Heart Of Patagonia (Southbound) with HX Hurtigruten Expeditions
Cruise
 (1)

15 Days (14 Nights) Valparaiso to Buenos Aires
Ship: MS Fridtjof Nansen
Departures: Oct 2025 to Oct 2026
Countries Visited: Chile, Argentina
Wave Offer
INSIDE
-
OCEANVIEW
$9,559
BALCONY
-
SUITE
$12,304
Save (per person) 2,431
From (per person) 9,559
View Trip
11 Day South America with MSC Cruises
Cruise
 (1)

11 Days (10 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 25 December 2025
Countries Visited: Uruguay, Argentina, Brazil
Early Booking Offer
INSIDE
$2,708
OCEANVIEW
$3,074
BALCONY
$3,312
SUITE
$4,510
From (per person) 2,708
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 29 December 2025
Countries Visited: Brazil
Early Booking Offer
INSIDE
$2,454
OCEANVIEW
$2,731
BALCONY
$3,117
SUITE
$4,622
From (per person) 2,454
View Trip
20 Day Falklands, South Georgia & Valdes Peninsula: In The Heart Of The Wilderness with Ponant
Cruise
 (1)

20 Days (19 Nights) Buenos Aires to Buenos Aires
Cruise Line: Ponant
Ship: Le Boreal
Departure: 11 March 2025
Countries Visited: Argentina, Falkland Islands, South Georgia Island
Exclusive Savings
INSIDE
-
OCEANVIEW
$17,393
BALCONY
$18,569
SUITE
$28,614
Save (per person) 327
From (per person) 17,393
View Trip
7 Day South America with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 13 December 2025
Countries Visited: Brazil
Early Booking Offer
INSIDE
$1,259
OCEANVIEW
$1,526
BALCONY
$1,754
SUITE
$2,377
From (per person) 1,259
View Trip
4 Day South America with MSC Cruises
Cruise
 (1)

4 Days (3 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 05 January 2025
Countries Visited: Brazil
Early Booking Offer
INSIDE
$1,159
OCEANVIEW
$1,406
BALCONY
$1,901
SUITE
$2,911
From (per person) 1,159
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Sao Paulo to São Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departures: Jan 2025 to Mar 2025
Countries Visited: Brazil
Early Booking OfferSave And Sail Offer
INSIDE
$835
OCEANVIEW
$915
BALCONY
$1,103
SUITE
$1,548
From (per person) 835
View Trip
15 Day South America Passage with Holland America
Cruise
 (2)

15 Days (14 Nights) San Antonio to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departures: Dec 2025 to Feb 2026
Countries Visited: Chile, Argentina, Falkland Islands, Uruguay
Have It All Offer
INSIDE
$4,219
OCEANVIEW
$4,615
BALCONY
$5,803
SUITE
$7,288
From (per person) 4,219
View Trip
7 Day South America with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Salvador to Salvador
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 16 December 2025
Countries Visited: Brazil
Early Booking Offer
INSIDE
$1,259
OCEANVIEW
$1,526
BALCONY
$1,754
SUITE
-
From (per person) 1,259
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departures: Jan 2025 to Jan 2025
Countries Visited: Brazil, Argentina, Uruguay
Save And Sail Offer
INSIDE
$1,443
OCEANVIEW
$1,493
BALCONY
$1,938
SUITE
$3,364
From (per person) 1,443
View Trip
7 Day South America with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 02 February 2025
Countries Visited: Brazil
Save And Sail Offer
INSIDE
$912
OCEANVIEW
$1,080
BALCONY
$1,318
SUITE
$2,436
From (per person) 912
View Trip
23 Day Barbados To Brazil & Buenos Aires Voyage with Azamara Cruises
Cruise
 (1)

23 Days (22 Nights) Bridgetown to Buenos Aires
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 17 January 2026
Countries Visited: Barbados, Trinidad and Tobago, French Guiana, Brazil (+2 more), Uruguay, Argentina
Circle Club Voyage
INSIDE
$10,250
OCEANVIEW
$10,884
BALCONY
$13,349
SUITE
$20,348
From (per person) 10,250
View Trip
5 Day South America with MSC Cruises
Cruise
 (1)

5 Days (4 Nights) Sao Paulo to Sao Paulo
Cruise Line: MSC Cruises
Ship: MSC Seaview
Departure: 20 March 2025
Countries Visited: Brazil
Save And Sail Offer
INSIDE
$786
OCEANVIEW
$915
BALCONY
$1,103
SUITE
$1,548
From (per person) 786
View Trip
7 Day South America with MSC Cruises
Cruise
 (1)

7 Days (6 Nights) Rio de Janeiro to Rio de Janeiro
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departures: Jan 2025 to Feb 2025
Countries Visited: Brazil
Save And Sail Offer
INSIDE
$912
OCEANVIEW
$1,080
BALCONY
$1,318
SUITE
$2,436
From (per person) 912
View Trip
9 Day South America with MSC Cruises
Cruise
 (1)

9 Days (8 Nights) Montevideo to Montevideo
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departures: Nov 2025 to Mar 2026
Countries Visited: Uruguay, Argentina, Brazil
Early Booking Offer
INSIDE
$1,375
OCEANVIEW
$1,662
BALCONY
$1,850
SUITE
$2,820
From (per person) 1,375
View Trip
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South & Central America Cruises

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Travel Styles

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Cities

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Routes

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Country Routes

Cruises from USA to Portugal Cruises from USA to Germany Cruises from Italy to England Cruises from Germany to England Cruises from France to Spain Cruises from Portugal to England Cruises from Portugal to France Cruises from Chile to USA Cruises from France to Brazil Cruises from France to USA Cruises from England to Canada Cruises from England to Germany Cruises from Dominican Republic to USA Cruises from Brazil to Spain Cruises from Canada to England Cruises from Argentina to Brazil Cruises from USA to Brazil Cruises from Argentina to Chile Cruises from Brazil to Italy Cruises from Argentina to USA Cruises from Peru to USA Cruises from Barbados to USA Cruises from Brazil to Argentina Cruises from Canada to USA Cruises from Chile to Argentina Cruises from England to Denmark Cruises from England to Italy Cruises from England to Spain Cruises from England to USA Cruises from France to Italy Cruises from French Polynesia to USA Cruises from Italy to Brazil Cruises from Italy to France Cruises from Italy to Portugal Cruises from Italy to Spain Cruises from Italy to USA Cruises from Panama to USA Cruises from Spain to Brazil Cruises from Peru to Ecuador Cruises from Portugal to Italy Cruises from Portugal to Spain Cruises from Portugal to USA Cruises from Spain to France Cruises from Spain to Italy Cruises from Spain to Portugal Cruises from Spain to USA Cruises from USA to Australia Cruises from USA to Barbados Cruises from USA to Canada Cruises from England to Portugal Cruises from USA to Chile Cruises from USA to England Cruises from USA to French Polynesia Cruises from USA to Holland Cruises from USA to Italy Cruises from Spain to England Cruises from USA to Panama Cruises from USA to Spain

Cruise Lines Exploring South & Central America

Azamara South America Cruises Celebrity Central America Cruises Cunard Central America Cruises HX Hurtigruten South America Expeditions MSC South America Cruises NCL Central America Cruises Oceania South America Cruises Ponant Central America Cruises Ponant South America Cruises Princess South America Cruises Regent Seven Seas South America Cruises Royal Caribbean Central America Cruises Seabourn South America Cruises Silversea South America Cruises Viking South America Cruises Viking Central America Cruises

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